Ntrk1 (neurotrophic receptor tyrosine kinase 1) - Rat Genome Database

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Gene: Ntrk1 (neurotrophic receptor tyrosine kinase 1) Rattus norvegicus
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Symbol: Ntrk1
Name: neurotrophic receptor tyrosine kinase 1
RGD ID: 620144
Description: Enables several functions, including GPI-linked ephrin receptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and positive regulation of cell communication. Acts upstream of or within cellular response to growth factor stimulus and protein autophosphorylation. Located in several cellular components, including cell surface; endosome; and neuronal cell body. Part of protein-containing complex. Used to study Parkinsonism; glaucoma; and myofascial pain syndrome. Biomarker of several diseases, including colitis; diabetic neuropathy; glaucoma; periodontitis; and retinal detachment. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1); PARTICIPATES IN apoptotic cell death pathway; endocytosis pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (S)-nicotine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: high affinity nerve growth factor receptor; neurotrophic tyrosine kinase, receptor, type 1; p140-TrkA; slow nerve growth factor receptor; Trk; trk precursor; trk-A; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin-related kinase A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,534,844 - 175,551,664 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2175,534,844 - 175,551,787 (-)EnsemblGRCr8
mRatBN7.22173,236,961 - 173,253,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,236,963 - 173,253,770 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2180,385,200 - 180,401,999 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,407,539 - 178,424,344 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02172,997,036 - 173,013,812 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,143,568 - 187,160,373 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,143,568 - 187,160,373 (-)Ensemblrn6Rnor6.0
Rnor_5.02206,548,566 - 206,565,385 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42179,838,740 - 179,855,545 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2167,186,754 - 167,203,558 (-)NCBICelera
RGSC_v3.12179,788,845 - 179,805,651 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
citalopram  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
dieldrin  (EXP,ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxycycline  (EXP)
echinacoside  (EXP,ISO)
endrin  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
ganglioside GM1  (EXP)
genistein  (ISO)
graphite  (EXP)
inulin  (ISO)
ketamine  (EXP)
LY294002  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
menadione  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
nickel atom  (EXP)
nicotine  (EXP,ISO)
nocodazole  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
PhIP  (ISO)
picoxystrobin  (ISO)
PNU-282987  (EXP)
ponatinib  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propiconazole  (EXP)
pyrazinecarboxamide  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP)
rac-lactic acid  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon guidance  (IMP)
axonogenesis involved in innervation  (IEA,ISO,ISS)
B cell differentiation  (ISO)
behavioral response to formalin induced pain  (ISO)
cell communication  (IEA)
cell differentiation  (IEA)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA,IEA)
cellular response to amyloid-beta  (ISO)
cellular response to growth factor stimulus  (IDA)
cellular response to nerve growth factor stimulus  (IBA,IDA,IEA,ISO)
cellular response to nicotine  (IDA)
circadian rhythm  (IEA,ISO)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
ephrin receptor signaling pathway  (IEA)
innervation  (ISO)
learning or memory  (IMP)
mechanoreceptor differentiation  (ISO)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of cellular process  (IDA)
negative regulation of neuron apoptotic process  (IEA,IMP,ISO)
nerve development  (IEA)
nerve growth factor signaling pathway  (IBA,IDA,IEA,ISO)
nervous system development  (IEA,ISO)
