Grn (granulin precursor) - Rat Genome Database

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Gene: Grn (granulin precursor) Rattus norvegicus
Analyze
Symbol: Grn
Name: granulin precursor
RGD ID: 61983
Description: Predicted to enable protein-folding chaperone binding activity. Involved in several processes, including chondrocyte proliferation; positive regulation of dendritic spine development; and response to estradiol. Is active in glutamatergic synapse. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acrogranin; epithelin; granulin; granulins; PEPI; PGRN; proepithelin; progranulin; prostate cancer cell-derived growth factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,887,834 - 87,893,938 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1087,886,122 - 87,893,936 (+)EnsemblGRCr8
mRatBN7.21087,387,672 - 87,393,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,387,638 - 87,393,775 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1092,424,835 - 92,430,942 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,890,037 - 91,896,139 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,283,370 - 87,289,472 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,377,103 - 90,383,207 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,376,933 - 90,383,205 (+)Ensemblrn6Rnor6.0
Rnor_5.01090,165,634 - 90,171,738 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41091,536,135 - 91,542,239 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1086,096,583 - 86,102,687 (+)NCBICelera
RGSC_v3.11091,552,883 - 91,556,599 (+)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) adipate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butyric acid  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
felbamate  (EXP)
fenamidone  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (EXP)
hypochlorous acid  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
LY294002  (EXP)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodimethylamine  (EXP)
nickel dichloride  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
nitroglycerin  (EXP)
Osajin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
Pomiferin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
pyrethrins  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation involved in immune response  (ISO,ISS)
blastocyst hatching  (ISO)
chondrocyte proliferation  (IMP)
embryo implantation  (ISO)
establishment of localization in cell  (IEA)
locomotory exploration behavior  (ISO)
lysosomal lumen acidification  (ISO,ISS)
lysosomal protein catabolic process  (ISO)
lysosomal transport  (ISO,ISS)
lysosome organization  (ISO,ISS)
maintenance of synapse structure  (ISO)
male mating behavior  (IMP)
microglial cell activation involved in immune response  (ISO,ISS)
negative regulation of hydrolase activity  (ISO)
negative regulation of inflammatory response  (ISO,ISS)
negative regulation of innate immune response  (ISO,ISS)
negative regulation of microglial cell activation  (ISO,ISS)
negative regulation of neuron apoptotic process  (ISO,ISS)
negative regulation of neutrophil activation  (ISO,ISS)
negative regulation of respiratory burst involved in inflammatory response  (ISO,ISS)
neural precursor cell proliferation  (IMP)
positive regulation of angiogenesis  (ISO,ISS)
positive regulation of aspartic-type peptidase activity  (ISO,ISS)
positive regulation of axon regeneration  (ISO,ISS)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of defense response to bacterium  (ISO,ISS)
positive regulation of dendritic spine development  (IMP)
positive regulation of endothelial cell migration  (ISO,ISS)
positive regulation of epithelial cell proliferation  (ISO,ISS)
positive regulation of inflammatory response to wounding  (ISO,ISS)
positive regulation of lysosome organization  (ISO,ISS)
positive regulation of neuron apoptotic process  (ISO,ISS)
positive regulation of neuron projection development  (IEA,IMP)
positive regulation of protein folding  (ISO,ISS)
protein stabilization  (ISO,ISS)
regulation of developmental process  (IEA)
regulation of inflammatory response  (IBA)
regulation of lysosome organization  (ISO)
response to estradiol  (IDA)
retina development in camera-type eye  (ISO)
signal transduction  (IEA)
synaptic vesicle endocytosis  (IMP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Low plasma progranulin levels in children with autism. Al-Ayadhi LY and Mostafa GA, J Neuroinflammation. 2011 Sep 5;8:111.
2. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Baker M, etal., Nature. 2006 Aug 24;442(7105):916-9. Epub 2006 Jul 16.
3. The complementary deoxyribonucleic acid sequence, tissue distribution, and cellular localization of the rat granulin precursor. Bhandari V, etal., Endocrinology 1993 Dec;133(6):2682-9.
