Oprd1 (opioid receptor, delta 1) - Rat Genome Database

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Gene: Oprd1 (opioid receptor, delta 1) Rattus norvegicus
Analyze
Symbol: Oprd1
Name: opioid receptor, delta 1
RGD ID: 3233
Description: Enables G protein-coupled enkephalin receptor activity and receptor serine/threonine kinase binding activity. Involved in several processes, including eating behavior; response to ethanol; and response to nicotine. Located in several cellular components, including axon terminus; dendrite membrane; and postsynaptic membrane. Is active in secretory vesicle; spine apparatus; and synaptic membrane. Used to study alcohol use disorder and myocardial infarction. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; drug dependence (multiple); opioid abuse; and withdrawal disorder. Orthologous to human OPRD1 (opioid receptor delta 1); INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; (R)-noradrenaline; (R,R)-tramadol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: D-OR-1; delta-type opioid receptor; DOR-1; opioid receptor A; Opioid receptor delta 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,590,244 - 149,624,999 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5149,590,244 - 149,624,999 (-)EnsemblGRCr8
mRatBN7.25144,306,188 - 144,340,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,306,188 - 144,340,960 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5147,005,532 - 147,040,056 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05148,775,378 - 148,809,896 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05148,764,406 - 148,799,337 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,288,126 - 150,323,063 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,288,126 - 150,323,063 (-)Ensemblrn6Rnor6.0
Rnor_5.05153,962,767 - 153,997,858 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45150,979,252 - 151,014,066 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5142,741,006 - 142,775,820 (-)NCBICelera
RGSC_v3.15150,989,290 - 151,024,105 (-)NCBI
RH 3.4 Map5965.9RGD
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP)
(R)-noradrenaline  (EXP)
(R,R)-tramadol  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
7-Hydroxymitragynine  (ISO)
acetylmethadol  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
buprenorphine  (EXP,ISO)
butorphanol  (EXP)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cannabidiol  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
cocaine  (EXP)
codeine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
DADLE  (ISO)
Deltorphin B  (EXP)
dextran sulfate  (ISO)
dextromethorphan  (EXP)
dextropropoxyphene  (EXP)
dextrorphan  (EXP)
dibutyl phthalate  (EXP)
DPDPE  (EXP,ISO)
DSLET  (EXP)
dynorphin A  (ISO)
eluxadoline  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
etonitazene  (EXP)
fentanyl  (EXP)
hydralazine  (ISO)
hydrocodone  (EXP)
Leu-enkephalin  (ISO)
Levallorphan  (EXP)
Levorphanol  (EXP)
lipopolysaccharide  (ISO)
loperamide  (ISO)
magnesium atom  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
mesalamine  (EXP)
methadone  (EXP)
methylmercury chloride  (ISO)
Mitragynine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
naloxone  (EXP)
naltrexone  (EXP)
Naltrindole  (EXP,ISO)
nicotine  (ISO)
Nonylphenol  (EXP)
oxycodone  (EXP)
paraquat  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serotonin  (EXP)
sulfadimethoxine  (EXP)
tapentadol  (EXP)
thioglycolic acid  (EXP)
titanium dioxide  (ISO)
tramadol  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
U69593  (EXP)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Characterization of a delta opioid receptor in rat pheochromocytoma cells. Abood ME and Tao Q, J Pharmacol Exp Ther. 1995 Sep;274(3):1566-73.
2. Molecular cloning and expression of a delta-opioid receptor from rat brain. Abood ME, etal., J Neurosci Res. 1994 Apr 15;37(6):714-9.
3. delta opioid receptor modulation of several voltage-dependent Ca(2+) currents in rat sensory neurons. Acosta CG and Lopez HS, J Neurosci. 1999 Oct 1;19(19):8337-48.
4. Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study. Beer B, etal., PLoS One. 2013 Sep 25;8(9):e75359. doi: 10.1371/journal.pone.0075359. eCollection 2013.
5. Identification of a signaling cascade that maintains constitutive d-opioid receptor incompetence in peripheral sensory neurons. Brackley AD, etal., J Biol Chem. 2017 May 26;292(21):8762-8772. doi: 10.1074/jbc.M117.776799. Epub 2017 Apr 5.
6. Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory. Charles AC, etal., Mol Pharmacol 2003 Jan;63(1):89-95.
7. Ultrastructural immunolabeling shows prominent presynaptic vesicular localization of delta-opioid receptor within both enkephalin- and nonenkephalin-containing axon terminals in the superficial layers of the rat cervical spinal cord. Cheng PY, etal., J Neurosci. 1995 Sep;15(9):5976-88.
8. Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females. Clarke TK, etal., Pharmacogenomics J. 2014 Jun;14(3):303-8. doi: 10.1038/tpj.2013.30. Epub 2013 Oct 15.
9. Case-control association analysis of polymorphisms in the δ-opioid receptor, OPRD1, with cocaine and opioid addicted populations. Crist RC, etal., Drug Alcohol Depend. 2013 Jan 1;127(1-3):122-8. doi: 10.1016/j.drugalcdep.2012.06.023. Epub 2012 Jul 12.
10. A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment. Crist RC, etal., Drug Alcohol Depend. 2016 Sep 1;166:268-71. doi: 10.1016/j.drugalcdep.2016.07.008. Epub 2016 Jul 14.
11. An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans. Crist RC, etal., Neuropsychopharmacology. 2013 Sep;38(10):2003-10. doi: 10.1038/npp.2013.99. Epub 2013 Apr 23.
12. Genetic polymorphisms in the opioid receptor delta 1 (OPRD1) gene are associated with methadone dose in methadone maintenance treatment for heroin dependence. Fang CP, etal., J Hum Genet. 2020 Apr;65(4):381-386. doi: 10.1038/s10038-019-0718-x. Epub 2020 Jan 7.
13. Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. Fryer RM, etal., J Pharmacol Exp Ther. 2000 Aug;294(2):451-7.
14. Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes. Fukuda K, etal., FEBS Lett 1993 Aug 2;327(3):311-4.
15. Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese. Gao X, etal., OMICS. 2017 Jul;21(7):404-412. doi: 10.1089/omi.2017.0057.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake. Granholm L, etal., Brain Res. 2017 Aug 1;1668:36-45. doi: 10.1016/j.brainres.2017.05.006. Epub 2017 May 13.
19. Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease. Hu Z, etal., Exp Ther Med. 2016 Jan;11(1):89-97. doi: 10.3892/etm.2015.2868. Epub 2015 Nov 13.
20. OPRD1 gene affects disease vulnerability and environmental stress in patients with heroin dependence in Han Chinese. Huang CC, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8;89:109-116. doi: 10.1016/j.pnpbp.2018.08.028. Epub 2018 Aug 30.
21. Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells. Huang P, etal., Biochem Pharmacol. 2007 Feb 15;73(4):534-49. Epub 2006 Nov 3.
22. Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat. Hurley RW, etal., Neuroscience. 2003;118(3):789-96.
23. NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. Israel Y, etal., Peptides. 2005 Jul;26(7):1167-75. Epub 2005 Feb 26.
24. kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. Joshi SK, etal., J Neurosci. 2000 Aug 1;20(15):5874-9.
25. OPRD1 rs569356 polymorphism has an effect on plasma norbuprenorphine levels and dose/kg-normalized norbuprenorphine values in individuals with opioid use disorder. Kaya-Akyüzlü D, etal., Environ Toxicol Pharmacol. 2023 Jun;100:104143. doi: 10.1016/j.etap.2023.104143. Epub 2023 May 3.
26. The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Krishnan-Sarin S, etal., Pharmacol Biochem Behav. 1995 Sep;52(1):153-9. doi: 10.1016/0091-3057(95)00080-g.
27. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
28. [Contribution of delta1-opioid receptors in regulation of cardiac resistance to ischemia-reperfusion] Lasukova TV, etal., Ross Fiziol Zh Im I M Sechenova. 2002 May;88(5):568-80.
29. Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system. Le Guen S, etal., Eur J Neurosci. 2003 Jun;17(11):2425-37. doi: 10.1046/j.1460-9568.2003.02678.x.
30. Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. Lee JW, etal., J Neurochem. 1998 May;70(5):2203-11.
31. Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. Leventhal L, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):538-44.
32. OPRD1 SNPs associated with opioid addiction are cis-eQTLs for the phosphatase and actin regulator 4 gene, PHACTR4, a mediator of cytoskeletal dynamics. Levran O, etal., Transl Psychiatry. 2021 May 25;11(1):316. doi: 10.1038/s41398-021-01439-y.
33. Analyzing Interaction of μ-, δ- and κ-opioid Receptor Gene Variants on Alcohol or Drug Dependence Using a Pattern Discovery-based Method. Li Z and Zhang H, J Addict Res Ther. 2013 May 14;Suppl 7:007.
34. Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients. Luo R, etal., Pharmacogenomics. 2017 Dec;18(18):1659-1670. doi: 10.2217/pgs-2017-0072. Epub 2017 Nov 27.
35. Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels. Maslov LN, etal., Life Sci. 2003 Jul 4;73(7):947-52.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. An analysis of genetic association in opioid dependence susceptibility. Nagaya D, etal., J Clin Pharm Ther. 2018 Feb;43(1):80-86. doi: 10.1111/jcpt.12585. Epub 2017 Jun 27.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Association of OPRD1 polymorphisms with heroin dependence in a large case-control series. Nelson EC, etal., Addict Biol. 2014 Jan;19(1):111-21. doi: 10.1111/j.1369-1600.2012.00445.x. Epub 2012 Apr 13.
40. Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors. Patwardhan AM, etal., J Neurosci. 2005 Sep 28;25(39):8825-32.
41. Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction. Peart JN, etal., J Cardiovasc Pharmacol. 2004 Mar;43(3):410-5.
42. Predictors of treatment retention and survival among methadone-maintained patients: A possible role for a functional delta opioid receptor gene variant. Peles E, etal., Drug Alcohol Depend. 2023 Sep 1;250:110903. doi: 10.1016/j.drugalcdep.2023.110903. Epub 2023 Jul 22.
43. GOA pipeline RGD automated data pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Association of OPRD1 Gene Variants with Opioid Dependence in Addicted Male Individuals Undergoing Methadone Treatment in the North of Iran. Sharafshah A, etal., J Psychoactive Drugs. 2017 Jul-Aug;49(3):242-251. doi: 10.1080/02791072.2017.1290303. Epub 2017 Mar 1.
47. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
48. The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients. Thomas PS, etal., Psychiatr Genet. 2021 Jun 1;31(3):88-94. doi: 10.1097/YPG.0000000000000279.
49. Chronic nicotine-induced changes in gene expression of delta and kappa-opioid receptors and their endogenous ligands in the mesocorticolimbic system of the rat. Ugur M, etal., Synapse. 2017 Sep;71(9). doi: 10.1002/syn.21985. Epub 2017 May 29.
50. Expression of material mRNA in the hypothalamus and frontal cortex in a rat model of fatal hypothermia. Umehara T, etal., Leg Med (Tokyo). 2011 Jul;13(4):165-70. doi: 10.1016/j.legalmed.2011.01.005. Epub 2011 Mar 5.
51. Variations in opioid receptor genes in neonatal abstinence syndrome. Wachman EM, etal., Drug Alcohol Depend. 2015 Oct 1;155:253-9. doi: 10.1016/j.drugalcdep.2015.07.001. Epub 2015 Jul 8.
52. Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: comparison with plasmalemmal mu-opioid receptors. Wang H and Pickel VM, J Neurosci. 2001 May 1;21(9):3242-50.
53. cDNA cloning of an orphan opiate receptor gene family member and its splice variant. Wang JB, etal., FEBS Lett 1994 Jul 4;348(1):75-9.
54. Ultrastructural localization of delta-1 opioid receptor in the dorsal raphe nucleus of the rat. Wang QP, etal., Synapse. 1997 Jul;26(3):243-53.
55. Methylation and expression quantitative trait loci rs1799971 in the OPRM1 gene and rs4654327 in the OPRD1 gene are associated with opioid use disorder. Yu J, etal., Neurosci Lett. 2023 Sep 25;814:137468. doi: 10.1016/j.neulet.2023.137468. Epub 2023 Sep 1.
56. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Zhang H, etal., Mol Psychiatry. 2008 May;13(5):531-43. doi: 10.1038/sj.mp.4002035. Epub 2007 Jul 10.
57. Chronic Oxycodone Self-administration Altered Reward-related Genes in the Ventral and Dorsal Striatum of C57BL/6J Mice: An RNA-seq Analysis. Zhang Y, etal., Neuroscience. 2018 Nov 21;393:333-349. doi: 10.1016/j.neuroscience.2018.07.032. Epub 2018 Jul 29.
