Syn2 (synapsin II) - Rat Genome Database

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Gene: Syn2 (synapsin II) Rattus norvegicus
Analyze
Symbol: Syn2
Name: synapsin II
RGD ID: 3798
Description: Enables calcium-dependent protein binding activity. Predicted to be involved in secretion by cell; synapse organization; and synaptic vesicle clustering. Located in synaptic vesicle. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SYN2 (synapsin II); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: synapsin 2; synapsin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,858,919 - 150,016,845 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4149,851,520 - 150,019,650 (+)EnsemblGRCr8
mRatBN7.24148,178,846 - 148,347,010 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,186,270 - 148,344,192 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4154,411,352 - 154,569,498 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,194,433 - 150,352,589 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04148,818,234 - 148,976,405 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,037,179 - 147,195,096 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,037,179 - 147,195,096 (+)Ensemblrn6Rnor6.0
Rnor_5.04210,326,340 - 210,483,842 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44151,255,241 - 151,413,220 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4137,080,501 - 137,237,898 (+)NCBICelera
RGSC_v3.14151,500,081 - 151,650,682 (+)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
ATP  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clozapine  (EXP,ISO)
cocaine  (ISO)
copper(II) chloride  (ISO)
curcumin  (ISO)
decabromodiphenyl ether  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-tocopherol  (ISO)
genistein  (ISO)
glycidol  (EXP)
haloperidol  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nitroglycerin  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
propanal  (ISO)
prostaglandin F2alpha  (EXP)
Ptaquiloside  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tacrine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Synapsin IIb interacts with the C-terminal SH2 and SH3 domains of PLCgamma1 and inhibits its enzymatic activity. Han SJ, etal., Cell Biol Int. 2004;28(12):943-8.
5. Synapsins as major neuronal Ca2+/S100A1-interacting proteins. Heierhorst J, etal., Biochem J. 1999 Dec 1;344 Pt 2:577-83.
6. Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Jaffrey SR, etal., Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3199-204. Epub 2002 Feb 26.
7. A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Lam PP, etal., Mol Biol Cell. 2007 Jul;18(7):2473-80. Epub 2007 Apr 18.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins. Sudhof TC, etal., Science 1989 Sep 29;245(4925):1474-80.
13. Synapsin II. Mapping of a domain in the NH2-terminal region which binds to small synaptic vesicles. Thiel G, etal., J Biol Chem. 1990 Sep 25;265(27):16527-33.
14. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
Additional References at PubMed
PMID:7777057   PMID:9593663   PMID:10358015   PMID:15071120   PMID:16413126   PMID:17114649   PMID:17634366   PMID:18535671   PMID:18945891   PMID:19292454   PMID:19609639   PMID:20338242  
PMID:22871113   PMID:25429150   PMID:28131823   PMID:28755400   PMID:29476059   PMID:32357304  


Genomics

Comparative Map Data
Syn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,858,919 - 150,016,845 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4149,851,520 - 150,019,650 (+)EnsemblGRCr8
mRatBN7.24148,178,846 - 148,347,010 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,186,270 - 148,344,192 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4154,411,352 - 154,569,498 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,194,433 - 150,352,589 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04148,818,234 - 148,976,405 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,037,179 - 147,195,096 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,037,179 - 147,195,096 (+)Ensemblrn6Rnor6.0
Rnor_5.04210,326,340 - 210,483,842 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44151,255,241 - 151,413,220 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4137,080,501 - 137,237,898 (+)NCBICelera
RGSC_v3.14151,500,081 - 151,650,682 (+)NCBI
Cytogenetic Map4q42NCBI
SYN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,004,388 - 12,192,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl312,004,388 - 12,192,032 (+)Ensemblhg38GRCh38
GRCh37312,045,862 - 12,233,532 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,020,862 - 12,208,532 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34312,020,864 - 12,207,885NCBI
Celera311,982,988 - 12,170,949 (+)NCBICelera