4. Progranulin mutations in Dutch familial frontotemporal lobar degeneration. Bronner IF, etal., Eur J Hum Genet. 2007 Mar;15(3):369-74. Epub 2007 Jan 17.
5. Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease. Brouwers N, etal., Neurology. 2008 Aug 26;71(9):656-64. Epub 2008 Jun 18.
6. Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. Chen-Plotkin AS, etal., Acta Neuropathol. 2010 Jan;119(1):111-22. Epub 2009 Aug 2.
7. Progranulin mutation causes frontotemporal dementia in the Swedish Karolinska family. Chiang HH, etal., Alzheimers Dement. 2008 Nov;4(6):414-20.
8. Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus. Chiba S, etal., J Reprod Dev. 2007 Apr;53(2):297-307. Epub 2006 Dec 20.
9. Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels. Cruchaga C, etal., Arch Neurol. 2011 May;68(5):581-6. Epub 2011 Jan 10.
10. Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly. Dickson DW, etal., Neurodegener Dis. 2010;7(1-3):170-4. Epub 2010 Mar 3.
11. The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment. Egashira Y, etal., J Neuroinflammation. 2013 Aug 23;10:105. doi: 10.1186/1742-2094-10-105.
12. Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males. Fenoglio C, etal., Genes Immun. 2010 Sep;11(6):497-503. Epub 2010 May 13.
13. Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members. Finch N, etal., Brain. 2009 Mar;132(Pt 3):583-91. doi: 10.1093/brain/awn352. Epub 2009 Jan 21.
14. Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration. Galimberti D, etal., Neurol Sci. 2013 Jun;34(6):899-903. doi: 10.1007/s10072-012-1151-5. Epub 2012 Jul 14.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Core features of frontotemporal dementia recapitulated in progranulin knockout mice. Ghoshal N, etal., Neurobiol Dis. 2011 Sep 10.
17. GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease. Jasinska-Myga B, etal., Eur J Neurol. 2009 Aug;16(8):909-11. doi: 10.1111/j.1468-1331.2009.02621.x. Epub 2009 Mar 31.
18. Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin. Kelley BJ, etal., Arch Neurol. 2010 Feb;67(2):171-7.
19. Further evidence for plasma progranulin as a biomarker in bipolar disorder. Kittel-Schneider S, etal., J Affect Disord. 2014 Mar;157:87-91. doi: 10.1016/j.jad.2014.01.006. Epub 2014 Jan 25.
20. Progranulin expression in advanced human atherosclerotic plaque. Kojima Y, etal., Atherosclerosis. 2009 Sep;206(1):102-8. Epub 2009 Feb 23.
21. Mutations in progranulin gene: clinical, pathological, and ribonucleic acid expression findings. Lopez de Munain A, etal., Biol Psychiatry. 2008 May 15;63(10):946-52. Epub 2007 Oct 22.
22. Reduced serum progranulin level might be associated with Parkinson's disease risk. Mateo I, etal., Eur J Neurol. 2013 Dec;20(12):1571-3. doi: 10.1111/ene.12090. Epub 2013 Feb 9.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Mukherjee O, etal., Ann Neurol. 2006 Sep;60(3):314-22.
25. Progranulin expression is upregulated after spinal contusion in mice. Naphade SB, etal., Acta Neuropathol. 2010 Jan;119(1):123-33. Epub 2009 Nov 28.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models. Pereson S, etal., J Pathol. 2009 Oct;219(2):173-81.
29. Activity-dependent secretion of progranulin from synapses. Petoukhov E, etal., J Cell Sci. 2013 Dec 1;126(Pt 23):5412-21. doi: 10.1242/jcs.132076. Epub 2013 Sep 17.
30. Microglial upregulation of progranulin as a marker of motor neuron degeneration. Philips T, etal., J Neuropathol Exp Neurol. 2010 Dec;69(12):1191-200.
31. Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations. Pickering-Brown SM, etal., Brain. 2008 Mar;131(Pt 3):721-31. doi: 10.1093/brain/awm331. Epub 2008 Jan 11.
32. The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth. Plowman GD, etal., J Biol Chem 1992 Jun 25;267(18):13073-8.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Comprehensive gene review and curation RGD comprehensive gene curation
37. Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation. Skoglund L, etal., Neurogenetics. 2009 Feb;10(1):27-34. Epub 2008 Oct 15.
