Foxa3 (forkhead box A3) - Rat Genome Database

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Gene: Foxa3 (forkhead box A3) Rattus norvegicus
Analyze
Symbol: Foxa3
Name: forkhead box A3
RGD ID: 2809
Description: Enables DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including negative regulation of cell population proliferation; positive regulation of hepatocyte differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in actin cytoskeleton and nucleoplasm. Orthologous to human FOXA3 (forkhead box A3); PARTICIPATES IN forkhead class A signaling pathway; maturity-onset diabetes of the young pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: forkhead box protein A3; Hepatocyte nuclear factor 3 gamma; hepatocyte nuclear factor 3, gamma; hepatocyte nuclear factor 3-gamma; HNF-3-gamma; HNF-3G; Hnf3g
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,790,111 - 87,800,259 (-)NCBIGRCr8
mRatBN7.2178,662,067 - 78,672,321 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,662,431 - 78,672,155 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,051,578 - 84,060,504 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,609,178 - 92,618,101 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,806,680 - 85,815,606 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,921,292 - 79,930,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,920,752 - 79,930,263 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,181,104 - 81,190,030 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,368,026 - 78,376,953 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,446,136 - 78,455,064 (-)NCBI
Celera173,128,615 - 73,137,542 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Foxa3RatExperimental Diabetes Mellitus  IEP 2315085mRNA:increased expression:liverRGD 
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Original Reference(s)
Foxa3RatProstatic Neoplasms  ISOFOXA3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22919386

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Original Reference(s)
Foxa3Rat(1->4)-beta-D-glucan multiple interactionsISOFoxa3 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of FOXA3 mRNACTDPMID:36331819
Foxa3Rat17alpha-ethynylestradiol multiple interactionsISOFoxa3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FOXA3 mRNACTDPMID:17942748
Foxa3Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of FOXA3 mRNACTDPMID:32145629
Foxa3Rat17beta-estradiol affects expressionISOFoxa3 (Mus musculus)6480464Estradiol affects the expression of FOXA3 mRNACTDPMID:39298647
Foxa3Rat2,2',5,5'-tetrachlorobiphenyl affects expressionISOFOXA3 (Homo sapiens)64804642 more ...CTDPMID:21703328
Foxa3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOFoxa3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of FOXA3 mRNACTDPMID:21570461 more ...
Foxa3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOFoxa3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of FOXA3 mRNACTDPMID:23238561 more ...
Foxa3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of FOXA3 mRNACTDPMID:23238561
Foxa3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOFOXA3 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of FOXA3 mRNACTDPMID:20106945 and PMID:21632981
Foxa3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of FOXA3 mRNA]CTDPMID:21215274
Foxa3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of FOXA3 mRNACTDPMID:16054898 more ...
Foxa3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOFoxa3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FOXA3 mRNA and [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of FOXA3 mRNACTDPMID:17942748 and PMID:25975270
Foxa3Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of FOXA3 mRNACTDPMID:21346803
Foxa3Rat3,3',4,4',5-pentachlorobiphenyl affects expressionISOFOXA3 (Homo sapiens)64804643 more ...CTDPMID:21703328
Foxa3Rat3,3',4,4'-tetrachlorobiphenyl multiple interactionsISOFoxa3 (Mus musculus)64804643 more ...CTDPMID:19467301
Foxa3Rat3-chloropropane-1,2-diol decreases expressionEXP 6480464alpha-Chlorohydrin results in decreased expression of FOXA3 mRNACTDPMID:28522335
Foxa3Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of FOXA3 mRNACTDPMID:19162173
Foxa3Rat4,4'-sulfonyldiphenol increases expressionISOFoxa3 (Mus musculus)6480464bisphenol S results in increased expression of FOXA3 mRNACTDPMID:39298647
Foxa3Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of FOXA3 mRNACTDPMID:31881176
Foxa3Rataflatoxin B1 multiple interactionsEXP 6480464[sulforaphane co-treated with Aflatoxin B1] affects the expression of FOXA3 mRNACTDPMID:25450479

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Biological Process
1 to 20 of 31 rows