Additional References at PubMed
PMID:8393575   PMID:8738226   PMID:9548483   PMID:9915326   PMID:10835636   PMID:12113946   PMID:12855366   PMID:14608598   PMID:14689476   PMID:15467355   PMID:15862537   PMID:16159882  
PMID:16316997   PMID:16325578   PMID:16405927   PMID:16514101   PMID:17175187   PMID:17352824   PMID:17513490   PMID:18417105   PMID:18541716   PMID:18559244   PMID:18572383   PMID:18579738  
PMID:18602454   PMID:19036960   PMID:19056363   PMID:19180644   PMID:19279569   PMID:19295160   PMID:19545549   PMID:19581316   PMID:19619588   PMID:19686472   PMID:19709398   PMID:20399742  
PMID:20574683   PMID:20615975   PMID:20730419   PMID:20977770   PMID:21280046   PMID:21444630   PMID:21600884   PMID:22072818   PMID:22184124   PMID:22200548   PMID:22575599   PMID:22592774  
PMID:22796630   PMID:23272051   PMID:23272113   PMID:23286559   PMID:23843537   PMID:23844255   PMID:24033469   PMID:24416361   PMID:24613828   PMID:24758591   PMID:24847082   PMID:24976397  
PMID:25480575   PMID:25639363   PMID:27246300   PMID:27376372   PMID:27568556   PMID:28645621   PMID:29262398   PMID:29563057   PMID:29687347   PMID:30132200   PMID:30560518   PMID:31030416  
PMID:32228617   PMID:33197884   PMID:35674691   PMID:36592113   PMID:39155080  


Genomics

Comparative Map Data
Oprd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,590,244 - 149,624,999 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5149,590,244 - 149,624,999 (-)EnsemblGRCr8
mRatBN7.25144,306,188 - 144,340,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,306,188 - 144,340,960 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5147,005,532 - 147,040,056 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05148,775,378 - 148,809,896 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05148,764,406 - 148,799,337 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,288,126 - 150,323,063 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,288,126 - 150,323,063 (-)Ensemblrn6Rnor6.0
Rnor_5.05153,962,767 - 153,997,858 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45150,979,252 - 151,014,066 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5142,741,006 - 142,775,820 (-)NCBICelera
RGSC_v3.15150,989,290 - 151,024,105 (-)NCBI
RH 3.4 Map5965.9RGD
Cytogenetic Map5q36NCBI
OPRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,812,170 - 28,871,267 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,812,170 - 28,871,267 (+)Ensemblhg38GRCh38
GRCh37129,138,682 - 29,197,779 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,011,241 - 29,062,795 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34128,959,269 - 29,010,821NCBI
Celera127,534,800 - 27,586,335 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef127,391,067 - 27,442,611 (+)NCBIHuRef
CHM1_1129,254,016 - 29,305,583 (+)NCBICHM1_1
T2T-CHM13v2.0128,654,162 - 28,713,229 (+)NCBIT2T-CHM13v2.0
Oprd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394131,834,980 - 131,872,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4131,838,037 - 131,871,797 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384132,110,188 - 132,144,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,110,726 - 132,144,486 (-)Ensemblmm10GRCm38
MGSCv374131,666,641 - 131,700,401 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364131,382,802 - 131,416,562 (-)NCBIMGSCv36mm8
Celera4130,271,660 - 130,305,734 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map464.78NCBI
Oprd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,866,758 - 7,913,399 (+)Ensembl
ChiLan1.0NW_0049554527,866,790 - 7,913,399 (+)NCBIChiLan1.0ChiLan1.0
OPRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21197,970,746 - 198,030,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,090,112 - 197,149,063 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,068,053 - 28,143,053 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,112,328 - 29,163,464 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,112,152 - 29,163,464 (+)EnsemblpanPan2panpan1.1
OPRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,685,129 - 71,721,692 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,689,084 - 71,721,875 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha268,264,922 - 68,297,415 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0272,248,368 - 72,280,856 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,247,773 - 72,281,077 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,077,265 - 69,109,751 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,084,707 - 70,117,198 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,082,831 - 71,115,319 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Oprd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505847,035,433 - 47,078,632 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,860,293 - 12,903,466 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,860,293 - 12,902,389 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,785,276 - 85,830,877 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1685,775,576 - 85,827,170 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,611,950 - 79,662,042 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OPRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120103,950,505 - 104,002,459 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603312,520,984 - 12,574,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oprd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476412,604,164 - 12,676,279 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476412,604,051 - 12,676,368 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Oprd1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1126,103,521 - 26,137,249 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Oprd1
