Ncoa3 (nuclear receptor coactivator 3) - Rat Genome Database

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Gene: Ncoa3 (nuclear receptor coactivator 3) Rattus norvegicus
Analyze
Symbol: Ncoa3
Name: nuclear receptor coactivator 3
RGD ID: 620109
Description: Enables several functions, including nuclear receptor binding activity; nuclear receptor coactivator activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including male gonad development; positive regulation of intracellular estrogen receptor signaling pathway; and regulation of DNA-templated transcription. Located in perinuclear region of cytoplasm. Used to study breast cancer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NCOA3 (nuclear receptor coactivator 3); PARTICIPATES IN estrogen signaling pathway; androgen signaling pathway; cortisol signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AIB-1; Aib1; amplified in breast cancer-1 protein homolog; NCoA-3; thyroid hormone receptor activator molecule 1; Tram-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,157,824 - 175,237,831 (+)NCBIGRCr8
mRatBN7.23154,738,566 - 154,821,395 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3154,738,581 - 154,818,594 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3158,538,937 - 158,619,397 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,037,941 - 167,118,397 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03164,779,584 - 164,860,043 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03162,692,176 - 162,788,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3162,692,185 - 162,787,548 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03168,863,837 - 168,959,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,168,492 - 157,196,566 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13157,079,533 - 157,100,362 (+)NCBI
Celera3153,323,587 - 153,406,335 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-gambogic acid  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
androst-4-ene-3,17-dione  (ISO)
arsenite(3-)  (ISO)
bazedoxifene  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
benzoates  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butamben  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clemizole  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
estrone  (ISO)
flavonol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
indometacin  (ISO)
kaempferol  (ISO)
leflunomide  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
permethrin  (ISO)
Phenoxybenzamine  (ISO)
phenylmercury acetate  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
chromatin binding  (ISO)
disordered domain specific binding  (IEA,ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific  (ISO)
histone acetyltransferase activity  (IEA,ISO)
histone H2AK5 acetyltransferase activity  (IEA)
histone H2AK9 acetyltransferase activity  (IEA)
histone H2BK12 acetyltransferase activity  (IEA)
histone H2BK5 acetyltransferase activity  (IEA)
histone H3K122 acetyltransferase activity  (IEA)
histone H3K14 acetyltransferase activity  (IEA)
histone H3K18 acetyltransferase activity  (IEA)
histone H3K23 acetyltransferase activity  (IEA)
histone H3K27 acetyltransferase activity  (IEA)
histone H3K36 acetyltransferase activity  (IEA)
histone H3K4 acetyltransferase activity  (IEA)
histone H3K56 acetyltransferase activity  (IEA)
histone H3K9 acetyltransferase activity  (IEA)
histone H4K12 acetyltransferase activity  (IEA)
histone H4K16 acetyltransferase activity  (IEA)
histone H4K5 acetyltransferase activity  (IEA)
histone H4K8 acetyltransferase activity  (IEA)
nuclear androgen receptor binding  (IPI)
nuclear estrogen receptor binding  (IPI)
nuclear receptor binding  (IBA,IEA,ISO)
obsolete nuclear receptor coactivator activity  (ISO)
peroxisome proliferator activated receptor binding  (IPI)
protein binding  (ISO)
protein dimerization activity  (IEA)
protein-containing complex binding  (IMP)
RNA polymerase II complex binding  (ISO,ISS)
RNA polymerase II transcription regulatory region sequence-specific DNA binding  (IDA)
transcription coactivator activity  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis. Asano J, etal., Cancer Sci. 2010 Apr;101(4):869-75. Epub 2009 Dec 8.
2. Effects of neonatal exposure to bisphenol A on steroid regulation of vascular endothelial growth factor expression and endothelial cell proliferation in the adult rat uterus. Bosquiazzo VL, etal., Biol Reprod. 2010 Jan;82(1):86-95. Epub 2009 Aug 19.
3. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
4. The activating enzyme of NEDD8 inhibits steroid receptor function. Fan M, etal., Mol Endocrinol 2002 Feb;16(2):315-30.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Role of estrogen receptor alpha transcriptional coregulators in tamoxifen resistance in breast cancer. Girault I, etal., Maturitas. 2006 Jul 20;54(4):342-51. Epub 2006 Jul 5.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Differential recruitment of p160 coactivators by glucocorticoid receptor between Schwann cells and astrocytes. Grenier J, etal., Mol Endocrinol. 2006 Feb;20(2):254-67. Epub 2005 Sep 22.
9. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
10. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
11. Differential regulation of steroid nuclear receptor coregulator expression between normal and neoplastic prostate epithelial cells. Heemers HV, etal., Prostate. 2010 Jun 15;70(9):959-70.
