Zfp36l1 (zinc finger protein 36, C3H type-like 1) - Rat Genome Database

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Gene: Zfp36l1 (zinc finger protein 36, C3H type-like 1) Rattus norvegicus
Analyze
Symbol: Zfp36l1
Name: zinc finger protein 36, C3H type-like 1
RGD ID: 62009
Description: Enables mRNA 3'-UTR AU-rich region binding activity. Involved in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay and positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Acts upstream of or within mRNA catabolic process. Located in cytosol. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Berg36; Brf1; butyrate response factor 1; cMG1; EGF-inducible protein CMG1; ERF1; mRNA decay activator protein ZFP36L1; TIS11b; TPA-induced sequence 11b; ZFP36-like 1; zinc finger protein 36, C3H1 type-like 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86104,663,396 - 104,669,815 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6104,663,399 - 104,687,979 (-)EnsemblGRCr8
mRatBN7.2698,930,705 - 98,935,748 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,930,718 - 98,935,748 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx699,353,158 - 99,358,199 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0699,652,241 - 99,657,282 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,039,210 - 99,044,249 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06103,308,032 - 103,313,074 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,308,045 - 103,313,074 (-)Ensemblrn6Rnor6.0
Rnor_5.06115,987,360 - 115,992,381 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46103,119,555 - 103,124,576 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera697,294,425 - 97,299,423 (-)NCBICelera
RGSC_v3.16103,123,010 - 103,128,032 (-)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carboplatin  (EXP)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
depsipeptide  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
organophosphorus compound  (EXP)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
promegestone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (ISO)
Shikonin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (IEA,ISO,ISS)
apoptotic process  (ISO)
cell population proliferation  (ISO)
cellular response to cAMP  (ISO)
cellular response to epidermal growth factor stimulus  (ISO,ISS)
cellular response to fibroblast growth factor stimulus  (ISO,ISS)
cellular response to glucocorticoid stimulus  (ISO,ISS)
cellular response to hypoxia  (ISO,ISS)
cellular response to insulin stimulus  (ISO,ISS)
cellular response to peptide hormone stimulus  (ISO,ISS)
cellular response to raffinose  (ISO,ISS)
cellular response to salt stress  (ISO,ISS)
cellular response to transforming growth factor beta stimulus  (ISO,ISS)
cellular response to tumor necrosis factor  (ISO,ISS)
chorio-allantoic fusion  (ISO)
embryonic organ development  (ISO)
ERK1 and ERK2 cascade  (ISO,ISS)
heart development  (ISO)
MAPK cascade  (ISO,ISS)
mesendoderm development  (ISO,ISS)
mRNA catabolic process  (IDA)
mRNA processing  (IEA)
mRNA transport  (IEA,ISO,ISS)
multicellular organism growth  (ISO)
negative regulation of erythrocyte differentiation  (ISO,ISS)
negative regulation of gene expression  (IEA)
negative regulation of mitotic cell cycle phase transition  (ISO,ISS)
negative regulation of translation  (IEA)
neural tube development  (ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  (IDA)
nuclear-transcribed mRNA poly(A) tail shortening  (IBA)
p38MAPK cascade  (ISO,ISS)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
positive regulation of fat cell differentiation  (ISO,ISS)
positive regulation of intracellular mRNA localization  (ISO,ISS)
positive regulation of monocyte differentiation  (ISO,ISS)
positive regulation of mRNA catabolic process  (IEA)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IDA,IEA)
proepicardium development  (ISO)
regulation of B cell differentiation  (ISO,ISS)
regulation of gene expression  (ISO,ISS)
regulation of keratinocyte apoptotic process  (ISO,ISS)
regulation of keratinocyte differentiation  (ISO,ISS)
regulation of keratinocyte proliferation  (ISO,ISS)
regulation of mRNA 3'-end processing  (ISO)
regulation of mRNA stability  (IDA,IEA,ISO,ISS)
regulation of myoblast differentiation  (ISO,ISS)
regulation of stem cell proliferation  (ISO,ISS)
regulation of translation  (ISO)
response to wounding  (ISO,ISS)
spongiotrophoblast layer development  (ISO)
T cell differentiation in thymus  (ISO,ISS)
vasculogenesis  (ISO)

