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Gene: Hsd3b5 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Hsd3b5

Name:

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5

RGD ID:

2838

Description:

Enables 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity and steroid binding activity. Involved in progesterone metabolic process; regulation of steroid biosynthetic process; and steroid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2); PARTICIPATES IN isoprenoid metabolic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

3 beta-HSD III; 3 beta-hydroxysteroid dehydrogenase 5; 3 beta-hydroxysteroid dehydrogenase type 3; 3 beta-hydroxysteroid dehydrogenase type 5; 3 beta-hydroxysteroid dehydrogenase type 5-like; 3 beta-hydroxysteroid dehydrogenase type III; 3 beta-hydroxysteroid dehydrogenase type V; 3-beta-HSD V; 3-beta-hydroxy-5-ene steroid dehydrogenase; dihydrotestosterone 3-ketoreductase; Hsd1; Hsd3b; Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; LOC108348209; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; NADPH-dependent 3-keto-steroid reductase Hsd3b5; progesterone reductase; RATHSDI; steroid delta-isomerase, 3 beta

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

Candidate Gene For:

Hcuc3

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	188,697,669 - 188,717,141 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	188,697,670 - 188,709,118 (-)	Ensembl				GRCr8
mRatBN7.2	2	186,008,944 - 186,028,417 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	186,008,943 - 186,020,393 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	193,657,598 - 193,676,873 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	191,466,848 - 191,486,172 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	186,290,168 - 186,309,440 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	200,615,910 - 200,633,317 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	200,584,986 - 200,692,335 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	220,060,508 - 220,087,584 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	193,249,949 - 193,269,979 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	178,496,737 - 178,516,049 (-)	NCBI		Celera
RGSC_v3.1	2	193,212,702 - 193,232,733 (-)	NCBI
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',5,5'-tetrabromobisphenol A (EXP)

acetamide (EXP)

acetamiprid (EXP)

ammonium chloride (EXP)

cyproterone acetate (EXP)

endosulfan (EXP)

fluconazole (EXP)

furan (EXP)

methapyrilene (EXP)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

oxybenzone (EXP)

sodium arsenite (EXP)

testosterone (EXP)

testosterone enanthate (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

triadimefon (EXP)

trichloroethene (EXP)

triclosan (EXP)

vitamin E (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

C21-steroid hormone metabolic process (IBA,IEA)

lipid metabolic process (IEA)

progesterone metabolic process (IDA)

regulation of steroid biosynthetic process (IDA)

steroid biosynthetic process (IBA,IDA,IEA,TAS)

steroid metabolic process (IEA)

Cellular Component

cytoplasm (IBA)

endoplasmic reticulum membrane (IEA)

mitochondrial membrane (IEA)

Molecular Function

3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity (IDA,IEA)

3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity (IEA)

5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IBA,IEA)

steroid binding (IDA)

steroid dehydrogenase activity (TAS)

Molecular Pathway Annotations Click to see Annotation Detail View

isoprenoid metabolic pathway (IDA)

steroid hormone biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	3 Beta-hydroxysteroid dehydrogenase expression in rat spinal cord.	Coirini H, etal., Neuroscience 2002;113(4):883-91.
2.	Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.	Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	The application of continuous monitoring microdensitometry to an analysis of NAD+ binding and 3 beta-hydroxy-delta 5-steroid dehydrogenase activity in the regressing corpus luteum of the pro-oestrous rat ovary.	Gordon M and Robertson WR, Histochem J. 1986 Jan;18(1):41-4.
5.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
6.	The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat.	Kuhn NJ and Briley MS, Biochem J. 1970 Apr;117(2):193-201.
7.	Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells.	Lo MJ and Lee SD, Immunol Cell Biol. 2006 Feb;84(1):38-43.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Ontogeny of immunoreactive and bioactive microsomal steroidogenic enzymes during adrenocortical development in rats.	Nagaya M, etal., Mol Cell Endocrinol. 1995 Oct 30;114(1-2):27-34.
10.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	Development of a quantitative assay method for 3 beta-hydroxy-delta 5-steroid dehydrogenase in the rat testis.	Qujeq D Steroids. 2002 Dec;67(13-14):1071-7.
13.	GOA pipeline	RGD automated data pipeline
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Structure and sexual dimorphic expression of a liver-specific rat 3 beta-hydroxysteroid dehydrogenase/isomerase.	Zhao HF, etal., Endocrinology 1990 Dec;127(6):3237-9.

