Serpine2 (serpin family E member 2) - Rat Genome Database

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Gene: Serpine2 (serpin family E member 2) Rattus norvegicus
Analyze
Symbol: Serpine2
Name: serpin family E member 2
RGD ID: 3748
Description: Enables heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including dense core granule biogenesis; embryo implantation; and negative regulation of blood coagulation. Located in extracellular space and neuronal cell body. Biomarker of brain edema and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2); PARTICIPATES IN fibrinolysis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Clozapine Regulated Gene; CRG; GDN; Gdnpn1; glia-derived nexin; glia-derived nexin / preotease nexin I; Glia-derived nexin/protease nexin I; peptidase inhibitor 7; PI-7; plasminogen activator inhibitor type 1; Pn-1; protease nexin 1; protease nexin I; protease nexin PN-1; serine (or cysteine) peptidase inhibitor, clade E, member 2; serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 2; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1) , member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease inhibitor 4; serpin E2; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serpin peptidase inhibitor, clade E, member 2; Spin4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8988,573,138 - 88,637,252 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl988,573,149 - 88,637,202 (-)EnsemblGRCr8
mRatBN7.2981,124,746 - 81,188,866 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,124,804 - 81,188,826 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx989,554,492 - 89,618,567 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0994,683,384 - 94,747,462 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0993,065,906 - 93,129,981 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0985,560,852 - 85,629,410 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,560,863 - 85,626,094 (-)Ensemblrn6Rnor6.0
Rnor_5.0985,312,140 - 85,375,577 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4979,091,414 - 79,166,330 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera978,614,628 - 78,678,321 (-)NCBICelera
RGSC_v3.1979,275,580 - 79,302,222 (-)NCBI
Cytogenetic Map9q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-chloroethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benomyl  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dinophysistoxin 1  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
mifepristone  (EXP)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naled  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (EXP,ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tartrazine  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of SERPINE2 gene with the risk of chronic obstructive pulmonary disease and spirometric phenotypes in northern Han Chinese population. An L, etal., Mol Biol Rep. 2012 Feb;39(2):1427-33. doi: 10.1007/s11033-011-0877-0. Epub 2011 May 25.
2. Conformational and biochemical characterization of a biologically active rat recombinant Protease Nexin-1 expressed in E. coli. Arcone R, etal., Biochim Biophys Acta. 2009 Apr;1794(4):602-14. Epub 2008 Dec 24.
3. The serpin protease-nexin 1 is present in rat aortic smooth muscle cells and is upregulated in L-NAME hypertensive rats. Bouton MC, etal., Arterioscler Thromb Vasc Biol 2003 Jan 1;23(1):142-7.
4. Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Bouton MC, etal., Circ Res. 2007 Apr 27;100(8):1174-81. Epub 2007 Mar 22.
5. SERPINE2 polymorphisms and chronic obstructive pulmonary disease. Cha SI, etal., J Korean Med Sci. 2009 Dec;24(6):1119-25. doi: 10.3346/jkms.2009.24.6.1119. Epub 2009 Nov 9.
6. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Demeo DL, etal., Am J Hum Genet. 2006 Feb;78(2):253-64. doi: 10.1086/499828. Epub 2005 Dec 15.
7. Molecular organization of the rat glia-derived nexin/protease nexin-1 promoter. Erno H and Monard D, Gene Expr 1993;3(2):163-74.
8. A Krox binding site regulates protease nexin-1 promoter activity in embryonic heart, cartilage and parts of the nervous system. Erno H, etal., Mech Dev 1996 Dec;60(2):139-50.
9. Excitotoxic brain lesion modifies binding to a USF binding site acting as a negative regulatory element in the Protease nexin-1 promoter. Erno H, etal., Mol Cell Neurosci 1996;8(1):28-37.
10. Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression. François D, etal., Lab Invest. 2014 Nov;94(11):1237-46. doi: 10.1038/labinvest.2014.111. Epub 2014 Sep 8.
11. Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases. Fujimoto K, etal., BMC Med Genet. 2010 Nov 10;11:159. doi: 10.1186/1471-2350-11-159.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Constitutive secretion of protease nexin-1 by glial cells and its regulation by G-protein-coupled receptors. Giau R, etal., J Neurosci. 2005 Sep 28;25(39):8995-9004.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Association of SERPINE2 with asthma. Himes BE, etal., Chest. 2011 Sep;140(3):667-674. doi: 10.1378/chest.10-2973. Epub 2011 Mar 24.
16. Increased expression and localization of a serine protease inhibitor, protease nexin-1 (PN-1), in the ovary and uterus during implantation in rat. Kim NK, etal., Thromb Res. 2001 Jul 15;103(2):135-42.
17. Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation. Kim T and Loh YP, Mol Biol Cell. 2006 Feb;17(2):789-98. Epub 2005 Nov 30.
18. Protease nexin-1 is expressed at the mouse met-/mesencephalic junction and FGF signaling regulates its promoter activity in primary met-/mesencephalic cells. Kury P, etal., Development 1997 Mar;124(6):1251-62.
19. SERPINE2 rs16865421 polymorphism is associated with a lower risk of chronic obstructive pulmonary disease in the Uygur population: A case-control study. Li L, etal., J Gene Med. 2019 Sep;21(9):e3106. doi: 10.1002/jgm.3106. Epub 2019 Aug 5.
20. Overexpression of SerpinE2/protease nexin-1 Contribute to Pathological Cardiac Fibrosis via increasing Collagen Deposition. Li X, etal., Sci Rep. 2016 Nov 23;6:37635. doi: 10.1038/srep37635.
21. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. An octamer-binding site is crucial for the activity of an enhancer active at the embryonic met-/mesencephalic junction. Mihailescu D, etal., Mech Dev 1999 Jun;84(1-2):55-67.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion. Niclou SP, etal., Eur J Neurosci. 1998 May;10(5):1590-607.
26. The glia-derived protease nexin 1 persists for over 1 year in rat brain areas selectively lesioned by transient global ischaemia. Nitsch C, etal., Eur J Neurosci. 1993 Mar 1;5(3):292-7.
27. Decreased levels of glia-derived nexin/protease nexin I in irradiated rat spinal cord in vivo. Rao JS, etal., Biochem Biophys Res Commun. 1993 Sep 15;195(2):853-8.
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Protease nexin-1: a cellular serpin down-regulated by thrombin in rat aortic smooth muscle cells. Richard B, etal., J Cell Physiol. 2004 Oct;201(1):138-45.
31. Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors. Riek-Burchardt M, etal., Neurosci Lett 2002 Aug 30;329(2):181-4.
32. cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily. Sommer J, etal., Biochemistry 1987 Oct 6;26(20):6407-10.
33. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
34. Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease. Wagner SL, etal., Proc Natl Acad Sci U S A. 1989 Nov;86(21):8284-8.
35. The expression and the role of protease nexin-1 on brain edema after intracerebral hemorrhage. Wu H, etal., J Neurol Sci. 2008 Jul 15;270(1-2):172-83. Epub 2008 Apr 28.
36. The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Zhu G, etal., Am J Respir Crit Care Med. 2007 Jul 15;176(2):167-73. doi: 10.1164/rccm.200611-1723OC. Epub 2007 Apr 19.
Additional References at PubMed
PMID:1298926   PMID:1554734   PMID:1691280   PMID:1939253   PMID:2037625   PMID:2337608   PMID:3279057   PMID:3997857   PMID:8889548   PMID:9169529   PMID:9757068   PMID:11248026  
PMID:12947022   PMID:15354176   PMID:15509762   PMID:16941024   PMID:17409116   PMID:17409231   PMID:18398001   PMID:19249338   PMID:19855083   PMID:20819545   PMID:20942929   PMID:22206666  
PMID:23106098   PMID:24006456   PMID:24769233  


Genomics

Comparative Map Data
Serpine2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8988,573,138 - 88,637,252 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl988,573,149 - 88,637,202 (-)EnsemblGRCr8
mRatBN7.2981,124,746 - 81,188,866 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,124,804 - 81,188,826 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx989,554,492 - 89,618,567 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0994,683,384 - 94,747,462 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0993,065,906 - 93,129,981 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0985,560,852 - 85,629,410 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,560,863 - 85,626,094 (-)Ensemblrn6Rnor6.0
Rnor_5.0985,312,140 - 85,375,577 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4979,091,414 - 79,166,330 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera978,614,628 - 78,678,321 (-)NCBICelera
RGSC_v3.1979,275,580 - 79,302,222 (-)NCBI
Cytogenetic Map9q34NCBI
SERPINE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,975,045 - 224,039,286 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,975,045 - 224,039,688 (-)Ensemblhg38GRCh38
GRCh372224,839,762 - 224,904,003 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,548,118 - 224,612,237 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342224,665,383 - 224,729,498NCBI
Celera2218,605,681 - 218,669,944 (-)NCBICelera
Cytogenetic Map2q36.1NCBI
HuRef2216,691,512 - 216,755,073 (-)NCBIHuRef
CHM1_12224,846,268 - 224,910,507 (-)NCBICHM1_1
T2T-CHM13v2.02224,458,312 - 224,522,521 (-)NCBIT2T-CHM13v2.0
Serpine2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39179,772,038 - 79,836,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl179,771,914 - 79,838,897 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38179,794,317 - 79,858,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl179,794,197 - 79,861,180 (-)Ensemblmm10GRCm38
