Rapgef1 (Rap guanine nucleotide exchange factor 1) - Rat Genome Database

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Pathways
Gene: Rapgef1 (Rap guanine nucleotide exchange factor 1) Rattus norvegicus
Analyze
Symbol: Rapgef1
Name: Rap guanine nucleotide exchange factor 1
RGD ID: 619793
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of Fc receptor mediated stimulatory signaling pathway; positive regulation of cellular component organization; and regulation of MAPK cascade. Located in perinuclear region of cytoplasm and phagocytic vesicle membrane. Part of protein-containing complex. Biomarker of anti-basement membrane glomerulonephritis and mesangial proliferative glomerulonephritis. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; E-cadherin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C3G; C3G-1; C3G-1, C3G-2; C3G-2; Grf2; Rap guanine nucleotide exchange factor (GEF) 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Rapgef1_v2 ; Rapgef1_v1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,296,211 - 33,414,119 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl333,296,230 - 33,414,119 (+)EnsemblGRCr8
mRatBN7.2312,898,349 - 13,016,234 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl312,898,266 - 13,013,984 (+)EnsemblmRatBN7.2
Rnor_6.038,189,594 - 8,307,077 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,192,575 - 8,304,976 (+)Ensemblrn6Rnor6.0
Rnor_5.0313,534,547 - 13,650,426 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.438,634,764 - 8,680,197 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera37,697,182 - 7,794,443 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. Chung J, etal., J Immunol. 2008 Oct 15;181(8):5501-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The Ras-mitogen-activated protein kinase pathway is critical for the activation of matrix metalloproteinase secretion and the invasiveness in v-crk-transformed 3Y1. Liu E, etal., Cancer Res. 2000 May 1;60(9):2361-4.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells. Rufanova VA, etal., Can J Physiol Pharmacol. 2010 Aug;88(8):808-16. doi: 10.1139/Y10-056.
10. C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis. Rufanova VA, etal., Kidney Int. 2009 Jan;75(1):31-40. doi: 10.1038/ki.2008.448. Epub 2008 Sep 10.
11. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
12. Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells. Schonherr C, etal., Oncogene. 2010 May 13;29(19):2817-30. doi: 10.1038/onc.2010.27. Epub 2010 Mar 1.
13. Identification of a novel splice variant of C3G which shows tissue-specific expression. Shivakrupa, etal., DNA Cell Biol 1999 Sep;18(9):701-8.
14. Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation. Wang Z, etal., Mol Cell Biol. 2006 Mar;26(6):2130-45.
Additional References at PubMed
PMID:9560161   PMID:10548487   PMID:12466202   PMID:12671687   PMID:14551197   PMID:14712229   PMID:16858399   PMID:17515907   PMID:17724123   PMID:21840392   PMID:23291598   PMID:23686869  
PMID:25621495   PMID:30152875  


Genomics

Comparative Map Data
Rapgef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,296,211 - 33,414,119 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl333,296,230 - 33,414,119 (+)EnsemblGRCr8
mRatBN7.2312,898,349 - 13,016,234 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl312,898,266 - 13,013,984 (+)EnsemblmRatBN7.2
Rnor_6.038,189,594 - 8,307,077 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,192,575 - 8,304,976 (+)Ensemblrn6Rnor6.0
Rnor_5.0313,534,547 - 13,650,426 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.438,634,764 - 8,680,197 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera37,697,182 - 7,794,443 (+)NCBICelera
Cytogenetic Map3p12NCBI
RAPGEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389131,576,775 - 131,740,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9131,576,758 - 131,740,117 (-)Ensemblhg38GRCh38
GRCh379134,452,162 - 134,615,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369133,441,978 - 133,602,746 (-)NCBIBuild 36Build 36hg18NCBI36
Celera9104,992,289 - 105,153,075 (-)NCBICelera
Cytogenetic Map9q34.13NCBI
HuRef9103,946,113 - 104,106,918 (-)NCBIHuRef
CHM1_19134,601,537 - 134,762,344 (-)NCBICHM1_1
T2T-CHM13v2.09143,789,743 - 143,952,984 (-)NCBIT2T-CHM13v2.0
Rapgef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39229,509,732 - 29,630,376 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl229,509,732 - 29,630,990 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38229,619,720 - 29,740,364 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl229,619,720 - 29,740,978 (+)Ensemblmm10GRCm38
MGSCv37229,475,240 - 29,595,883 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36229,441,729 - 29,562,372 (+)NCBIMGSCv36mm8
Celera229,325,793 - 29,447,456 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map220.32NCBI
Rapgef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555131,226,205 - 1,315,922 (-)Ensembl
ChiLan1.0NW_0049555131,224,418 - 1,328,176 (-)NCBIChiLan1.0ChiLan1.0
RAPGEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2117,615,567 - 7,778,048 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan197,617,923 - 7,780,395 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09102,698,970 - 102,861,482 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19131,337,001 - 131,468,336 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9131,337,001 - 131,495,664 (-)EnsemblpanPan2panpan1.1
RAPGEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1952,429,204 - 52,566,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl952,450,597 - 52,563,778 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha951,696,813 - 51,835,167 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0953,332,127 - 53,471,097 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl953,332,194 - 53,469,116 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1952,105,371 - 52,243,070 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0952,430,365 - 52,567,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0952,522,579 - 52,661,232 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rapgef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947198,537,011 - 198,642,163 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648718,305,488 - 18,410,952 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648718,305,537 - 18,411,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1271,494,248 - 271,600,920 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11271,494,243 - 271,624,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21305,502,204 - 305,633,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1126,407,030 - 6,566,200 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl126,437,454 - 6,567,436 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660798,999,335 - 9,158,519 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247604,376,713 - 4,474,837 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247604,376,733 - 4,474,834 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rapgef1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v156,992,705 - 7,083,748 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rapgef1
691 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:279
Count of miRNA genes:110
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000019220, ENSRNOT00000060977, ENSRNOT00000074424
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH129681  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,015,971 - 13,016,175 (+)MAPPERmRatBN7.2
Rnor_6.038,306,815 - 8,307,018NCBIRnor6.0
Rnor_5.0313,650,164 - 13,650,367UniSTSRnor5.0
Celera37,794,181 - 7,794,384UniSTS
RH 3.4 Map335.3UniSTS
Cytogenetic Map3p12UniSTS
BF386172  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2312,994,988 - 12,995,157 (+)MAPPERmRatBN7.2
Rnor_6.038,285,833 - 8,286,001NCBIRnor6.0
Rnor_5.0313,629,182 - 13,629,350UniSTSRnor5.0
Celera37,773,187 - 7,773,355UniSTS
RH 3.4 Map321.9UniSTS
Cytogenetic Map3p12UniSTS
UniSTS:234364  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,015,379 - 13,015,561 (+)MAPPERmRatBN7.2
Rnor_6.038,306,223 - 8,306,404NCBIRnor6.0
Rnor_5.0313,649,572 - 13,649,753UniSTSRnor5.0
Celera37,793,589 - 7,793,770UniSTS
Cytogenetic Map3p12UniSTS
UniSTS:224268  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2312,972,261 - 12,972,447 (+)MAPPERmRatBN7.2
Rnor_6.038,251,757 - 8,251,942NCBIRnor6.0
Rnor_5.0313,596,245 - 13,596,430UniSTSRnor5.0
RGSC_v3.438,660,842 - 8,661,027UniSTSRGSC3.4
Celera37,750,720 - 7,750,905UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ249986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000060977   ⟹   ENSRNOP00000057696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl333,319,405 - 33,414,118 (+)Ensembl
mRatBN7.2 Ensembl312,921,409 - 13,013,984 (+)Ensembl
Rnor_6.0 Ensembl38,192,575 - 8,304,976 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093970   ⟹   ENSRNOP00000081072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl333,296,332 - 33,414,118 (+)Ensembl
mRatBN7.2 Ensembl312,898,266 - 13,013,984 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095571   ⟹   ENSRNOP00000082703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl333,296,230 - 33,414,119 (+)Ensembl
mRatBN7.2 Ensembl312,953,944 - 13,013,984 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099738   ⟹   ENSRNOP00000080887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl333,319,405 - 33,414,118 (+)Ensembl
mRatBN7.2 Ensembl312,955,327 - 13,013,984 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108449   ⟹   ENSRNOP00000088594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl333,296,230 - 33,414,119 (+)Ensembl
mRatBN7.2 Ensembl312,898,266 - 13,013,984 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000161849   ⟹   ENSRNOP00000102988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl333,296,334 - 33,414,118 (+)Ensembl
RefSeq Acc Id: NM_001427397   ⟹   NP_001414326
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,296,230 - 33,414,119 (+)NCBI
RefSeq Acc Id: XM_006233902   ⟹   XP_006233964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,579 - 13,016,234 (+)NCBI
Rnor_6.038,189,596 - 8,307,077 (+)NCBI
Rnor_5.0313,534,547 - 13,650,426 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761683   ⟹   XP_008759905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,566 - 13,016,234 (+)NCBI
Rnor_6.038,189,594 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761684   ⟹   XP_008759906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,568 - 13,016,234 (+)NCBI
Rnor_6.038,189,595 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761685   ⟹   XP_008759907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,566 - 13,016,234 (+)NCBI
Rnor_6.038,189,594 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761686   ⟹   XP_008759908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,569 - 13,016,234 (+)NCBI
Rnor_6.038,189,595 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592102   ⟹   XP_017447591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,561 - 13,016,234 (+)NCBI
Rnor_6.038,189,594 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592108   ⟹   XP_017447597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,573 - 13,016,234 (+)NCBI