12. Expression of sex steroid receptors and their co-factors in normal and malignant breast tissue: AIB1 is a carcinoma-specific co-activator. Hudelist G, etal., Breast Cancer Res Treat. 2003 Mar;78(2):193-204.
13. Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis. Igarashi-Migitaka J, etal., Eur J Endocrinol. 2005 Oct;153(4):595-604.
14. Novel glucocorticoid receptor coactivator effector mechanisms. Jenkins BD, etal., Trends Endocrinol Metab. 2001 Apr;12(3):122-6.
15. Evidence for estrogenic contamination of the MAPK inhibitor PD98059. Long X, etal., Endocrinology 2001 Dec;142(12):5390-3.
16. Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status. Martinez de Arrieta C, etal., Endocrinology. 2000 May;141(5):1693-8.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. The human glucocorticoid receptor: molecular basis of biologic function. Nicolaides NC, etal., Steroids. 2010 Jan;75(1):1-12. Epub 2009 Oct 7.
20. The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay. Ozers MS, etal., Biochemistry. 2007 Jan 23;46(3):683-95.
21. Prepubertal genistein exposure affects erbB2/Akt signal and reduces rat mammary tumorigenesis. Peng JH, etal., Eur J Cancer Prev. 2010 Mar;19(2):110-9.
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Rochette-Egly C and Germain P, Nucl Recept Signal. 2009 May 8;7:e005.
27. SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein. Sun Y, etal., J Biol Chem. 2011 May 27;286(21):18623-32. Epub 2011 Mar 24.
28. Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditions. Trousson A, etal., J Steroid Biochem Mol Biol. 2007 May;104(3-5):305-11. Epub 2007 Mar 23.
29. The synergistic effect of dexamethasone and all-trans-retinoic acid on hepatic phosphoenolpyruvate carboxykinase gene expression involves the coactivator p300. Wang XL, etal., J Biol Chem. 2004 Aug 13;279(33):34191-200. Epub 2004 May 27.
30. Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors. Wasserman L, etal., Int J Obes Relat Metab Disord. 2004 Jan;28(1):49-56.
Additional References at PubMed
PMID:9238002   PMID:9267036   PMID:10751423   PMID:10823921   PMID:10906038   PMID:11015591   PMID:11555636   PMID:11823864   PMID:12477932   PMID:12917342   PMID:15001550   PMID:15831516  
PMID:16109736   PMID:17082781   PMID:17223341   PMID:18570454   PMID:18798693   PMID:20685850   PMID:22977234   PMID:23019124   PMID:25132457   PMID:26105073   PMID:27601327   PMID:36116109  


Genomics

Comparative Map Data
Ncoa3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,157,824 - 175,237,831 (+)NCBIGRCr8
mRatBN7.23154,738,566 - 154,821,395 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3154,738,581 - 154,818,594 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3158,538,937 - 158,619,397 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,037,941 - 167,118,397 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03164,779,584 - 164,860,043 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03162,692,176 - 162,788,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3162,692,185 - 162,787,548 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03168,863,837 - 168,959,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,168,492 - 157,196,566 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13157,079,533 - 157,100,362 (+)NCBI
Celera3153,323,587 - 153,406,335 (+)NCBICelera
Cytogenetic Map3q42NCBI
NCOA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382047,501,887 - 47,656,872 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2047,501,887 - 47,656,877 (+)EnsemblGRCh38hg38GRCh38
GRCh372046,130,631 - 46,285,616 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362045,564,064 - 45,719,023 (+)NCBINCBI36Build 36hg18NCBI36
Build 342045,564,063 - 45,719,019NCBI
Celera2042,844,227 - 42,999,274 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2042,872,332 - 43,026,949 (+)NCBIHuRef
CHM1_12046,033,477 - 46,188,916 (+)NCBICHM1_1
T2T-CHM13v2.02049,240,095 - 49,395,274 (+)NCBIT2T-CHM13v2.0
Ncoa3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392165,834,557 - 165,915,162 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2165,834,545 - 165,915,162 (+)EnsemblGRCm39 Ensembl
GRCm382165,992,637 - 166,073,242 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2165,992,636 - 166,073,242 (+)EnsemblGRCm38mm10GRCm38
MGSCv372165,818,137 - 165,898,742 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362165,726,090 - 165,761,651 (+)NCBIMGSCv36mm8
Celera2171,928,977 - 172,011,677 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map286.22NCBI
Ncoa3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544510,024,308 - 10,052,472 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544510,020,916 - 10,085,318 (-)NCBIChiLan1.0ChiLan1.0
NCOA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22153,240,803 - 53,395,781 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12053,233,900 - 53,388,887 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02043,838,227 - 43,992,407 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12044,919,348 - 45,073,549 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2045,000,422 - 45,073,549 (+)Ensemblpanpan1.1panPan2