192 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:100
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000014084
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Mgh21  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85149,661,912 - 149,662,130 (+)Marker Load Pipeline
mRatBN7.25144,377,876 - 144,378,094 (+)MAPPERmRatBN7.2
Rnor_6.05150,360,936 - 150,361,153NCBIRnor6.0
Rnor_5.05154,034,053 - 154,034,270UniSTSRnor5.0
RGSC_v3.45151,060,403 - 151,060,621RGDRGSC3.4
RGSC_v3.45151,060,404 - 151,060,621UniSTSRGSC3.4
Celera5142,812,193 - 142,812,410UniSTS
RGSC_v3.15151,070,442 - 151,070,660RGD
RH 3.4 Map5988.6UniSTS
RH 3.4 Map5988.6RGD
RH 2.0 Map5157.0RGD
Cytogenetic Map5q36UniSTS
D5Rat103  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85149,642,129 - 149,642,320 (+)Marker Load Pipeline
mRatBN7.25144,358,090 - 144,358,281 (+)MAPPERmRatBN7.2
Rnor_6.05150,340,838 - 150,341,028NCBIRnor6.0
Rnor_5.05154,014,163 - 154,014,353UniSTSRnor5.0
RGSC_v3.45151,039,766 - 151,039,956UniSTSRGSC3.4
RGSC_v3.45151,039,725 - 151,039,965RGDRGSC3.4
Celera5142,792,480 - 142,792,670UniSTS
RGSC_v3.15151,049,805 - 151,049,995RGD
RH 3.4 Map5964.21UniSTS
RH 3.4 Map5964.21RGD
SHRSP x BN Map580.7699RGD
SHRSP x BN Map580.7699UniSTS
Cytogenetic Map5q36UniSTS
RH94603  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85149,590,274 - 149,590,427 (+)Marker Load Pipeline
mRatBN7.25144,306,218 - 144,306,372 (+)MAPPERmRatBN7.2
Rnor_6.05150,288,157 - 150,288,309NCBIRnor6.0
Rnor_5.05153,962,798 - 153,962,950UniSTSRnor5.0
RGSC_v3.45150,979,283 - 150,979,435UniSTSRGSC3.4
Celera5142,741,037 - 142,741,188UniSTS
RH 3.4 Map5965.9UniSTS
Cytogenetic Map5q36UniSTS
BE119486  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25144,316,650 - 144,316,823 (+)MAPPERmRatBN7.2
Rnor_6.05150,298,478 - 150,298,650NCBIRnor6.0
Rnor_5.05153,973,040 - 153,973,212UniSTSRnor5.0
RGSC_v3.45150,990,090 - 150,990,262UniSTSRGSC3.4
Celera5142,751,643 - 142,751,815UniSTS
RH 3.4 Map5965.41UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 5 39 113 30 23 10 6 10 6 136 63 2 96 50 63 13 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000014084   ⟹   ENSRNOP00000014084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5149,590,244 - 149,624,999 (-)Ensembl
mRatBN7.2 Ensembl5144,306,188 - 144,340,960 (-)Ensembl
Rnor_6.0 Ensembl5150,288,126 - 150,323,063 (-)Ensembl
RefSeq Acc Id: NM_012617   ⟹   NP_036749
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85149,590,244 - 149,624,999 (-)NCBI
mRatBN7.25144,306,188 - 144,340,960 (-)NCBI
Rnor_6.05150,288,126 - 150,323,063 (-)NCBI
Rnor_5.05153,962,767 - 153,997,858 (-)NCBI
RGSC_v3.45150,979,252 - 151,014,066 (-)RGD
Celera5142,741,006 - 142,775,820 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036749 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19939 (Get FASTA)   NCBI Sequence Viewer  
  BAA03851 (Get FASTA)   NCBI Sequence Viewer  
  EDL80617 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014084
  ENSRNOP00000014084.2
GenBank Protein P33533 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036749   ⟸   NM_012617
- UniProtKB: P33533 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014084   ⟸   ENSRNOT00000014084
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33533-F1-model_v2 AlphaFold P33533 1-372 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3233 AgrOrtholog
BioCyc Gene G2FUF-39716 BioCyc
Ensembl Genes ENSRNOG00000010531 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014084 ENTREZGENE
  ENSRNOT00000014084.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Delta_opi_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Opioid_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:24613 UniProtKB/Swiss-Prot
NCBI Gene 24613 ENTREZGENE
PANTHER DELTA-TYPE OPIOID RECEPTOR UniProtKB/Swiss-Prot
  NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB OPRD1 RGD
PhenoGen Oprd1 PhenoGen
PRINTS DELTAOPIOIDR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
  OPIOIDR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010531 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC224017
UniProt A6ISR6_RAT UniProtKB/TrEMBL
  OPRD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Oprd1  Opioid receptor delta 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction may interact with micro-opioid receptors to effect action potentials in GH3 cells 729249