neuron development  (ISO)
neuron projection development  (IEA,ISO)
neurotrophin signaling pathway  (IEA)
neurotrophin TRK receptor signaling pathway  (IEA,ISO,ISS)
olfactory nerve development  (IEP)
peptidyl-tyrosine autophosphorylation  (ISO,ISS)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO,ISS)
positive regulation of GTPase activity  (ISO,ISS)
positive regulation of neuron projection development  (IBA,ISO,ISS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IDA,IEA)
positive regulation of programmed cell death  (IDA)
positive regulation of Ras protein signal transduction  (ISO,ISS)
positive regulation of synapse assembly  (ISO)
positive regulation of synaptic transmission, glutamatergic  (IMP)
programmed cell death  (IEA)
programmed cell death involved in cell development  (IDA)
protein autophosphorylation  (IDA,ISO)
protein phosphorylation  (ISO,ISS)
response to activity  (IDA)
response to axon injury  (IEP)
response to electrical stimulus  (IDA)
response to ethanol  (IEP)
response to hydrostatic pressure  (IEP)
response to nicotine  (IDA)
response to nutrient levels  (IDA)
response to xenobiotic stimulus  (IDA)
Sertoli cell development  (IMP)
spermatogenesis  (IEP)
sympathetic nervous system development  (IEA,ISO,ISS)

Cellular Component
axon  (IBA,IDA,IEA,ISO)
cell surface  (IDA,IEA,ISO)
cytoplasm  (IEA,ISO)
dendrite  (IDA)
early endosome  (IDA,IEA,ISO)
early endosome membrane  (IEA)
Golgi membrane  (TAS)
late endosome  (IDA,IEA,ISO)
late endosome membrane  (IEA)
membrane  (IEA)
mitochondrion  (IDA)
neuronal cell body  (IDA)
plasma membrane  (IBA,IDA,IEA,ISO,ISS,TAS)
protein-containing complex  (IDA,IEA,ISO)
receptor complex  (IBA,IEA,ISO)
recycling endosome  (IDA)
recycling endosome membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes . Al-Gayyar MM, etal., Diabetologia. 2011 Mar;54(3):669-80. Epub 2010 Dec 7.
2. Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons. Allard S, etal., Neurobiol Aging. 2018 Jul;67:10-20. doi: 10.1016/j.neurobiolaging.2018.03.002. Epub 2018 Mar 9.
3. Chronic and acute models of retinal neurodegeneration TrkA activity are neuroprotective whereas p75NTR activity is neurotoxic through a paracrine mechanism. Bai Y, etal., J Biol Chem. 2010 Dec 10;285(50):39392-400. Epub 2010 Oct 13.
4. Targeted silencing of TrkA expression in rat forebrain neurons via the p75 receptor. Berhanu DA and Rush RA, Neuroscience. 2008 Jun 2;153(4):1115-25. Epub 2008 Mar 22.
5. Functional nerve growth factor and trkA autocrine/paracrine circuits in adult rat cortex are revealed by episodic ethanol exposure and withdrawal. Bruns MB and Miller MW, J Neurochem. 2007 Mar;100(5):1155-68.
6. Localization of nerve growth factor (NGF) receptors in the mitochondrial compartment: characterization and putative role. Carito V, etal., Biochim Biophys Acta. 2012 Feb;1820(2):96-103. doi: 10.1016/j.bbagen.2011.10.015. Epub 2011 Nov 21.
7. Treadmill exercise improves cognitive function and facilitates nerve growth factor signaling by activating mitogen-activated protein kinase/extracellular signal-regulated kinase1/2 in the streptozotocin-induced diabetic rat hippocampus. Chae CH, etal., Neuroscience. 2009 Dec 29;164(4):1665-73. Epub 2009 Oct 2.
8. Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures. Conti G, etal., Neurosci Res. 2009 Oct;65(2):201-9. Epub 2009 Jul 9.
9. Gender differences in neurotrophin and glutamate receptor expression in cholinergic nucleus basalis neurons during the progression of Alzheimer's disease. Counts SE, etal., J Chem Neuroanat. 2011 Oct;42(2):111-7. Epub 2011 Mar 17.
10. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. Cozza A, etal., J Alzheimers Dis. 2008 Sep;15(1):61-70.
11. Expression of nerve growth factor receptors is correlated with progression and prognosis of human pancreatic cancer. Dang C, etal., J Gastroenterol Hepatol. 2006 May;21(5):850-8.
12. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Dmitrieva VG, etal., Cell Mol Neurobiol. 2010 Jan;30(1):71-9. Epub 2009 Jul 25.
13. Increased cutaneous NGF and CGRP-labelled trkA-positive intra-epidermal nerve fibres in rat diabetic skin. Evans L, etal., Neurosci Lett. 2011 Oct 25.
