Nr4a3 (nuclear receptor subfamily 4, group A, member 3) - Rat Genome Database

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Gene: Nr4a3 (nuclear receptor subfamily 4, group A, member 3) Rattus norvegicus
Analyze
Symbol: Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
RGD ID: 61882
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; nuclear glucocorticoid receptor binding activity; and protein homodimerization activity. Involved in several processes, including animal organ regeneration; positive regulation of cardiac muscle hypertrophy; and regulation of type B pancreatic cell proliferation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in extraskeletal myxoid chondrosarcoma. Orthologous to human NR4A3 (nuclear receptor subfamily 4 group A member 3); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neuron-derived orphan receptor; neuron-derived orphan receptor 1; neuron-derived orphan receptor 1/2; NOR-2; nuclear hormone receptor NOR-1/NOR-2; nuclear receptor subfamily 4 group A member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8567,157,141 - 67,198,287 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl567,157,375 - 67,198,285 (+)EnsemblGRCr8
mRatBN7.2562,361,588 - 62,401,489 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl562,361,822 - 62,402,733 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx564,336,680 - 64,376,440 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0566,155,972 - 66,195,731 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0566,125,439 - 66,165,198 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0563,781,801 - 63,822,890 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,781,801 - 63,821,637 (+)Ensemblrn6Rnor6.0
Rnor_5.0568,298,772 - 68,339,861 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4564,713,468 - 64,753,311 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera565,193,786 - 65,233,628 (-)NCBICelera
RGSC_v3.1564,718,506 - 64,758,343 (+)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,8-cineole  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (EXP,ISO)
azathioprine  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium acetate  (EXP,ISO)
Calcimycin  (ISO)
cannabidiol  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
dipentyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenoterol  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glyphosate  (EXP)
graphite  (EXP)
haloperidol  (EXP)
hydrogen cyanide  (ISO)
ionomycin  (ISO)
isoprenaline  (ISO)
kainic acid  (EXP)
ketamine  (EXP)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
mabuterol  (ISO)
malathion  (ISO)
melphalan  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
mevalonic acid  (ISO)
milrinone  (EXP)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
organophosphorus compound  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenformin  (EXP)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propan-2-ol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
Salmeterol xinafoate  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium hypochlorite  (ISO)
Soman  (EXP)
styrene  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
torcetrapib  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
triphenylstannane  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
animal organ regeneration  (IEP)
axon guidance  (ISO)
cellular respiration  (ISO,ISS)
cellular response to catecholamine stimulus  (ISO,ISS)
cellular response to corticotropin-releasing hormone stimulus  (IBA,ISO,ISS)
cellular response to leptin stimulus  (ISO,ISS)
common myeloid progenitor cell proliferation  (ISO,ISS)
energy homeostasis  (ISO,ISS)
fat cell differentiation  (ISO,ISS)
gastrulation  (ISO,ISS)
hippocampus development  (ISO)
inner ear morphogenesis  (ISO)
intracellular receptor signaling pathway  (IEA)
intracellular signal transduction  (ISO,ISS)
mast cell degranulation  (ISO,ISS)
mesoderm formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
neuromuscular process controlling balance  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of cardiac muscle hypertrophy  (IMP)
positive regulation of cell cycle  (ISO)
positive regulation of D-glucose transmembrane transport  (ISO,ISS)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (ISO,ISS)
positive regulation of feeding behavior  (ISO,ISS)
positive regulation of leukocyte apoptotic process  (ISO)
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway  (ISO,ISS)
positive regulation of mast cell cytokine production  (ISO,ISS)
positive regulation of monocyte aggregation  (ISO,ISS)
positive regulation of smooth muscle cell proliferation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of smooth muscle cell proliferation  (ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA)
regulation of type B pancreatic cell proliferation  (IMP)
response to hydrogen peroxide  (ISO)
response to peptide hormone  (IEP)
semicircular canal morphogenesis  (ISO)
vestibular reflex  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The orphan receptor NOR1 participates in isoprenaline-induced cardiac hypertrophy by regulating PARP-1. Feng XJ, etal., Br J Pharmacol. 2015 Jun;172(11):2852-63. doi: 10.1111/bph.13091. Epub 2015 Mar 26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Maira M, etal., Mol Cell Biol. 1999 Nov;19(11):7549-57.
4. Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor. Martens C, etal., Mol Endocrinol. 2005 Apr;19(4):885-97. Epub 2004 Dec 9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Ohkura N, etal., Biochem Biophys Res Commun 1994 Dec 30;205(3):1959-65.
8. NOR-2 (neuron-derived orphan receptor), a brain zinc finger protein, is highly induced during liver regeneration. Petropoulos I, etal., FEBS Lett. 1995 Sep 25;372(2-3):273-8.
9. TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77. Rambaud J, etal., J Biol Chem. 2009 May 22;284(21):14147-56. doi: 10.1074/jbc.M809023200. Epub 2009 Mar 25.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Nkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Tessem JS, etal., Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5242-7. doi: 10.1073/pnas.1320953111. Epub 2014 Mar 24.