Additional References at PubMed

PMID:1298957	PMID:12477932	PMID:15489334	PMID:16020475	PMID:17428656	PMID:18511507	PMID:30884106

Genomics

Variants

Variants in Hsd3b5
186 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	80
Count of miRNA genes:	69
Interacting mature miRNAs:	71
Transcripts:	ENSRNOT00000026290
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	163997722	225110681	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	169358774	214358774	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	149957381	221199885	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	138595962	205135428	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	124537199	209621565	Rat
1581578	Cm49	Cardiac mass QTL 49	4.9	0.01	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	145807215	220931416	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	122597372	215234002	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	154723085	199723085	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	145807215	190807215	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	154723085	199723085	Rat
10043139	Iddm55	Insulin dependent diabetes mellitus QTL 55	3.1	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	150313808	195313808	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	154723085	199723085	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	205135267	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	154723085	199723085	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170652929	215652929	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	220931218	Rat
4889834	Pur24	Proteinuria QTL 24	5.8	0.014	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	171994826	205135428	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	188565047	233565047	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	154723085	199723085	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	139067258	192287892	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	184856304	229856304	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	184856304	229856304	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	159440760	195313808	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	144882354	205135428	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
1357991	Ael2	Aortic elastin QTL 2	4.2	0.000071	aorta elastin amount (VT:0003905)	aortic elastin	2	169227906	214227906	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	184856304	229856304	Rat
1578671	Bmd10	Bone mineral density QTL 10	5.4		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	175931416	220931416	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	182024327	227024327	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	159440760	228950743	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	184482291	229482291	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	143746578	205135428	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150096616	195096616	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	145306936	212705578	Rat
7488929	Bp366	Blood pressure QTL 366		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	187663373	195783351	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	186850607	231850607	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	147287892	192287892	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	223841096	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150096616	195096616	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	182635347	227635347	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	220008837	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	184856304	229856304	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	165453811	210453811	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	163253030	208253030	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166372086	229820014	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat

Markers in Region

D2Wox25

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	186,009,113 - 186,009,259 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	200,585,156 - 200,585,297	NCBI	Rnor6.0
Rnor_6.0	2	200,616,080 - 200,616,223	NCBI	Rnor6.0
Rnor_5.0	2	220,089,124 - 220,089,267	UniSTS	Rnor5.0
Rnor_5.0	2	220,060,678 - 220,060,819	UniSTS	Rnor5.0
RGSC_v3.4	2	193,250,119 - 193,250,260	UniSTS	RGSC3.4
RGSC_v3.4	2	193,250,118 - 193,250,260	RGD	RGSC3.4
Celera	2	178,496,907 - 178,497,024	UniSTS
RGSC_v3.1	2	193,212,872 - 193,213,014	RGD
RH 3.4 Map	2	1257.6	RGD
RH 3.4 Map	2	1257.6	UniSTS
RH 2.0 Map	2	951.6	RGD
Cytogenetic Map	2	q34	UniSTS

D2Arb20

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	188,697,845 - 188,698,083 (+)	Marker Load Pipeline
mRatBN7.2	2	186,009,118 - 186,009,356 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	200,616,085 - 200,616,320	NCBI	Rnor6.0
Rnor_6.0	2	200,585,161 - 200,585,394	NCBI	Rnor6.0
Rnor_5.0	2	220,089,129 - 220,089,364	UniSTS	Rnor5.0
Rnor_5.0	2	220,060,683 - 220,060,916	UniSTS	Rnor5.0
RGSC_v3.4	2	193,250,123 - 193,250,357	RGD	RGSC3.4
RGSC_v3.4	2	193,250,124 - 193,250,357	UniSTS	RGSC3.4
Celera	2	178,496,912 - 178,497,121	UniSTS
RGSC_v3.1	2	193,212,877 - 193,213,111	RGD
RH 3.4 Map	2	1261.2	RGD
RH 3.4 Map	2	1261.2	UniSTS
RH 2.0 Map	2	952.9	RGD
SHRSP x BN Map	2	73.6298	RGD
Cytogenetic Map	2	q34	UniSTS

RH132844

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	186,003,657 - 186,003,855 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	200,610,624 - 200,610,821	NCBI	Rnor6.0
Rnor_6.0	2	200,579,700 - 200,579,897	NCBI	Rnor6.0
Rnor_5.0	2	220,083,668 - 220,083,865	UniSTS	Rnor5.0
Rnor_5.0	2	220,055,222 - 220,055,419	UniSTS	Rnor5.0
RGSC_v3.4	2	193,244,663 - 193,244,860	UniSTS	RGSC3.4
Celera	2	178,491,451 - 178,491,648	UniSTS
RH 3.4 Map	2	1260.1	UniSTS
Cytogenetic Map	2	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
8	10	20	46	69	67	37	24	37	6	150	66	29	31	43	30	3	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC092571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M67465	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026290 ⟹ ENSRNOP00000026290