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IDA)
nucleus  (IEA,ISO,ISS)
P-body  (IEA,ISO,ISS)
ribonucleoprotein complex  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The nucleotide sequence of a cDNA encoding an EGF-inducible gene indicates the existence of a new family of mitogen-induced genes. Gomperts M, etal., Oncogene 1990 Jul;5(7):1081-3.
4. Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail. Lai WS and Blackshear PJ, J Biol Chem. 2001 Jun 22;276(25):23144-54. Epub 2001 Mar 28.
5. Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. Lai WS, etal., J Biol Chem. 2000 Jun 9;275(23):17827-37.
6. Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease. Lai WS, etal., Mol Cell Biol. 2003 Jun;23(11):3798-812.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. Schmidlin M, etal., EMBO J. 2004 Dec 8;23(24):4760-9. Epub 2004 Nov 11.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7575462   PMID:11796723   PMID:12198173   PMID:15226444   PMID:15467755   PMID:15687258   PMID:15814898   PMID:16396499   PMID:17013884   PMID:17369404   PMID:17889962   PMID:18326031  
PMID:19179481   PMID:20166898   PMID:20622884   PMID:20702587   PMID:21832157   PMID:22658674   PMID:22701344   PMID:24700863   PMID:24733888   PMID:25014217   PMID:25106868   PMID:26542173  
PMID:27102483   PMID:27182009   PMID:38653384  


Genomics

Comparative Map Data
Zfp36l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86104,663,396 - 104,669,815 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6104,663,399 - 104,687,979 (-)EnsemblGRCr8
mRatBN7.2698,930,705 - 98,935,748 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,930,718 - 98,935,748 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx699,353,158 - 99,358,199 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0699,652,241 - 99,657,282 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,039,210 - 99,044,249 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06103,308,032 - 103,313,074 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,308,045 - 103,313,074 (-)Ensemblrn6Rnor6.0
Rnor_5.06115,987,360 - 115,992,381 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46103,119,555 - 103,124,576 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera697,294,425 - 97,299,423 (-)NCBICelera
RGSC_v3.16103,123,010 - 103,128,032 (-)NCBI
Cytogenetic Map6q24NCBI
ZFP36L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381468,787,655 - 68,796,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1468,787,655 - 68,796,253 (-)Ensemblhg38GRCh38
GRCh371469,254,372 - 69,262,960 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361468,324,128 - 68,329,538 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341468,324,127 - 68,329,538NCBI
Celera1449,313,123 - 49,318,532 (-)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1449,422,410 - 49,430,997 (-)NCBIHuRef
CHM1_11469,192,821 - 69,201,405 (-)NCBICHM1_1
T2T-CHM13v2.01462,994,521 - 63,003,244 (-)NCBIT2T-CHM13v2.0
Zfp36l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,154,534 - 80,159,787 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,154,528 - 80,159,787 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381280,107,760 - 80,113,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,107,754 - 80,113,013 (-)Ensemblmm10GRCm38
MGSCv371281,208,747 - 81,214,000 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361281,026,600 - 81,031,853 (-)NCBIMGSCv36mm8
Celera1281,572,651 - 81,577,898 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1236.46NCBI
Zfp36l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554661,541,323 - 1,546,617 (+)Ensembl
ChiLan1.0NW_0049554661,541,367 - 1,546,617 (+)NCBIChiLan1.0ChiLan1.0
ZFP36L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21569,902,452 - 69,911,122 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11469,118,962 - 69,127,451 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01449,372,058 - 49,379,116 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11468,247,341 - 68,255,805 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1468,247,347 - 68,255,805 (-)EnsemblpanPan2panpan1.1
ZFP36L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1842,663,287 - 42,668,665 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl842,664,223 - 42,668,514 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha842,352,777 - 42,358,311 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0842,893,323 - 42,898,832 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl842,893,325 - 42,898,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1842,507,658 - 42,513,193 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0842,582,437 - 42,587,961 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0842,941,809 - 42,947,345 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Zfp36l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864062,140,623 - 62,145,363 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649512,045,377 - 12,051,536 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649512,045,679 - 12,050,737 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFP36L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl792,490,017 - 92,495,554 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1792,490,069 - 92,495,864 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2798,803,589 - 98,809,023 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFP36L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12446,000,222 - 46,005,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2445,999,623 - 46,006,218 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605334,233,922 - 34,240,910 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfp36l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473432,251,114 - 32,257,211 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473432,251,100 - 32,256,458 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Zfp36l1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1794,191,663 - 94,196,965 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zfp36l1
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:51
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000041735
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat

