Ppp1cb (protein phosphatase 1 catalytic subunit beta) - Rat Genome Database

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Gene: Ppp1cb (protein phosphatase 1 catalytic subunit beta) Rattus norvegicus
Analyze
Symbol: Ppp1cb
Name: protein phosphatase 1 catalytic subunit beta
RGD ID: 3376
Description: Enables phosphoprotein phosphatase activity. Involved in protein dephosphorylation; regulation of glycogen biosynthetic process; and regulation of glycogen catabolic process. Located in glycogen granule. Part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta); PARTICIPATES IN glycogen biosynthetic pathway; glycogen degradation pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: PP-1B; PP1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; protein phosphatase 1, catalytic subunit, beta isozyme; protein phosphatase-1a; serine/threonine-protein phosphatase PP1-beta catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ppp1cb-ps1   Ppp1cb-ps7  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8629,681,099 - 29,712,835 (-)NCBIGRCr8
mRatBN7.2623,958,813 - 23,992,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl623,960,998 - 23,992,824 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx624,260,597 - 24,292,337 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0624,576,477 - 24,608,213 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0624,065,465 - 24,097,720 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0623,548,507 - 23,581,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl623,549,317 - 23,581,052 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0633,416,540 - 33,448,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4624,067,544 - 24,099,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1624,070,497 - 24,102,233 (-)NCBI
Celera623,460,146 - 23,491,883 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
ampicillin  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
clobetasol  (ISO)
clozapine  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (EXP)
hexane  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metronidazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
nefazodone  (EXP)
neomycin  (EXP)
nimesulide  (EXP)
Nonylphenol  (EXP)
Nutlin-3  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
Propiverine  (EXP)
pyrimidifen  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin. Carmody LC, etal., FASEB J. 2008 Jun;22(6):1660-71. doi: 10.1096/fj.07-092841. Epub 2008 Jan 23.
2. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Ceulemans H and Bollen M, Physiol Rev. 2004 Jan;84(1):1-39.
3. Differential expression of protein phosphatase 1 isoforms in mammalian brain. da Cruz e Silva EF, etal., J Neurosci 1995 May;15(5 Pt 1):3375-89.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. AMP-activated protein kinase: also regulated by ADP? Hardie DG, etal., Trends Biochem Sci. 2011 Sep;36(9):470-7. doi: 10.1016/j.tibs.2011.06.004. Epub 2011 Jul 23.
6. Interaction of the ribosomal protein, L5, with protein phosphatase type 1. Hirano K, etal., J Biol Chem. 1995 Aug 25;270(34):19786-90.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography. Moorhead G, etal., FEBS Lett. 1995 Apr 3;362(2):101-5.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas. Sasaki K, etal., Jpn J Cancer Res 1990 Dec;81(12):1272-80.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Par-4: a new activator of myosin phosphatase. Vetterkind S, etal., Mol Biol Cell. 2010 Apr 1;21(7):1214-24. doi: 10.1091/mbc.E09-08-0711. Epub 2010 Feb 3.
17. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:1653777   PMID:2174876   PMID:9755872   PMID:11162467   PMID:12065664   PMID:14640981   PMID:15247246   PMID:15489334   PMID:19199708   PMID:20124353   PMID:20354225   PMID:20516061  
PMID:21423176   PMID:21471512   PMID:21630459   PMID:21700703   PMID:21712997   PMID:21930935   PMID:24270157   PMID:25931508   PMID:26702053  


Genomics

Comparative Map Data
Ppp1cb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8629,681,099 - 29,712,835 (-)NCBIGRCr8
mRatBN7.2623,958,813 - 23,992,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl623,960,998 - 23,992,824 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx624,260,597 - 24,292,337 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0624,576,477 - 24,608,213 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0624,065,465 - 24,097,720 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0623,548,507 - 23,581,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl623,549,317 - 23,581,052 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0633,416,540 - 33,448,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4624,067,544 - 24,099,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1624,070,497 - 24,102,233 (-)NCBI