14. Nicotine increases the expression of neurotrophin receptor tyrosine kinase receptor A in basal forebrain cholinergic neurons. Formaggio E, etal., Neuroscience. 2010 Mar 17;166(2):580-9. Epub 2010 Jan 4.
15. Anti-NGF treatment reduces bone resorption in periodontitis. Gaspersic R, etal., J Dent Res. 2010 May;89(5):515-20. Epub 2010 Mar 3.
16. Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay. Gassei K, etal., Reproduction. 2008 Oct;136(4):459-69. Epub 2008 Jul 25.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. Goldbart AD, etal., Pediatr Res. 2007 Oct;62(4):489-94.
20. Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion. Hajebrahimi Z, etal., Neurosci Lett. 2008 Aug 29;441(3):261-6. Epub 2008 Jun 21.
21. Involvement of NGF in the rat model of persistent muscle pain associated with taut band. Hayashi K, etal., J Pain. 2011 Oct;12(10):1059-68. Epub 2011 Jun 30.
22. Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. Herbst R, etal., Development 2002 Dec;129(23):5449-60.
23. Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. Hisata S, etal., J Cell Biol. 2007 Aug 27;178(5):843-60.
24. Alterations in neurotrophin and neurotrophin-receptor localization in Hirschsprung's disease. Hoehner JC, etal., J Pediatr Surg. 1996 Nov;31(11):1524-9.
25. Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis. Huehne K, etal., Neuromuscul Disord. 2008 Feb;18(2):159-66. Epub 2008 Feb 20.
26. TrkA pathway(s) is involved in regulation of TRPM7 expression in hippocampal neurons subjected to ischemic-reperfusion and oxygen-glucose deprivation. Jiang H, etal., Brain Res Bull. 2008 May 15;76(1-2):124-30. Epub 2008 Feb 12.
27. Molecular kinetics of nerve growth factor receptor trafficking and activation. Jullien J, etal., J Biol Chem 2002 Oct 11;277(41):38700-8.
28. Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. Lazaridis I, etal., PLoS Biol. 2011 Apr;9(4):e1001051. doi: 10.1371/journal.pbio.1001051. Epub 2011 Apr 26.
29. Inhibition of p75(NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells. Lebrun-Julien F, etal., Mol Cell Neurosci. 2009 Apr;40(4):410-20. Epub 2008 Dec 25.
30. Neonatal tissue damage facilitates nociceptive synaptic input to the developing superficial dorsal horn via NGF-dependent mechanisms. Li J and Baccei ML, Pain. 2011 Aug;152(8):1846-55. Epub 2011 May 6.
31. GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. Li X, etal., Mol Biol Cell. 2015 Dec 1;26(24):4412-26. doi: 10.1091/mbc.E15-02-0087. Epub 2015 Oct 7.
32. Effect of amyloid peptides on the increase in TrkA receptor expression induced by nicotine in vitro and in vivo. Li XD, etal., J Mol Neurosci. 2005;27(3):325-36.
33. Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis. Li Y, etal., Reprod Biol Endocrinol. 2011 Mar 8;9:30.
34. Novel neurotrophic tyrosine kinase receptor type 1 gene mutation associated with congenital insensitivity to pain with anhidrosis. Lin YP, etal., J Child Neurol. 2010 Dec;25(12):1548-51. Epub 2010 Jul 20.
35. A high soy diet enhances neurotropin receptor and Bcl-XL gene expression in the brains of ovariectomized female rats. Lovekamp-Swan T, etal., Brain Res. 2007 Jul 23;1159:54-66. Epub 2007 May 26.
36. Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA. MacDonald JI, etal., J Biol Chem. 2000 Jun 16;275(24):18225-33.
37. Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3. MacDonald JI, etal., J Mol Neurosci. 1999 Aug-Oct;13(1-2):141-58.
38. Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats. Manni L, etal., Diabetologia. 2011 Jul;54(7):1900-8. Epub 2011 Mar 23.
39. A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. Marler KJ, etal., J Neurosci. 2008 Nov 26;28(48):12700-12. doi: 10.1523/JNEUROSCI.1915-08.2008.
40. Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation. Matrone C, etal., Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11358-63. doi: 10.1073/pnas.0904998106. Epub 2009 Jun 19.
41. The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor. Meakin SO, etal., Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2374-8.
42. The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain. Miller R, etal., Brain Res 2002 Sep 20;950(1-2):137-47.
43. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):101-13. doi: 10.1002/neu.20009.
44. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):114-26. doi: 10.1002/neu.20010.
45. Differential regulation of the expression of neurotrophin receptors in rat extraocular motoneurons after lesion. Morcuende S, etal., J Comp Neurol. 2011 Aug 15;519(12):2335-52. doi: 10.1002/cne.22630.
46. Impaired glucose tolerance and insulinopenia in the GK-rat causes peripheral neuropathy. Murakawa Y, etal., Diabetes Metab Res Rev. 2002 Nov-Dec;18(6):473-83.
47. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
48. NGF/TrkA-mediated Kidins220/ARMS signaling activated in the allergic airway challenge in mice. Ni X, etal., Ann Allergy Asthma Immunol. 2010 Oct;105(4):299-306.
49. Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nikoletopoulou V, etal., Nature. 2010 Sep 2;467(7311):59-63. doi: 10.1038/nature09336.
50. Ultrastructural localization of the neurotrophin receptor (TrkA) in cultured rat pheochromocytoma PC12 Cells: three-dimensional image analysis by high voltage electron microscopy. Nishida T, etal., Biomed Res. 2007 Jun;28(3):161-7.
51. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
52. [Changes of nerve growth factor and its receptors in the lung tissues in asthmatic rats and their effects on the airway inflammation]. Ouyang RY, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Dec;30(6):660-5.
53. Expression of beta-nerve growth factor and its receptor in rat seminiferous epithelium: specific function at the onset of meiosis. Parvinen M, etal., J Cell Biol. 1992 May;117(3):629-41. doi: 10.1083/jcb.117.3.629.
54. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
55. Colitis elicits differential changes in the expression levels of receptor tyrosine kinase TrkA and TrkB in colonic afferent neurons: a possible involvement of axonal transport. Qiao LY and Grider JR, Pain. 2010 Oct;151(1):117-27. Epub 2010 Jul 16.
56. Differential up-regulation of neurotrophin receptors and functional activity of neurotrophins on peripheral blood eosinophils of patients with allergic rhinitis, atopic dermatitis and nonatopic subjects. Raap U, etal., Clin Exp Allergy. 2008 Sep;38(9):1493-8. Epub 2008 Jul 17.
57. Gangliosides activate Trk receptors by inducing the release of neurotrophins. Rabin SJ, etal., J Biol Chem 2002 Dec 20;277(51):49466-72.
58. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
59. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
60. Neurotrophin system activation in bronchoalveolar lavage fluid immune cells in pulmonary sarcoidosis. Ricci A, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2005 Oct;22(3):186-94.
61. Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. Robinson KN, etal., J Biol Chem. 2005 Jan 7;280(1):225-35. Epub 2004 Oct 28.
62. Sequential expression of Trks A, B, and C in the regenerating olfactory neuroepithelium. Roskams AJ, etal., J Neurosci. 1996 Feb 15;16(4):1294-307.
63. Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions. Ross GM, etal., Eur J Neurosci. 1998 Mar;10(3):890-8.
64. Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation. Rotthier A, etal., Brain. 2009 Oct;132(Pt 10):2699-711. Epub 2009 Aug 3.
65. Age-related regional differences in cardiac nerve growth factor expression. Saygili E, etal., Age (Dordr). 2012 Jun;34(3):659-67. doi: 10.1007/s11357-011-9262-0. Epub 2011 May 11.
66. Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma. Sposato V, etal., Neurosci Lett. 2008 Nov 28;446(1):20-4. Epub 2008 Sep 18.
67. Nerve growth factor helps protect retina in experimental retinal detachment. Sun X, etal., Ophthalmologica. 2008;222(1):58-61. Epub 2007 Dec 19.
