Pck1 (phosphoenolpyruvate carboxykinase 1) - Rat Genome Database

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Gene: Pck1 (phosphoenolpyruvate carboxykinase 1) Rattus norvegicus
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Symbol: Pck1
Name: phosphoenolpyruvate carboxykinase 1
RGD ID: 3267
Description: Enables several functions, including anion binding activity; manganese ion binding activity; and nucleoside diphosphate kinase activity. Involved in several processes, including cellular response to carbohydrate stimulus; cellular response to organonitrogen compound; and cellular response to salt stress. Located in cytoplasm. Used to study type 2 diabetes mellitus. Biomarker of metabolic dysfunction-associated steatohepatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1); PARTICIPATES IN gluconeogenesis pathway; glycolysis/gluconeogenesis pathway; forkhead class A signaling pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (20S)-ginsenoside Rg3.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GTP; MGC93820; PCK; Pepck; PEPCK-C; Phosphoenolpyruvate carboxykinase; phosphoenolpyruvate carboxykinase (GTP); phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase 1, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic (GTP); phosphoenolpyruvate carboxykinase, cytosolic [GTP]; phosphoenolpyruvate carboxylase; RATPEPCK; serine-protein kinase PCK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83182,348,572 - 182,354,521 (+)NCBIGRCr8
mRatBN7.23161,930,256 - 161,936,205 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,930,256 - 161,936,191 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3165,729,451 - 165,735,381 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03174,233,477 - 174,239,426 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,970,227 - 171,976,157 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03171,213,936 - 171,219,885 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3171,213,936 - 171,219,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03177,278,783 - 177,284,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43164,012,410 - 164,018,359 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13163,918,445 - 163,924,394 (+)NCBI
Celera3161,118,524 - 161,124,473 (+)NCBICelera
RH 3.4 Map31498.6RGD
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (EXP)
1,2-dichloroethane  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-phenoxybenzoic acid  (EXP)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
9-cis-retinoic acid  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-linolenic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
betulin  (ISO)
bezafibrate  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bucladesine  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroethene  (ISO)
choline  (ISO)
chromium atom  (ISO)
ciglitazone  (ISO)
clemizole  (ISO)
clofibrate  (EXP,ISO)
Clofop  (ISO)
clopidogrel  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cortisol  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (EXP)
DDT  (EXP)
dexamethasone  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
Diosbulbin B  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
duvoglustat  (ISO)
endosulfan  (EXP,ISO)
ethanol  (EXP)
farnesol  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
ginsenoside Rg2  (ISO)
glucagon  (EXP)
glucose  (ISO)
glyburide  (EXP)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (ISO)
hexadecanoic acid  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
imiquimod  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
iron(III) nitrilotriacetate  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (EXP)
lovastatin  (ISO)
malathion  (EXP)
MeIQ  (ISO)
MeIQx  (ISO)
menadione  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mifepristone  (EXP,ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naringin  (ISO)
nefazodone  (EXP)
nicotinic acid  (EXP,ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
oleic acid  (ISO)
ozone  (EXP,ISO)
palmitoleic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP,ISO)
phlorizin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
prednisolone  (ISO)
prednisone  (ISO)
procyanidin B1  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
Rutamarin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
selenic acid  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium acetate trihydrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP)
sulconazole  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
telbivudine  (EXP)
teriflunomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
wortmannin  (EXP)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular hyperosmotic response  (IEP)
cellular hyperosmotic salinity response  (IEP)
cellular hypotonic response  (IEP)
cellular hypotonic salinity response  (IEP)
cellular response to cAMP  (IEP)
cellular response to dexamethasone stimulus  (IBA)
cellular response to fructose stimulus  (IEP)
cellular response to glucagon stimulus  (IEP)
cellular response to glucose stimulus  (IBA,IDA,ISO)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IBA,IEP,ISO,ISS)
cellular response to interleukin-1  (IEP)
cellular response to phorbol 13-acetate 12-myristate  (IEP)
cellular response to potassium ion starvation  (ISO)
cellular response to raffinose  (IEP)
cellular response to retinoic acid  (IEP)
cellular response to tumor necrosis factor  (IEP)
gluconeogenesis  (IBA,IDA,IEA,ISO,TAS)
glucose homeostasis  (IDA)
glucose metabolic process  (IMP,ISO)
glyceraldehyde-3-phosphate biosynthetic process  (ISO)
glycerol biosynthetic process from pyruvate  (IBA,IDA,ISO)
hepatocyte differentiation  (IBA)
lipid metabolic process  (ISO)
oxaloacetate metabolic process  (IBA,IDA,ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of memory T cell differentiation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
propionate catabolic process  (IBA)
regulation of lipid biosynthetic process  (ISO,ISS)
response to activity  (IEP)
response to bacterium  (ISO)
response to insulin  (ISO,ISS)
response to interleukin-6  (IEP)
response to lipid  (IEP)
response to lipopolysaccharide  (IEP)
response to methionine  (IEP)
response to nutrient levels  (IEP)
response to starvation  (IBA)
tricarboxylic acid metabolic process  (ISO)

Cellular Component
cytoplasm  (IDA)
cytosol  (IBA,ISO,ISS,TAS)
endoplasmic reticulum  (ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Balan MD, etal., Biochemistry. 2015 Sep 29;54(38):5878-87. doi: 10.1021/acs.biochem.5b00822. Epub 2015 Sep 11.
3. Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver. Ballard FJ and Hanson RW, Biochem J. 1967 Sep;104(3):866-71.
4. Purification of phosphoenolpyruvate carboxykinase from the cytosol fraction of rat liver and the immunochemical demonstration of differences between this enzyme and the mitochondrial phosphoenolpyruvate carboxykinase. Ballard FJ and Hanson RW, J Biol Chem. 1969 Oct 25;244(20):5625-30.
5. Evidence that stimulation of gluconeogenesis by fatty acid is mediated through thermodynamic mechanisms. Berry MN, etal., FEBS Lett. 1988 Apr 11;231(1):19-24.
6. Acute and selective regulation of glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase in adipose tissue by thiazolidinediones in type 2 diabetes. Cadoudal T, etal., Diabetologia. 2007 Mar;50(3):666-75. Epub 2007 Jan 23.
7. Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus. Cao H, etal., J Clin Endocrinol Metab. 2004 Feb;89(2):898-903.
8. Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism. Caton PW, etal., J Endocrinol. 2011 Mar;208(3):273-83. doi: 10.1530/JOE-10-0190. Epub 2011 Jan 6.
9. Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase. Caton PW, etal., Life Sci. 2009 May 22;84(21-22):738-44. doi: 10.1016/j.lfs.2009.02.024. Epub 2009 Mar 4.
10. Merit of physical exercise to reverse the higher gene expression of hepatic phosphoenolpyruvate carboxykinase in obese Zucker rats. Chang SP, etal., Life Sci. 2006 Jun 13;79(3):240-6. Epub 2006 Feb 3.
11. Inhibition of glucagon-signaling and downstream actions by interleukin 1beta and tumor necrosis factor alpha in cultured primary rat hepatocytes. Christ B Horm Metab Res. 2008 Jan;40(1):18-23.
12. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
13. A Leu184Val polymorphism in PCK1 gene is associated with type 2 diabetes in Eastern Chinese population with BMI<23 kg/m2. Dong Y, etal., Diabetes Res Clin Pract. 2009 Feb;83(2):227-32. Epub 2008 Dec 13.
14. PEPCK mRNA localization in proximal tubule and gene regulation during metabolic acidosis. Drewnowsk KD, etal., J Physiol Pharmacol 2002 Mar;53(1):3-20.
15. Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. Dunten P, etal., J Mol Biol. 2002 Feb 15;316(2):257-64.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice. Gomez-Valades AG, etal., Diabetes. 2008 Aug;57(8):2199-210. Epub 2008 Apr 28.
18. Overcoming diabetes-induced hyperglycemia through inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP) with RNAi. Gomez-Valades AG, etal., Mol Ther. 2006 Feb;13(2):401-10. Epub 2005 Nov 3.
19. Association of the promoter polymorphism -232C/G of the phosphoenolpyruvate carboxykinase gene (PCK1) with Type 2 diabetes mellitus. Gouni-Berthold I, etal., Diabet Med. 2006 Apr;23(4):419-25.
20. Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. Hamilton G, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):508-16.
21. Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis. Hu YB, etal., Drug Des Devel Ther. 2018 Jul 16;12:2213-2221. doi: 10.2147/DDDT.S170518. eCollection 2018.
22. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
23. Nutrigenomic effects of germinated brown rice and its bioactives on hepatic gluconeogenic genes in type 2 diabetic rats and HEPG2 cells. Imam MU and Ismail M, Mol Nutr Food Res. 2013 Mar;57(3):401-11. doi: 10.1002/mnfr.201200429. Epub 2013 Jan 10.
24. Efficient delivery of siRNA using dendritic poly(L-lysine) for loss-of-function analysis. Inoue Y, etal., J Control Release. 2008 Feb 18;126(1):59-66. Epub 2007 Nov 6.
25. Interaction of a liver-specific factor with an enhancer 4.8 kilobases upstream of the phosphoenolpyruvate carboxykinase gene. Ip YT, etal., Mol Cell Biol 1990 Jul;10(7):3770-81.
26. Pretranslational regulation of tyrosine aminotransferase and phosphoenolpyruvate carboxykinase (GTP) synthesis by glucagon and dexamethasone in adult rat hepatocytes. Iynedjian PB, etal., Biochem J. 1985 Jan 1;225(1):77-84.
27. Structure, mechanism and regulation of pyruvate carboxylase. Jitrapakdee S, etal., Biochem J. 2008 Aug 1;413(3):369-87.
28. Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Johnson TA, etal., Biochemistry. 2016 Jan 26;55(3):575-87. doi: 10.1021/acs.biochem.5b01215. Epub 2016 Jan 13.
29. Cell volume regulates liver phosphoenolpyruvate carboxykinase and fructose-1,6-bisphosphatase genes. Kaiser S, Am J Physiol. 1998 Mar;274(3):G509-17. doi: 10.1152/ajpgi.1998.274.3.G509.
30. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
31. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
32. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
33. Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. Latorre-Muro P, etal., Mol Cell. 2018 Sep 6;71(5):718-732.e9. doi: 10.1016/j.molcel.2018.07.031.
34. Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species. Lelli SM, etal., Toxicology. 2005 Dec;216(1):49-58. Epub 2005 Aug 24.
35. Impact of interleukin-6 on the glucose metabolic capacity in rat liver. Lienenluke B and Christ B, Histochem Cell Biol. 2007 Oct;128(4):371-7. Epub 2007 Sep 6.
36. Characterization of 3-[(Carboxymethyl)thio]picolinic Acid: A Novel Inhibitor of Phosphoenolpyruvate Carboxykinase. Mcleod MJ, etal., Biochemistry. 2019 Sep 17;58(37):3918-3926. doi: 10.1021/acs.biochem.9b00583. Epub 2019 Sep 6.
37. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
38. Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity. Miller WH, etal., J Biol Chem. 1992 Oct 15;267(29):21220-4.
39. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. Effects of bis(alpha-furancarboxylato)oxovanadium(IV) on glucose metabolism in fat-fed/streptozotocin-diabetic rats. Niu Y, etal., Eur J Pharmacol. 2007 Oct 31;572(2-3):213-9. Epub 2007 Jun 19.
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. Effect of reduced maternal inspired oxygen on hepatic glucose metabolism in the rat fetus. Parimi PS, etal., Pediatr Res. 2003 Feb;53(2):325-32.
43. HNF4alpha contributes to glucose formation in aged rat hepatocytes. Park EY, etal., Exp Gerontol. 2013 Dec;48(12):1518-25. doi: 10.1016/j.exger.2013.10.011. Epub 2013 Oct 29.
44. Genomic and metabolic responses to methionine-restricted and methionine-restricted, cysteine-supplemented diets in Fischer 344 rat inguinal adipose tissue, liver and quadriceps muscle. Perrone CE, etal., J Nutrigenet Nutrigenomics. 2012;5(3):132-57. doi: 10.1159/000339347. Epub 2012 Oct 9.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
47. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
48. GOA pipeline RGD automated data pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. Shulman JM, etal., PLoS One. 2010 Jun 21;5(6):e11244. doi: 10.1371/journal.pone.0011244.
52. Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin. Song S, etal., Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E275-82.
53. Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats. Strakovsky RS, etal., J Physiol. 2011 Jun 1;589(Pt 11):2707-17. doi: 10.1113/jphysiol.2010.203950. Epub 2011 Mar 28.
54. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
55. Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid. Sullivan SM and Holyoak T, Biochemistry. 2007 Sep 4;46(35):10078-88. Epub 2007 Aug 9.
56. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
57. Large-scale study of the -232C > G polymorphism of PCK1 in Type 2 diabetes. Wegner L, etal., Diabet Med. 2006 Oct;23(10):1140-4.
58. Different transcription factor binding arrays modulate the cAMP responsivity of the phosphoenolpyruvate carboxykinase gene promoter. Wilson HL, etal., J Biol Chem 2002 Nov 15;277(46):43895-902. Epub 2002 Sep 16.
59. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
60. Phosphoenolpyruvate carboxykinase is induced in growth-arrested hepatoma cells.PG - 1513-20 Zeitouni N, etal., Biochem Biophys Res Commun 2002 Feb 8;290(5):1513-20.
61. Retinoids induced Pck1 expression and attenuated insulin-mediated suppression of its expression via activation of retinoic acid receptor in primary rat hepatocytes. Zhang Y, etal., Mol Cell Biochem. 2011 Sep;355(1-2):1-8. doi: 10.1007/s11010-011-0831-4. Epub 2011 Apr 26.
62. Gluconeogenesis in developing rat kidney cortex. Zorzoli A, etal., Biochem J. 1969 Jan;111(2):181-5.
Additional References at PubMed
PMID:1716357   PMID:2909519   PMID:2993287   PMID:3015903   PMID:6090458   PMID:6304730   PMID:9242918   PMID:10224131   PMID:11792850   PMID:11916968   PMID:11968005   PMID:12409311  
PMID:12788931   PMID:12947022   PMID:14744869   PMID:15147725   PMID:15489334   PMID:15604115   PMID:15733865   PMID:16126724   PMID:17158265   PMID:17211624   PMID:17678617   PMID:17903369  
PMID:17964299   PMID:18304430   PMID:18492826   PMID:18772387   PMID:19056867   PMID:19458124   PMID:19521512   PMID:19548567   PMID:19850730   PMID:20167786   PMID:20797423   PMID:21504969  
PMID:21731709   PMID:22142627   PMID:22808220   PMID:23012479   PMID:23015202   PMID:23376485   PMID:26348778   PMID:26681041   PMID:26971250   PMID:27724862   PMID:29601231   PMID:30445425  
PMID:31180589   PMID:32036699   PMID:35462799  


Genomics

Comparative Map Data
Pck1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83182,348,572 - 182,354,521 (+)NCBIGRCr8
mRatBN7.23161,930,256 - 161,936,205 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,930,256 - 161,936,191 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3165,729,451 - 165,735,381 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03174,233,477 - 174,239,426 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,970,227 - 171,976,157 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03171,213,936 - 171,219,885 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3171,213,936 - 171,219,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03177,278,783 - 177,284,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43164,012,410 - 164,018,359 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13163,918,445 - 163,924,394 (+)NCBI
Celera3161,118,524 - 161,124,473 (+)NCBICelera
RH 3.4 Map31498.6RGD
Cytogenetic Map3q42NCBI
PCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382057,561,110 - 57,568,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2057,561,080 - 57,568,121 (+)EnsemblGRCh38hg38GRCh38
GRCh372056,136,166 - 56,143,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362055,569,543 - 55,574,922 (+)NCBINCBI36Build 36hg18NCBI36
Build 342055,569,542 - 55,574,922NCBI
Celera2052,876,507 - 52,881,880 (+)NCBICelera
Cytogenetic Map20q13.31NCBI
HuRef2052,917,936 - 52,923,310 (+)NCBIHuRef
CHM1_12056,037,177 - 56,042,551 (+)NCBICHM1_1
T2T-CHM13v2.02059,338,907 - 59,345,912 (+)NCBIT2T-CHM13v2.0
Pck1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392172,994,866 - 173,001,067 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2172,994,841 - 173,001,066 (+)EnsemblGRCm39 Ensembl
GRCm382173,153,073 - 173,159,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2173,153,048 - 173,159,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv372172,978,574 - 172,984,755 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362172,796,012 - 172,802,193 (+)NCBIMGSCv36mm8
Celera2179,118,257 - 179,124,444 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map295.79NCBI
Pck1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554451,908,946 - 1,915,002 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554451,909,012 - 1,914,032 (-)NCBIChiLan1.0ChiLan1.0
PCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22163,312,601 - 63,317,945 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12063,305,720 - 63,311,064 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02053,901,738 - 53,907,090 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12055,179,549 - 55,184,920 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2055,179,429 - 55,184,920 (+)Ensemblpanpan1.1panPan2
PCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12442,538,858 - 42,544,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2442,538,882 - 42,544,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2441,785,578 - 41,791,088 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02443,403,776 - 43,409,160 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2443,403,838 - 43,409,160 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12442,488,683 - 42,493,998 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02442,628,235 - 42,633,550 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02443,286,331 - 43,291,858 (+)NCBIUU_Cfam_GSD_1.0
Pck1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640182,939,216 - 182,945,488 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936530361,872 - 367,005 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936530361,872 - 367,005 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1757,930,432 - 57,936,522 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11757,930,507 - 57,936,523 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21765,094,783 - 65,100,751 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.126,550,806 - 6,556,499 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl26,549,652 - 6,556,478 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605054,608,451 - 54,614,130 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pck1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474123,985,675 - 23,989,790 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474123,985,257 - 23,990,354 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pck1
37 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:55
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000031586
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
D3Mgh26  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3161,114,063 - 161,114,271UniSTS
RH 3.4 Map31497.9UniSTS
RH 3.4 Map31497.9RGD
RH 2.0 Map31013.8RGD
FHH x ACI Map3103.83RGD
Cytogenetic Map3q42UniSTS
D9Mit10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,935,792 - 161,935,942 (+)MAPPERmRatBN7.2
Rnor_6.03171,219,473 - 171,219,622NCBIRnor6.0
Rnor_5.03177,284,320 - 177,284,469UniSTSRnor5.0
RGSC_v3.43164,017,946 - 164,018,096RGDRGSC3.4
RGSC_v3.43164,017,947 - 164,018,096UniSTSRGSC3.4
RGSC_v3.13163,923,982 - 163,924,132RGD
Celera3161,124,061 - 161,124,210UniSTS
RH 3.4 Map31495.5UniSTS
RH 3.4 Map31495.5RGD
RH 2.0 Map31013.5RGD
Cytogenetic Map3q42UniSTS
D3Arb24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,935,834 - 161,936,089 (+)MAPPERmRatBN7.2
Rnor_6.03171,219,515 - 171,219,769NCBIRnor6.0
Rnor_5.03177,284,362 - 177,284,616UniSTSRnor5.0
RGSC_v3.43164,017,988 - 164,018,243RGDRGSC3.4
RGSC_v3.43164,017,989 - 164,018,243UniSTSRGSC3.4
RGSC_v3.13163,924,024 - 163,924,279RGD
Celera3161,124,103 - 161,124,357UniSTS
RH 2.0 Map31012.8RGD
Cytogenetic Map3q42UniSTS
PMC152262P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,934,097 - 161,934,271 (+)MAPPERmRatBN7.2
Rnor_6.03171,217,778 - 171,217,951NCBIRnor6.0
Rnor_5.03177,282,625 - 177,282,798UniSTSRnor5.0
RGSC_v3.43164,016,252 - 164,016,425UniSTSRGSC3.4
Celera3161,122,366 - 161,122,539UniSTS
Cytogenetic Map3q42UniSTS
PMC86435P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,930,677 - 161,931,227 (+)MAPPERmRatBN7.2
Rnor_6.03171,214,358 - 171,214,907NCBIRnor6.0
Rnor_5.03177,279,205 - 177,279,754UniSTSRnor5.0
RGSC_v3.43164,012,832 - 164,013,381UniSTSRGSC3.4
Celera3161,118,946 - 161,119,495UniSTS
Cytogenetic Map3q42UniSTS
PMC133887P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,929,820 - 161,930,160 (+)MAPPERmRatBN7.2
Rnor_6.03171,213,501 - 171,213,840NCBIRnor6.0
Rnor_5.03177,278,348 - 177,278,687UniSTSRnor5.0
RGSC_v3.43164,011,975 - 164,012,314UniSTSRGSC3.4
Celera3161,118,089 - 161,118,428UniSTS
Cytogenetic Map3q42UniSTS
Pck1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,933,962 - 161,934,036 (+)MAPPERmRatBN7.2
Rnor_6.03171,217,643 - 171,217,716NCBIRnor6.0
Rnor_5.03177,282,490 - 177,282,563UniSTSRnor5.0
RGSC_v3.43164,016,117 - 164,016,190UniSTSRGSC3.4
Celera3161,122,231 - 161,122,304UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 10 10 10 12
Medium 2 1 28 13 7 13 1 1 15 6 8 1
Low 1 15 5 4 9 4 7 8 9 4 20 2 7