  
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Original Reference(s)
Foxa3Ratanatomical structure morphogenesis involved_inIBAFB:FBgn0000659 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Foxa3Ratcell differentiation involved_inIBAFB:FBgn0000659 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Foxa3Ratcell differentiation involved_inIEAUniProtKB-KW:KW-02211600115GO_REF:0000043UniProtGO_REF:0000043
Foxa3Ratcellular response to starvation acts_upstream_of_or_withinISOFoxa3 (Mus musculus)1624291MGI:2178218 PMID:11546810RGDPMID:11546810
Foxa3Ratcellular response to starvation acts_upstream_of_or_withinIEAUniProtKB:P35584 and ensembl:ENSMUSP000000431731600115GO_REF:0000107EnsemblGO_REF:0000107
Foxa3Ratchromatin organization involved_inIEAUniProtKB-KW:KW-01561600115GO_REF:0000043UniProtGO_REF:0000043
Foxa3Rathematopoietic stem cell homeostasis acts_upstream_of_or_withinISOFoxa3 (Mus musculus)1624291 PMID:26880577RGDPMID:26880577
Foxa3Rathematopoietic stem cell homeostasis acts_upstream_of_or_withinIEAUniProtKB:P35584 and ensembl:ENSMUSP000000431731600115GO_REF:0000107EnsemblGO_REF:0000107
Foxa3Ratintracellular glucose homeostasis involved_inTAS 8553889PMID:9369482UniProt 
Foxa3Ratintracellular glucose homeostasis acts_upstream_of_or_withinIEAUniProtKB:P35584 and ensembl:ENSMUSP000000431731600115GO_REF:0000107EnsemblGO_REF:0000107
Foxa3Ratintracellular glucose homeostasis acts_upstream_of_or_withinISOFoxa3 (Mus musculus)1624291MGI:2178218 PMID:11546810RGDPMID:11546810
Foxa3Ratnegative regulation of cell population proliferation  IMP 2315086 RGD 
Foxa3Ratpositive regulation of hepatocyte differentiation  IMP 2315086 RGD 
Foxa3Ratpositive regulation of transcription by RNA polymerase II involved_inIDA 8553889PMID:9369482UniProt 
Foxa3Ratpositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIEAUniProtKB:P35584 and ensembl:ENSMUSP000000431731600115GO_REF:0000107EnsemblGO_REF:0000107
Foxa3Ratpositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:P55318 and ensembl:ENSP000003040041600115GO_REF:0000107EnsemblGO_REF:0000107
Foxa3Ratpositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOFoxa3 (Mus musculus)1624291MGI:1353422 PMID:19759516RGDPMID:19759516
Foxa3Ratpositive regulation of transcription by RNA polymerase II involved_inIEAARBA:ARBA000279961600115GO_REF:0000117UniProtGO_REF:0000117
Foxa3Ratpositive regulation of transcription by RNA polymerase II involved_inISOFOXA3 (Homo sapiens)1624291 PMID:12695546RGDPMID:12695546
Foxa3Ratregulation of DNA-templated transcription  IDA 625455 RGD 
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Cellular Component
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Original Reference(s)
Foxa3Ratactin cytoskeleton located_inIEAUniProtKB:P55318 and ensembl:ENSP000003040041600115GO_REF:0000107EnsemblGO_REF:0000107
Foxa3Ratactin cytoskeleton located_inISOFOXA3 (Homo sapiens)1624291 RGDGO_REF:0000052
Foxa3Ratnucleoplasm located_inIEAUniProtKB:P55318 and ensembl:ENSP000003040041600115GO_REF:0000107EnsemblGO_REF:0000107
Foxa3Ratnucleoplasm located_inISOFOXA3 (Homo sapiens)1624291 RGDGO_REF:0000052
Foxa3Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Foxa3Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Foxa3Ratnucleus located_inIEAUniRule:UR0004137411600115GO_REF:0000104UniProtGO_REF:0000104
Foxa3Ratnucleus located_inISOFoxa3 (Mus musculus)1624291 PMID:8306889RGDPMID:8306889
Foxa3Ratnucleus located_inIEAUniProtKB:P35584 and ensembl:ENSMUSP000000431731600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
1 to 20 of 24 rows

  
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Original Reference(s)
Foxa3RatDNA binding  TAS 625455 RGD 
Foxa3RatDNA binding enablesIEAARBA:ARBA000292241600115GO_REF:0000117UniProtGO_REF:0000117
Foxa3RatDNA binding enablesISOFoxa3 (Mus musculus)1624291 PMID:7683413RGDPMID:7683413
Foxa3RatDNA binding enablesIEAUniRule:UR0004137411600115GO_REF:0000104UniProtGO_REF:0000104
Foxa3RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Foxa3RatDNA binding enablesIEAUniProtKB:P35584 and ensembl:ENSMUSP000000431731600115GO_REF:0000107EnsemblGO_REF:0000107
Foxa3RatDNA binding  IDA 625455 RGD 
Foxa3RatDNA-binding transcription factor activity  TAS 625455 RGD 
Foxa3RatDNA-binding transcription factor activity enablesIEAUniProtKB:P55318 and ensembl:ENSP000003040041600115GO_REF:0000107EnsemblGO_REF:0000107
Foxa3RatDNA-binding transcription factor activity enablesIEAARBA:ARBA000282951600115GO_REF:0000117UniProtGO_REF:0000117
Foxa3RatDNA-binding transcription factor activity enablesIEAInterPro:IPR001766 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Foxa3RatDNA-binding transcription factor activity enablesISOFOXA3 (Homo sapiens)1624291 PMID:12695546RGDPMID:12695546
Foxa3RatDNA-binding transcription factor activity  IDA 625455 RGD 
Foxa3RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0000659 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Foxa3Ratprotein binding enablesISOFOXA3 (Homo sapiens)1624291UniProtKB:P22607 more ...RGDPMID:32814053
Foxa3Ratprotein domain specific binding enablesIEAInterPro:IPR0136381600115GO_REF:0000002InterProGO_REF:0000002
Foxa3RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAMGI:1096329 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Foxa3Ratsequence-specific DNA binding enablesIEAInterPro:IPR001766 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Foxa3Ratsequence-specific DNA binding enablesISOFoxa3 (Mus musculus)1624291 PMID:8306889RGDPMID:8306889
Foxa3Ratsequence-specific DNA binding enablesIEAUniProtKB:P35584 and ensembl:ENSMUSP000000431731600115GO_REF:0000107EnsemblGO_REF:0000107
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Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Foxa3Ratmaturity-onset diabetes of the young pathway  IEA 6907045 KEGGrno:04950

Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
Foxa3Ratforkhead class A signaling pathway  ISOFOXA3 (Homo sapiens)6484113 PIDPID:200226
Foxa3Ratforkhead class A signaling pathway  ISOFOXA3 (Homo sapiens)6484113 PIDPID:200087

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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Gene expression of the three members of hepatocyte nuclear factor-3 is differentially regulated by nutritional and hormonal factors. Imae M, etal., J Endocrinol. 2000 Oct;167(1):R1-5.
3. The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation. Lin B, etal., Biochemistry. 1997 Nov 18;36(46):14096-106.
4. Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression. Liu Y, etal., Biochem J 2002 Sep 1;366(Pt 2):633-41.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Adenovirus-transferred HNF-3 gamma conserves some liver functions in primary cultured hepatocytes of adult rats. Nakamura T, etal., Biochem Biophys Res Commun. 1998 Dec 18;253(2):352-7.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:1672118   PMID:7683413   PMID:8306889   PMID:8332212   PMID:11546810   PMID:12695546   PMID:17488644   PMID:18239190   PMID:19759516   PMID:25896100   PMID:28358366   PMID:37528786  



Foxa3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,790,111 - 87,800,259 (-)NCBIGRCr8
mRatBN7.2178,662,067 - 78,672,321 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,662,431 - 78,672,155 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,051,578 - 84,060,504 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,609,178 - 92,618,101 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,806,680 - 85,815,606 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,921,292 - 79,930,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,920,752 - 79,930,263 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,181,104 - 81,190,030 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,368,026 - 78,376,953 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,446,136 - 78,455,064 (-)NCBI
Celera173,128,615 - 73,137,542 (-)NCBICelera
Cytogenetic Map1q21NCBI
FOXA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,864,326 - 45,873,797 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,863,989 - 45,873,797 (+)EnsemblGRCh38hg38GRCh38
GRCh371946,367,584 - 46,377,055 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,059,358 - 51,068,895 (+)NCBINCBI36Build 36hg18NCBI36
Celera1943,172,554 - 43,182,091 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,796,032 - 42,805,584 (+)NCBIHuRef
CHM1_11946,369,977 - 46,379,501 (+)NCBICHM1_1
T2T-CHM13v2.01948,691,764 - 48,701,238 (+)NCBIT2T-CHM13v2.0
Foxa3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39718,747,208 - 18,757,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl718,747,209 - 18,757,463 (-)EnsemblGRCm39 Ensembl
GRCm38719,013,283 - 19,023,539 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,013,284 - 19,023,538 (-)EnsemblGRCm38mm10GRCm38
MGSCv37719,598,632 - 19,608,888 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,171,805 - 18,182,061 (-)NCBIMGSCv36mm8
Celera716,424,993 - 16,435,230 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.46NCBI
Foxa3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574293,344 - 302,002 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955574293,344 - 301,955 (+)NCBIChiLan1.0ChiLan1.0
FOXA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,029,299 - 52,039,689 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,900,693 - 53,911,081 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,873,933 - 42,883,479 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,410,294 - 51,419,483 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,410,473 - 51,418,744 (+)Ensemblpanpan1.1panPan2
FOXA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,749,142 - 109,757,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,748,926 - 109,757,006 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,234,450 - 109,242,454 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,281,914 - 110,289,921 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,281,781 - 110,290,035 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,957,939 - 109,965,942 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,592,626 - 109,600,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,461,391 - 110,469,396 (-)NCBIUU_Cfam_GSD_1.0
Foxa3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,849,096 - 17,856,150 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367062,196,468 - 2,203,113 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367062,196,530 - 2,202,924 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,181,114 - 52,188,774 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,181,095 - 52,188,777 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,444,473 - 47,452,404 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOXA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,309,439 - 39,320,102 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,310,108 - 39,320,095 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607318,951,536 - 18,962,292 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Foxa3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248327,338,478 - 7,350,658 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248327,339,612 - 7,350,651 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Foxa3
51 total Variants