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	200,584,986 - 200,692,335 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079754 ⟹ ENSRNOP00000072555

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	188,697,670 - 188,709,118 (-)	Ensembl
mRatBN7.2 Ensembl	2	186,008,943 - 186,020,393 (-)	Ensembl
Rnor_6.0 Ensembl	2	200,615,909 - 200,625,434 (-)	Ensembl

RefSeq Acc Id:

NM_012584 ⟹ NP_036716

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	188,697,671 - 188,717,018 (-)	NCBI
mRatBN7.2	2	186,008,944 - 186,028,294 (-)	NCBI
Rnor_6.0	2	200,615,910 - 200,633,317 (-)	NCBI
Rnor_5.0	2	220,060,508 - 220,087,584 (-)	NCBI
RGSC_v3.4	2	193,249,949 - 193,269,979 (-)	RGD
Celera	2	178,496,737 - 178,516,049 (-)	RGD

Sequence:

show sequence

TGCCTTCAGGGTCTCCAACCCTTGGAAACAAAACGACCACCACACATCTACTGTTCTCTCAACT
ATCTGCTTCCTGTGTTGACCATGCCTGGGTGGAGCTGCCTGGTGACAGGAGCAGGAGGATTTCT
GGGCCAGAGGATTGTCCAAATGTTGGTGCAAGAGAAAGAGCTGCAGGAGGTCAGAGTCCTGTAT
AGGACCTTCAGTCCAAAACACAAAGAGGAACTGTCCAAGCTGCAGACAAAAGCCAAGGTGACGG
TACTGAGGGGAGACATTGTGGATGCCCAGTTCCTGAGGAGAGCGTGCCAGGGCATGTCCGTCAT
CATCCACACCGCTGCTGCCCTTGATATCGCAGGCTTCCTGCCCAGGCAGACCATCCTAGATGTC
AATGTGAAAGGTACTCAGCTCCTGTTGGATGCTTGTGTGGAAGCCAGCGTACCAGCCTTCATCT
ACAGCAGCTCAACAGGTGTGGCTGGACCAAACTCCTACAAGGAGACCATCCTGAACGACCGTGA
GGAAGAGCATCGTGAAAGCACATGGTCAAATCCATACCCATACAGCAAAAGGATGGCCGAGAAG
GCAGTGCTGGCAGCCAATGGGAGCATCCTGAAAAATGGTGGCACTTTTCATACATGTGCCTTAA
GACTCCCATTCATCTATGGGGAAGAAAGCCAAATCATTTCAACCATGGTAAATAGAGCACTCAA
GAACAACAGCATAATTAAAAGACATGCCACATTCTCCATAGCCAACCCAGTGTATGTGGGTAAT
GCAGCCTGGGCACACATTCTGGCTGCCAGGGGCCTTCGAGACCCCGAGAAGTCACAAAGCATCC
AAGGACAGTTCTACTACATCTCAGATGACACCCCTCACCAAAGCTATGATGATTTAAATTATAC
CCTGAGCAAAGAATGGGGCTTCTGCCTTGATTCCAGTTGGAGCCTTCCTCTGCCCCTGCTCTAC
TGGCTTGCCTTCCTGCTGGAAACTGTGAGCTTCCTGCTGCGTCCATTTTACAACTATAGGCCAC
CCTTTAACCGCTTCATGGTCACGATCTTAAATAGCGTGTTTACCATTTCCTACAAGAAAGCTCA
GAGAGATCTGGGCTATGAGCCACTTGTCAGCTGGGAGGAAGCCAAGCAAAAAACCTCGGAGTGG
ATCGGGACACTAGTGGAGCAACACAGGGAGACACTGGACACAAAGTCTCAATGATGGGAAGAGG
GCAGGGACATGGCCCCGGGTGTTACCCCGTCCTCCAGCCAGGAACTCAGAAATAATCCAACTCT
TACAGTTTTATTTTATACACTCTCCAACTGGTCTTCAGGTCACCAGAAACCTTAAGAGTCACTG
GCCCAGTCACCTGAACAAGGTGCAGGGGACATCATGTAGAAGGAATAAAACTGCCTGCCTCTTG
TGACACCTGGGTGTTCATTCACCTGCCATGTGGTATCACAAACAGAAGTAGGATCTCAGCTGGC
ATCAAAACTTCTTCTTTCTTACTTACCCCATATTAAGTAATGTTTATAGGAAGTAATGTTTGTA
GGTGGGGCTTGAGCTCCCACACTAGAGTCAGGAGGCAAAACCATGCTGAAGTTCTATATAGCAA
ACCAAACCTGAGAGTACTTTCCTGATCACTACAATAGCAAGAGAGCAAGAGCGAGAGTGAGAGC
AAGAGCGAGAGAGGGAGGGAGGAAGGGAGGAAAGGGGATGGAGGGAGGGAGGAAGGGAAGGAGA
GAGAGAGAGAGAGAGAGAGAGAGAGCATCACCATTTCACATAGGGTGTGAACAGAGTAGGAAAT
CACTTTGTTTCTCATTTACCAAGAGACCATCTGAAAGAATCTGCCTTTCTTTGCCCCTGTCATA
CCAAGAAACCTTATTTTCGCTTATTGGACAATGTTCTATGGTATAAAAAATAAGAGTTGTCTGG
TTCTGGGAATAAAACTAAATTCCAAGG

