Pcca (propionyl-CoA carboxylase subunit alpha) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pcca (propionyl-CoA carboxylase subunit alpha) Rattus norvegicus
Analyze
Symbol: Pcca
Name: propionyl-CoA carboxylase subunit alpha
RGD ID: 3264
Description: Predicted to enable enzyme binding activity and propionyl-CoA carboxylase activity. Predicted to be involved in amino acid catabolic process and fatty acid catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be part of catalytic complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCA (propionyl-CoA carboxylase subunit alpha); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC687008; PCCase alpha subunit; PCCase subunit alpha; propanoyl-CoA:carbon dioxide ligase alpha subunit; propanoyl-CoA:carbon dioxide ligase subunit alpha; propionyl CoA carboxylase, alpha polypeptide; Propionyl Coenzyme A carboxylase alpha polypeptide; Propionyl Coenzyme A carboxylase, alpha polypeptide; propionyl-CoA carboxylase alpha chain, mitochondrial; propionyl-CoA carboxylase alpha subunit; propionyl-coenzyme A carboxylase, alpha polypeptide; similar to Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (PCCase alpha subunit) (Propanoyl-CoA:carbon dioxide ligase alpha subunit)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815106,034,586 - 106,374,908 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl15106,034,610 - 106,374,908 (+)EnsemblGRCr8
mRatBN7.21599,627,955 - 99,969,555 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1599,627,982 - 99,968,266 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx15103,560,589 - 103,901,667 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015104,665,702 - 105,000,289 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015101,592,936 - 101,927,542 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.015108,960,509 - 109,306,879 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15108,960,562 - 109,306,603 (+)Ensemblrn6Rnor6.0
Rnor_5.015112,346,155 - 112,477,427 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.015112,502,385 - 112,687,789 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.415107,659,723 - 108,028,929 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1598,401,724 - 98,738,731 (+)NCBICelera
RGSC_v3.115107,675,589 - 108,044,696 (+)NCBI
RH 3.4 Map15692.11RGD
Cytogenetic Map15q25NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
aconitine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium trinitrate  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
genistein  (ISO)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methapyrilene  (EXP,ISO)
N-nitrosomorpholine  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PhIP  (EXP)
phlorizin  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
temozolomide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
catalytic complex  (IEA,ISO)
mitochondrial matrix  (IEA,ISO,ISS)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Sequence analysis, biogenesis, and mitochondrial import of the alpha-subunit of rat liver propionyl-CoA carboxylase. Browner MF, etal., J Biol Chem 1989 Jul 25;264(21):12680-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Three novel splice mutations in the PCCA gene causing identical exon skipping in propionic acidemia patients. Richard E, etal., Hum Genet. 1997 Nov;101(1):93-6.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:6765947   PMID:8434582   PMID:8889548   PMID:11461925   PMID:13752080   PMID:14651853   PMID:15060005   PMID:16023992   PMID:18614015   PMID:19157941   PMID:19699272   PMID:26316108  
PMID:31505169  


Genomics

Comparative Map Data
Pcca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815106,034,586 - 106,374,908 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl15106,034,610 - 106,374,908 (+)EnsemblGRCr8
mRatBN7.21599,627,955 - 99,969,555 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1599,627,982 - 99,968,266 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx15103,560,589 - 103,901,667 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015104,665,702 - 105,000,289 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015101,592,936 - 101,927,542 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.015108,960,509 - 109,306,879 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15108,960,562 - 109,306,603 (+)Ensemblrn6Rnor6.0
Rnor_5.015112,346,155 - 112,477,427 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.015112,502,385 - 112,687,789 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.415107,659,723 - 108,028,929 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1598,401,724 - 98,738,731 (+)NCBICelera
RGSC_v3.115107,675,589 - 108,044,696 (+)NCBI
RH 3.4 Map15692.11RGD
Cytogenetic Map15q25NCBI
PCCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813100,089,093 - 100,530,435 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13100,089,015 - 100,530,437 (+)Ensemblhg38GRCh38
GRCh3713100,741,347 - 101,182,689 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361399,539,338 - 99,980,690 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341399,539,402 - 99,980,687NCBI