Cytogenetic Map3p25.2NCBI
HuRef311,979,136 - 12,167,274 (+)NCBIHuRef
CHM1_1311,995,629 - 12,183,794 (+)NCBICHM1_1
T2T-CHM13v2.0312,002,345 - 12,190,266 (+)NCBIT2T-CHM13v2.0
Syn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,111,863 - 115,259,587 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6115,111,863 - 115,258,967 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386115,134,902 - 115,282,626 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,134,902 - 115,282,006 (+)Ensemblmm10GRCm38
MGSCv376115,084,920 - 115,232,644 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366115,916,516 - 116,057,028 (+)NCBIMGSCv36mm8
MGSCv366115,100,521 - 115,240,707 (+)NCBIMGSCv36mm8
Celera6116,972,908 - 117,121,654 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.2NCBI
Syn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,678,491 - 14,717,270 (+)Ensembl
ChiLan1.0NW_00495542914,676,286 - 14,724,625 (+)NCBIChiLan1.0ChiLan1.0
SYN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2211,996,087 - 12,180,017 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1312,000,852 - 12,184,778 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0311,935,680 - 12,118,981 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1312,275,084 - 12,465,806 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl312,282,573 - 12,464,413 (+)EnsemblpanPan2panpan1.1
SYN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,368,348 - 6,569,355 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl206,369,122 - 6,568,508 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha206,404,468 - 6,604,803 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0206,397,481 - 6,598,475 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl206,397,505 - 6,598,637 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1206,115,658 - 6,316,632 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0206,466,601 - 6,671,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0206,442,191 - 6,642,971 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Syn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,360,718 - 17,449,110 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366021,461,338 - 1,507,272 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366021,460,602 - 1,506,509 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,050,535 - 68,221,496 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11368,050,015 - 68,221,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21375,262,707 - 75,435,410 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SYN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12247,994,593 - 48,171,291 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2248,092,452 - 48,171,492 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041118,328,888 - 118,521,429 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Syn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624956303,011 - 349,857 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624956302,239 - 467,319 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Syn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1631,427,870 - 31,542,973 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Syn2
1123 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:101
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000011292
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
D4Got124  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,190,092 - 148,190,377 (+)MAPPERmRatBN7.2
Rnor_6.04147,041,002 - 147,041,286NCBIRnor6.0
Rnor_5.04210,330,163 - 210,330,447UniSTSRnor5.0
RGSC_v3.44151,259,064 - 151,259,348UniSTSRGSC3.4
RGSC_v3.44151,259,063 - 151,259,348RGDRGSC3.4
Celera4137,084,324 - 137,084,624UniSTS
RGSC_v3.14151,503,905 - 151,504,189RGD
RH 3.4 Map4950.41UniSTS
RH 3.4 Map4950.41RGD
RH 2.0 Map4937.5RGD
Cytogenetic Map4q42UniSTS
AI841723  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,343,960 - 148,344,105 (+)MAPPERmRatBN7.2
Rnor_6.04147,194,865 - 147,195,009NCBIRnor6.0
Rnor_5.04210,483,611 - 210,483,755UniSTSRnor5.0
RGSC_v3.44151,412,989 - 151,413,133UniSTSRGSC3.4
Celera4137,237,667 - 137,237,811UniSTS
Cytogenetic Map4q42UniSTS
RH143121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,324,575 - 148,324,813 (+)MAPPERmRatBN7.2
Rnor_6.04147,175,480 - 147,175,717NCBIRnor6.0
Rnor_5.04210,464,226 - 210,464,463UniSTSRnor5.0
RGSC_v3.44151,393,604 - 151,393,841UniSTSRGSC3.4
Celera4137,218,282 - 137,218,519UniSTS
RH 3.4 Map4952.1UniSTS
Cytogenetic Map4q42UniSTS
BI295795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,337,050 - 148,337,251 (+)MAPPERmRatBN7.2
Rnor_6.04147,187,955 - 147,188,155NCBIRnor6.0
Rnor_5.04210,476,701 - 210,476,901UniSTSRnor5.0
RGSC_v3.44151,406,079 - 151,406,279UniSTSRGSC3.4
