Fgf23 (fibroblast growth factor 23) - Rat Genome Database

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Gene: Fgf23 (fibroblast growth factor 23) Rattus norvegicus
Analyze
Symbol: Fgf23
Name: fibroblast growth factor 23
RGD ID: 620178
Description: Predicted to enable growth factor activity and type 1 fibroblast growth factor receptor binding activity. Involved in several processes, including cellular response to leptin stimulus; cellular response to parathyroid hormone stimulus; and cellular response to vitamin D. Located in extracellular space. Biomarker of chronic kidney disease and uremia. Human ortholog(s) of this gene implicated in autosomal dominant hypophosphatemic rickets. Orthologous to human FGF23 (fibroblast growth factor 23); PARTICIPATES IN fibroblast growth factor signaling pathway; melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FGF-23; Fgf8b; fibroblast growth factor 8b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,600,439 - 161,609,991 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4161,600,383 - 161,609,991 (+)EnsemblGRCr8
mRatBN7.24159,914,267 - 159,923,821 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,914,272 - 159,923,821 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4166,144,203 - 166,151,883 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,927,113 - 161,934,785 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,561,155 - 160,568,833 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,622,404 - 159,630,082 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,622,404 - 159,630,082 (+)Ensemblrn6Rnor6.0
Rnor_5.04231,971,932 - 231,990,610 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44163,468,604 - 163,476,325 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4148,629,372 - 148,637,127 (+)NCBICelera
RGSC_v3.14163,713,539 - 163,721,261 (+)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid  (ISO)
adenine  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
chondroitin sulfate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
D-mannitol  (EXP,ISO)
dermatan sulfate  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dibenzofurans  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
ethylparaben  (ISO)
folic acid  (ISO)
glycerol 2-phosphate  (ISO)
heparin  (ISO)
hyaluronic acid  (ISO)
hydrazine  (ISO)
lipopolysaccharide  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
ozone  (ISO)
pamidronate  (ISO)
paracetamol  (ISO)
PD 0325901  (EXP)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenylarsine oxide  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (EXP)
ranitidine  (EXP)
resveratrol  (ISO)
SB 203580  (ISO)
silicon dioxide  (ISO)
sodium atom  (ISO)
sodium chlorate  (ISO)
sodium chloride  (EXP,ISO)
tetrachloromethane  (EXP)
theophylline  (EXP)
titanium dioxide  (ISO)
valproic acid  (ISO)
vitamin D  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Intravenous phosphate loading increases fibroblast growth factor 23 in uremic rats. Arai-Nunota N, etal., PLoS One. 2014 Mar 13;9(3):e91096. doi: 10.1371/journal.pone.0091096. eCollection 2014.
2. The parathyroid is a target organ for FGF23 in rats. Ben-Dov IZ, etal., J Clin Invest. 2007 Dec;117(12):4003-8.
3. The relationship between fibroblast growth factor 23 and osteoporosis in postmenopausal women. Celik E, etal., Minerva Med. 2013 Oct;104(5):497-504.
4. Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23. DeLuca S, etal., J Pathol. 2008 Nov;216(3):345-55. doi: 10.1002/path.2409.
5. Fibroblast growth factor 23 contributes to diminished bone mineral density in childhood inflammatory bowel disease. El-Hodhod MA, etal., BMC Gastroenterol. 2012 May 2;12:44. doi: 10.1186/1471-230X-12-44.
6. Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Galitzer H, etal., Kidney Int. 2010 Feb;77(3):211-8. doi: 10.1038/ki.2009.464. Epub 2009 Dec 16.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. An autosomal dominant hypophosphatemic rickets phenotype in a Tunisian family caused by a new FGF23 missense mutation. Gribaa M, etal., J Bone Miner Metab. 2010;28(1):111-5. doi: 10.1007/s00774-009-0111-5. Epub 2009 Aug 5.
9. Premature aging in vitamin D receptor mutant mice. Keisala T, etal., J Steroid Biochem Mol Biol. 2009 Jul;115(3-5):91-7. doi: 10.1016/j.jsbmb.2009.03.007. Epub 2009 Mar 31.
10. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Larsson T, etal., Endocrinology. 2004 Jul;145(7):3087-94. Epub 2004 Feb 26.
11. PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Lavi-Moshayoff V, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F882-9. doi: 10.1152/ajprenal.00360.2010. Epub 2010 Aug 4.