38. Progranulin genetic variability contributes to amyotrophic lateral sclerosis. Sleegers K, etal., Neurology. 2008 Jul 22;71(4):253-9. Epub 2008 Jan 9.
39. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
40. Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats. Suzuki M, etal., Physiol Behav. 2000 Mar;68(5):707-13.
41. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Tang W, etal., Science. 2011 Apr 22;332(6028):478-84. Epub 2011 Mar 10.
42. Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses. Tapia L, etal., J Neurosci. 2011 Aug 3;31(31):11126-32.
43. Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis. Vercellino M, etal., Mult Scler. 2011 Oct;17(10):1194-201. Epub 2011 May 25.
44. An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population. Viswanathan J, etal., Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):747-50. doi: 10.1002/ajmg.b.30889.
45. Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation. Xu K, etal., J Biol Chem. 2007 Apr 13;282(15):11347-55. Epub 2007 Feb 15.
46. Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. Zhu S, etal., Brain Res. 2013 Sep 12;1530:54-65. doi: 10.1016/j.brainres.2013.07.023. Epub 2013 Jul 22.
Additional References at PubMed
PMID:2236009   PMID:2268320   PMID:11068878   PMID:12524533   PMID:12526812   PMID:14651853   PMID:15901638   PMID:16493179   PMID:18378771   PMID:20026663   PMID:20479936   PMID:21092856  
PMID:22206666   PMID:22658674   PMID:23041626   PMID:23376485   PMID:23533145   PMID:24006456   PMID:24625528   PMID:26370502   PMID:27571908   PMID:27789271   PMID:28073925   PMID:28453791  
PMID:28541286   PMID:28609022   PMID:28743268   PMID:29992506   PMID:31640144   PMID:39218796  


Genomics

Comparative Map Data
Grn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,887,834 - 87,893,938 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1087,886,122 - 87,893,936 (+)EnsemblGRCr8
mRatBN7.21087,387,672 - 87,393,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,387,638 - 87,393,775 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1092,424,835 - 92,430,942 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,890,037 - 91,896,139 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,283,370 - 87,289,472 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,377,103 - 90,383,207 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,376,933 - 90,383,205 (+)Ensemblrn6Rnor6.0
Rnor_5.01090,165,634 - 90,171,738 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41091,536,135 - 91,542,239 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1086,096,583 - 86,102,687 (+)NCBICelera
RGSC_v3.11091,552,883 - 91,556,599 (+)NCBI
Cytogenetic Map10q32.1NCBI
GRN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,345,302 - 44,353,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,345,108 - 44,353,106 (+)Ensemblhg38GRCh38
GRCh371742,422,670 - 42,430,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,778,017 - 39,785,996 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341739,778,016 - 39,785,996NCBI
Celera1739,132,112 - 39,140,095 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,186,768 - 38,194,753 (+)NCBIHuRef
CHM1_11742,658,166 - 42,666,146 (+)NCBICHM1_1
T2T-CHM13v2.01745,199,297 - 45,207,105 (+)NCBIT2T-CHM13v2.0
Grn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,321,333 - 102,327,635 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,321,141 - 102,327,874 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811102,430,507 - 102,436,809 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,430,315 - 102,437,048 (+)Ensemblmm10GRCm38
MGSCv3711102,291,636 - 102,298,123 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611102,246,597 - 102,252,895 (+)NCBIMGSCv36mm8
Celera11114,140,482 - 114,146,970 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
Grn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,368,428 - 17,372,377 (+)Ensembl
ChiLan1.0NW_00495545117,368,600 - 17,371,981 (+)NCBIChiLan1.0ChiLan1.0
