Pth1r (parathyroid hormone 1 receptor) - Rat Genome Database

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Gene: Pth1r (parathyroid hormone 1 receptor) Rattus norvegicus
Analyze
Symbol: Pth1r
Name: parathyroid hormone 1 receptor
RGD ID: 3442
Description: Enables parathyroid hormone receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of inositol phosphate biosynthetic process. Located in apical plasma membrane; basolateral plasma membrane; and brush border membrane. Part of receptor complex. Used to study hypercalcemia. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; parathyroid hormone signaling pathway; G protein mediated signaling pathway via Galphas family; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: parathyroid hormone receptor; parathyroid hormone receptor 1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; Pthr; Pthr1; PTHrel
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,572,295 - 119,597,405 (-)NCBIGRCr8
mRatBN7.28110,693,910 - 110,725,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,697,485 - 110,719,729 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,312,093 - 116,331,737 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,511,292 - 114,530,936 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,354,091 - 112,373,739 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08118,984,531 - 119,012,803 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8118,988,053 - 119,012,671 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,325,190 - 118,353,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,099,763 - 115,119,362 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,119,118 - 115,139,954 (-)NCBI
Celera8109,981,641 - 110,001,215 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
clofibric acid  (EXP)
cypermethrin  (ISO)
cytarabine  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
fenvalerate  (EXP)
folic acid  (EXP)
FR900359  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
glycerol 2-phosphate  (ISO)
glycitein  (ISO)
glycitin  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
losartan  (EXP)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methoxychlor  (EXP)
methylmercury(1+)  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium fluoride  (EXP,ISO)
telmisartan  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Abou-Samra AB, etal., Proc Natl Acad Sci U S A 1992 Apr 1;89(7):2732-6.
2. PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption. Decker E, etal., Am J Hum Genet. 2008 Dec;83(6):781-6. doi: 10.1016/j.ajhg.2008.11.006.
3. Recessive mutations in PTHR1 cause contrasting skeletal dysplasias in Eiken and Blomstrand syndromes. Duchatelet S, etal., Hum Mol Genet. 2005 Jan 1;14(1):1-5. Epub 2004 Nov 3.
4. Transmembrane residues of the parathyroid hormone (PTH)/PTH-related peptide receptor that specifically affect binding and signaling by agonist ligands. Gardella TJ, etal., J Biol Chem. 1996 May 31;271(22):12820-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Characterization of PTH/PTHrP receptor in rat duodenum: effects of ageing. Gentili C, etal., J Cell Biochem. 2003 Apr 15;88(6):1157-67.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity. Iida-Klein A, etal., J Biol Chem. 1997 Mar 14;272(11):6882-9.
9. Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2. Johnston CA, etal., Structure. 2008 Jul;16(7):1086-94. doi: 10.1016/j.str.2008.04.010.
10. PTHrP and PTH/PTHrP receptor 1 expression in odontogenic cells of normal and HHM model rat incisors. Kato A, etal., Toxicol Pathol. 2005;33(4):456-64.
11. Parathyroid hormone signaling in bone and kidney. Lee M and Partridge NC, Curr Opin Nephrol Hypertens. 2009 Jul;18(4):298-302. doi: 10.1097/MNH.0b013e32832c2264.
12. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28.
13. The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells. Mahon MJ Mol Endocrinol. 2009 Oct;23(10):1691-701. doi: 10.1210/me.2009-0164. Epub 2009 Jul 16.
14. Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies. Mannstadt M, etal., J Biol Chem. 1998 Jul 3;273(27):16890-6.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes. Pausova Z, etal., Genomics 1994 Mar 1;20(1):20-6.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Identification of six novel PTH1R mutations in families with a history of primary failure of tooth eruption. Risom L, etal., PLoS One. 2013 Sep 18;8(9):e74601. doi: 10.1371/journal.pone.0074601. eCollection 2013.
21. Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia. Schipani E, etal., N Engl J Med. 1996 Sep 5;335(10):708-14.
22. Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Vilardaga JP, etal., Cell Mol Life Sci. 2011 Jan;68(1):1-13. doi: 10.1007/s00018-010-0465-9. Epub 2010 Aug 12.