NCOA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2434,585,305 - 34,728,674 (+)NCBICanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2434,585,305 - 34,728,674 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2434,044,925 - 34,190,239 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02435,293,645 - 35,438,878 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2435,293,662 - 35,438,852 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12434,528,192 - 34,678,477 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02434,667,908 - 34,813,062 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02435,208,068 - 35,353,609 (+)NCBIUU_Cfam_GSD_1.0
Ncoa3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640190,446,492 - 190,514,236 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365145,901,601 - 5,967,865 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365145,900,135 - 5,967,862 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCOA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1749,528,179 - 49,663,200 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11749,528,275 - 49,660,471 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21755,850,658 - 55,874,660 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCOA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1216,270,218 - 16,423,381 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl216,273,717 - 16,423,318 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605064,808,267 - 64,961,547 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncoa3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247907,232,519 - 7,358,684 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247907,229,152 - 7,358,627 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1204
Count of miRNA genes:275
Interacting mature miRNAs:334
Transcripts:ENSRNOT00000007768, ENSRNOT00000044234, ENSRNOT00000066122
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
RH131538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23154,821,165 - 154,821,352 (+)MAPPERmRatBN7.2
Rnor_6.03162,790,436 - 162,790,622NCBIRnor6.0
Rnor_5.03168,961,281 - 168,961,467UniSTSRnor5.0
RGSC_v3.43157,196,337 - 157,196,523UniSTSRGSC3.4
Celera3153,406,106 - 153,406,292UniSTS
RH 3.4 Map31441.0UniSTS
Cytogenetic Map3q42UniSTS
RH134691  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.43157,195,567 - 157,195,757UniSTSRGSC3.4
Celera3153,405,336 - 153,405,526UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000007768   ⟹   ENSRNOP00000007768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3154,738,581 - 154,818,594 (+)Ensembl
Rnor_6.0 Ensembl3162,692,185 - 162,787,548 (+)Ensembl
RefSeq Acc Id: NM_053454   ⟹   NP_445906
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,157,824 - 175,237,831 (+)NCBI
mRatBN7.23154,738,581 - 154,818,594 (+)NCBI
Protein Sequences
Protein RefSeqs NP_445906 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG42837 (Get FASTA)   NCBI Sequence Viewer  
  AAH88343 (Get FASTA)   NCBI Sequence Viewer  
  EDL96443 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007768.7
GenBank Protein Q9EPU2 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000007768   ⟸   ENSRNOT00000007768
RefSeq Acc Id: NP_445906   ⟸   NM_053454
- UniProtKB: F1M8E5 (UniProtKB/TrEMBL),   A6JXG6 (UniProtKB/TrEMBL)
Protein Domains
bHLH   DUF1518   PAS

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692700
Promoter ID:EPDNEW_R3206
Type:initiation region
Name:Ncoa3_1
Description:nuclear receptor coactivator 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03162,692,200 - 162,692,260EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620109 AgrOrtholog
BioCyc Gene G2FUF-46784 BioCyc
Ensembl Genes ENSRNOG00000005616 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007768.8 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  6.10.140.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7367980 IMAGE-MGC_LOAD
InterPro DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  HLH_dom UniProtKB/TrEMBL
  Nuc_rcpt_coact UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_Ncoa-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_Ncoa_int_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_rcpt_coactivator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_fold UniProtKB/TrEMBL
  SRC/p160_LXXLL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109640 IMAGE-MGC_LOAD
NCBI Gene 84584 ENTREZGENE
PANTHER PTHR10684 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10684:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCOA_u2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rec_co-act UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRC-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NCOA3 RGD
PhenoGen Ncoa3 PhenoGen
PIRSF Nuclear_receptor_coactivator UniProtKB/TrEMBL
PROSITE HLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005616 RatGTEx
SMART DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
  SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69125 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JXG6 ENTREZGENE, UniProtKB/TrEMBL
  F1M8E5 ENTREZGENE, UniProtKB/TrEMBL
  NCOA3_RAT UniProtKB/Swiss-Prot
  Q5I0G5_RAT UniProtKB/TrEMBL
  Q9EPU2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Ncoa3  nuclear receptor coactivator 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ncoa3  nuclear receptor coactivator 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process increases the transcriptional effect of estrotgen-like contamination in some batches of PD98059, a MAPK inhibitor 727330