Rnor_6.038,189,595 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106157   ⟹   XP_038962085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,553 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106158   ⟹   XP_038962086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,555 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106159   ⟹   XP_038962087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,561 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106160   ⟹   XP_038962088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,296,211 - 33,414,119 (+)NCBI
mRatBN7.2312,898,349 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106161   ⟹   XP_038962089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,566 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106162   ⟹   XP_038962090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,559 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106163   ⟹   XP_038962091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,553 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106164   ⟹   XP_038962092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,296,211 - 33,414,119 (+)NCBI
mRatBN7.2312,898,349 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106165   ⟹   XP_038962093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,559 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106167   ⟹   XP_038962095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,563 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106168   ⟹   XP_038962096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,568 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106169   ⟹   XP_038962097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
mRatBN7.2312,918,579 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_063284486   ⟹   XP_063140556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,296,211 - 33,414,119 (+)NCBI
RefSeq Acc Id: XM_063284487   ⟹   XP_063140557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,296,211 - 33,414,119 (+)NCBI
RefSeq Acc Id: XM_063284488   ⟹   XP_063140558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,296,211 - 33,414,119 (+)NCBI
RefSeq Acc Id: XM_063284489   ⟹   XP_063140559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,296,211 - 33,414,119 (+)NCBI
RefSeq Acc Id: XM_063284490   ⟹   XP_063140560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
RefSeq Acc Id: XM_063284491   ⟹   XP_063140561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
RefSeq Acc Id: XM_063284492   ⟹   XP_063140562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
RefSeq Acc Id: XM_063284493   ⟹   XP_063140563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,308,681 - 33,414,119 (+)NCBI
RefSeq Acc Id: XM_063284494   ⟹   XP_063140564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,296,211 - 33,414,119 (+)NCBI
RefSeq Acc Id: XM_063284495   ⟹   XP_063140565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,296,211 - 33,414,119 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414326 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233964 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759905 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759906 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759907 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759908 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447591 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447597 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962085 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962086 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962087 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962088 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962089 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962090 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962091 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962092 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962093 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962095 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962096 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962097 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140556 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140557 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140558 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140559 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140560 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140561 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140562 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140563 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140564 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140565 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAB59566 (Get FASTA)   NCBI Sequence Viewer  
  EDL93379 (Get FASTA)   NCBI Sequence Viewer  
  EDL93380 (Get FASTA)   NCBI Sequence Viewer  
  EDL93381 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057696.5
  ENSRNOP00000080887
  ENSRNOP00000080887.2
  ENSRNOP00000081072
  ENSRNOP00000081072.1
  ENSRNOP00000082703
  ENSRNOP00000082703.2
  ENSRNOP00000088594
  ENSRNOP00000088594.1
  ENSRNOP00000102988
  ENSRNOP00000102988.1
RefSeq Acc Id: XP_006233964   ⟸   XM_006233902
- Peptide Label: isoform X25
- UniProtKB: A0A8I5ZRV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759905   ⟸   XM_008761683
- Peptide Label: isoform X6
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759906   ⟸   XM_008761684