12. Magnesium deficiency increases serum fibroblast growth factor-23 levels in rats. Matsuzaki H, etal., Magnes Res. 2013 Jan-Feb;26(1):18-23. doi: 10.1684/mrh.2013.0331.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men. Mirza MA, etal., J Bone Miner Res. 2011 Apr;26(4):857-64. doi: 10.1002/jbmr.263.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. NO_AUTHOR Nat Genet. 2000 Nov;26(3):345-8.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. 1,25-dihydroxyvitamin D(3) regulation of fibroblast growth factor-23 expression in bone cells: evidence for primary and secondary mechanisms modulated by leptin and interleukin-6. Saini RK, etal., Calcif Tissue Int. 2013 Apr;92(4):339-53. doi: 10.1007/s00223-012-9683-5. Epub 2012 Dec 22.
24. Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production. Saito H, etal., J Biol Chem 2003 Jan 24;278(4):2206-11. Epub 2002 Nov 04.
25. Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo. Saito H, etal., J Biol Chem. 2005 Jan 28;280(4):2543-9. Epub 2004 Nov 5.
26. Regulation of fibroblast growth factor 23 production in bone in uremic rats. Saji F, etal., Nephron Physiol. 2009;111(4):p59-66. doi: 10.1159/000210389. Epub 2009 Apr 1.
27. Label-free quantitative proteomics identifies Smarca4 is involved in vascular calcification. Wang C, etal., Ren Fail. 2019 Nov;41(1):220-228. doi: 10.1080/0886022X.2019.1591997.
28. Renal expression of FGF23 in progressive renal disease of diabetes and the effect of ACE inhibitor. Zanchi C, etal., PLoS One. 2013 Aug 14;8(8):e70775. doi: 10.1371/journal.pone.0070775. eCollection 2013.
Additional References at PubMed
PMID:11409890   PMID:15040831   PMID:15579309   PMID:16020653   PMID:16436388   PMID:16638743   PMID:17086194   PMID:17350357   PMID:18282132   PMID:18442315   PMID:19628670   PMID:19966287  
PMID:20200094   PMID:20844473   PMID:21525854   PMID:22006328   PMID:23872713   PMID:24088960   PMID:24259513   PMID:24373521   PMID:24402093   PMID:24801007   PMID:25792238   PMID:25858796  
PMID:26186634   PMID:26311115   PMID:26631141   PMID:26657069   PMID:26878191   PMID:27457912   PMID:27624533   PMID:28339837   PMID:28341272   PMID:28694529   PMID:28782829   PMID:29073196  
PMID:29395333   PMID:29518087   PMID:29633272   PMID:29882057   PMID:30365152   PMID:30539338   PMID:30921339   PMID:31001900   PMID:31540546   PMID:32184468   PMID:32699940   PMID:32901861  
PMID:34184338   PMID:34731356   PMID:35011602   PMID:35091320   PMID:35268016   PMID:35373859   PMID:36102251   PMID:37704925   PMID:37814911   PMID:37992803   PMID:38134554  


Genomics

Comparative Map Data
Fgf23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,600,439 - 161,609,991 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4161,600,383 - 161,609,991 (+)EnsemblGRCr8
mRatBN7.24159,914,267 - 159,923,821 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,914,272 - 159,923,821 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4166,144,203 - 166,151,883 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,927,113 - 161,934,785 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,561,155 - 160,568,833 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,622,404 - 159,630,082 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,622,404 - 159,630,082 (+)Ensemblrn6Rnor6.0
Rnor_5.04231,971,932 - 231,990,610 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44163,468,604 - 163,476,325 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4148,629,372 - 148,637,127 (+)NCBICelera
RGSC_v3.14163,713,539 - 163,721,261 (+)NCBI
Cytogenetic Map4q42NCBI
FGF23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38124,368,227 - 4,379,712 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl124,368,227 - 4,379,712 (-)Ensemblhg38GRCh38
GRCh37124,477,393 - 4,488,878 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,347,654 - 4,359,155 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34124,347,653 - 4,359,155NCBI
Celera126,099,463 - 6,110,952 (-)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef124,334,034 - 4,345,523 (-)NCBIHuRef
CHM1_1124,477,002 - 4,488,504 (-)NCBICHM1_1
T2T-CHM13v2.0124,375,010 - 4,386,480 (-)NCBIT2T-CHM13v2.0
Fgf23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396127,049,865 - 127,059,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6127,049,865 - 127,058,371 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386127,072,902 - 127,082,296 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6127,072,902 - 127,081,408 (+)Ensemblmm10GRCm38
MGSCv376127,022,920 - 127,031,426 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366127,038,593 - 127,046,844 (+)NCBIMGSCv36mm8
Celera6128,754,493 - 128,762,966 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.92NCBI
Fgf23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554132,182,459 - 2,192,279 (-)Ensembl