Celera623,460,146 - 23,491,883 (-)NCBICelera
Cytogenetic Map6q14NCBI
PPP1CB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38228,751,604 - 28,802,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl228,751,640 - 28,802,940 (+)EnsemblGRCh38hg38GRCh38
GRCh37228,974,470 - 29,025,806 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36228,828,118 - 28,879,310 (+)NCBINCBI36Build 36hg18NCBI36
Build 34228,886,264 - 28,937,456NCBI
Celera228,820,144 - 28,871,300 (+)NCBICelera
Cytogenetic Map2p23.2NCBI
HuRef228,716,532 - 28,767,764 (+)NCBIHuRef
CHM1_1228,904,700 - 28,955,863 (+)NCBICHM1_1
T2T-CHM13v2.0228,795,220 - 28,846,552 (+)NCBIT2T-CHM13v2.0
Ppp1cb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39532,616,192 - 32,651,057 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl532,616,187 - 32,674,777 (+)EnsemblGRCm39 Ensembl
GRCm38532,458,848 - 32,493,713 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl532,458,843 - 32,517,433 (+)EnsemblGRCm38mm10GRCm38
MGSCv37532,761,343 - 32,796,085 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36532,735,841 - 32,769,335 (+)NCBIMGSCv36mm8
Celera529,932,959 - 29,967,634 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.33NCBI
Ppp1cb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546910,662,032 - 10,682,398 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546910,657,029 - 10,682,398 (+)NCBIChiLan1.0ChiLan1.0
PPP1CB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21297,705,718 - 97,757,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A97,709,065 - 97,761,608 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A28,758,176 - 28,809,561 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A28,863,650 - 28,889,401 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A28,862,083 - 28,889,401 (+)Ensemblpanpan1.1panPan2
PPP1CB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11722,680,691 - 22,699,999 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1722,679,783 - 22,699,999 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1722,457,238 - 22,494,559 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01723,225,044 - 23,264,565 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1723,225,011 - 23,268,395 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11722,524,746 - 22,562,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01722,577,001 - 22,614,723 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01722,693,483 - 22,730,878 (+)NCBIUU_Cfam_GSD_1.0
Ppp1cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629266,837,482 - 66,858,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364933,981,370 - 4,002,667 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364933,981,364 - 4,002,083 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1CB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3110,437,688 - 110,474,891 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13110,437,681 - 110,474,896 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23117,257,014 - 117,275,122 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1CB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11478,802,295 - 78,852,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1478,804,548 - 78,852,682 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604533,280,709 - 33,332,417 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1cb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473810,689,152 - 10,730,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473810,689,395 - 10,730,171 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1cb
129 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:684
Count of miRNA genes:294
Interacting mature miRNAs:365
Transcripts:ENSRNOT00000006190
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61753252124011952Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat

Markers in Region
RH139638  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2623,991,569 - 23,991,761 (+)MAPPERmRatBN7.2
Rnor_6.0623,579,887 - 23,580,078NCBIRnor6.0
Rnor_5.0633,447,111 - 33,447,302UniSTSRnor5.0
RGSC_v3.4624,098,115 - 24,098,306UniSTSRGSC3.4
Celera623,490,718 - 23,490,909UniSTS
Cytogenetic Map6q13UniSTS
RH140505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2623,991,661 - 23,991,752 (+)MAPPERmRatBN7.2
Rnor_6.0623,579,979 - 23,580,069NCBIRnor6.0
Rnor_5.0633,447,203 - 33,447,293UniSTSRnor5.0
RGSC_v3.4624,098,207 - 24,098,297UniSTSRGSC3.4
Celera623,490,810 - 23,490,900UniSTS
Cytogenetic Map6q13UniSTS
AA901261  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6q13UniSTS
Ppp1cb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,356,391 - 68,356,761 (+)MAPPERmRatBN7.2
Rnor_6.0171,924,104 - 71,924,473NCBIRnor6.0
Rnor_5.0173,311,615 - 73,311,984UniSTSRnor5.0