- Peptide Label: isoform X11
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759907   ⟸   XM_008761685
- Peptide Label: isoform X14
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759908   ⟸   XM_008761686
- Peptide Label: isoform X17
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447591   ⟸   XM_017592102
- Peptide Label: isoform X3
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447597   ⟸   XM_017592108
- Peptide Label: isoform X21
- UniProtKB: A0A8I5ZQV4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057696   ⟸   ENSRNOT00000060977
RefSeq Acc Id: XP_038962088   ⟸   XM_039106160
- Peptide Label: isoform X5
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962092   ⟸   XM_039106164
- Peptide Label: isoform X12
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962085   ⟸   XM_039106157
- Peptide Label: isoform X1
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962091   ⟸   XM_039106163
- Peptide Label: isoform X10
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962086   ⟸   XM_039106158
- Peptide Label: isoform X2
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962090   ⟸   XM_039106162
- Peptide Label: isoform X9
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962093   ⟸   XM_039106165
- Peptide Label: isoform X13
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962087   ⟸   XM_039106159
- Peptide Label: isoform X4
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962095   ⟸   XM_039106167
- Peptide Label: isoform X19
- UniProtKB: A0A8I5ZQV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962089   ⟸   XM_039106161
- Peptide Label: isoform X7
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962096   ⟸   XM_039106168
- Peptide Label: isoform X23
- UniProtKB: A0A8I5ZRV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962097   ⟸   XM_039106169
- Peptide Label: isoform X28
- UniProtKB: A0A8I5ZUL6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088594   ⟸   ENSRNOT00000108449
Ensembl Acc Id: ENSRNOP00000081072   ⟸   ENSRNOT00000093970
Ensembl Acc Id: ENSRNOP00000080887   ⟸   ENSRNOT00000099738
Ensembl Acc Id: ENSRNOP00000082703   ⟸   ENSRNOT00000095571
RefSeq Acc Id: XP_063140556   ⟸   XM_063284486
- Peptide Label: isoform X8
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140564   ⟸   XM_063284494
- Peptide Label: isoform X27
- UniProtKB: A0A8I5ZQV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140557   ⟸   XM_063284487
- Peptide Label: isoform X15
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140559   ⟸   XM_063284489
- Peptide Label: isoform X18
- UniProtKB: A0A8I6A6H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140558   ⟸   XM_063284488
- Peptide Label: isoform X16
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140565   ⟸   XM_063284495
- Peptide Label: isoform X29
- UniProtKB: A0A8I5ZUL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414326   ⟸   NM_001427397
- UniProtKB: A0A8I6A6H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140560   ⟸   XM_063284490
- Peptide Label: isoform X20
- UniProtKB: A0A8I5ZQV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140561   ⟸   XM_063284491
- Peptide Label: isoform X22
- UniProtKB: A0A8I5ZQV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140562   ⟸   XM_063284492
- Peptide Label: isoform X24
- UniProtKB: A0A8I5ZRV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140563   ⟸   XM_063284493
- Peptide Label: isoform X26
- UniProtKB: A0A8I5ZUL6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102988   ⟸   ENSRNOT00000161849
Protein Domains
N-terminal Ras-GEF   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8L9-F1-model_v2 AlphaFold F1M8L9 1-1253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619793 AgrOrtholog
BioCyc Gene G2FUF-50258 BioCyc
Ensembl Genes ENSRNOG00000014316 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060977.7 UniProtKB/TrEMBL
  ENSRNOT00000093970 ENTREZGENE
  ENSRNOT00000093970.2 UniProtKB/TrEMBL
  ENSRNOT00000095571 ENTREZGENE
  ENSRNOT00000095571.2 UniProtKB/TrEMBL
  ENSRNOT00000099738 ENTREZGENE
  ENSRNOT00000099738.2 UniProtKB/TrEMBL
  ENSRNOT00000108449 ENTREZGENE
  ENSRNOT00000108449.2 UniProtKB/TrEMBL
  ENSRNOT00000161849 ENTREZGENE
  ENSRNOT00000161849.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/TrEMBL
NCBI Gene 63881 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 UniProtKB/TrEMBL
Pfam RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PhenoGen Rapgef1 PhenoGen
PROSITE RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014316 RatGTEx
SMART RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
Superfamily-SCOP Ras_GEF UniProtKB/TrEMBL
UniProt A0A8I5ZQV4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRV1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUL6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6H6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L2G5_RAT UniProtKB/TrEMBL
  A6JTR6_RAT UniProtKB/TrEMBL
  A6JTR7_RAT UniProtKB/TrEMBL
  A6JTR8_RAT UniProtKB/TrEMBL
  F1M8L9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Rapgef1  Rap guanine nucleotide exchange factor 1  Rapgef1  Rap guanine nucleotide exchange factor (GEF) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rapgef1  Rap guanine nucleotide exchange factor (GEF) 1  Grf2  C3G protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Grf2  C3G protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein variant C3G-2 contains a 51 amino acid insertion 632980
gene_transcript variant C3G-2 is expressed at high levels in testis while variant C3G-1 is present in most other tissues 632980