ChiLan1.0NW_0049554132,182,459 - 2,192,279 (-)NCBIChiLan1.0ChiLan1.0
FGF23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2109,910,396 - 9,919,599 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1129,902,683 - 9,916,357 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0124,479,116 - 4,488,797 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,400,802 - 4,412,000 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,400,802 - 4,412,000 (-)EnsemblpanPan2panpan1.1
FGF23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12740,501,655 - 40,511,785 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2740,501,731 - 40,509,766 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha276,170,287 - 6,180,384 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02740,857,426 - 40,867,540 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2740,857,191 - 40,866,460 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12740,746,195 - 40,756,275 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,771,149 - 40,781,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,580,979 - 5,591,077 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fgf23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945104,622,105 - 104,630,138 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366064,555,034 - 4,561,961 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366064,555,034 - 4,561,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl566,028,776 - 66,038,740 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1566,028,591 - 66,038,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2568,250,524 - 68,260,006 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,398,318 - 4,408,415 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,398,675 - 4,407,209 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660633,836,189 - 3,845,260 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248601,479,303 - 1,486,323 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248601,478,712 - 1,486,808 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fgf23
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1620,820,952 - 20,828,685 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fgf23
31 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:63
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000026888
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 3 23 86 28 27 7 56 7 6 124 95 9 70 13 22 20 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000078299   ⟹   ENSRNOP00000075536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4159,622,404 - 159,630,082 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107111   ⟹   ENSRNOP00000087703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4161,600,383 - 161,609,991 (+)Ensembl
mRatBN7.2 Ensembl4159,914,272 - 159,923,821 (+)Ensembl
RefSeq Acc Id: NM_130754   ⟹   NP_570110
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84161,600,439 - 161,609,991 (+)NCBI
mRatBN7.24159,914,267 - 159,923,821 (+)NCBI
Rnor_6.04159,622,404 - 159,630,082 (+)NCBI
Rnor_5.04231,971,932 - 231,990,610 (-)NCBI
RGSC_v3.44163,468,604 - 163,476,325 (+)RGD
Celera4148,629,372 - 148,637,127 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_570110 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB84108 (Get FASTA)   NCBI Sequence Viewer  
  EDM01818 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087703
  ENSRNOP00000087703.1
GenBank Protein Q8VI82 (Get FASTA)   NCBI Sequence Viewer  
  VDK10967 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_570110   ⟸   NM_130754
- Peptide Label: precursor
- UniProtKB: Q8VI82 (UniProtKB/Swiss-Prot),   A6ILX1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075536   ⟸   ENSRNOT00000078299
Ensembl Acc Id: ENSRNOP00000087703   ⟸   ENSRNOT00000107111

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VI82-F1-model_v2 AlphaFold Q8VI82 1-251 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620178 AgrOrtholog
BioCyc Gene G2FUF-42950 BioCyc
Ensembl Genes ENSRNOG00000052205 Ensembl
  ENSRNOG00000066556 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000107111 ENTREZGENE
  ENSRNOT00000107111.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot
  IL1/FGF UniProtKB/Swiss-Prot
KEGG Report rno:170583 UniProtKB/Swiss-Prot
NCBI Gene 170583 ENTREZGENE
PANTHER PTHR11486 UniProtKB/Swiss-Prot
Pfam FGF UniProtKB/Swiss-Prot
PhenoGen Fgf23 PhenoGen
PROSITE HBGF_FGF UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052205 RatGTEx
  ENSRNOG00000066556 RatGTEx
SMART FGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot
UniProt A6ILX1 ENTREZGENE, UniProtKB/TrEMBL
  FGF23_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Fgf23  fibroblast growth factor 23      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fgf23  fibroblast growth factor 23      Symbol and Name status set to provisional 70820 PROVISIONAL