Celera1381,585,804 - 82,027,260 (+)NCBICelera
Cytogenetic Map13q32.3NCBI
HuRef1381,336,606 - 81,778,760 (+)NCBIHuRef
CHM1_113100,711,146 - 101,152,990 (+)NCBICHM1_1
T2T-CHM13v2.01399,302,579 - 99,745,721 (+)NCBIT2T-CHM13v2.0
Pcca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914122,721,822 - 123,127,372 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14122,771,736 - 123,128,512 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3814122,484,365 - 122,889,944 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14122,534,324 - 122,891,100 (+)Ensemblmm10GRCm38
MGSCv3714122,933,550 - 123,289,166 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3614121,669,524 - 122,025,008 (+)NCBIMGSCv36mm8
Celera14121,094,262 - 121,448,288 (+)NCBICelera
Cytogenetic Map14E5NCBI
cM Map1465.99NCBI
Pcca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540410,317,640 - 10,661,496 (-)Ensembl
ChiLan1.0NW_00495540410,317,640 - 10,719,148 (-)NCBIChiLan1.0ChiLan1.0
PCCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214101,616,111 - 102,056,078 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113100,283,182 - 100,723,379 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01381,259,313 - 81,699,117 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113100,390,959 - 100,837,772 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13100,390,959 - 100,837,772 (+)EnsemblpanPan2panpan1.1
PCCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12249,965,134 - 50,428,025 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2250,023,369 - 50,428,027 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2249,745,683 - 50,208,149 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02250,406,847 - 50,870,032 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2250,464,478 - 50,870,032 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12250,114,652 - 50,516,893 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02250,090,509 - 50,553,146 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02250,127,751 - 50,590,508 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pcca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945185,393,912 - 185,784,766 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647210,164,642 - 10,501,878 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647210,167,387 - 10,501,824 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCCA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1168,920,929 - 69,286,430 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11168,920,923 - 69,286,431 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21176,363,099 - 76,547,559 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCCA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1378,722,186 - 79,156,049 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl378,722,286 - 79,156,863 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604635,224,719 - 35,662,275 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479310,691,224 - 11,100,853 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479310,691,224 - 11,099,905 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pcca
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1122,006,261 - 2,310,828 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:250
Count of miRNA genes:135
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000019144, ENSRNOT00000057429
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1582194914108192169Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1574735564106469153Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)1561710951106710951Rat
1358354Srcrt5Stress Responsive Cort QTL 53.38blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1582503470108192169Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1583700787108192169Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1582714037106778197Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1567399137108192169Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1582194914108192169Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1564571127108192169Rat
7411646Foco21Food consumption QTL 2123.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1584278281108192169Rat

Markers in Region
D15Rat63  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr815106,200,699 - 106,200,875 (+)Marker Load Pipeline
mRatBN7.21599,794,071 - 99,794,247 (+)MAPPERmRatBN7.2
Rnor_6.015109,133,729 - 109,133,904NCBIRnor6.0
Rnor_5.015112,515,664 - 112,515,839UniSTSRnor5.0
RGSC_v3.415107,849,473 - 107,849,649RGDRGSC3.4
RGSC_v3.415107,849,474 - 107,849,649UniSTSRGSC3.4
Celera1598,564,878 - 98,565,053UniSTS
RGSC_v3.115107,865,254 - 107,865,429RGD
RH 3.4 Map15710.8UniSTS
RH 3.4 Map15710.8RGD
RH 2.0 Map15611.6RGD
FHH x ACI Map1573.9699RGD
Cytogenetic Map15q25UniSTS
D15Got102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21599,948,518 - 99,948,686 (+)MAPPERmRatBN7.2
Rnor_6.015109,287,130 - 109,287,299NCBIRnor6.0
Rnor_5.015112,668,040 - 112,668,209UniSTSRnor5.0
RGSC_v3.415108,008,042 - 108,008,212RGDRGSC3.4
RGSC_v3.415108,008,043 - 108,008,212UniSTSRGSC3.4
Celera1598,718,982 - 98,719,151UniSTS
