Sstr2 (somatostatin receptor 2) - Rat Genome Database

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Gene: Sstr2 (somatostatin receptor 2) Rattus norvegicus
Analyze
Symbol: Sstr2
Name: somatostatin receptor 2
RGD ID: 3763
Description: Enables PDZ domain binding activity and somatostatin receptor activity. Involved in several processes, including brain development; cellular response to estradiol stimulus; and peristalsis. Predicted to be located in membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Predicted to be active in neuron projection and plasma membrane. Orthologous to human SSTR2 (somatostatin receptor 2); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Smstr2; somatostatin receptor subtype 2; somatostatin receptor type 2; somatotropin release-inhibiting factor receptor; SRIF-1; SS-2-R; SS2-R; SS2R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81099,163,353 - 99,170,519 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1099,162,740 - 99,183,863 (+)EnsemblGRCr8
mRatBN7.21098,664,204 - 98,671,370 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1098,664,216 - 98,674,351 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10103,716,316 - 103,723,467 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010103,179,358 - 103,186,509 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01098,584,256 - 98,591,422 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010102,136,283 - 102,143,449 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10102,136,283 - 102,143,434 (+)Ensemblrn6Rnor6.0
Rnor_5.010101,816,029 - 101,823,337 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410103,246,880 - 103,254,444 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1097,271,562 - 97,278,691 (+)NCBICelera
RGSC_v3.110103,261,249 - 103,268,805 (+)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (EXP)
glycidol  (EXP)
graphite  (EXP)
hydrogen chloride  (ISO)
inulin  (ISO)
lanreotide  (EXP)
lipopolysaccharide  (ISO)
malathion  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
neomycin  (ISO)
octreotide  (ISO)
okadaic acid  (ISO)
parathion  (ISO)
pasireotide  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
permethrin  (ISO)
phenylmercury acetate  (ISO)
picrotoxin  (EXP)
propanal  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
somatostatin  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vincristine  (ISO)
zinc oxide  (ISO)
zolpidem  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Somatostatin sst(2) receptors inhibit peristalsis in the rat and mouse jejunum. Abdu F, etal., Am J Physiol Gastrointest Liver Physiol 2002 Apr;282(4):G624-33.
2. Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma, but does not involve mutations in the somatostatin receptor 2(SSTR2) gene at 17q24. Abel F, etal., Br J Cancer 1999 Dec;81(8):1402-9.
3. Identification of multiple somatostatin receptors in the rat somatosensory cortex during development. Bologna E and Leroux P, J Comp Neurol. 2000 May 15;420(4):466-80.
4. Expression changes of somatostatin receptor subtypes sst2A, sst2B, sst3 and sst4 after a cortical contusion trauma in rats. Braun H, etal., Brain Res. 2002 Mar 15;930(1-2):191-9.
5. Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat. Bruno JF, etal., Endocrinology. 1994 Nov;135(5):1787-92.
6. Intra-islet somatostatin regulates glucagon release via type 2 somatostatin receptors in rats. Cejvan K, etal., Diabetes 2003 May;52(5):1176-81.
7. Inhibitory control of growth hormone secretion by somatostatin in rat pituitary GC cells: sst(2) but not sst(1) receptors are coupled to inhibition of single-cell intracellular free calcium concentrations. Cervia D, etal., Neuroendocrinology 2002 Aug;76(2):99-110.
8. Effect of 17beta-estradiol on somatostatin receptor expression and inhibitory effects on growth hormone and prolactin release in rat pituitary cell cultures. Djordjijevic D, etal., Endocrinology. 1998 May;139(5):2272-7.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Expression cloning of a rat brain somatostatin receptor cDNA. Kluxen FW, etal., Proc Natl Acad Sci U S A 1992 May 15;89(10):4618-22.
11. Identification of proteins interacting with the rat somatostatin receptor subtype 2. Kreienkamp HJ, etal., J Physiol Paris. 2000 May-Aug;94(3-4):193-8.
12. Expression of the five somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotrophes: quantitative analysis by double-layer immunofluorescence confocal microscopy. Kumar U, etal., Endocrinology. 1997 Oct;138(10):4473-6.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Role of glucocorticoids in the regulation of pituitary somatostatin receptor subtype (sst1-sst5) mRNA levels: evidence for direct and somatostatin-mediated effects. Park S, etal., Neuroendocrinology. 2003 Sep;78(3):163-75.
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Somatostatin immunoreactivity in axon terminals in rat nucleus tractus solitarii arising from central nucleus of amygdala: coexistence with GABA and postsynaptic expression of sst2A receptor. Saha S, etal., J Chem Neuroanat 2002 Jun;24(1):1-13.