68. Skoura - a genetic island for congenital insensitivity to pain and anhidrosis among Moroccan Jews, as determined by a novel mutation in the NTRK1 gene. Suriu C, etal., Clin Genet. 2009 Mar;75(3):230-6.
69. Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas. Suzuki T, etal., J Natl Cancer Inst. 1993 Mar 3;85(5):377-84.
70. Effects of high-affinity nerve growth factor receptor inhibitors on symptoms in the NC/Nga mouse atopic dermatitis model. Takano N, etal., Br J Dermatol. 2007 Feb;156(2):241-6.
71. Chronic antipsychotic treatment: protracted decreases in phospho-TrkA levels in the rat hippocampus. Terry AV Jr, etal., Int J Neuropsychopharmacol. 2010 Jul;13(6):799-805. Epub 2010 Jan 11.
72. Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats. Terry AV Jr, etal., Physiol Behav. 2011 Feb 1;102(2):149-57. Epub 2010 Nov 6.
73. Presence of nerve growth factor and TrkA expression in the SVZ of EAE rats: evidence for a possible functional significance. Triaca V, etal., Exp Neurol. 2005 Jan;191(1):53-64.
74. Novel NTRK1 mutations cause hereditary sensory and autonomic neuropathy type IV: demonstration of a founder mutation in the Turkish population. Tuysuz B, etal., Neurogenetics. 2008 May;9(2):119-25. Epub 2008 Mar 6.
75. Local administration of a synthetic cell-penetrating peptide antagonizing TrkA function suppresses inflammatory pain in rats. Ueda K, etal., J Pharmacol Sci. 2010;112(4):438-43. Epub 2010 Mar 30.
76. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Van Kanegan MJ and Strack S, Mol Cell Biol. 2009 Feb;29(3):662-74. doi: 10.1128/MCB.01242-08. Epub 2008 Nov 24.
77. Dual association of a TRKA polymorphism with schizophrenia. Van Schijndel JE, etal., Psychiatr Genet. 2011 Jun;21(3):125-31.
78. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. Wan J, etal., J Neurosci. 2008 Sep 3;28(36):9002-12. doi: 10.1523/JNEUROSCI.0767-08.2008.
79. Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling. Wang T, etal., Acta Pharmacol Sin. 2010 Jul;31(7):765-74. doi: 10.1038/aps.2010.69. Epub 2010 Jun 28.
80. Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum. Wang ZY, etal., Neuroscience. 2010 Jan 20;165(2):485-91. doi: 10.1016/j.neuroscience.2009.10.045.
81. Guiding adult Mammalian sensory axons during regeneration. Webber CA, etal., J Neuropathol Exp Neurol. 2008 Mar;67(3):212-22.
82. [A study on expressions of nerve growth factor and its receptor tyrosine kinase receptor A in lung bronchiolar epithelial cells of chronic obstructive pulmonary disease patients]. Xiao Y and Xu YJ, Zhonghua Jie He He Hu Xi Za Zhi. 2011 Jan;34(1):34-8.
83. Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor. Yano H, etal., J Neurosci Res. 2000 Feb 1;59(3):356-64.
84. Nerve growth factor applied onto the olfactory epithelium alleviates degenerative changes of the olfactory receptor neurons following axotomy. Yasuno H, etal., Brain Res. 2000 Dec 22;887(1):53-62.
85. Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth. Zhang Y, etal., J Biol Chem. 2009 May 1;284(18):12469-79. Epub 2009 Mar 5.
