Mdh2 (malate dehydrogenase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mdh2 (malate dehydrogenase 2) Rattus norvegicus
Analyze
Symbol: Mdh2
Name: malate dehydrogenase 2
RGD ID: 619719
Description: Enables L-malate dehydrogenase (NADP+) activity and identical protein binding activity. Involved in malate metabolic process. Located in mitochondrial matrix. Used to study brain ischemia; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2); PARTICIPATES IN citric acid cycle pathway; fructose-1,6-bisphosphatase deficiency pathway; fumaric aciduria pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase, mitochondrial; Mor1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,530,886 - 26,543,841 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1226,530,881 - 26,543,841 (-)EnsemblGRCr8
mRatBN7.21220,894,269 - 20,907,225 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,894,262 - 20,907,271 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1222,036,216 - 22,049,189 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,648,634 - 22,661,607 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,715,096 - 21,728,069 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,941,451 - 23,954,406 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,941,448 - 23,954,431 (-)Ensemblrn6Rnor6.0
Rnor_5.01225,938,703 - 25,951,658 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41222,021,302 - 22,034,257 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1222,657,034 - 22,669,988 (-)NCBICelera
RGSC_v3.11222,008,565 - 22,021,518 (-)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
D-gluconic acid  (EXP)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dinophysistoxin 1  (ISO)
Diosbulbin B  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
FR900359  (ISO)
furfural  (ISO)
gedunin  (ISO)
hydrogen peroxide  (EXP)
indometacin  (EXP)
inulin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
mitoxantrone  (ISO)
Monobutylphthalate  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP)
ouabain  (ISO)
ozone  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
PhIP  (EXP)
pirinixic acid  (ISO)
Propiverine  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
membrane  (IEA,ISO)
mitochondrial matrix  (IDA,IEA,ISO)
mitochondrion  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Chow KM, etal., Biochim Biophys Acta. 2005 May 25;1723(1-3):292-301. Epub 2005 Mar 10.
2. Effects of ischemia and pharmacological treatment on subcellular fractions from neonatal rat brain. Curti D, etal., Farmaco Sci. 1982 Apr;37(4):275-82.
3. Cross-linking of mitochondrial matrix proteins in situ. D'Souza SF and Srere PA, Biochim Biophys Acta. 1983 Jul 29;724(1):40-51.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Adriamycin induced myocardial failure in rats: Protective role of Centella asiatica. Gnanapragasam A, etal., Mol Cell Biochem. 2006 Jun 20;.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Isolation and nucleotide sequence of a cDNA clone encoding rat mitochondrial malate dehydrogenase. Grant PM, etal., Nucleic Acids Res 1986 Aug 11;14(15):6053-66.
8. Effect of alpha-tocopherol on mitochondrial electron transport in experimental myocardial infarction in rats. Ithayarasi AP and Shyamala Devi C, Indian J Biochem Biophys. 1998 Apr;35(2):115-9.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Preparation and properties of mitochondria derived from synaptosomes. Lai JC and Clark JB, Biochem J. 1976 Feb 15;154(2):423-32.
11. Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Long J, etal., Life Sci. 2006 Sep 5;79(15):1466-72. Epub 2006 May 7.
12. Purification and properties of the cytosolic and mitochondrial forms of aspartate aminotransferase and malate dehydrogenase from rat heart. Mavrides C and Nadeau G, Biochem Cell Biol. 1987 Mar;65(3):239-44.
13. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. McKenna MC, etal., Biochem Pharmacol. 2006 Feb 14;71(4):399-407. Epub 2005 Dec 20.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Role of NADH shuttles in glucose-induced insulin secretion from fetal beta-cells. Tan C, etal., Diabetes. 2002 Oct;51(10):2989-96.
23. Rat liver mitochondrial malate dehydrogenase: purification, kinetic properties, and role in ethanol metabolism. Wiseman MS, etal., Arch Biochem Biophys. 1991 Oct;290(1):191-6.
24. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
Additional References at PubMed
PMID:3828294   PMID:5496232   PMID:6576816   PMID:8117664   PMID:12865426   PMID:14651853   PMID:15489334   PMID:16740313   PMID:16751257   PMID:17603759   PMID:17634366   PMID:18614015  
PMID:19056867   PMID:19717454   PMID:20080761   PMID:20167786   PMID:20458337   PMID:20833797   PMID:21630459   PMID:22082260   PMID:22658674   PMID:22681889   PMID:23376485   PMID:23533145  
PMID:23602810   PMID:26316108   PMID:27989324   PMID:29476059  


Genomics

Comparative Map Data
Mdh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,530,886 - 26,543,841 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1226,530,881 - 26,543,841 (-)EnsemblGRCr8
mRatBN7.21220,894,269 - 20,907,225 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,894,262 - 20,907,271 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1222,036,216 - 22,049,189 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,648,634 - 22,661,607 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,715,096 - 21,728,069 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,941,451 - 23,954,406 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,941,448 - 23,954,431 (-)Ensemblrn6Rnor6.0
Rnor_5.01225,938,703 - 25,951,658 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41222,021,302 - 22,034,257 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1222,657,034 - 22,669,988 (-)NCBICelera
RGSC_v3.11222,008,565 - 22,021,518 (-)NCBI
Cytogenetic Map12q12NCBI
MDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38776,048,106 - 76,067,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl776,048,050 - 76,067,508 (+)Ensemblhg38GRCh38
GRCh37775,677,424 - 75,696,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,515,329 - 75,533,867 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34775,322,043 - 75,340,579NCBI
Celera770,545,928 - 70,564,452 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,763,958 - 70,782,483 (+)NCBIHuRef
CHM1_1775,607,380 - 75,625,901 (+)NCBICHM1_1
T2T-CHM13v2.0777,335,642 - 77,355,027 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2775,010,457 - 75,028,995 (+)NCBI
Mdh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,807,503 - 135,819,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,807,334 - 135,819,252 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385135,778,649 - 135,790,386 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,778,480 - 135,790,398 (+)Ensemblmm10GRCm38
MGSCv375136,254,519 - 136,266,256 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365136,063,276 - 136,075,013 (+)NCBIMGSCv36mm8
Celera5132,786,019 - 132,797,756 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.4NCBI
Mdh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,819,406 - 14,837,142 (+)Ensembl
ChiLan1.0NW_00495545614,819,406 - 14,833,547 (+)NCBIChiLan1.0ChiLan1.0
MDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2693,888,151 - 93,906,812 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17142,152,789 - 142,171,414 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0767,953,759 - 67,973,270 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1782,497,799 - 82,517,411 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,497,800 - 82,516,526 (+)EnsemblpanPan2panpan1.1
MDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,389,266 - 7,405,311 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha69,085,235 - 9,101,096 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.067,209,447 - 7,225,514 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,209,439 - 7,225,504 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,178,719 - 7,194,795 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,142,165 - 7,158,017 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,305,587 - 7,321,452 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mdh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,827,961 - 131,842,493 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,194,032 - 2,208,651 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,194,074 - 2,208,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,120,083 - 10,132,752 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1310,120,121 - 10,132,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.239,953,279 - 9,965,866 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,294,021 - 10,313,079 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,294,021 - 10,313,970 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660706,107,854 - 6,127,132 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mdh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,837,023 - 14,850,988 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474014,837,699 - 14,850,126 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mdh2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11618,233,650 - 18,246,719 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mdh2
141 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:105
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000001958
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
11530002Bss119Bone structure and strength QTL 11916.394e-17lumbar vertebra area (VT:0010570)lumbar vertebra area (CMO:0001688)122651003826983303Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
D12Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81226,530,997 - 26,531,086 (+)Marker Load Pipeline
mRatBN7.21220,894,380 - 20,894,469 (+)MAPPERmRatBN7.2
