Il2ra (interleukin 2 receptor subunit alpha) - Rat Genome Database

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Gene: Il2ra (interleukin 2 receptor subunit alpha) Rattus norvegicus
Analyze
Symbol: Il2ra
Name: interleukin 2 receptor subunit alpha
RGD ID: 2895
Description: Enables interleukin-2 receptor activity. Involved in inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; and positive regulation of T cell proliferation. Located in cell surface. Used to study Korean hemorrhagic fever; asthma; and diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 1-nitropropane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-2 receptor alpha subunit; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; IL2RAC; interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain; interleukin-2 receptor alpha chain; interleukin-2 receptor subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,759,802 - 71,808,475 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1771,759,802 - 71,808,507 (-)EnsemblGRCr8
mRatBN7.21766,849,974 - 66,898,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,849,974 - 66,898,697 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1770,337,084 - 70,384,350 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01774,165,907 - 74,213,174 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01768,208,899 - 68,256,163 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,500,672 - 70,547,929 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1770,499,083 - 70,548,071 (-)Ensemblrn6Rnor6.0
Rnor_5.01772,204,467 - 72,250,556 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41778,050,491 - 78,097,802 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1766,355,852 - 66,402,955 (-)NCBICelera
RGSC_v3.11778,061,323 - 78,108,635 (-)NCBI
RH 3.4 Map17636.4RGD
Cytogenetic Map17q12.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-alpha-phellandrene  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthaleneacetic acid  (ISO)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
2-tert-butylhydroquinone  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
beclomethasone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
capsiate  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cordycepin  (ISO)
cortisol  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
Didecyldimethylammonium  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
fragrance  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
hexachlorobenzene  (EXP)
indole-3-acetic acid  (ISO)
ionomycin  (EXP,ISO)
isopentenyl diphosphate  (ISO)
lactacystin  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
mesalamine  (ISO)
methotrexate  (ISO)
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nonanoic acid  (ISO)
o-anisidine  (ISO)
ouabain  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
Pentoxifylline  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalaldehyde  (ISO)
pimecrolimus  (ISO)
poly(I:C)  (ISO)
procyanidin B3  (ISO)
propofol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (EXP)
prostratin  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
sulfasalazine  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiopental  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (EXP)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
WR-1065  (ISO)
zalcitabine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D). Alcina A, etal., PLoS One. 2009;4(1):e4137. Epub 2009 Jan 6.
2. Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis. Aricha R, etal., J Immunol. 2008 Feb 15;180(4):2132-9.
3. [Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia]. Chen L, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):203-208. doi: 10.3760/cma.j.issn.1001-0939.2020.03.013.
4. Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis. Desai B, etal., Exp Lung Res. 2011 May;37(4):227-38. Epub 2011 Feb 11.
5. Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host. Easterbrook JD, etal., Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15502-7. Epub 2007 Sep 18.
6. IL-2 protects T cell hybrids from the cytolytic effect of glucocorticoids. Synergistic effect of IL-2 and dexamethasone in the induction of high-affinity IL-2 receptors. Fernandez-Ruiz E, etal., J Immunol. 1989 Dec 15;143(12):4146-51.
7. Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. Fulton RB, etal., J Immunol. 2010 Aug 15;185(4):2382-92. Epub 2010 Jul 16.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Immunosuppression for neural xenografts: a comparison of cyclosporin and anti-CD25 monoclonal antibody. Honey CR and Shen H, J Neurosurg. 1999 Jul;91(1):109-13.
11. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Hou H, etal., Clin Exp Immunol. 2020 Jul;201(1):76-84. doi: 10.1111/cei.13450. Epub 2020 May 15.
12. Duration of STAT5 activation influences the response of interleukin-2 receptor alpha gene to different cytokines. Imbert V and Renauld PR, Eur Cytokine Netw. 1999 Mar;10(1):71-8.
13. Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population. Kawasaki E, etal., J Clin Endocrinol Metab. 2009 Mar;94(3):947-52. Epub 2008 Dec 23.
14. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
15. CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice. Liu F, etal., PLoS One. 2010 Nov 3;5(11):e15404.
16. Correlation Between Relative Nasopharyngeal Virus RNA Load and Lymphocyte Count Disease Severity in Patients with COVID-19. Liu Y, etal., Viral Immunol. 2020 Apr 10. doi: 10.1089/vim.2020.0062.
17. Alleviating allergic airway diseases by means of short-term administration of IL-2 and dexamethasone. Ma J, etal., J Allergy Clin Immunol. 2011 Jun;127(6):1447-56.e6. Epub 2011 Mar 4.
18. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. Maier LM, etal., PLoS Genet. 2009 Jan;5(1):e1000322. Epub 2009 Jan 2.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134. Nolte-'t Hoen EN, etal., J Leukoc Biol. 2008 Jan;83(1):112-21. Epub 2007 Oct 10.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Molecular cloning of cDNAs for the rat interleukin 2 receptor alpha and beta chain genes: differentially regulated gene activity in response to mitogenic stimulation. Page TH and Dallman MJ, Eur J Immunol 1991 Sep;21(9):2133-8.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells. Preston JA, etal., Eur Respir J. 2011 Jan;37(1):53-64. Epub 2010 Jun 4.