GRN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,557,091 - 20,565,084 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,521,447 - 22,529,431 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,046,329 - 13,054,236 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,211,784 - 13,219,793 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,211,784 - 13,219,609 (-)EnsemblpanPan2panpan1.1
GRN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,077,430 - 19,085,443 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,077,427 - 19,082,268 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha918,467,174 - 18,474,620 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0919,771,801 - 19,779,240 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,771,806 - 19,779,115 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,625,608 - 18,633,045 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,808,582 - 18,816,025 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,952,849 - 18,960,290 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,390,156 - 18,401,106 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541793,523 - 800,217 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936541793,548 - 800,271 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,893,770 - 18,900,446 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11218,893,772 - 18,900,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,212,414 - 19,216,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,037,344 - 62,045,765 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,036,412 - 62,045,614 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607732,804,031 - 32,812,724 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795704,252 - 707,165 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624795704,066 - 708,721 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1961,725,875 - 61,732,077 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grn
59 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:145
Interacting mature miRNAs:169
Transcripts:ENSRNOT00000028557, ENSRNOT00000040472
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Wox31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,393,632 - 87,393,760 (+)MAPPERmRatBN7.2
Rnor_6.01090,383,063 - 90,383,190NCBIRnor6.0
Rnor_5.01090,171,594 - 90,171,721UniSTSRnor5.0
RGSC_v3.41091,542,095 - 91,542,222UniSTSRGSC3.4
Celera1086,102,543 - 86,102,670UniSTS
Cytogenetic Map10q32.1UniSTS
D10Wox30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,393,676 - 87,393,763 (+)MAPPERmRatBN7.2
Rnor_6.01090,383,107 - 90,383,193NCBIRnor6.0
Rnor_5.01090,171,638 - 90,171,724UniSTSRnor5.0
RGSC_v3.41091,542,139 - 91,542,225UniSTSRGSC3.4
Celera1086,102,587 - 86,102,673UniSTS
Cytogenetic Map10q32.1UniSTS
RH128403  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,393,473 - 87,393,670 (+)MAPPERmRatBN7.2
Rnor_6.01090,382,904 - 90,383,100NCBIRnor6.0
Rnor_5.01090,171,435 - 90,171,631UniSTSRnor5.0
RGSC_v3.41091,541,936 - 91,542,132UniSTSRGSC3.4
Celera1086,102,384 - 86,102,580UniSTS
Cytogenetic Map10q32.1UniSTS
D16195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,393,599 - 87,393,772 (+)MAPPERmRatBN7.2
Rnor_6.01090,383,030 - 90,383,202NCBIRnor6.0
Rnor_5.01090,171,561 - 90,171,733UniSTSRnor5.0
RGSC_v3.41091,542,062 - 91,542,234UniSTSRGSC3.4
Celera1086,102,510 - 86,102,682UniSTS
Cytogenetic Map10q32.1UniSTS
RH138782  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,389,133 - 87,389,267 (+)MAPPERmRatBN7.2
Rnor_6.01090,378,564 - 90,378,697NCBIRnor6.0
Rnor_5.01090,167,095 - 90,167,228UniSTSRnor5.0
RGSC_v3.41091,537,596 - 91,537,729UniSTSRGSC3.4
Celera1086,098,044 - 86,098,177UniSTS
RH 3.4 Map10879.99UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028557   ⟹   ENSRNOP00000028557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,890,217 - 87,893,935 (+)Ensembl
mRatBN7.2 Ensembl1087,387,638 - 87,393,767 (+)Ensembl
Rnor_6.0 Ensembl1090,376,933 - 90,383,205 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000040472   ⟹   ENSRNOP00000043881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,887,834 - 87,893,936 (+)Ensembl
mRatBN7.2 Ensembl1087,387,672 - 87,393,775 (+)Ensembl