RGSC_v3.4168,210,694 - 68,211,063UniSTSRGSC3.4
RGSC_v3.4167,082,822 - 67,083,191UniSTSRGSC3.4
Celera168,734,949 - 68,735,318UniSTS
Cytogenetic Map6q13UniSTS
Ppp1cb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,355,837 - 68,356,274 (+)MAPPERmRatBN7.2
mRatBN7.21922,982,218 - 22,982,680 (+)MAPPERmRatBN7.2
Rnor_6.0171,923,550 - 71,923,986NCBIRnor6.0
Rnor_6.01929,370,983 - 29,371,444NCBIRnor6.0
Rnor_5.01940,279,142 - 40,279,603UniSTSRnor5.0
Rnor_5.0173,311,061 - 73,311,497UniSTSRnor5.0
Cytogenetic Map6q13UniSTS
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000006190   ⟹   ENSRNOP00000006190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl623,960,999 - 23,992,824 (-)Ensembl
Rnor_6.0 Ensembl623,549,317 - 23,581,052 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099315   ⟹   ENSRNOP00000076771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl623,965,641 - 23,983,570 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102151   ⟹   ENSRNOP00000086316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl623,962,766 - 23,992,471 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119348   ⟹   ENSRNOP00000091459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl623,960,998 - 23,983,570 (-)Ensembl
RefSeq Acc Id: NM_013065   ⟹   NP_037197
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8629,681,099 - 29,712,835 (-)NCBI
mRatBN7.2623,960,998 - 23,992,735 (-)NCBI
Rnor_6.0623,549,316 - 23,581,052 (-)NCBI
Rnor_5.0633,416,540 - 33,448,276 (-)NCBI
RGSC_v3.4624,067,544 - 24,099,280 (-)RGD
Celera623,460,146 - 23,491,883 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111812   ⟹   XP_038967740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8629,681,099 - 29,712,655 (-)NCBI
mRatBN7.2623,958,813 - 23,992,770 (-)NCBI
RefSeq Acc Id: NP_037197   ⟸   NM_013065
- UniProtKB: P62142 (UniProtKB/Swiss-Prot),   A6HA24 (UniProtKB/TrEMBL),   A0A8I6ABP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006190   ⟸   ENSRNOT00000006190
RefSeq Acc Id: XP_038967740   ⟸   XM_039111812
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000091459   ⟸   ENSRNOT00000119348
Ensembl Acc Id: ENSRNOP00000076771   ⟸   ENSRNOT00000099315
Ensembl Acc Id: ENSRNOP00000086316   ⟸   ENSRNOT00000102151
Protein Domains
Serine/threonine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62142-F1-model_v2 AlphaFold P62142 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694419
Promoter ID:EPDNEW_R4944
Type:multiple initiation site
Name:Ppp1cb_1
Description:protein phosphatase 1 catalytic subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0623,581,000 - 23,581,060EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3376 AgrOrtholog
BioCyc Gene G2FUF-38379 BioCyc
Ensembl Genes ENSRNOG00000004612 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055020055 UniProtKB/Swiss-Prot
  ENSRNOG00060012972 UniProtKB/Swiss-Prot
  ENSRNOG00065021145 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006190.5 UniProtKB/Swiss-Prot
  ENSRNOT00000099315.1 UniProtKB/TrEMBL
  ENSRNOT00000102151.1 UniProtKB/TrEMBL
  ENSRNOT00000119348.1 UniProtKB/TrEMBL
  ENSRNOT00055034337 UniProtKB/Swiss-Prot
  ENSRNOT00060022123 UniProtKB/Swiss-Prot
  ENSRNOT00065036006 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623630 IMAGE-MGC_LOAD
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP1_catalytic_subunit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STPPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25594 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72523 IMAGE-MGC_LOAD
NCBI Gene 25594 ENTREZGENE
PANTHER SERINE/THREONINE PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT-RELATED UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STPPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PPP1CB RGD
PhenoGen Ppp1cb PhenoGen
PRINTS STPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004612 RatGTEx
  ENSRNOG00055020055 RatGTEx
  ENSRNOG00060012972 RatGTEx
  ENSRNOG00065021145 RatGTEx
SMART PP2Ac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZJA1_RAT UniProtKB/TrEMBL
  A0A8I6A5W1_RAT UniProtKB/TrEMBL
  A0A8I6ABP0 ENTREZGENE, UniProtKB/TrEMBL
  A6HA24 ENTREZGENE, UniProtKB/TrEMBL
  P62142 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P37140 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Ppp1cb  protein phosphatase 1 catalytic subunit beta  Ppp1cb  protein phosphatase 1, catalytic subunit, beta isozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Ppp1cb  protein phosphatase 1, catalytic subunit, beta isozyme  Ppp1cb  protein phosphatase 1, catalytic subunit, beta isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ppp1cb  Protein phosphatase 1, catalytic subunit, beta isoform      Symbol and Name status set to approved 70586 APPROVED