18. Spinal somatostatin SSTR2A receptors are preferentially up-regulated and involved in thermonociception but not mechanonociception. Song P, etal., Exp Neurol 2002 Dec;178(2):280-7.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Differential expression of multiple somatostatin receptors in the rat cerebellum during development. Viollet C, etal., J Neurochem. 1997 Jun;68(6):2263-72.
21. Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis. Yuferov V, etal., Synapse 2003 Jun 15;48(4):157-69.
22. The localization of messenger ribonucleic acids for somatostatin receptors 1, 2, and 3 in rat testis. Zhu LJ, etal., Endocrinology. 1998 Jan;139(1):350-7.
23. Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain. Zitzer H, etal., J Biol Chem. 1999 Nov 12;274(46):32997-3001.
Additional References at PubMed
PMID:1346068   PMID:1348934   PMID:7929134   PMID:8386508   PMID:9166719   PMID:9437026   PMID:10373412   PMID:11250922   PMID:12403839   PMID:12639941   PMID:12665520   PMID:12895520  
PMID:15601946   PMID:15728843   PMID:16000155   PMID:16280179   PMID:16379030   PMID:16543371   PMID:17327372   PMID:17347306   PMID:17521381   PMID:17603546   PMID:17617126   PMID:17706880  
PMID:17706924   PMID:18363859   PMID:18566118   PMID:18793718   PMID:18795252   PMID:19001189   PMID:19434240   PMID:19910453   PMID:20814067   PMID:21539874   PMID:21795688   PMID:23073237  
PMID:23473742   PMID:23913690   PMID:24368669   PMID:24412308   PMID:24828612   PMID:24846611   PMID:24978951   PMID:25926390   PMID:26311777   PMID:26462807   PMID:28991052   PMID:29380671  
PMID:29522573   PMID:30291955   PMID:30544226   PMID:30609928   PMID:32315148   PMID:33045023   PMID:34487822  


Genomics

Comparative Map Data
Sstr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81099,163,353 - 99,170,519 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1099,162,740 - 99,183,863 (+)EnsemblGRCr8
mRatBN7.21098,664,204 - 98,671,370 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1098,664,216 - 98,674,351 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10103,716,316 - 103,723,467 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010103,179,358 - 103,186,509 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01098,584,256 - 98,591,422 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010102,136,283 - 102,143,449 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10102,136,283 - 102,143,434 (+)Ensemblrn6Rnor6.0
Rnor_5.010101,816,029 - 101,823,337 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410103,246,880 - 103,254,444 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1097,271,562 - 97,278,691 (+)NCBICelera
RGSC_v3.110103,261,249 - 103,268,805 (+)NCBI
Cytogenetic Map10q32.1NCBI
SSTR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381773,165,010 - 73,176,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1773,165,010 - 73,176,633 (+)Ensemblhg38GRCh38
GRCh371771,161,149 - 71,172,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361768,672,755 - 68,679,689 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341768,672,754 - 68,679,655NCBI
Celera1767,744,235 - 67,751,169 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1766,570,255 - 66,577,187 (+)NCBIHuRef
CHM1_11771,225,325 - 71,232,224 (+)NCBICHM1_1
T2T-CHM13v2.01774,054,801 - 74,066,425 (+)NCBIT2T-CHM13v2.0
Sstr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911113,510,153 - 113,516,854 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11113,510,168 - 113,516,854 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811113,619,327 - 113,626,028 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11113,619,342 - 113,626,028 (+)Ensemblmm10GRCm38
MGSCv3711113,485,571 - 113,486,950 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611113,435,574 - 113,441,985 (+)NCBIMGSCv36mm8
Celera11125,379,798 - 125,381,177 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1179.05NCBI
Sstr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547860,489 - 90,209 (-)Ensembl
ChiLan1.0NW_00495547861,126 - 123,806 (-)NCBIChiLan1.0ChiLan1.0
SSTR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21989,182,442 - 89,194,105 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11794,007,294 - 94,018,946 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01767,093,013 - 67,099,086 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11772,549,167 - 72,556,106 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1772,553,506 - 72,554,615 (+)EnsemblpanPan2panpan1.1
SSTR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.196,989,488 - 7,004,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl96,996,874 - 7,000,778 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha97,620,598 - 7,621,707 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.097,662,314 - 7,677,653 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.197,712,309 - 7,713,418 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.097,815,153 - 7,816,262 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.097,876,175 - 7,877,284 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sstr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056027,552,830 - 7,558,761 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366551,051,447 - 1,052,556 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366551,050,835 - 1,056,609 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SSTR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl127,783,431 - 7,789,488 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1127,783,401 - 7,789,483 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2128,063,456 - 8,069,876 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SSTR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11648,462,472 - 48,470,586 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1648,464,342 - 48,465,451 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607719,280,096 - 19,290,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sstr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248013,198,204 - 3,206,481 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248013,198,137 - 3,205,936 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sstr2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1975,682,951 - 75,690,131 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sstr2
85 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:77
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000003734, ENSRNOT00000003735
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AU047965  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21098,665,236 - 98,665,482 (+)MAPPERmRatBN7.2
Rnor_6.010102,137,316 - 102,137,561NCBIRnor6.0
Rnor_5.010101,817,062 - 101,817,307UniSTSRnor5.0
RGSC_v3.410103,247,913 - 103,248,158UniSTSRGSC3.4
Celera1097,272,595 - 97,272,840UniSTS
Cytogenetic Map10q32.1UniSTS
SSTR2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21098,669,935 - 98,670,339 (+)MAPPERmRatBN7.2
Rnor_6.010102,142,015 - 102,142,418NCBIRnor6.0
Rnor_5.010101,821,903 - 101,822,306UniSTSRnor5.0
RGSC_v3.410103,253,010 - 103,253,413UniSTSRGSC3.4
Celera1097,277,257 - 97,277,660UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 7 32 136 78 77 46 32 46 6 225 93 9 113 64 84 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000003735   ⟹   ENSRNOP00000003735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1099,163,522 - 99,170,229 (+)Ensembl
mRatBN7.2 Ensembl1098,664,357 - 98,671,080 (+)Ensembl
Rnor_6.0 Ensembl10102,136,283 - 102,143,434 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116317   ⟹   ENSRNOP00000094133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1099,163,738 - 99,174,856 (+)Ensembl
mRatBN7.2 Ensembl1098,664,216 - 98,674,351 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133830   ⟹   ENSRNOP00000110504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1099,162,740 - 99,183,863 (+)Ensembl
RefSeq Acc Id: NM_019348   ⟹   NP_062221
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81099,163,353 - 99,170,519 (+)NCBI
mRatBN7.21098,664,204 - 98,671,370 (+)NCBI
Rnor_6.010102,136,283 - 102,143,449 (+)NCBI
Rnor_5.010101,816,029 - 101,823,337 (+)NCBI
RGSC_v3.410103,246,880 - 103,254,444 (+)RGD
Celera1097,271,562 - 97,278,691 (+)RGD
Sequence:
RefSeq Acc Id: NP_062221   ⟸   NM_019348
- UniProtKB: P30680 (UniProtKB/Swiss-Prot),   A6HKG0 (UniProtKB/TrEMBL),   A6HKF9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003735   ⟸   ENSRNOT00000003735
Ensembl Acc Id: ENSRNOP00000094133   ⟸   ENSRNOT00000116317
Ensembl Acc Id: ENSRNOP00000110504   ⟸   ENSRNOT00000133830
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30680-F1-model_v2 AlphaFold P30680 1-369 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3763 AgrOrtholog
BioCyc Gene G2FUF-22761 BioCyc
Ensembl Genes ENSRNOG00000002793 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003735.4 UniProtKB/Swiss-Prot
  ENSRNOT00000116317.1 UniProtKB/Swiss-Prot
  ENSRNOT00000133830 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Somatstn_rcpt UniProtKB/Swiss-Prot
  Somatstn_rcpt_2 UniProtKB/Swiss-Prot
KEGG Report rno:54305 UniProtKB/Swiss-Prot
NCBI Gene 54305 ENTREZGENE
PANTHER NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot
  SOMATOSTATIN RECEPTOR TYPE 2 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Sstr2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  SOMATOSTATNR UniProtKB/Swiss-Prot
  SOMATOSTTN2R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002793 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC223639
UniProt A6HKF9 ENTREZGENE, UniProtKB/TrEMBL
  A6HKG0 ENTREZGENE, UniProtKB/TrEMBL
  P30680 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Sstr2  somatostatin receptor 2      Symbol and Name updated 629477 APPROVED
2003-03-12 Sstr2  somatostatin receptor 2  Smstr2  somatostatin receptor 2  Data merged from RGD:620193 628472 PROVISIONAL
2002-08-07 Smstr2  somatostatin receptor 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Sstr2  somatostatin receptor subtype 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain cortex and hippocampus 70025
gene_physical_interaction binds to somatotropin release-inhibiting factor (SRIF) 70025
gene_process inhibits peristalsis in the jejunum upon binding to somatostatin 737668
gene_process may modulate activity of neurons in nucleus tractus solitarii from the central nucleus of the amygdala in response to fear or emotional stimuli 730237
gene_process activation with somatostatin inhibits release of glucagon but not insulin in islets 1299053
gene_product putative transmembrane G-protein coupled receptor 70025