Additional References at PubMed
PMID:8185578   PMID:8397094   PMID:8662561   PMID:8895385   PMID:9832460   PMID:11606467   PMID:12194850   PMID:12787396   PMID:15618618   PMID:15630249   PMID:15670850   PMID:15691895  
PMID:16476422   PMID:16574786   PMID:16672315   PMID:16728497   PMID:17384996   PMID:17627912   PMID:17872377   PMID:18202147   PMID:18450967   PMID:18480546   PMID:19188335   PMID:19574446  
PMID:19674967   PMID:19855984   PMID:20356821   PMID:20843475   PMID:21832055   PMID:22508055   PMID:22554804   PMID:23376485   PMID:23546599   PMID:25278090   PMID:27160269   PMID:27996060  
PMID:30504697   PMID:30926678  


Genomics

Comparative Map Data
Pth1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,572,295 - 119,597,405 (-)NCBIGRCr8
mRatBN7.28110,693,910 - 110,725,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,697,485 - 110,719,729 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,312,093 - 116,331,737 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,511,292 - 114,530,936 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,354,091 - 112,373,739 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08118,984,531 - 119,012,803 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8118,988,053 - 119,012,671 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,325,190 - 118,353,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,099,763 - 115,119,362 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,119,118 - 115,139,954 (-)NCBI
Celera8109,981,641 - 110,001,215 (-)NCBICelera
Cytogenetic Map8q32NCBI
PTH1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,877,721 - 46,903,799 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,877,721 - 46,903,799 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,919,211 - 46,945,289 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,894,240 - 46,920,293 (+)NCBINCBI36Build 36hg18NCBI36
Build 34346,894,239 - 46,920,291NCBI
Celera346,857,742 - 46,883,797 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,962,340 - 46,988,376 (+)NCBIHuRef
CHM1_1346,869,336 - 46,895,385 (+)NCBICHM1_1
T2T-CHM13v2.0346,894,119 - 46,920,191 (+)NCBIT2T-CHM13v2.0
Pth1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,551,132 - 110,576,213 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,551,153 - 110,576,213 (-)EnsemblGRCm39 Ensembl
GRCm389110,722,085 - 110,747,145 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,722,085 - 110,747,145 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,624,589 - 110,649,649 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,567,070 - 110,587,116 (-)NCBIMGSCv36mm8
Celera9110,451,883 - 110,476,939 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.56NCBI
Pth1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,273,431 - 25,296,471 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,274,269 - 25,291,984 (-)NCBIChiLan1.0ChiLan1.0
PTH1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,838,269 - 46,860,276 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,843,039 - 46,865,045 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,777,945 - 46,804,039 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,882,369 - 47,905,573 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,894,901 - 47,905,431 (+)Ensemblpanpan1.1panPan2
PTH1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12041,905,265 - 41,924,712 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2041,905,273 - 41,925,794 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2041,821,510 - 41,840,986 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,386,625 - 42,411,859 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,387,839 - 42,407,309 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,629,493 - 41,648,962 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,030,456 - 42,049,920 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,311,419 - 42,330,892 (-)NCBIUU_Cfam_GSD_1.0
Pth1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118201,124,949 - 201,144,052 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936596674,088 - 693,213 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936596674,088 - 693,191 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTH1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,753,326 - 29,775,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,749,940 - 29,775,361 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,998,092 - 33,023,626 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTH1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,287,877 - 8,309,736 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl228,289,398 - 8,311,256 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041158,837,510 - 158,863,786 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pth1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473074,371,294 - 74,390,262 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473074,371,614 - 74,392,344 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pth1r
183 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000028435
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
AW532874  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,697,395 - 110,697,569 (+)MAPPERmRatBN7.2
Rnor_6.08118,988,015 - 118,988,188NCBIRnor6.0
Rnor_5.08118,328,671 - 118,328,844UniSTSRnor5.0
RGSC_v3.48115,099,570 - 115,099,743UniSTSRGSC3.4
Celera8109,981,448 - 109,981,621UniSTS
RH 3.4 Map81192.1UniSTS
Cytogenetic Map8q32UniSTS
PMC135637P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,697,310 - 110,697,617 (+)MAPPERmRatBN7.2
Rnor_6.08118,987,930 - 118,988,236NCBIRnor6.0
Rnor_5.08118,328,586 - 118,328,892UniSTSRnor5.0
RGSC_v3.48115,099,485 - 115,099,791UniSTSRGSC3.4
