Rapgef1 (Rap guanine nucleotide exchange factor 1) - Rat Genome Database

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Gene: Rapgef1 (Rap guanine nucleotide exchange factor 1) Chinchilla lanigera
Analyze
Symbol: Rapgef1
Name: Rap guanine nucleotide exchange factor 1
RGD ID: 8898630
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN blood vessel development (ortholog); canonical Wnt signaling pathway (ortholog); cell-cell adhesion (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; E-cadherin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH anti-basement membrane glomerulonephritis (ortholog); Ehlers-Danlos syndrome classic type 1 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); early endosome (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Rap guanine nucleotide exchange factor (GEF) 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555131,226,205 - 1,315,922 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555131,224,418 - 1,328,176 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rapgef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555131,226,205 - 1,315,922 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555131,224,418 - 1,328,176 (-)NCBIChiLan1.0ChiLan1.0
RAPGEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389131,576,775 - 131,740,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9131,576,770 - 131,740,076 (-)EnsemblGRCh38hg38GRCh38
GRCh379134,452,162 - 134,615,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369133,441,978 - 133,602,746 (-)NCBINCBI36Build 36hg18NCBI36
Celera9104,992,289 - 105,153,075 (-)NCBICelera
Cytogenetic Map9q34.13NCBI
HuRef9103,946,113 - 104,106,918 (-)NCBIHuRef
CHM1_19134,601,537 - 134,762,344 (-)NCBICHM1_1
T2T-CHM13v2.09143,789,743 - 143,952,984 (-)NCBIT2T-CHM13v2.0
Rapgef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39229,509,732 - 29,630,376 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl229,509,732 - 29,630,990 (+)EnsemblGRCm39 Ensembl
GRCm38229,619,720 - 29,740,364 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl229,619,720 - 29,740,978 (+)EnsemblGRCm38mm10GRCm38
MGSCv37229,475,240 - 29,595,883 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36229,441,729 - 29,562,372 (+)NCBIMGSCv36mm8
Celera229,325,793 - 29,447,456 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map220.32NCBI
Rapgef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,296,211 - 33,414,119 (+)NCBIGRCr8
mRatBN7.2312,898,349 - 13,016,234 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl312,898,266 - 13,013,984 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.038,189,594 - 8,307,077 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,192,575 - 8,304,976 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0313,534,547 - 13,650,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.438,634,764 - 8,680,197 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera37,697,182 - 7,794,443 (+)NCBICelera
Cytogenetic Map3p12NCBI
RAPGEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2117,615,567 - 7,778,048 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan197,617,923 - 7,780,395 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09102,698,970 - 102,861,482 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19131,337,001 - 131,468,336 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9131,337,001 - 131,495,664 (-)Ensemblpanpan1.1panPan2
RAPGEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1952,429,204 - 52,566,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl952,450,597 - 52,563,778 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha951,696,813 - 51,835,167 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0953,332,127 - 53,471,097 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl953,332,194 - 53,469,116 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1952,105,371 - 52,243,070 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0952,430,365 - 52,567,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0952,522,579 - 52,661,232 (+)NCBIUU_Cfam_GSD_1.0
Rapgef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947198,537,011 - 198,642,163 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648718,305,488 - 18,410,952 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648718,305,537 - 18,411,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1271,494,248 - 271,600,920 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11271,494,243 - 271,624,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21305,502,204 - 305,633,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1126,407,030 - 6,566,200 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl126,437,454 - 6,567,436 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660798,999,335 - 9,158,519 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247604,376,713 - 4,474,837 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247604,376,733 - 4,474,834 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000010414   ⟹   ENSCLAP00000010284
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555131,226,205 - 1,315,922 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000010415   ⟹   ENSCLAP00000010285
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555131,226,205 - 1,315,922 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000010416   ⟹   ENSCLAP00000010286
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555131,226,205 - 1,276,748 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000010417   ⟹   ENSCLAP00000010287
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555131,226,205 - 1,276,748 (-)Ensembl
RefSeq Acc Id: XM_013506678   ⟹   XP_013362132
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555131,224,418 - 1,325,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013506679   ⟹   XP_013362133
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555131,224,418 - 1,316,071 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013506680   ⟹   XP_013362134
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555131,224,418 - 1,328,176 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013506681   ⟹   XP_013362135
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555131,224,418 - 1,284,786 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013506682   ⟹   XP_013362136
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555131,224,418 - 1,325,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013506683   ⟹   XP_013362137
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555131,224,418 - 1,325,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013506684   ⟹   XP_013362138
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555131,224,418 - 1,325,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013506685   ⟹   XP_013362139
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555131,224,418 - 1,325,296 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013362134   ⟸   XM_013506680
- Peptide Label: isoform X3
- UniProtKB: A0A8C2YMV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362137   ⟸   XM_013506683
- Peptide Label: isoform X6
- UniProtKB: A0A8C2YMU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362139   ⟸   XM_013506685
- Peptide Label: isoform X8
- UniProtKB: A0A8C2VBF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362138   ⟸   XM_013506684
- Peptide Label: isoform X7
- UniProtKB: A0A8C2VBF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362136   ⟸   XM_013506682
- Peptide Label: isoform X5
- UniProtKB: A0A8C2V5G2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362132   ⟸   XM_013506678
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YMV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362133   ⟸   XM_013506679
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YMV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362135   ⟸   XM_013506681
- Peptide Label: isoform X4
- UniProtKB: A0A8C2YMV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000010284   ⟸   ENSCLAT00000010414
RefSeq Acc Id: ENSCLAP00000010285   ⟸   ENSCLAT00000010415
RefSeq Acc Id: ENSCLAP00000010286   ⟸   ENSCLAT00000010416
RefSeq Acc Id: ENSCLAP00000010287   ⟸   ENSCLAT00000010417
Protein Domains
N-terminal Ras-GEF   Ras-GEF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000007111 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000010414 ENTREZGENE
  ENSCLAT00000010414.1 UniProtKB/TrEMBL
  ENSCLAT00000010415.1 UniProtKB/TrEMBL
  ENSCLAT00000010416 ENTREZGENE
  ENSCLAT00000010416.1 UniProtKB/TrEMBL
  ENSCLAT00000010417 ENTREZGENE
  ENSCLAT00000010417.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
NCBI Gene Rapgef1 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 UniProtKB/TrEMBL
Pfam RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PROSITE RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
Superfamily-SCOP SSF48366 UniProtKB/TrEMBL
UniProt A0A8C2V5G2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VBF7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YMU9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YMV2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Rapgef1  Rap guanine nucleotide exchange factor 1    Rap guanine nucleotide exchange factor (GEF) 1  Symbol and/or name change 5135510 APPROVED