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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61882 Species: Rattus norvegicus RGD Object: Gene Symbol: Nr4a3 Name: nuclear receptor subfamily 4, group A, member 3

Acc ID: CHEBI:33216 Term: bisphenol A Definition: A bisphenol that has formula C15H16O2. CasRN: 80-05-7 Chemical ID: MESH:C006780

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:62174	6480464	CTD	bisphenol A results in increased expression of NR4A3 mRNA	PMID:14967926
multiple interactions	EXP		6480464	CTD	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NR4A3 promoter	PMID:23359474