Celera8109,981,363 - 109,981,669UniSTS
Cytogenetic Map8q32UniSTS
UniSTS:498400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,697,607 - 110,697,973 (+)MAPPERmRatBN7.2
Rnor_6.08118,988,227 - 118,988,592NCBIRnor6.0
Rnor_5.08118,328,883 - 118,329,248UniSTSRnor5.0
RGSC_v3.48115,099,782 - 115,100,147UniSTSRGSC3.4
Celera8109,981,660 - 109,982,025UniSTS
Cytogenetic Map8q32UniSTS
UniSTS:498482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,702,709 - 110,702,777 (+)MAPPERmRatBN7.2
Rnor_6.08118,993,329 - 118,993,396NCBIRnor6.0
Rnor_5.08118,333,845 - 118,333,912UniSTSRnor5.0
RGSC_v3.48115,104,883 - 115,104,950UniSTSRGSC3.4
Celera8109,986,754 - 109,986,821UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028435   ⟹   ENSRNOP00000028435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8110,697,485 - 110,718,329 (-)Ensembl
Rnor_6.0 Ensembl8118,988,053 - 119,012,671 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100155   ⟹   ENSRNOP00000084523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8110,697,485 - 110,718,502 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100984   ⟹   ENSRNOP00000094940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8110,697,485 - 110,718,502 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108530   ⟹   ENSRNOP00000080822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8110,697,485 - 110,719,729 (-)Ensembl
RefSeq Acc Id: NM_020073   ⟹   NP_064458
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,575,972 - 119,595,571 (-)NCBI
mRatBN7.28110,697,589 - 110,717,192 (-)NCBI
Rnor_6.08118,988,208 - 119,007,807 (-)NCBI
Rnor_5.08118,325,190 - 118,353,210 (-)NCBI
RGSC_v3.48115,099,763 - 115,119,362 (-)RGD
Celera8109,981,641 - 110,001,215 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243999   ⟹   XP_006244061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,572,295 - 119,596,821 (-)NCBI
mRatBN7.28110,693,910 - 110,718,516 (-)NCBI
Rnor_6.08118,984,531 - 119,009,104 (-)NCBI
Rnor_5.08118,325,190 - 118,353,210 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006244002   ⟹   XP_006244064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,572,295 - 119,596,384 (-)NCBI
mRatBN7.28110,693,910 - 110,717,192 (-)NCBI
Rnor_6.08118,984,531 - 119,007,778 (-)NCBI
Rnor_5.08118,325,190 - 118,353,210 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082024   ⟹   XP_038937952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,572,295 - 119,597,405 (-)NCBI
mRatBN7.28110,693,910 - 110,718,518 (-)NCBI
RefSeq Acc Id: NP_064458   ⟸   NM_020073
- Peptide Label: precursor
- UniProtKB: P25961 (UniProtKB/Swiss-Prot),   A6I3G4 (UniProtKB/TrEMBL),   A6I3G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244061   ⟸   XM_006243999
- Peptide Label: isoform X2
- UniProtKB: P25961 (UniProtKB/Swiss-Prot),   A6I3G4 (UniProtKB/TrEMBL),   A6I3G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244064   ⟸   XM_006244002
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZQF2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028435   ⟸   ENSRNOT00000028435
RefSeq Acc Id: XP_038937952   ⟸   XM_039082024
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000084523   ⟸   ENSRNOT00000100155
Ensembl Acc Id: ENSRNOP00000094940   ⟸   ENSRNOT00000100984
Ensembl Acc Id: ENSRNOP00000080822   ⟸   ENSRNOT00000108530
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25961-F1-model_v2 AlphaFold P25961 1-591 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696335
Promoter ID:EPDNEW_R6859
Type:initiation region
Name:Pth1r_1
Description:parathyroid hormone 1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08119,012,634 - 119,012,694EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3442 AgrOrtholog
BioCyc Gene G2FUF-29059 BioCyc
Ensembl Genes ENSRNOG00000020948 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055007695 UniProtKB/Swiss-Prot
  ENSRNOG00060020032 UniProtKB/Swiss-Prot
  ENSRNOG00065004853 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028435.5 UniProtKB/Swiss-Prot
  ENSRNOT00000100155.1 UniProtKB/TrEMBL
  ENSRNOT00000100984.1 UniProtKB/TrEMBL
  ENSRNOT00000108530.1 UniProtKB/TrEMBL
  ENSRNOT00055012880 UniProtKB/Swiss-Prot
  ENSRNOT00060034689 UniProtKB/Swiss-Prot
  ENSRNOT00065007057 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_parathyroid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56813 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Pth1r ENTREZGENE
PANTHER PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45620:SF27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pth1r PhenoGen
PRINTS GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTRHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020948 RatGTEx
  ENSRNOG00055007695 RatGTEx
  ENSRNOG00060020032 RatGTEx
  ENSRNOG00065004853 RatGTEx
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF111418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZQF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIQ2_RAT UniProtKB/TrEMBL
  A0A8I6GBX8_RAT UniProtKB/TrEMBL
  A6I3G4 ENTREZGENE, UniProtKB/TrEMBL
  A6I3G5 ENTREZGENE, UniProtKB/TrEMBL
  P25961 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Pth1r  parathyroid hormone 1 receptor  Pthr1  parathyroid hormone receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Pthr1  parathyroid hormone receptor 1  Pthr  parathyroid hormone receptor  Symbol and Name updated 629477 APPROVED
2003-03-11   parathyroid hormone receptor  Pthr  Parathyroid hormone/parathyroid hormone-related peptide receptor  Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2002-06-10 Pthr  Parathyroid hormone/parathyroid hormone-related peptide receptor      Symbol and Name status set to approved 70586 APPROVED