MGSCv37179,790,896 - 79,855,240 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36179,673,221 - 79,737,660 (-)NCBIMGSCv36mm8
Celera179,823,073 - 79,887,353 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map140.97NCBI
Serpine2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545310,027,104 - 10,076,645 (+)Ensembl
ChiLan1.0NW_00495545310,049,822 - 10,076,155 (+)NCBIChiLan1.0ChiLan1.0
SERPINE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213126,595,223 - 126,659,147 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B126,610,192 - 126,673,686 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B111,221,317 - 111,285,491 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B229,797,659 - 229,854,027 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B229,797,655 - 229,861,040 (-)EnsemblpanPan2panpan1.1
SERPINE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13729,699,551 - 29,750,151 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3729,700,024 - 29,724,228 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3730,534,229 - 30,591,635 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03729,723,835 - 29,781,464 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3729,723,718 - 29,781,490 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13729,633,656 - 29,691,135 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03729,569,650 - 29,627,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03729,584,772 - 29,642,251 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Serpine2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,299,482 - 179,325,465 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365695,642,264 - 5,668,323 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365695,642,328 - 5,668,278 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15125,748,394 - 125,816,215 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115125,748,383 - 125,777,788 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,183,910 - 139,249,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110109,921,619 - 109,988,137 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10109,921,598 - 109,987,513 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604089,416,611 - 89,482,995 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpine2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248231,261,406 - 1,326,917 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248231,261,458 - 1,326,261 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Serpine2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14152,852,977 - 152,916,762 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Serpine2
184 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:72
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000020919
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)98672213292642305Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
AU047411  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2981,189,752 - 81,189,924 (+)MAPPERmRatBN7.2
Rnor_6.0985,627,032 - 85,627,201NCBIRnor6.0
Rnor_5.0985,376,489 - 85,376,658UniSTSRnor5.0
RGSC_v3.4979,167,267 - 79,167,436UniSTSRGSC3.4
Celera978,679,252 - 78,679,421UniSTS
Cytogenetic Map9q34UniSTS
RH140749  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2981,124,865 - 81,124,999 (+)MAPPERmRatBN7.2
mRatBN7.26140,485,411 - 140,485,545 (-)MAPPERmRatBN7.2
mRatBN7.2981,124,865 - 81,124,999 (-)MAPPERmRatBN7.2
mRatBN7.26140,485,411 - 140,485,545 (+)MAPPERmRatBN7.2
Rnor_6.0985,560,972 - 85,561,105NCBIRnor6.0
Rnor_6.06147,447,365 - 147,447,498NCBIRnor6.0
Rnor_5.0985,312,260 - 85,312,393UniSTSRnor5.0
Rnor_5.06156,356,829 - 156,356,962UniSTSRnor5.0
RGSC_v3.46146,869,648 - 146,869,781UniSTSRGSC3.4
RGSC_v3.4979,091,534 - 79,091,667UniSTSRGSC3.4
Celera978,614,746 - 78,614,879UniSTS
Celera6138,128,445 - 138,128,578UniSTS
Cytogenetic Map9q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 90 59 6 350 190 11 143 77 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ007480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY780673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ199747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF110312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK357674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV726078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000020919   ⟹   ENSRNOP00000020919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,574,712 - 88,637,202 (-)Ensembl
mRatBN7.2 Ensembl981,126,320 - 81,188,826 (-)Ensembl
Rnor_6.0 Ensembl985,560,863 - 85,626,094 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077331   ⟹   ENSRNOP00000072257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,573,149 - 88,637,202 (-)Ensembl
mRatBN7.2 Ensembl981,124,804 - 81,188,826 (-)Ensembl