Below cutoff 25 12 12 2 12 2 16 4 11 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031586   ⟹   ENSRNOP00000030913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,930,256 - 161,936,191 (+)Ensembl
Rnor_6.0 Ensembl3171,213,936 - 171,219,871 (+)Ensembl
RefSeq Acc Id: NM_198780   ⟹   NP_942075
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,348,572 - 182,354,521 (+)NCBI
mRatBN7.23161,930,256 - 161,936,205 (+)NCBI
Rnor_6.03171,213,936 - 171,219,885 (+)NCBI
Rnor_5.03177,278,783 - 177,284,732 (+)NCBI
RGSC_v3.43164,012,410 - 164,018,359 (+)RGD
Celera3161,118,524 - 161,124,473 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_942075   ⟸   NM_198780
- UniProtKB: P07379 (UniProtKB/Swiss-Prot),   A6KKZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030913   ⟸   ENSRNOT00000031586
Protein Domains
Phosphoenolpyruvate carboxykinase C-terminal P-loop   Phosphoenolpyruvate carboxykinase GTP-utilising N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07379-F1-model_v2 AlphaFold P07379 1-622 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692711
Promoter ID:EPDNEW_R3236
Type:single initiation site
Name:Pck1_1
Description:phosphoenolpyruvate carboxykinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03171,213,936 - 171,213,996EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3267 AgrOrtholog
BioCyc Gene G2FUF-46515 BioCyc
Ensembl Genes ENSRNOG00000028616 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055000874 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031586 ENTREZGENE
  ENSRNOT00000031586.7 UniProtKB/Swiss-Prot
  ENSRNOT00055001468 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.449.10 UniProtKB/Swiss-Prot
  3.90.228.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphoenolpyruvate Carboxykinase, domain 1 UniProtKB/TrEMBL
  Phosphoenolpyruvate Carboxykinase, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110760 IMAGE-MGC_LOAD
InterPro PEP_carboxykin_GTP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEP_carboxykinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEP_carboxykinase_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEP_carboxykinase_GTP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEP_carboxykinase_GTP_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEP_carboxykinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362282 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93820 IMAGE-MGC_LOAD
NCBI Gene Pck1 ENTREZGENE
PANTHER PHOSPHOENOLPYRUVATE CARBOXYKINASE UniProtKB/TrEMBL
  PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP] UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11561 UniProtKB/Swiss-Prot
Pfam PEPCK_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPCK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pck1 PhenoGen
PIRSF PEP_carboxykinase_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PEPCK_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028616 RatGTEx
  ENSRNOG00055000874 RatGTEx
Superfamily-SCOP PEP carboxykinase N-terminal domain UniProtKB/TrEMBL
  PEP carboxykinase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF68923 UniProtKB/Swiss-Prot
UniProt A6KKZ5 ENTREZGENE, UniProtKB/TrEMBL
  A6KKZ6_RAT UniProtKB/TrEMBL
  A6KKZ7_RAT UniProtKB/TrEMBL
  A6KKZ8_RAT UniProtKB/TrEMBL
  A6KKZ9_RAT UniProtKB/TrEMBL
  P07379 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Pck1  phosphoenolpyruvate carboxykinase 1  Pck1  phosphoenolpyruvate carboxykinase 1 (soluble)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Pck1  phosphoenolpyruvate carboxykinase 1 (soluble)  Pck1  phosphoenolpyruvate carboxykinase 1, cytosolic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Pck1  phosphoenolpyruvate carboxykinase 1, cytosolic  Pck1  phosphoenolpyruvate carboxykinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pck1  phosphoenolpyruvate carboxykinase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Pck1  phosphoenolpyruvate carboxykinase 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease increased expression is correlated with the growth arrest of hepatoma cells 625518
gene_expression found mainly in liver, kidney and adipocytes 625518
gene_expression expressed in intestine 625518
gene_process an immediate-early response gene for liver regeneration 625518
gene_process functions in gluconeogenesis 625518
gene_regulation regulated by thyroid hormone, prolactin, diacyl glycerol, pH and retinoic acid 625518
gene_regulation regulated by insulin, glucocorticoids, cAMP, and diet 625518