Additional References at PubMed
PMID:7914660   PMID:8961274   PMID:9155013   PMID:11784868   PMID:12709428   PMID:13129926   PMID:15155786   PMID:15456880   PMID:16945922   PMID:18325999   PMID:18945812   PMID:19103603  
PMID:19150624   PMID:19153266   PMID:19164597   PMID:19270309   PMID:19359610   PMID:19523439   PMID:20558821   PMID:20566846   PMID:20851110   PMID:21868379   PMID:22936731   PMID:23390133  
PMID:23554459   PMID:23897430   PMID:24022864   PMID:24584059   PMID:24586680   PMID:24806827   PMID:25451221   PMID:25852083   PMID:27221116   PMID:33840679   PMID:38943627  


Genomics

Comparative Map Data
Nr4a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8567,157,141 - 67,198,287 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl567,157,375 - 67,198,285 (+)EnsemblGRCr8
mRatBN7.2562,361,588 - 62,401,489 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl562,361,822 - 62,402,733 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx564,336,680 - 64,376,440 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0566,155,972 - 66,195,731 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0566,125,439 - 66,165,198 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0563,781,801 - 63,822,890 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,781,801 - 63,821,637 (+)Ensemblrn6Rnor6.0
Rnor_5.0568,298,772 - 68,339,861 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4564,713,468 - 64,753,311 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera565,193,786 - 65,233,628 (-)NCBICelera
RGSC_v3.1564,718,506 - 64,758,343 (+)NCBI
Cytogenetic Map5q22NCBI
NR4A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38999,821,885 - 99,866,891 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl999,821,855 - 99,866,891 (+)Ensemblhg38GRCh38
GRCh379102,584,167 - 102,629,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369101,623,958 - 101,668,994 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34999,668,563 - 99,708,728NCBI
Celera973,097,532 - 73,142,572 (+)NCBICelera
Cytogenetic Map9q31.1NCBI
HuRef972,183,339 - 72,228,487 (+)NCBIHuRef
CHM1_19102,730,616 - 102,775,645 (+)NCBICHM1_1
T2T-CHM13v2.09111,993,520 - 112,038,527 (+)NCBIT2T-CHM13v2.0
Nr4a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39448,045,098 - 48,086,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl448,045,153 - 48,086,447 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38448,045,078 - 48,086,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl448,045,153 - 48,086,447 (+)Ensemblmm10GRCm38
MGSCv37448,064,120 - 48,096,224 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36448,072,348 - 48,104,452 (+)NCBIMGSCv36mm8
Celera448,073,263 - 48,105,416 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.07NCBI
Nr4a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541925,779,178 - 25,818,706 (-)Ensembl
ChiLan1.0NW_00495541925,779,368 - 25,817,445 (-)NCBIChiLan1.0ChiLan1.0
NR4A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21139,597,195 - 39,640,348 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1939,599,566 - 39,642,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0970,907,056 - 70,950,221 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1999,028,151 - 99,049,949 (+)NCBIPanPan1.1PanPan1.1panPan2
NR4A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11156,806,506 - 56,846,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1156,812,804 - 56,847,689 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1155,238,295 - 55,278,535 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01157,915,798 - 57,956,020 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1157,915,647 - 57,955,434 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11156,420,068 - 56,460,272 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01156,444,924 - 56,485,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01157,144,349 - 57,184,553 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nr4a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947171,704,489 - 171,743,204 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365248,252,381 - 8,289,157 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365248,252,321 - 8,290,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR4A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1241,570,010 - 241,611,727 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11241,569,867 - 241,611,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21269,813,286 - 269,852,707 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR4A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11239,568,085 - 39,611,704 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1239,567,852 - 39,606,837 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660352,937,605 - 2,981,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr4a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248251,097,432 - 1,141,446 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248251,098,915 - 1,141,373 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nr4a3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11101,130,273 - 101,171,318 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nr4a3
218 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:438
Count of miRNA genes:234
Interacting mature miRNAs:323
Transcripts:ENSRNOT00000008302
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
D5Wox30  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8567,196,634 - 67,196,783 (+)Marker Load Pipeline