Rnor_6.0 Ensembl985,560,892 - 85,617,954 (-)Ensembl
RefSeq Acc Id: NM_019197   ⟹   NP_062070
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,573,138 - 88,637,202 (-)NCBI
mRatBN7.2981,124,746 - 81,188,816 (-)NCBI
Rnor_6.0985,560,852 - 85,626,094 (-)NCBI
Rnor_5.0985,312,140 - 85,375,577 (-)NCBI
RGSC_v3.4979,091,414 - 79,166,330 (-)RGD
Celera978,614,628 - 78,678,321 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245162   ⟹   XP_006245224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,573,138 - 88,637,252 (-)NCBI
mRatBN7.2981,124,842 - 81,188,866 (-)NCBI
Rnor_6.0985,560,987 - 85,626,141 (-)NCBI
Rnor_5.0985,312,140 - 85,375,577 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083112   ⟹   XP_038939040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,573,138 - 88,637,240 (-)NCBI
mRatBN7.2981,124,842 - 81,188,842 (-)NCBI
RefSeq Acc Id: XM_063266812   ⟹   XP_063122882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,573,138 - 88,601,834 (-)NCBI
RefSeq Acc Id: NP_062070   ⟸   NM_019197
- Peptide Label: precursor
- UniProtKB: P07092 (UniProtKB/Swiss-Prot),   A0A0G2K2I7 (UniProtKB/TrEMBL),   A6JW83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245224   ⟸   XM_006245162
- Peptide Label: isoform X1
- UniProtKB: P07092 (UniProtKB/Swiss-Prot),   A0A0G2K2I7 (UniProtKB/TrEMBL),   A6JW83 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072257   ⟸   ENSRNOT00000077331
Ensembl Acc Id: ENSRNOP00000020919   ⟸   ENSRNOT00000020919
RefSeq Acc Id: XP_038939040   ⟸   XM_039083112
- Peptide Label: isoform X1
- UniProtKB: P07092 (UniProtKB/Swiss-Prot),   A0A0G2K2I7 (UniProtKB/TrEMBL),   A6JW83 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122882   ⟸   XM_063266812
- Peptide Label: isoform X1
- UniProtKB: P07092 (UniProtKB/Swiss-Prot),   A0A0G2K2I7 (UniProtKB/TrEMBL),   A6JW83 (UniProtKB/TrEMBL)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07092-F1-model_v2 AlphaFold P07092 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696794
Promoter ID:EPDNEW_R7318
Type:single initiation site
Name:Serpine2_1
Description:serpin family E member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0985,626,107 - 85,626,167EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3748 AgrOrtholog
BioCyc Gene G2FUF-27006 BioCyc
Ensembl Genes ENSRNOG00000015461 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000077331 ENTREZGENE
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot
  3.30.497.10 UniProtKB/Swiss-Prot
  Serpins superfamily UniProtKB/Swiss-Prot
InterPro Serpin_CS UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot
  Serpin_fam UniProtKB/Swiss-Prot
  Serpin_sf UniProtKB/Swiss-Prot
  Serpin_sf_1 UniProtKB/Swiss-Prot
  Serpin_sf_2 UniProtKB/Swiss-Prot
KEGG Report rno:29366 UniProtKB/Swiss-Prot
NCBI Gene 29366 ENTREZGENE
PANTHER GLIA-DERIVED NEXIN UniProtKB/Swiss-Prot
  PTHR11461 UniProtKB/Swiss-Prot
Pfam Serpin UniProtKB/Swiss-Prot
PhenoGen Serpine2 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015461 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot
TIGR TC228852
UniProt A0A0G2K2I7 ENTREZGENE, UniProtKB/TrEMBL
  A6JW81_RAT UniProtKB/TrEMBL
  A6JW82_RAT UniProtKB/TrEMBL
  A6JW83 ENTREZGENE, UniProtKB/TrEMBL
  G3V7Z4_RAT UniProtKB/TrEMBL
  GDN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpine2  serpin family E member 2  Serpine2  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Serpine2  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2  Serpine2  serpin peptidase inhibitor, clade E, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-03-05 Serpine2  serpin peptidase inhibitor, clade E, member 2  Serpine2  serine (or cysteine) peptidase inhibitor, clade E, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Serpine2  serine (or cysteine) peptidase inhibitor, clade E, member 2  Serpine2  serine (or cysteine) proteinase inhibitor, clade E, member 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-05-03 Serpine2  serine (or cysteine) proteinase inhibitor, clade E, member 2   Gdnpn1  serine (or cysteine) proteinase inhibitor, clade E, member 2   Data merged from RGD:2678 737654 APPROVED
2003-04-09 Gdnpn1  serine (or cysteine) proteinase inhibitor, clade E, member 2     Glia-derived nexin/protease nexin I  Name updated 629478 APPROVED
2002-06-10 Gdnpn1  Glia-derived nexin/protease nexin I      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Serpine2  serine (or cysteine) proteinase inhibitor, clade E, member 2       Name updated 70584 APPROVED
2001-11-02 Serpine2  serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1) , member 2      Symbol and Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript promoter contains five SP1 consensus sites, four consensus sites for the MyoD1 transcription factor, and one binding site for the transcription factors NGFI-A, NGFI-C, Krox-20, and Wilms tumor factor 632811