Celera4137,230,757 - 137,230,957UniSTS
RH 3.4 Map4950.71UniSTS
Cytogenetic Map4q42UniSTS
AF096867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,336,768 - 148,336,876 (+)MAPPERmRatBN7.2
Rnor_6.04147,187,673 - 147,187,780NCBIRnor6.0
Rnor_5.04210,476,419 - 210,476,526UniSTSRnor5.0
RGSC_v3.44151,405,797 - 151,405,904UniSTSRGSC3.4
Celera4137,230,475 - 137,230,582UniSTS
Cytogenetic Map4q42UniSTS
RH132165  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,302,616 - 148,302,801 (+)MAPPERmRatBN7.2
Rnor_6.04147,153,526 - 147,153,710NCBIRnor6.0
Rnor_5.04210,442,272 - 210,442,456UniSTSRnor5.0
RGSC_v3.44151,371,650 - 151,371,834UniSTSRGSC3.4
Celera4137,196,429 - 137,196,613UniSTS
RH 3.4 Map4951.9UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 148 64 62 32 34 32 6 241 127 3 131 58 92 30 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011292   ⟹   ENSRNOP00000011292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,851,520 - 150,019,650 (+)Ensembl
mRatBN7.2 Ensembl4148,186,270 - 148,344,192 (+)Ensembl
Rnor_6.0 Ensembl4147,037,179 - 147,195,096 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106627   ⟹   ENSRNOP00000084691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,859,043 - 150,019,650 (+)Ensembl
mRatBN7.2 Ensembl4148,186,394 - 148,344,192 (+)Ensembl
RefSeq Acc Id: NM_001034020   ⟹   NP_001029192
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,858,919 - 150,016,845 (+)NCBI
mRatBN7.24148,186,270 - 148,344,204 (+)NCBI
Rnor_6.04147,037,179 - 147,195,096 (+)NCBI
Rnor_5.04210,326,340 - 210,483,842 (+)NCBI
RGSC_v3.44151,255,241 - 151,413,220 (+)RGD
Celera4137,080,501 - 137,237,898 (+)RGD
Sequence:
RefSeq Acc Id: NM_019159   ⟹   NP_062032
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,858,919 - 150,009,454 (+)NCBI
mRatBN7.24148,186,270 - 148,336,813 (+)NCBI
Rnor_6.04147,037,179 - 147,187,717 (+)NCBI
Rnor_5.04210,326,340 - 210,483,842 (+)NCBI
RGSC_v3.44151,255,241 - 151,413,220 (+)RGD
Celera4137,080,501 - 137,230,519 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001029192   ⟸   NM_001034020
- Peptide Label: isoform 1
- UniProtKB: Q9Z1H0 (UniProtKB/Swiss-Prot),   Q63537 (UniProtKB/Swiss-Prot),   G3V733 (UniProtKB/TrEMBL),   A6IKX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_062032   ⟸   NM_019159
- Peptide Label: isoform 2
- UniProtKB: A6IKY0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011292   ⟸   ENSRNOT00000011292
Ensembl Acc Id: ENSRNOP00000084691   ⟸   ENSRNOT00000106627
Protein Domains
Synapsin ATP-binding   Synapsin pre-ATP-grasp

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63537-F1-model_v2 AlphaFold Q63537 1-586 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693319
Promoter ID:EPDNEW_R3843
Type:initiation region
Name:Syn2_1
Description:synapsin II
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04147,037,185 - 147,037,245EPDNEW
RGD ID:13693327
Promoter ID:EPDNEW_R3844
Type:single initiation site
Name:AC128901_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04147,122,082 - 147,122,142EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3798 AgrOrtholog
BioCyc Gene G2FUF-43328 BioCyc
Ensembl Genes ENSRNOG00000008157 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000011292 ENTREZGENE
Gene3D-CATH 3.30.1490.20 UniProtKB/Swiss-Prot
  3.40.50.20 UniProtKB/Swiss-Prot
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot
InterPro ATP_grasp_subdomain_1 UniProtKB/Swiss-Prot
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot
  Synapsin UniProtKB/Swiss-Prot
  Synapsin_ATP-bd_dom UniProtKB/Swiss-Prot
  Synapsin_CS UniProtKB/Swiss-Prot
  Synapsin_P_site UniProtKB/Swiss-Prot
  Synapsin_pre-ATP-grasp_dom UniProtKB/Swiss-Prot
KEGG Report rno:29179 UniProtKB/Swiss-Prot
NCBI Gene 29179 ENTREZGENE
PANTHER PTHR10841:SF20 UniProtKB/Swiss-Prot
  SYNAPSIN UniProtKB/Swiss-Prot
Pfam Synapsin UniProtKB/Swiss-Prot
  Synapsin_C UniProtKB/Swiss-Prot
  Synapsin_N UniProtKB/Swiss-Prot
PhenoGen Syn2 PhenoGen
PRINTS SYNAPSIN UniProtKB/Swiss-Prot
PROSITE SYNAPSIN_1 UniProtKB/Swiss-Prot
  SYNAPSIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008157 RatGTEx
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot
  SSF52440 UniProtKB/Swiss-Prot
UniProt A0A8I5ZYM8_RAT UniProtKB/TrEMBL
  A6IKX9 ENTREZGENE, UniProtKB/TrEMBL
  A6IKY0 ENTREZGENE, UniProtKB/TrEMBL
  A6IKY1_RAT UniProtKB/TrEMBL
  G3V733 ENTREZGENE, UniProtKB/TrEMBL
  Q63537 ENTREZGENE
  Q9Z1H0 ENTREZGENE
  SYN2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9Z1H0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Syn2  synapsin II    synapsin 2  Name updated 1299863 APPROVED
2002-06-10 Syn2  synapsin 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression protein expressed in nerve terminals 70028