mRatBN7.2562,401,082 - 62,401,231 (+)MAPPERmRatBN7.2
Rnor_6.0563,821,238 - 63,821,386NCBIRnor6.0
Rnor_5.0568,338,209 - 68,338,357UniSTSRnor5.0
RGSC_v3.4564,752,905 - 64,753,053UniSTSRGSC3.4
Celera565,194,044 - 65,194,192UniSTS
Cytogenetic Map5q22UniSTS
PMC133552P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,368,056 - 62,368,486 (+)MAPPERmRatBN7.2
Rnor_6.0563,788,213 - 63,788,642NCBIRnor6.0
Rnor_5.0568,305,184 - 68,305,613UniSTSRnor5.0
RGSC_v3.4564,719,880 - 64,720,309UniSTSRGSC3.4
Celera565,226,787 - 65,227,216UniSTS
Cytogenetic Map5q22UniSTS
RH141611  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,400,896 - 62,401,113 (+)MAPPERmRatBN7.2
Rnor_6.0563,821,052 - 63,821,268NCBIRnor6.0
Rnor_5.0568,338,023 - 68,338,239UniSTSRnor5.0
RGSC_v3.4564,752,719 - 64,752,935UniSTSRGSC3.4
Celera565,194,162 - 65,194,378UniSTS
RH 3.4 Map5413.0UniSTS
Cytogenetic Map5q22UniSTS
BF390776  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,402,511 - 62,402,678 (+)MAPPERmRatBN7.2
Rnor_6.0563,822,667 - 63,822,833NCBIRnor6.0
Rnor_5.0568,339,638 - 68,339,804UniSTSRnor5.0
RGSC_v3.4564,754,334 - 64,754,500UniSTSRGSC3.4
Celera565,192,598 - 65,192,764UniSTS
RH 3.4 Map5416.7UniSTS
Cytogenetic Map5q22UniSTS
PMC133552P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8567,164,788 - 67,165,141 (+)Marker Load Pipeline
mRatBN7.2562,369,234 - 62,369,588 (+)MAPPERmRatBN7.2
Rnor_6.0563,789,391 - 63,789,744NCBIRnor6.0
Rnor_5.0568,306,362 - 68,306,715UniSTSRnor5.0
RGSC_v3.4564,721,058 - 64,721,411UniSTSRGSC3.4
Celera565,225,685 - 65,226,038UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 67 66 35 91 35 6 326 191 11 143 76 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008302   ⟹   ENSRNOP00000008302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl567,157,375 - 67,198,285 (+)Ensembl
mRatBN7.2 Ensembl562,361,822 - 62,402,733 (+)Ensembl
Rnor_6.0 Ensembl563,781,801 - 63,821,637 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000142521   ⟹   ENSRNOP00000109143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl567,159,493 - 67,198,285 (+)Ensembl
RefSeq Acc Id: NM_031628   ⟹   NP_113816
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,157,198 - 67,197,041 (+)NCBI
mRatBN7.2562,361,645 - 62,401,489 (+)NCBI
Rnor_6.0563,781,801 - 63,821,644 (+)NCBI
Rnor_5.0568,298,772 - 68,339,861 (+)NCBI
RGSC_v3.4564,713,468 - 64,753,311 (+)RGD
Celera565,193,786 - 65,233,628 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110691   ⟹   XP_038966619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,157,141 - 67,198,287 (+)NCBI
mRatBN7.2562,361,588 - 62,399,680 (+)NCBI
RefSeq Acc Id: XM_039110692   ⟹   XP_038966620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,158,042 - 67,198,287 (+)NCBI
mRatBN7.2562,362,196 - 62,399,680 (+)NCBI
RefSeq Acc Id: XM_063288331   ⟹   XP_063144401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,161,973 - 67,198,287 (+)NCBI
RefSeq Acc Id: NP_113816   ⟸   NM_031628
- UniProtKB: Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   Q9QWQ3 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008302   ⟸   ENSRNOT00000008302
RefSeq Acc Id: XP_038966619   ⟸   XM_039110691
- Peptide Label: isoform X1
- UniProtKB: Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   Q9QWQ3 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966620   ⟸   XM_039110692
- Peptide Label: isoform X1
- UniProtKB: Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   Q9QWQ3 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144401   ⟸   XM_063288331
- Peptide Label: isoform X1
- UniProtKB: Q9QWQ3 (UniProtKB/Swiss-Prot),   Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000109143   ⟸   ENSRNOT00000142521
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51179-F1-model_v2 AlphaFold P51179 1-628 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693723
Promoter ID:EPDNEW_R4247
Type:single initiation site
Name:Nr4a3_1
Description:nuclear receptor subfamily 4, group A, member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0563,781,889 - 63,781,949EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61882 AgrOrtholog
BioCyc Gene G2FUF-41362 BioCyc
Ensembl Genes ENSRNOG00000005964 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008302 ENTREZGENE
  ENSRNOT00000008302.5 UniProtKB/Swiss-Prot
  ENSRNOT00000142521 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  NOR1_rcpt UniProtKB/Swiss-Prot
  Nuc_orph_rcpt UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:58853 UniProtKB/Swiss-Prot
NCBI Gene 58853 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
  NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 3 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PhenoGen Nr4a3 PhenoGen
PRINTS NORNUCRECPTR UniProtKB/Swiss-Prot
  NUCLEARECPTR UniProtKB/Swiss-Prot
  STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005964 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
TIGR TC207340
UniProt A0ABK0M306_RAT UniProtKB/TrEMBL
  A6KJG2 ENTREZGENE, UniProtKB/TrEMBL
  A6KJG4_RAT UniProtKB/TrEMBL
  A6KJG5_RAT UniProtKB/TrEMBL
  NR4A3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2XPY2 ENTREZGENE
  Q63516 ENTREZGENE
  Q9QWQ3 ENTREZGENE
UniProt Secondary Q2XPY2 UniProtKB/Swiss-Prot
  Q63516 UniProtKB/Swiss-Prot
  Q9QWQ3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr4a3  nuclear receptor subfamily 4, group A, member 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds to the B1a response-element 61676