27. Presence of Activated Airway T Lymphocytes in Human Puumala Hantavirus Disease. Rasmuson J, etal., Chest. 2011 Mar 24.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor. Sharfe N, etal., Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3168-71.
32. Dose-dependent recruitment of CD25+ and CD26+ T cells in a novel F344 rat model of asthma. Skripuletz T, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1564-71. Epub 2007 Mar 9.
33. Characterization of Multiple Sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis. Thessen Hedreul M, etal., J Neuroimmunol. 2009 May 29;210(1-2):30-9. Epub 2009 Mar 9.
34. Prevention of diabetes: effect of mycophenolate mofetil and anti-CD25 on onset of diabetes in the DRBB rat. Ugrasbul F, etal., Pediatr Diabetes. 2008 Dec;9(6):596-601. Epub 2008 May 21.
35. Role of IL-2 in rat fetal thymocyte development. Varas A, etal., Int Immunol. 1997 Oct;9(10):1589-99.
36. High-level expression of a functional humanized single-chain variable fragment antibody against CD25 in Pichia pastoris. Wan L, etal., Appl Microbiol Biotechnol. 2008 Nov;81(1):33-41. Epub 2008 Aug 13.
Additional References at PubMed
PMID:2467293   PMID:7477352   PMID:7584142   PMID:7688139   PMID:8125140   PMID:8262055   PMID:8755570   PMID:8769481   PMID:10072077   PMID:10760791   PMID:12702495   PMID:12867038  
PMID:14990792   PMID:15240714   PMID:15294943   PMID:15368291   PMID:15728238   PMID:15843532   PMID:15909309   PMID:16227984   PMID:16301745   PMID:16973387   PMID:17082577   PMID:18628982  
PMID:18641307   PMID:18792410   PMID:18832572   PMID:18958875   PMID:19008373   PMID:19159826   PMID:19723499   PMID:19884905   PMID:19934022   PMID:21460847   PMID:21508411   PMID:22072979  
PMID:23416241   PMID:29772575  


Genomics

Comparative Map Data
Il2ra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,759,802 - 71,808,475 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1771,759,802 - 71,808,507 (-)EnsemblGRCr8
mRatBN7.21766,849,974 - 66,898,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,849,974 - 66,898,697 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1770,337,084 - 70,384,350 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01774,165,907 - 74,213,174 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01768,208,899 - 68,256,163 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,500,672 - 70,547,929 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1770,499,083 - 70,548,071 (-)Ensemblrn6Rnor6.0
Rnor_5.01772,204,467 - 72,250,556 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41778,050,491 - 78,097,802 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1766,355,852 - 66,402,955 (-)NCBICelera
RGSC_v3.11778,061,323 - 78,108,635 (-)NCBI
RH 3.4 Map17636.4RGD
Cytogenetic Map17q12.2NCBI
IL2RA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38106,010,689 - 6,062,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl106,010,689 - 6,062,370 (-)Ensemblhg38GRCh38
GRCh37106,052,652 - 6,104,330 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36106,093,512 - 6,144,278 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34106,093,511 - 6,144,278NCBI
Celera105,982,579 - 6,033,743 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,979,490 - 6,030,662 (-)NCBIHuRef
CHM1_1106,052,649 - 6,103,793 (-)NCBICHM1_1
T2T-CHM13v2.0106,011,401 - 6,062,560 (-)NCBIT2T-CHM13v2.0
Il2ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39211,647,603 - 11,698,005 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl211,647,618 - 11,698,004 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38211,642,792 - 11,693,194 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl211,642,807 - 11,693,193 (+)Ensemblmm10GRCm38
MGSCv37211,564,419 - 11,614,821 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36211,560,703 - 11,611,044 (+)NCBIMGSCv36mm8
Celera211,560,200 - 11,610,847 (+)NCBICelera
Cytogenetic Map2A1NCBI
cM Map28.91NCBI
Il2ra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542122,641,511 - 22,694,913 (-)Ensembl
ChiLan1.0NW_00495542122,642,004 - 22,694,729 (-)NCBIChiLan1.0ChiLan1.0
IL2RA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2818,563,961 - 18,618,076 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11018,569,284 - 18,623,389 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0106,053,549 - 6,103,863 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1106,037,664 - 6,086,018 (-)NCBIPanPan1.1PanPan1.1panPan2
IL2RA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1229,892,130 - 29,948,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl229,894,125 - 29,944,643 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha226,924,836 - 26,975,354 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0230,275,012 - 30,330,188 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl230,275,175 - 30,327,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1227,372,288 - 27,422,786 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,208,376 - 28,259,290 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0228,928,272 - 28,977,130 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il2ra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934432,349,142 - 32,390,487 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364848,544,062 - 8,555,332 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364848,514,333 - 8,555,392 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL2RA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1064,948,563 - 65,001,142 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11064,948,149 - 65,001,320 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,153,916 - 71,162,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL2RA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.196,134,961 - 6,187,731 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl96,141,430 - 6,149,447 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605111,438,032 - 11,490,878 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il2ra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624775924,648 - 942,354 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624775927,337 - 991,062 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Il2ra
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11417,673,194 - 17,716,675 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il2ra
591 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:709
Count of miRNA genes:295
Interacting mature miRNAs:395
Transcripts:ENSRNOT00000073144
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)177061350286062352Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat

Markers in Region
RH143008  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21766,850,057 - 66,850,177 (+)MAPPERmRatBN7.2
Rnor_6.01770,499,236 - 70,499,355NCBIRnor6.0
Rnor_5.01772,203,031 - 72,203,150UniSTSRnor5.0
RGSC_v3.41778,049,055 - 78,049,174UniSTSRGSC3.4
Celera1766,354,416 - 66,354,535UniSTS
RH 3.4 Map17658.2UniSTS
Cytogenetic Map17q12.3UniSTS
RH94535  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81771,761,330 - 71,761,519 (+)Marker Load Pipeline
RH 3.4 Map17636.4UniSTS
Cytogenetic Map17q12.3UniSTS
fb22g09.x1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21766,858,666 - 66,859,585 (+)MAPPERmRatBN7.2
Rnor_6.01770,507,845 - 70,508,763NCBIRnor6.0
Rnor_5.01772,211,640 - 72,212,558UniSTSRnor5.0
RGSC_v3.41778,057,664 - 78,058,574UniSTSRGSC3.4
Celera1766,363,025 - 66,363,943UniSTS
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 7 53 116 76 75 44 92 44 6 319 176 9 90 80 84 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000073144   ⟹   ENSRNOP00000066383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,759,802 - 71,808,507 (-)Ensembl
mRatBN7.2 Ensembl1766,849,974 - 66,898,697 (-)Ensembl
Rnor_6.0 Ensembl1770,499,083 - 70,548,071 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159718   ⟹   ENSRNOP00000100032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,759,802 - 71,786,125 (-)Ensembl
RefSeq Acc Id: NM_013163   ⟹   NP_037295
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,761,322 - 71,808,475 (-)NCBI
mRatBN7.21766,851,494 - 66,898,665 (-)NCBI
Rnor_6.01770,500,672 - 70,547,929 (-)NCBI
Rnor_5.01772,204,467 - 72,250,556 (-)NCBI
RGSC_v3.41778,050,491 - 78,097,802 (-)RGD
Celera1766,355,852 - 66,402,955 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095399   ⟹   XP_038951327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,759,802 - 71,773,909 (-)NCBI
mRatBN7.21766,849,974 - 66,864,084 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037295 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951327 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41428 (Get FASTA)   NCBI Sequence Viewer  
  EDL78597 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066383
  ENSRNOP00000066383.1
GenBank Protein P26897 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037295   ⟸   NM_013163
- Peptide Label: precursor
- UniProtKB: P26897 (UniProtKB/Swiss-Prot),   A6JLS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066383   ⟸   ENSRNOT00000073144
RefSeq Acc Id: XP_038951327   ⟸   XM_039095399
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000100032   ⟸   ENSRNOT00000159718
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26897-F1-model_v2 AlphaFold P26897 1-267 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2895 AgrOrtholog
BioCyc Gene G2FUF-8799 BioCyc
Ensembl Genes ENSRNOG00000047647 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073144 ENTREZGENE
  ENSRNOT00000073144.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.28.230 UniProtKB/Swiss-Prot
  Complement Module, domain 1 UniProtKB/Swiss-Prot
InterPro IL-2_rcpt_alpha UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
KEGG Report rno:25704 UniProtKB/Swiss-Prot
NCBI Gene 25704 ENTREZGENE
PANTHER INTERLEUKIN-2 RECEPTOR SUBUNIT ALPHA UniProtKB/Swiss-Prot
  PTHR10573 UniProtKB/Swiss-Prot
Pfam Sushi UniProtKB/Swiss-Prot
PhenoGen Il2ra PhenoGen
PROSITE SUSHI UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047647 RatGTEx
SMART CCP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot
UniProt A0ABK0KYE5_RAT UniProtKB/TrEMBL
  A6JLS0 ENTREZGENE, UniProtKB/TrEMBL
  IL2RA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Il2ra  interleukin 2 receptor subunit alpha  Il2ra  interleukin 2 receptor, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Il2ra  interleukin 2 receptor, alpha  Il2ra  interleukin 2 receptor, alpha chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Il2ra  Interleukin 2 receptor, alpha chain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is upregulated following lymphocyte activation 728928