Rnor_6.0 Ensembl1090,377,103 - 90,383,205 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124158   ⟹   ENSRNOP00000112424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,887,652 - 87,893,934 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136929   ⟹   ENSRNOP00000110253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,886,122 - 87,893,936 (+)Ensembl
RefSeq Acc Id: NM_001145842   ⟹   NP_001139314
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,887,834 - 87,893,938 (+)NCBI
mRatBN7.21087,387,672 - 87,393,777 (+)NCBI
Rnor_6.01090,377,103 - 90,383,207 (+)NCBI
Rnor_5.01090,165,634 - 90,171,738 (+)NCBI
RGSC_v3.41091,536,135 - 91,542,239 (+)RGD
Celera1086,096,583 - 86,102,687 (+)RGD
Sequence:
RefSeq Acc Id: NM_017113   ⟹   NP_058809
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,887,834 - 87,893,938 (+)NCBI
mRatBN7.21087,387,672 - 87,393,777 (+)NCBI
Rnor_6.01090,377,103 - 90,383,207 (+)NCBI
Rnor_5.01090,165,634 - 90,171,738 (+)NCBI
RGSC_v3.41091,536,135 - 91,542,239 (+)RGD
Celera1086,096,583 - 86,102,687 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767981   ⟹   XP_008766203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,887,854 - 87,893,938 (+)NCBI
mRatBN7.21087,387,752 - 87,393,762 (+)NCBI
Rnor_6.01090,377,173 - 90,383,103 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058809   ⟸   NM_017113
- Peptide Label: isoform a precursor
- UniProtKB: G3V8V1 (UniProtKB/TrEMBL),   A6HJK0 (UniProtKB/TrEMBL),   A6HJK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139314   ⟸   NM_001145842
- Peptide Label: isoform b precursor
- UniProtKB: F1LMP7 (UniProtKB/TrEMBL),   Q6IN42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766203   ⟸   XM_008767981
- Peptide Label: isoform X1
- UniProtKB: P23785 (UniProtKB/Swiss-Prot),   A6HJK4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028557   ⟸   ENSRNOT00000028557
Ensembl Acc Id: ENSRNOP00000043881   ⟸   ENSRNOT00000040472
Ensembl Acc Id: ENSRNOP00000110253   ⟸   ENSRNOT00000136929
Ensembl Acc Id: ENSRNOP00000112424   ⟸   ENSRNOT00000124158
Protein Domains
GRANULINS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23785-F1-model_v2 AlphaFold P23785 1-588 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697788
Promoter ID:EPDNEW_R8312
Type:initiation region
Name:Grn_1
Description:granulin precursor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01090,377,118 - 90,377,178EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61983 AgrOrtholog
BioCyc Gene G2FUF-23107 BioCyc
Ensembl Genes ENSRNOG00000021031 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028557 ENTREZGENE
  ENSRNOT00000040472 ENTREZGENE
  ENSRNOT00000124158 ENTREZGENE
Gene3D-CATH 2.10.25.160 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7098196 IMAGE-MGC_LOAD
InterPro Granulin UniProtKB/Swiss-Prot
  Granulin_fam UniProtKB/Swiss-Prot
  Granulin_sf UniProtKB/Swiss-Prot
KEGG Report rno:29143 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91745 IMAGE-MGC_LOAD
NCBI Gene 29143 ENTREZGENE
PANTHER PROGRANULIN UniProtKB/Swiss-Prot
  PTHR12274 UniProtKB/Swiss-Prot
Pfam Granulin UniProtKB/Swiss-Prot
PhenoGen Grn PhenoGen
PROSITE GRANULINS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021031 RatGTEx
SMART GRAN UniProtKB/Swiss-Prot
Superfamily-SCOP Granulin repeat UniProtKB/Swiss-Prot
UniProt A0ABK0LYC5_RAT UniProtKB/TrEMBL
  A0ABK0M0I1_RAT UniProtKB/TrEMBL
  A6HJK0 ENTREZGENE, UniProtKB/TrEMBL
  A6HJK1 ENTREZGENE, UniProtKB/TrEMBL
  A6HJK2_RAT UniProtKB/TrEMBL
  A6HJK3_RAT UniProtKB/TrEMBL
  A6HJK4 ENTREZGENE, UniProtKB/TrEMBL
  A6HJK5_RAT UniProtKB/TrEMBL
  A6HJK6_RAT UniProtKB/TrEMBL
  A6HJK7_RAT UniProtKB/TrEMBL
  A6HJK8_RAT UniProtKB/TrEMBL
  A6HJK9_RAT UniProtKB/TrEMBL
  F1LMP7 ENTREZGENE, UniProtKB/TrEMBL
  G3V8V1 ENTREZGENE, UniProtKB/TrEMBL
  GRN_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IN42 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-20 Grn  granulin precursor  Grn  granulin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grn  granulin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein epithelin precursor is processed to epithelin 1 and epithelin 2 proteins 61623