hide sequence

RefSeq Acc Id:

XM_039101717 ⟹ XP_038957645

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	188,697,669 - 188,717,141 (-)	NCBI
mRatBN7.2	2	186,009,622 - 186,028,417 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_036716	(Get FASTA)	NCBI Sequence Viewer
	XP_038957645	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41352	(Get FASTA)	NCBI Sequence Viewer
	AAH92571	(Get FASTA)	NCBI Sequence Viewer
	EDL85561	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072555
GenBank Protein	P27364	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_036716 ⟸ NM_012584

- UniProtKB:

Q569C6 (UniProtKB/Swiss-Prot), P27364 (UniProtKB/Swiss-Prot), A0A0G2JSR3 (UniProtKB/TrEMBL), A6K3D9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPGWSCLVTGAGGFLGQRIVQMLVQEKELQEVRVLYRTFSPKHKEELSKLQTKAKVTVLRGDIV
DAQFLRRACQGMSVIIHTAAALDIAGFLPRQTILDVNVKGTQLLLDACVEASVPAFIYSSSTGV
AGPNSYKETILNDREEEHRESTWSNPYPYSKRMAEKAVLAANGSILKNGGTFHTCALRLPFIYG
EESQIISTMVNRALKNNSIIKRHATFSIANPVYVGNAAWAHILAARGLRDPEKSQSIQGQFYYI
SDDTPHQSYDDLNYTLSKEWGFCLDSSWSLPLPLLYWLAFLLETVSFLLRPFYNYRPPFNRFMV
TILNSVFTISYKKAQRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000072555 ⟸ ENSRNOT00000079754

Ensembl Acc Id:

ENSRNOP00000026290 ⟸ ENSRNOT00000026290

RefSeq Acc Id:	XP_038957645 ⟸ XM_039101717
- Peptide Label:	isoform X1
- UniProtKB:	Q569C6 (UniProtKB/Swiss-Prot), P27364 (UniProtKB/Swiss-Prot)

Protein Domains

3-beta hydroxysteroid dehydrogenase/isomerase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P27364-F1-model_v2	AlphaFold	P27364	1-373	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2838	AgrOrtholog
BioCyc Gene	G2FUF-51911	BioCyc
Ensembl Genes	ENSRNOG00000019417	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000079754	ENTREZGENE
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7369915	IMAGE-MGC_LOAD
InterPro	3Beta_OHSteriod_DH/Estase	UniProtKB/Swiss-Prot
	Lipid_A_modif_metabolic_enz	UniProtKB/Swiss-Prot
	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:24470	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108750	IMAGE-MGC_LOAD
NCBI Gene	24470	ENTREZGENE
PANTHER	BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA	UniProtKB/Swiss-Prot
	SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2	UniProtKB/Swiss-Prot
Pfam	3Beta_HSD	UniProtKB/Swiss-Prot
PhenoGen	Hsd3b5	PhenoGen
RatGTEx	ENSRNOG00000019417	RatGTEx
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot
UniProt	3BHS5_RAT	UniProtKB/Swiss-Prot
	A0A0G2JSR3	ENTREZGENE, UniProtKB/TrEMBL
	A6K3D9	ENTREZGENE, UniProtKB/TrEMBL
	P27364	ENTREZGENE
	Q569C6	ENTREZGENE
UniProt Secondary	Q569C6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Hsd3b5	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	LOC108348209	3 beta-hydroxysteroid dehydrogenase type 5-like	Data merged from RGD:11516134	737654	PROVISIONAL
2016-08-02	LOC108348209	3 beta-hydroxysteroid dehydrogenase type 5-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-12-18	Hsd3b5	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Hsd3b	steroid delta-isomerase, 3 beta	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2005-01-20	Hsd3b	steroid delta-isomerase, 3 beta		hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase	Name updated	1299863	APPROVED
2002-06-10	Hsd3b	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase			Name updated	70585	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_function	bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid and of ketosteroids	61038
gene_process	plays a role in hormonal steroid biosynthesis	61038

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)