Markers in Region
AI409945  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2698,937,381 - 98,937,543 (+)MAPPERmRatBN7.2
Rnor_6.06103,314,708 - 103,314,869NCBIRnor6.0
Rnor_5.06115,994,015 - 115,994,176UniSTSRnor5.0
RGSC_v3.46103,126,210 - 103,126,371UniSTSRGSC3.4
Celera697,301,057 - 97,301,218UniSTS
RH 3.4 Map6703.1UniSTS
Cytogenetic Map6q24UniSTS
G15966  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2698,930,451 - 98,930,655 (+)MAPPERmRatBN7.2
Rnor_6.06103,307,779 - 103,307,982NCBIRnor6.0
Rnor_5.06115,987,107 - 115,987,310UniSTSRnor5.0
RGSC_v3.46103,119,302 - 103,119,505UniSTSRGSC3.4
Celera697,294,172 - 97,294,375UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083677   ⟹   ENSRNOP00000075412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6104,664,258 - 104,686,993 (-)Ensembl
mRatBN7.2 Ensembl698,930,718 - 98,935,748 (-)Ensembl
Rnor_6.0 Ensembl6103,308,045 - 103,313,074 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135662   ⟹   ENSRNOP00000103496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6104,663,399 - 104,676,043 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135902   ⟹   ENSRNOP00000101166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6104,663,661 - 104,687,979 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145131   ⟹   ENSRNOP00000105992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6104,663,661 - 104,670,337 (-)Ensembl
RefSeq Acc Id: NM_017172   ⟹   NP_058868
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,663,648 - 104,668,690 (-)NCBI
mRatBN7.2698,930,705 - 98,935,748 (-)NCBI
Rnor_6.06103,308,032 - 103,313,074 (-)NCBI
Rnor_5.06115,987,360 - 115,992,381 (-)NCBI
RGSC_v3.46103,119,555 - 103,124,576 (-)RGD
Celera697,294,425 - 97,299,423 (-)RGD
Sequence:
RefSeq Acc Id: XM_063261577   ⟹   XP_063117647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,663,396 - 104,669,815 (-)NCBI
Protein Sequences
Protein RefSeqs NP_058868 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117647 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA36826 (Get FASTA)   NCBI Sequence Viewer  
  CAA60379 (Get FASTA)   NCBI Sequence Viewer  
  EDM03735 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075412.1
GenBank Protein P17431 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058868   ⟸   NM_017172
- UniProtKB: Q6LAU8 (UniProtKB/Swiss-Prot),   P17431 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075412   ⟸   ENSRNOT00000083677
RefSeq Acc Id: XP_063117647   ⟸   XM_063261577
- Peptide Label: isoform X1
- UniProtKB: Q6LAU8 (UniProtKB/Swiss-Prot),   P17431 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000103496   ⟸   ENSRNOT00000135662
Ensembl Acc Id: ENSRNOP00000105992   ⟸   ENSRNOT00000145131
Ensembl Acc Id: ENSRNOP00000101166   ⟸   ENSRNOT00000135902
Protein Domains
C3H1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17431-F1-model_v2 AlphaFold P17431 1-338 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694697
Promoter ID:EPDNEW_R5220
Type:multiple initiation site
Name:Zfp36l1_1
Description:zinc finger protein 36, C3H type-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06103,313,096 - 103,313,156EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62009 AgrOrtholog
BioCyc Gene G2FUF-36942 BioCyc
Ensembl Genes ENSRNOG00000058646 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083677.2 UniProtKB/Swiss-Prot
Gene3D-CATH Zinc finger, CCCH-type UniProtKB/Swiss-Prot
InterPro Tis11B_N UniProtKB/Swiss-Prot
  ZFP36-like UniProtKB/Swiss-Prot
  Znf_CCCH UniProtKB/Swiss-Prot
  Znf_CCCH_sf UniProtKB/Swiss-Prot
KEGG Report rno:29344 UniProtKB/Swiss-Prot
NCBI Gene 29344 ENTREZGENE
PANTHER MRNA DECAY ACTIVATOR PROTEIN ZFP36L1 UniProtKB/Swiss-Prot
  PTHR12547 UniProtKB/Swiss-Prot
Pfam Tis11B_N UniProtKB/Swiss-Prot
  zf-CCCH UniProtKB/Swiss-Prot
PhenoGen Zfp36l1 PhenoGen
PROSITE ZF_C3H1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000058646 RatGTEx
SMART ZnF_C3H1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF90229 UniProtKB/Swiss-Prot
TIGR TC216827
UniProt A0ABK0L369_RAT UniProtKB/TrEMBL
  A0ABK0L808_RAT UniProtKB/TrEMBL
  A0ABK0LQP1_RAT UniProtKB/TrEMBL
  A6HCI0_RAT UniProtKB/TrEMBL
  P17431 ENTREZGENE
  Q6LAU8 ENTREZGENE
  TISB_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6LAU8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Zfp36l1  zinc finger protein 36, C3H type-like 1      Name updated 70584 APPROVED
2002-02-27 Zfp36l1  zinc finger protein 36, C3H type-like 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains zinc-finger domain with a repeating cys-his motif 61544
gene_product member of the TIS11 family of early response genes 61544
gene_protein protein contains 338 aa residues 61544