Snai2 (snail family transcriptional repressor 2) - Rat Genome Database

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Gene: Snai2 (snail family transcriptional repressor 2) Rattus norvegicus
Analyze
Symbol: Snai2
Name: snail family transcriptional repressor 2
RGD ID: 3722
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in cellular response to fibroblast growth factor stimulus and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2); INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neural crest transcription factor Slug; Slug; Slug chicken homolog; Slug, chicken homolog; snail family zinc finger 2; snail homolog 2; snail homolog 2 (Drosophila); zinc finger protein SNAI2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81199,686,934 - 99,690,349 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1199,686,934 - 99,690,349 (-)EnsemblGRCr8
mRatBN7.21186,182,788 - 86,186,203 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1186,181,909 - 86,186,200 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1194,927,965 - 94,930,275 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01187,586,463 - 87,588,772 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01186,642,722 - 86,645,032 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01190,404,421 - 90,406,730 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1190,403,333 - 90,406,797 (-)Ensemblrn6Rnor6.0
Rnor_5.01193,462,645 - 93,464,954 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1184,915,524 - 84,917,833 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,4-dithiothreitol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-Dihydroxybenzophenone  (ISO)
2-ethylhexan-1-ol  (ISO)
2-Ethylhexanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3'-diindolylmethane  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acrylonitrile  (ISO)
acteoside  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
AM-251  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brequinar  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
Destruxin B  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
Dictamnine  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
embelin  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
erlotinib hydrochloride  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
ferulic acid  (ISO)
flavonol  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
Ginkgoic acid  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoorientin  (ISO)
isoprene  (ISO)
isorhapontigenin  (ISO)
ketamine  (ISO)
L-1,4-dithiothreitol  (ISO)
lapatinib  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
LY294002  (ISO)
mangiferin  (ISO)
melatonin  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
NMS-873  (ISO)
Nonylphenol  (ISO)
Nutlin-3  (ISO)
oridonin  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
patulin  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pifithrin-alpha hydrobromide  (ISO)
plerixafor  (ISO)
pyrimidifen  (ISO)
quartz  (ISO)
quercetin  (EXP)
quercitrin  (ISO)
rac-lactic acid  (ISO)
reparixin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sorafenib  (ISO)
sotorasib  (ISO)
stattic  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tacrolimus hydrate  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
triacsin C  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cartilage morphogenesis  (ISO)
cell migration  (ISO)
cell migration involved in endocardial cushion formation  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to ionizing radiation  (ISO)
chromatin organization  (ISO)
desmosome disassembly  (ISO)
DNA-templated transcription  (IEA)
epithelial to mesenchymal transition  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
epithelium development  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell adhesion involved in substrate-bound cell migration  (ISO)
negative regulation of cell adhesion mediated by integrin  (ISO)
negative regulation of chondrocyte differentiation  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of keratinocyte proliferation  (ISO)
negative regulation of stem cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,IMP,ISO)
negative regulation of vitamin D biosynthetic process  (ISO)
negative regulation of vitamin D receptor signaling pathway  (ISO)
neural crest cell development  (ISO)
Notch signaling pathway  (ISO)
osteoblast differentiation  (ISO)
pigmentation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of fat cell differentiation  (ISO)
regulation of bicellular tight junction assembly  (ISO)
regulation of branching involved in salivary gland morphogenesis  (ISO)
regulation of chemokine production  (ISO)
regulation of DNA-templated transcription  (IBA)
regulation of osteoblast differentiation  (ISO)
response to radiation  (ISO)
roof of mouth development  (ISO)
sensory perception of sound  (ISO)
substrate-dependent cell migration  (ISO)
white fat cell differentiation  (ISO)

Cellular Component
chromatin  (ISO)
cytoplasm  (IEA,ISO)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. SLUG (SNAI2) deletions in patients with Waardenburg disease. Sanchez-Martin M, etal., Hum Mol Genet. 2002 Dec 1;11(25):3231-6.
11. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. Savagner P, etal., J Cell Biol 1997 Jun 16;137(6):1403-19.
12. E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells. Schmidt CR, etal., Surgery. 2005 Aug;138(2):306-12.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10518215   PMID:10866665   PMID:11912130   PMID:12833143   PMID:15314165   PMID:15737616   PMID:16286009   PMID:16707493   PMID:17376812   PMID:17905753   PMID:17916597   PMID:17984306  
PMID:18089804   PMID:18223155   PMID:18485278   PMID:18663143   PMID:18716062   PMID:19502595   PMID:19756381   PMID:20032500   PMID:20046880   PMID:20128911   PMID:20671187   PMID:21182836  
PMID:25893292   PMID:26246400   PMID:28488774  


