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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3722
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snai2
Name: snail family transcriptional repressor 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Snai2decreases expressionISOSnai2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of SNAI2 mRNAPMID:15894712 PMID:19770486 PMID:21715664
Snai2decreases expressionISOSNAI2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of SNAI2 mRNAPMID:27221058 PMID:30659931
Snai2increases expressionISOSNAI2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of SNAI2 mRNA; Benzo(a)pyrene results in increased expression of SNAI2 proteinPMID:30236600 PMID:32234424
Snai2increases methylationISOSNAI2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SNAI2 exonPMID:27901495
Snai2multiple interactionsISOSnai2 (Mus musculus)6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SNAI2 mRNAPMID:15894712
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