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:203
Interacting mature miRNAs:227
Transcripts:ENSRNOT00000019219
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 47 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat

1 to 10 of 47 rows
UniSTS:235614  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,662,489 - 78,662,609 (+)MAPPERmRatBN7.2
Rnor_6.0179,921,268 - 79,921,387NCBIRnor6.0
Rnor_5.0181,181,080 - 81,181,199UniSTSRnor5.0
RGSC_v3.4178,368,002 - 78,368,121UniSTSRGSC3.4
Celera173,128,591 - 73,128,710UniSTS
Cytogenetic Map1q21-q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 24 75 90 89 59 24 59 6 191 70 55 45 60 30



Ensembl Acc Id: ENSRNOT00000019219   ⟹   ENSRNOP00000019219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,662,514 - 78,671,441 (-)Ensembl
Rnor_6.0 Ensembl179,920,752 - 79,930,263 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108885   ⟹   ENSRNOP00000091555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,662,431 - 78,672,155 (-)Ensembl
RefSeq Acc Id: NM_017077   ⟹   NP_058773
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,790,558 - 87,799,485 (-)NCBI
mRatBN7.2178,662,514 - 78,671,441 (-)NCBI
Rnor_6.0179,921,292 - 79,930,219 (-)NCBI
Rnor_5.0181,181,104 - 81,190,030 (-)NCBI
RGSC_v3.4178,368,026 - 78,376,953 (-)RGD
Celera173,128,615 - 73,137,542 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101386   ⟹   XP_038957314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,790,111 - 87,800,259 (-)NCBI
mRatBN7.2178,662,067 - 78,672,321 (-)NCBI
RefSeq Acc Id: NP_058773   ⟸   NM_017077
- UniProtKB: P32183 (UniProtKB/Swiss-Prot),   A6J8I9 (UniProtKB/TrEMBL),   G3V7T9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019219   ⟸   ENSRNOT00000019219
RefSeq Acc Id: XP_038957314   ⟸   XM_039101386
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000091555   ⟸   ENSRNOT00000108885
Fork-head

Name Modeler Protein Id AA Range Protein Structure
AF-P32183-F1-model_v2 AlphaFold P32183 1-354 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689755
Promoter ID:EPDNEW_R279
Type:single initiation site
Name:Foxa3_1
Description:forkhead box A3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0179,930,271 - 79,930,331EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-60543 BioCyc
Ensembl Genes ENSRNOG00000014256 Ensembl
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro FH_FOXA3 UniProtKB/Swiss-Prot
  Fork-head_N UniProtKB/Swiss-Prot
  Fork_head_dom UniProtKB/Swiss-Prot
  FOX_domain-containing UniProtKB/Swiss-Prot
  TF_fork_head_CS_1 UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:25100 UniProtKB/Swiss-Prot
NCBI Gene 25100 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN UniProtKB/Swiss-Prot
  HEPATOCYTE NUCLEAR FACTOR 3-GAMMA UniProtKB/Swiss-Prot
Pfam Forkhead UniProtKB/Swiss-Prot
  Forkhead_N UniProtKB/Swiss-Prot
PhenoGen Foxa3 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_1 UniProtKB/Swiss-Prot
  FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014256 RatGTEx
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt A0A8I6AFN0_RAT UniProtKB/TrEMBL
  A6J8I9 ENTREZGENE, UniProtKB/TrEMBL
  A6J8J0_RAT UniProtKB/TrEMBL
  FOXA3_RAT UniProtKB/Swiss-Prot
  G3V7T9 ENTREZGENE, UniProtKB/TrEMBL
  P32183 ENTREZGENE
  Q76N13 ENTREZGENE, UniProtKB/TrEMBL
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Foxa3  forkhead box A3  Hnf3g  hepatocyte nuclear factor 3, gamma  Symbol and Name updated 1299863 APPROVED
2002-11-06 Hnf3g  hepatocyte nuclear factor 3, gamma    Hepatocyte nuclear factor 3 gamma  Name updated 625702 APPROVED
2002-06-10 Hnf3g  Hepatocyte nuclear factor 3 gamma      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expressed in liver, pancreatic islets and intestine during embryonic development 625455
gene_function D binding protein 625455
gene_function binds to the rat proglucagon gene G2 promoter element 625455
gene_process binds to the proglucagon gene G2 element but does not control the expression of islet or intestine proglucagon gene 625455