Rnor_6.01223,941,563 - 23,941,651NCBIRnor6.0
Rnor_5.01225,938,815 - 25,938,903UniSTSRnor5.0
RGSC_v3.41222,021,413 - 22,021,502RGDRGSC3.4
RGSC_v3.41222,021,414 - 22,021,502UniSTSRGSC3.4
Celera1222,657,146 - 22,657,234UniSTS
RGSC_v3.11222,008,677 - 22,008,766RGD
RH 3.4 Map12299.1RGD
RH 3.4 Map12299.1UniSTS
RH 2.0 Map12221.8RGD
Cytogenetic Map12q12UniSTS
BM390639  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,895,923 - 20,896,126 (+)MAPPERmRatBN7.2
Rnor_6.01223,943,106 - 23,943,308NCBIRnor6.0
Rnor_5.01225,940,358 - 25,940,560UniSTSRnor5.0
RGSC_v3.41222,022,957 - 22,023,159UniSTSRGSC3.4
Celera1222,658,689 - 22,658,891UniSTS
RH 3.4 Map12302.2UniSTS
Cytogenetic Map12q12UniSTS
RH127736  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81226,531,066 - 26,531,607 (+)Marker Load Pipeline
mRatBN7.21220,894,449 - 20,894,990 (+)MAPPERmRatBN7.2
Rnor_6.01223,941,632 - 23,942,172NCBIRnor6.0
Rnor_5.01225,938,884 - 25,939,424UniSTSRnor5.0
RGSC_v3.41222,021,483 - 22,022,023UniSTSRGSC3.4
Celera1222,657,215 - 22,657,755UniSTS
RH 3.4 Map12301.31UniSTS
Cytogenetic Map12q12UniSTS
RH142438  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81226,530,912 - 26,531,085 (+)Marker Load Pipeline
mRatBN7.21220,894,295 - 20,894,468 (+)MAPPERmRatBN7.2
Rnor_6.01223,941,478 - 23,941,650NCBIRnor6.0
Rnor_5.01225,938,730 - 25,938,902UniSTSRnor5.0
RGSC_v3.41222,021,329 - 22,021,501UniSTSRGSC3.4
Celera1222,657,061 - 22,657,233UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001958   ⟹   ENSRNOP00000001958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1226,530,886 - 26,543,841 (-)Ensembl
mRatBN7.2 Ensembl1220,894,262 - 20,907,271 (-)Ensembl
Rnor_6.0 Ensembl1223,941,448 - 23,954,431 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112030   ⟹   ENSRNOP00000090657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1226,530,881 - 26,538,207 (-)Ensembl
mRatBN7.2 Ensembl1220,894,262 - 20,901,591 (-)Ensembl
RefSeq Acc Id: NM_031151   ⟹   NP_112413
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,530,886 - 26,543,841 (-)NCBI
mRatBN7.21220,894,269 - 20,907,225 (-)NCBI
Rnor_6.01223,941,451 - 23,954,406 (-)NCBI
Rnor_5.01225,938,703 - 25,951,658 (-)NCBI
RGSC_v3.41222,021,302 - 22,034,257 (-)RGD
Celera1222,657,034 - 22,669,988 (-)RGD
Sequence:
RefSeq Acc Id: NP_112413   ⟸   NM_031151
- Peptide Label: precursor
- UniProtKB: Q6GSM4 (UniProtKB/Swiss-Prot),   P04636 (UniProtKB/Swiss-Prot),   A6J0B0 (UniProtKB/TrEMBL),   A0A8I6ABC9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001958   ⟸   ENSRNOT00000001958
Ensembl Acc Id: ENSRNOP00000090657   ⟸   ENSRNOT00000112030
Protein Domains
Lactate/malate dehydrogenase C-terminal   Lactate/malate dehydrogenase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04636-F1-model_v2 AlphaFold P04636 1-338 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698547
Promoter ID:EPDNEW_R9070
Type:initiation region
Name:Mdh2_1
Description:malate dehydrogenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01223,954,387 - 23,954,447EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619719 AgrOrtholog
BioCyc Gene G2FUF-19631 BioCyc
BioCyc Pathway MALATE-ASPARTATE-SHUTTLE-PWY [malate/L-aspartate shuttle pathway] BioCyc
  PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image MALATE-ASPARTATE-SHUTTLE-PWY BioCyc
  PWY-5690 BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000001440 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001958 ENTREZGENE
  ENSRNOT00000001958.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.110.10 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918633 IMAGE-MGC_LOAD
InterPro L-lactate/malate_DH UniProtKB/Swiss-Prot
  Lactate/malate_DH_C UniProtKB/Swiss-Prot
  Lactate/malate_DH_N UniProtKB/Swiss-Prot
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/Swiss-Prot
  Malate_DH_AS UniProtKB/Swiss-Prot
  Malate_DH_type1 UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:81829 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72779 IMAGE-MGC_LOAD
NCBI Gene 81829 ENTREZGENE
PANTHER MALATE AND LACTATE DEHYDROGENASE UniProtKB/Swiss-Prot
  MALATE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Ldh_1_C UniProtKB/Swiss-Prot
  Ldh_1_N UniProtKB/Swiss-Prot
PhenoGen Mdh2 PhenoGen
PIRSF Lac_mal_DH UniProtKB/Swiss-Prot
PROSITE MDH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001440 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
  SSF56327 UniProtKB/Swiss-Prot
UniProt A0A8I6ABC9 ENTREZGENE, UniProtKB/TrEMBL
  A6J0B0 ENTREZGENE, UniProtKB/TrEMBL
  MDHM_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q0QF43_RAT UniProtKB/TrEMBL
  Q6GSM4 ENTREZGENE
UniProt Secondary Q6GSM4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Mdh2  malate dehydrogenase 2  Mdh2  malate dehydrogenase 2, NAD (mitochondrial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-10 Mdh2  malate dehydrogenase 2, NAD (mitochondrial)  Mor1  malate dehydrogenase, mitochondrial  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2003-04-09 Mor1  malate dehydrogenase, mitochondrial      Symbol and Name updated 629477 APPROVED
2003-03-12 Mor1  malate dehydrogenase, mitochondrial  Mdh2  malate dehydrogenase 2  Data merged from RGD:3071 628472 PROVISIONAL
2002-11-06 Mdh2  malate dehydrogenase 2    Malate dehydrogenase 2, NAD (mitochondrial)  Name updated 625702 APPROVED
2002-08-07 Mor1  malate dehydrogenase mitochondrial      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Mdh2  Malate dehydrogenase 2, NAD (mitochondrial)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a mitochondrial import sequence 633303