RGSC_v3.115108,023,823 - 108,023,992RGD
RH 3.4 Map15726.3UniSTS
RH 3.4 Map15726.3RGD
RH 2.0 Map15628.0RGD
Cytogenetic Map15q25UniSTS
RH94721  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr815106,374,644 - 106,374,797 (+)Marker Load Pipeline
mRatBN7.21599,968,005 - 99,968,158 (+)MAPPERmRatBN7.2
Rnor_6.015109,306,616 - 109,306,768NCBIRnor6.0
Rnor_5.015112,687,526 - 112,687,678UniSTSRnor5.0
RGSC_v3.415108,028,666 - 108,028,818UniSTSRGSC3.4
Celera1598,738,468 - 98,738,620UniSTS
RH 3.4 Map15692.11UniSTS
Cytogenetic Map15q25UniSTS
RH144434  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21599,662,146 - 99,662,421 (+)MAPPERmRatBN7.2
Rnor_6.015108,994,717 - 108,994,991NCBIRnor6.0
Rnor_5.015112,380,733 - 112,381,007UniSTSRnor5.0
RGSC_v3.415107,694,050 - 107,694,324UniSTSRGSC3.4
Celera1598,435,849 - 98,436,123UniSTS
RH 3.4 Map15710.3UniSTS
Cytogenetic Map15q25UniSTS
BE107713  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21599,746,171 - 99,746,327 (+)MAPPERmRatBN7.2
Rnor_6.015109,081,293 - 109,081,448NCBIRnor6.0
Rnor_5.015112,464,083 - 112,464,238UniSTSRnor5.0
Celera1598,517,236 - 98,517,391UniSTS
RH 3.4 Map15708.6UniSTS
Cytogenetic Map15q25UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000077482   ⟹   ENSRNOP00000072844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,034,619 - 106,374,905 (+)Ensembl
mRatBN7.2 Ensembl1599,627,986 - 99,968,266 (+)Ensembl
Rnor_6.0 Ensembl15108,960,562 - 109,306,603 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081906   ⟹   ENSRNOP00000073510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,034,654 - 106,374,908 (+)Ensembl
mRatBN7.2 Ensembl1599,628,018 - 99,968,266 (+)Ensembl
Rnor_6.0 Ensembl15108,960,562 - 109,306,603 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094922   ⟹   ENSRNOP00000082095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,034,610 - 106,374,905 (+)Ensembl
mRatBN7.2 Ensembl1599,627,986 - 99,968,266 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096028   ⟹   ENSRNOP00000087798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,034,654 - 106,374,908 (+)Ensembl
mRatBN7.2 Ensembl1599,628,018 - 99,968,266 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097463   ⟹   ENSRNOP00000076923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,034,654 - 106,374,908 (+)Ensembl
mRatBN7.2 Ensembl1599,627,994 - 99,968,266 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099022   ⟹   ENSRNOP00000082674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,034,618 - 106,374,908 (+)Ensembl
mRatBN7.2 Ensembl1599,627,982 - 99,966,023 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100907   ⟹   ENSRNOP00000078501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,034,618 - 106,374,908 (+)Ensembl
mRatBN7.2 Ensembl1599,627,986 - 99,968,266 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157380   ⟹   ENSRNOP00000104325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,034,618 - 106,371,634 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158762   ⟹   ENSRNOP00000104837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,034,618 - 106,374,904 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000169991   ⟹   ENSRNOP00000100967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,034,618 - 106,374,908 (+)Ensembl
RefSeq Acc Id: NM_019330   ⟹   NP_062203
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,034,618 - 106,374,908 (+)NCBI
mRatBN7.21599,627,986 - 99,968,269 (+)NCBI
Rnor_6.015108,960,530 - 109,306,879 (+)NCBI
Rnor_5.015112,346,155 - 112,477,427 (+)NCBI
Rnor_5.015112,502,385 - 112,687,789 (+)NCBI
RGSC_v3.415107,659,723 - 108,028,929 (+)RGD
Celera1598,401,724 - 98,738,731 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093664   ⟹   XP_038949592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,034,586 - 106,374,908 (+)NCBI
mRatBN7.21599,627,955 - 99,968,269 (+)NCBI
RefSeq Acc Id: XM_063274647   ⟹   XP_063130717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,034,586 - 106,374,908 (+)NCBI
RefSeq Acc Id: XM_063274648   ⟹   XP_063130718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,034,586 - 106,374,908 (+)NCBI
RefSeq Acc Id: XM_063274649   ⟹   XP_063130719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,034,586 - 106,374,908 (+)NCBI
RefSeq Acc Id: XM_063274650   ⟹   XP_063130720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,034,586 - 106,374,908 (+)NCBI
RefSeq Acc Id: XM_063274651   ⟹   XP_063130721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,062,009 - 106,374,908 (+)NCBI
RefSeq Acc Id: NP_062203   ⟸   NM_019330
- UniProtKB: A6HUM3 (UniProtKB/TrEMBL),   A0A8I5ZL37 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072844   ⟸   ENSRNOT00000077482
Ensembl Acc Id: ENSRNOP00000073510   ⟸   ENSRNOT00000081906
RefSeq Acc Id: XP_038949592   ⟸   XM_039093664
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZL37 (UniProtKB/TrEMBL),   A0A8I5ZWE0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082095   ⟸   ENSRNOT00000094922
Ensembl Acc Id: ENSRNOP00000082674   ⟸   ENSRNOT00000099022
Ensembl Acc Id: ENSRNOP00000087798   ⟸   ENSRNOT00000096028
Ensembl Acc Id: ENSRNOP00000078501   ⟸   ENSRNOT00000100907