Genomics

Comparative Map Data
Snai2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81199,686,934 - 99,690,349 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1199,686,934 - 99,690,349 (-)EnsemblGRCr8
mRatBN7.21186,182,788 - 86,186,203 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1186,181,909 - 86,186,200 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1194,927,965 - 94,930,275 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01187,586,463 - 87,588,772 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01186,642,722 - 86,645,032 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01190,404,421 - 90,406,730 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1190,403,333 - 90,406,797 (-)Ensemblrn6Rnor6.0
Rnor_5.01193,462,645 - 93,464,954 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1184,915,524 - 84,917,833 (-)NCBICelera
Cytogenetic Map11q23NCBI
SNAI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38848,917,598 - 48,921,429 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl848,917,598 - 48,921,740 (-)Ensemblhg38GRCh38
GRCh37849,830,157 - 49,833,988 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36849,992,789 - 49,996,541 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34849,992,795 - 49,996,541NCBI
Celera845,817,447 - 45,821,199 (-)NCBICelera
Cytogenetic Map8q11.21NCBI
HuRef845,294,292 - 45,298,055 (-)NCBIHuRef
CHM1_1849,882,550 - 49,886,313 (-)NCBICHM1_1
T2T-CHM13v2.0849,295,468 - 49,299,299 (-)NCBIT2T-CHM13v2.0
Snai2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391614,523,716 - 14,527,259 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1614,523,716 - 14,527,249 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381614,705,852 - 14,709,395 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1614,705,852 - 14,709,385 (+)Ensemblmm10GRCm38
MGSCv371614,705,952 - 14,709,478 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361614,619,437 - 14,622,963 (+)NCBIMGSCv36mm8
Celera1615,292,698 - 15,296,242 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map1610.07NCBI
Snai2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554548,758,636 - 8,764,427 (-)Ensembl
ChiLan1.0NW_0049554548,759,860 - 8,763,603 (-)NCBIChiLan1.0ChiLan1.0
SNAI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2764,549,281 - 64,553,640 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1840,242,786 - 40,246,461 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0845,341,857 - 45,345,544 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1842,727,135 - 42,730,736 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl842,723,971 - 42,730,904 (-)EnsemblpanPan2panpan1.1
SNAI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1291,154,132 - 1,156,653 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl291,154,036 - 1,156,653 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha291,580,366 - 1,582,888 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0291,209,732 - 1,213,335 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl291,210,224 - 1,213,476 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1291,151,831 - 1,154,347 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0291,378,544 - 1,381,065 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0291,416,068 - 1,418,591 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Snai2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530378,624,121 - 78,627,846 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365903,813,888 - 3,817,642 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365903,813,916 - 3,817,642 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNAI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl479,264,880 - 79,268,475 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1479,264,880 - 79,268,475 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2486,680,198 - 86,683,793 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNAI2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1845,043,381 - 45,047,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl845,043,393 - 45,046,978 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603996,972,541 - 96,976,202 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snai2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247356,594,695 - 6,598,757 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247356,594,564 - 6,598,288 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Snai2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14149,252 - 152,559 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:45
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000073049
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat

Markers in Region
Snai2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21186,183,953 - 86,184,995 (+)MAPPERmRatBN7.2
Rnor_6.01190,404,575 - 90,405,616NCBIRnor6.0
Rnor_5.01193,462,799 - 93,463,840UniSTSRnor5.0
Celera1184,915,678 - 84,916,719UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 136 91 90 59 27 59 6 283 126 11 115 74 89 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000073049   ⟹   ENSRNOP00000064195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1199,686,934 - 99,690,349 (-)Ensembl
mRatBN7.2 Ensembl1186,181,909 - 86,186,200 (-)Ensembl
Rnor_6.0 Ensembl1190,403,333 - 90,406,797 (-)Ensembl
RefSeq Acc Id: NM_013035   ⟹   NP_037167
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81199,686,934 - 99,690,349 (-)NCBI
mRatBN7.21186,182,788 - 86,186,203 (-)NCBI
Rnor_6.01190,404,421 - 90,406,730 (-)NCBI
Rnor_5.01193,462,645 - 93,464,954 (-)NCBI
Celera1184,915,524 - 84,917,833 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037167 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB58706 (Get FASTA)   NCBI Sequence Viewer  
  AAM19227 (Get FASTA)   NCBI Sequence Viewer  
  EDL77832 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064195
  ENSRNOP00000064195.1
GenBank Protein O08954 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037167   ⟸   NM_013035
- UniProtKB: Q8R482 (UniProtKB/Swiss-Prot),   O08954 (UniProtKB/Swiss-Prot),   A6JSS5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064195   ⟸   ENSRNOT00000073049
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08954-F1-model_v2 AlphaFold O08954 1-268 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698356
Promoter ID:EPDNEW_R8880
Type:initiation region
Name:Snai2_1
Description:snail family transcriptional repressor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01190,406,824 - 90,406,884EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3722 AgrOrtholog
BioCyc Gene G2FUF-20529 BioCyc
Ensembl Genes ENSRNOG00000047699 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073049 ENTREZGENE
  ENSRNOT00000073049.3 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro Snail/Krueppel_Znf UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:25554 UniProtKB/Swiss-Prot
NCBI Gene 25554 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/Swiss-Prot
  ZINC FINGER PROTEIN SNAI2 UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Snai2 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047699 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
TIGR TC237455
UniProt A6JSS5 ENTREZGENE, UniProtKB/TrEMBL
  O08954 ENTREZGENE
  Q8R482 ENTREZGENE
  SNAI2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8R482 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Snai2  snail family transcriptional repressor 2  Snai2  snail family zinc finger 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-06-05 Snai2  snail family zinc finger 2  Snai2  snail homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Snai2  snail homolog 2 (Drosophila)  Slug  Slug, chicken homolog  Symbol and Name updated 629477 APPROVED
2002-06-10 Slug  Slug, chicken homolog      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process induces desmosome dissociation, cell spreading, and initiation of cell separation 730035