Additional References at PubMed
PMID:1281417   PMID:2927393   PMID:7854358   PMID:8325889   PMID:8815902   PMID:9856458   PMID:10207144   PMID:10808049   PMID:10908605   PMID:11244088   PMID:11248116   PMID:11251075  
PMID:11551509   PMID:11731452   PMID:11750876   PMID:11877420   PMID:11927634   PMID:12151805   PMID:12471037   PMID:12810599   PMID:12849738   PMID:12858046   PMID:12882321   PMID:12882335  
PMID:12909622   PMID:12911749   PMID:12944916   PMID:14622124   PMID:14698082   PMID:15240558   PMID:15262992   PMID:15282267   PMID:15376326   PMID:15459109   PMID:15488758   PMID:15533302  
PMID:15737746   PMID:15753086   PMID:15834419   PMID:15911341   PMID:16118792   PMID:16195402   PMID:16195501   PMID:16207814   PMID:16219032   PMID:16246731   PMID:16284401   PMID:16306406  
PMID:16597733   PMID:16644033   PMID:16729028   PMID:16738245   PMID:16819522   PMID:16860569   PMID:17020011   PMID:17072373   PMID:17196528   PMID:17202489   PMID:17215105   PMID:17215246  
PMID:17380122   PMID:17506493   PMID:17548467   PMID:17640889   PMID:17700442   PMID:17822405   PMID:17952852   PMID:17967490   PMID:18174161   PMID:18187921   PMID:18191823   PMID:18299325  
PMID:18337399   PMID:18419753   PMID:18751719   PMID:18957307   PMID:19162192   PMID:19403809   PMID:19533291   PMID:19565663   PMID:19585233   PMID:19607811   PMID:19701634   PMID:19762468  
PMID:19818769   PMID:20209132   PMID:20333299   PMID:21150695   PMID:21151572   PMID:21187090   PMID:21199218   PMID:21295348   PMID:21312342   PMID:21411748   PMID:21429296   PMID:22028877  
PMID:22073361   PMID:22384148   PMID:22419059   PMID:22496904   PMID:23100034   PMID:23115187   PMID:23158009   PMID:23228124   PMID:23382219   PMID:23589303   PMID:23615109   PMID:23749991  
PMID:23785138   PMID:23809594   PMID:23821557   PMID:23928917   PMID:24006492   PMID:24040018   PMID:24198040   PMID:24265310   PMID:24270184   PMID:24316227   PMID:24480438   PMID:24484474  
PMID:24613359   PMID:24760869   PMID:24872407   PMID:25545984   PMID:25644424   PMID:25662281   PMID:25708205   PMID:26588713   PMID:26642930   PMID:27334657   PMID:27445338   PMID:27655914  
PMID:27830679   PMID:28197073   PMID:28758954   PMID:28877995   PMID:29325876   PMID:29450621   PMID:30308237   PMID:30592331   PMID:31113619   PMID:31440771   PMID:31831796   PMID:31875259  
PMID:32024191   PMID:33043964   PMID:33125501   PMID:34943971   PMID:36575400   PMID:38725127  


Genomics

Comparative Map Data
Ntrk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,534,844 - 175,551,664 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2175,534,844 - 175,551,787 (-)EnsemblGRCr8
mRatBN7.22173,236,961 - 173,253,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,236,963 - 173,253,770 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2180,385,200 - 180,401,999 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,407,539 - 178,424,344 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02172,997,036 - 173,013,812 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,143,568 - 187,160,373 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,143,568 - 187,160,373 (-)Ensemblrn6Rnor6.0
Rnor_5.02206,548,566 - 206,565,385 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42179,838,740 - 179,855,545 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2167,186,754 - 167,203,558 (-)NCBICelera
RGSC_v3.12179,788,845 - 179,805,651 (-)NCBI
Cytogenetic Map2q34NCBI
NTRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,815,750 - 156,881,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,815,636 - 156,881,850 (+)Ensemblhg38GRCh38
GRCh371156,785,542 - 156,851,642 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,052,166 - 155,118,266 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341153,643,743 - 153,664,715NCBI
Celera1129,856,788 - 129,922,861 (+)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1128,143,945 - 128,209,968 (+)NCBIHuRef
CHM1_11158,181,737 - 158,247,825 (+)NCBICHM1_1
T2T-CHM13v2.01155,952,603 - 156,018,667 (+)NCBIT2T-CHM13v2.0
Ntrk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39387,685,551 - 87,702,549 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl387,685,551 - 87,702,469 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38387,778,244 - 87,795,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl387,778,244 - 87,795,162 (-)Ensemblmm10GRCm38
MGSCv37387,582,166 - 87,599,084 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36387,864,171 - 87,881,089 (-)NCBIMGSCv36mm8