Ensembl Acc Id: ENSRNOP00000076923   ⟸   ENSRNOT00000097463
RefSeq Acc Id: XP_063130717   ⟸   XM_063274647
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZVD4 (UniProtKB/TrEMBL),   A0A8I5ZL37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130718   ⟸   XM_063274648
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K5P9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130719   ⟸   XM_063274649
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K401 (UniProtKB/TrEMBL),   A6HUM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130720   ⟸   XM_063274650
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZL37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130721   ⟸   XM_063274651
- Peptide Label: isoform X6
- UniProtKB: A0A8I5YBZ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104325   ⟸   ENSRNOT00000157380
Ensembl Acc Id: ENSRNOP00000100967   ⟸   ENSRNOT00000169991
Ensembl Acc Id: ENSRNOP00000104837   ⟸   ENSRNOT00000158762
Protein Domains
ATP-grasp   Biotin carboxylation   Biotinyl-binding   Lipoyl-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14882-F1-model_v2 AlphaFold P14882 1-737 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699893
Promoter ID:EPDNEW_R10408
Type:single initiation site
Name:AC123185_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015108,956,394 - 108,956,454EPDNEW
RGD ID:13699885
Promoter ID:EPDNEW_R10409
Type:initiation region
Name:Pcca_1
Description:propionyl-CoA carboxylase alpha subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015108,960,526 - 108,960,586EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3264 AgrOrtholog
BioCyc Gene G2FUF-12336 BioCyc
BioCyc Pathway PROPIONMET-PWY [propanoyl CoA degradation I] BioCyc
BioCyc Pathway Image PROPIONMET-PWY BioCyc
Ensembl Genes ENSRNOG00000057042 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000077482 ENTREZGENE
  ENSRNOT00000094922 ENTREZGENE
  ENSRNOT00000097463 ENTREZGENE
Gene3D-CATH 2.40.50.100 UniProtKB/Swiss-Prot
  3.30.1490.20 UniProtKB/Swiss-Prot
  3.30.700.30 UniProtKB/Swiss-Prot
  3.40.50.20 UniProtKB/Swiss-Prot
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot
InterPro ATP-grasp UniProtKB/Swiss-Prot
  ATP_grasp_subdomain_1 UniProtKB/Swiss-Prot
  BC-like_N UniProtKB/Swiss-Prot
  Biotin_BS UniProtKB/Swiss-Prot
  Biotin_carboxylase_complex UniProtKB/Swiss-Prot
  Biotin_carboxylation_dom UniProtKB/Swiss-Prot
  Biotin_COase_C UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/Swiss-Prot
  PCC_BT UniProtKB/Swiss-Prot
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot
  Rudment_hybrid_motif UniProtKB/Swiss-Prot
  Single_hybrid_motif UniProtKB/Swiss-Prot
KEGG Report rno:687008 UniProtKB/Swiss-Prot
NCBI Gene Pcca ENTREZGENE
PANTHER CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE UniProtKB/Swiss-Prot
  METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot
Pfam Biotin_carb_C UniProtKB/Swiss-Prot
  Biotin_carb_N UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot
  CPSase_L_D2 UniProtKB/Swiss-Prot
  PCC_BT UniProtKB/Swiss-Prot
PhenoGen Pcca PhenoGen
PROSITE ATP_GRASP UniProtKB/Swiss-Prot
  BIOTIN UniProtKB/Swiss-Prot
  BIOTINYL_LIPOYL UniProtKB/Swiss-Prot
  CPSASE_1 UniProtKB/Swiss-Prot
  CPSASE_2 UniProtKB/Swiss-Prot
  PS50979 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000057042 RatGTEx
SMART Biotin_carb_C UniProtKB/Swiss-Prot
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot
  SSF51230 UniProtKB/Swiss-Prot
  SSF51246 UniProtKB/Swiss-Prot
  SSF52440 UniProtKB/Swiss-Prot
TIGR TC205059
UniProt A0A0G2K401 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K5P9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5YBZ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZL37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVD4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8G9_RAT UniProtKB/TrEMBL
  A0ABK0L7R9_RAT UniProtKB/TrEMBL
  A0ABK0LIX3_RAT UniProtKB/TrEMBL
  A0ABK0LQL6_RAT UniProtKB/TrEMBL
  A6HUM3 ENTREZGENE, UniProtKB/TrEMBL
  A6HUM4 ENTREZGENE, UniProtKB/TrEMBL
  P14882 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-04 Pcca  propionyl-CoA carboxylase subunit alpha  Pcca  propionyl-CoA carboxylase alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-20 Pcca  propionyl-CoA carboxylase alpha subunit  Pcca  propionyl CoA carboxylase, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-01 Pcca  propionyl CoA carboxylase, alpha polypeptide  Pcca  propionyl-coenzyme A carboxylase, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-05 Pcca  propionyl-coenzyme A carboxylase, alpha polypeptide  LOC687008  similar to Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (PCCase alpha subunit) (Propanoyl-CoA:carbon dioxide ligase alpha subunit)  Data merged from RGD:1590160 737654 APPROVED
2006-11-20 LOC687008  similar to Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (PCCase alpha subunit) (Propanoyl-CoA:carbon dioxide ligase alpha subunit)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Pcca  Propionyl Coenzyme A carboxylase, alpha polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein may contain a biotinylated lysine residue 633579