RGD Reference Report - Dual association of a TRKA polymorphism with schizophrenia. - Rat Genome Database

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Dual association of a TRKA polymorphism with schizophrenia.

Authors: Van Schijndel, JE  Van Zweeden, M  Van Loo, KM  Djurovic, S  Andreassen, OA  Hansen, T  Werge, T  Nyegaard, M  Sorensen, KM  Nordentoft, M  Mortensen, PB  Mors, O  Borglum, AD  Del-Favero, J  Norrback, KF  Adolfsson, R  De Hert, M  Claes, S  Cichon, S  Rietschel, M  Nothen, MM  Kallunki, P  Pedersen, JT  Martens, GJ 
Citation: Van Schijndel JE, etal., Psychiatr Genet. 2011 Jun;21(3):125-31.
RGD ID: 5684534
Pubmed: PMID:21317683   (View Abstract at PubMed)
DOI: DOI:10.1097/YPG.0b013e3283437194   (Journal Full-text)

OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups. RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
schizophrenia susceptibilityIAGP 5684534DNA:SNPs:cds:rs6336 and rs6339RGD 
schizophrenia susceptibilityISONTRK1 (Homo sapiens)5684534; 5684534DNA:SNPs:cds:rs6336 and rs6339RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ntrk1  (neurotrophic receptor tyrosine kinase 1)

Genes (Mus musculus)
Ntrk1  (neurotrophic tyrosine kinase, receptor, type 1)

Genes (Homo sapiens)
NTRK1  (neurotrophic receptor tyrosine kinase 1)


Additional Information