Celera387,816,061 - 87,832,981 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.62NCBI
Ntrk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,929,704 - 2,947,579 (+)Ensembl
ChiLan1.0NW_0049555452,929,704 - 2,947,579 (+)NCBIChiLan1.0ChiLan1.0
NTRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2192,962,864 - 92,984,198 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1192,697,515 - 92,718,687 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1136,007,476 - 136,047,355 (+)EnsemblpanPan2panpan1.1
NTRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,140,931 - 41,159,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,140,879 - 41,159,288 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha740,627,981 - 40,646,334 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0741,003,176 - 41,021,761 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,003,175 - 41,037,050 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1740,785,455 - 40,803,799 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0740,838,471 - 40,856,834 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,121,978 - 41,140,332 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ntrk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,971,788 - 26,991,308 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365806,002,120 - 6,021,709 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365806,002,168 - 6,021,690 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,219,516 - 93,255,981 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1493,219,509 - 93,237,944 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24101,791,572 - 101,810,021 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NTRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1206,987,903 - 7,027,381 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl206,987,905 - 7,008,670 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660386,276,759 - 6,297,741 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntrk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,989,138 - 2,005,577 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248851,989,027 - 2,005,474 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ntrk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1365,766,019 - 65,782,780 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ntrk1
71 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:46
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000018961, ENSRNOT00000044046
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837178247591Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
7771605Memor19Memory QTL 190.00001exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)2172499769175588177Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
7771603Bp371Blood pressure QTL 3710.00001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172499769175588177Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2175279960178247591Rat

Markers in Region
D5Mgh7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82175,552,875 - 175,553,019 (+)Marker Load Pipeline
mRatBN7.22173,254,996 - 173,255,140 (+)MAPPERmRatBN7.2
Rnor_6.02187,161,600 - 187,161,743NCBIRnor6.0
Rnor_5.02206,566,598 - 206,566,741UniSTSRnor5.0
RGSC_v3.42179,856,771 - 179,856,915RGDRGSC3.4
RGSC_v3.42179,856,772 - 179,856,915UniSTSRGSC3.4
Celera2167,204,785 - 167,204,918UniSTS
RGSC_v3.12179,806,877 - 179,807,021RGD
Cytogenetic Map2q34UniSTS
D2Arb14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,254,993 - 173,255,208 (+)MAPPERmRatBN7.2
Rnor_6.02187,161,597 - 187,161,811NCBIRnor6.0
Rnor_5.02206,566,595 - 206,566,809UniSTSRnor5.0
RGSC_v3.42179,856,768 - 179,856,983RGDRGSC3.4
RGSC_v3.42179,856,769 - 179,856,983UniSTSRGSC3.4
Celera2167,204,782 - 167,204,986UniSTS
RGSC_v3.12179,806,874 - 179,807,089RGD
Cytogenetic Map2q34UniSTS
RH126965  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,242,538 - 173,242,743 (+)MAPPERmRatBN7.2
Rnor_6.02187,149,144 - 187,149,348NCBIRnor6.0
Rnor_5.02206,554,142 - 206,554,346UniSTSRnor5.0
RGSC_v3.42179,844,316 - 179,844,520UniSTSRGSC3.4
Celera2167,192,330 - 167,192,534UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 10 25 145 71 69 39 27 39 6 199 81 8 124 66 80 30 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000018961   ⟹   ENSRNOP00000018961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2175,534,844 - 175,551,649 (-)Ensembl
mRatBN7.2 Ensembl2173,236,963 - 173,253,770 (-)Ensembl
Rnor_6.0 Ensembl2187,143,568 - 187,160,373 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092760   ⟹   ENSRNOP00000076015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,147,599 - 187,149,017 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092780   ⟹   ENSRNOP00000075951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,247,148 - 173,253,610 (-)Ensembl
Rnor_6.0 Ensembl2187,154,102 - 187,160,215 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,147,564 - 187,148,886 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,147,564 - 187,148,886 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115670   ⟹   ENSRNOP00000079821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2175,534,844 - 175,551,647 (-)Ensembl
mRatBN7.2 Ensembl2173,236,963 - 173,253,770 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119500   ⟹   ENSRNOP00000085208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2175,534,844 - 175,551,588 (-)Ensembl
mRatBN7.2 Ensembl2173,236,963 - 173,253,709 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140731   ⟹   ENSRNOP00000111834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2175,534,844 - 175,551,787 (-)Ensembl
RefSeq Acc Id: NM_021589   ⟹   NP_067600
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,534,844 - 175,551,649 (-)NCBI
mRatBN7.22173,236,963 - 173,253,770 (-)NCBI
Rnor_6.02187,143,568 - 187,160,373 (-)NCBI
Rnor_5.02206,548,566 - 206,565,385 (-)NCBI
RGSC_v3.42179,838,740 - 179,855,545 (-)RGD
Celera2167,186,754 - 167,203,558 (-)RGD
Sequence:
RefSeq Acc Id: XM_039103004   ⟹   XP_038958932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,534,844 - 175,551,664 (-)NCBI
mRatBN7.22173,236,961 - 173,253,806 (-)NCBI
RefSeq Acc Id: XM_063282427   ⟹   XP_063138497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,534,844 - 175,551,295 (-)NCBI
RefSeq Acc Id: NP_067600   ⟸   NM_021589
- Peptide Label: precursor
- UniProtKB: P35739 (UniProtKB/Swiss-Prot),   A6J617 (UniProtKB/TrEMBL),   A0A8I6A1S2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075951   ⟸   ENSRNOT00000092780
Ensembl Acc Id: ENSRNOP00000076015   ⟸   ENSRNOT00000092760
Ensembl Acc Id: ENSRNOP00000018961   ⟸   ENSRNOT00000018961
RefSeq Acc Id: XP_038958932   ⟸   XM_039103004
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A1S2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079821   ⟸   ENSRNOT00000115670
Ensembl Acc Id: ENSRNOP00000085208   ⟸   ENSRNOT00000119500
RefSeq Acc Id: XP_063138497   ⟸   XM_063282427
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000111834   ⟸   ENSRNOT00000140731
Protein Domains
Growth factor receptor NTRK leucine rich repeat C-   Ig-like   Ig-like C2-type   LRRCT   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35739-F1-model_v2 AlphaFold P35739 1-799 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620144 AgrOrtholog
BioCyc Gene G2FUF-52535 BioCyc
Ensembl Genes ENSRNOG00000013953 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018961 ENTREZGENE
  ENSRNOT00000018961.4 UniProtKB/Swiss-Prot
  ENSRNOT00000115670.1 UniProtKB/Swiss-Prot
  ENSRNOT00000119500 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  NTRK_C2 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RTK UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_neurotrophic_rcpt_1 UniProtKB/Swiss-Prot
  Tyr_kinase_NGF_rcpt UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot
KEGG Report rno:59109 UniProtKB/Swiss-Prot
NCBI Gene 59109 ENTREZGENE
PANTHER HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  TPKR_C2 UniProtKB/Swiss-Prot
PhenoGen Ntrk1 PhenoGen
PRINTS NTKRECEPTOR UniProtKB/Swiss-Prot
  NTKRECEPTOR1 UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013953 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF48726 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6A1S2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M885_RAT UniProtKB/TrEMBL
  A6J617 ENTREZGENE, UniProtKB/TrEMBL
  A6J618_RAT UniProtKB/TrEMBL
  NTRK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JIW6_RAT UniProtKB/TrEMBL
  Q9JIW7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Ntrk1  neurotrophic receptor tyrosine kinase 1  Ntrk1  neurotrophic tyrosine kinase, receptor, type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ntrk1  neurotrophic tyrosine kinase, receptor, type 1    trk precursor  Name updated 1299863 APPROVED
2002-08-07 Ntrk1  trk precursor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein activated by GM1 ganglioside 727459