Gsta2 (glutathione S-transferase alpha 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gsta2 (glutathione S-transferase alpha 2) Rattus norvegicus
Analyze
Symbol: Gsta2 (Ensembl: Gsta5)
Name: glutathione S-transferase alpha 2 (Ensembl:glutathione S-transferase alpha 5)
RGD ID: 2754
Description: Enables several functions, including dinitrosyl-iron complex binding activity; glutathione binding activity; and glutathione transferase activity. Involved in response to nutrient levels and xenobiotic catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA2 (glutathione S-transferase alpha 2); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (RS)-goitrin; 1,2-dimethylhydrazine; 1-Cyano-2-hydroxy-3-butene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 13-hydroperoxyoctadecadienoate peroxidase; androst-5-ene-3,17-dione isomerase; glutathione S-transferase A2; glutathione S-transferase alpha-1; glutathione S-transferase Ya subunit; glutathione S-transferase Ya-1; glutathione S-transferase, alpha 2; Glutathione-S-transferase alpha type (Yc?); Glutathione-S-transferase, alpha type (Yc?); glutathione-S-transferase, alpha type2; GST 1-1; GST 1a-1a; GST A1-1; GST B; GST Ya1; Gsta1; ligandin
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8888,064,829 - 88,077,168 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl888,064,616 - 88,077,092 (-)EnsemblGRCr8
mRatBN7.2879,184,535 - 79,196,827 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,184,322 - 79,196,798 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx884,705,976 - 84,719,310 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,982,644 - 82,995,978 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,805,340 - 80,818,674 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,640,081 - 85,645,621 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0885,197,052 - 85,202,588 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4883,299,249 - 83,312,958 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera878,931,925 - 78,944,156 (-)NCBICelera
RGSC_v3.1883,318,303 - 83,332,012 (-)NCBI
Cytogenetic Map8q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(RS)-goitrin  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-dioxane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Cyano-2-hydroxy-3-butene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-imidazole  (EXP)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-allylphenol  (EXP)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4'-hydroxyacetophenone  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-Chloronitrobenzene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-Propylphenol  (EXP)
5-bromo-2'-deoxyuridine  (ISO)
5-Hydroxythalidomide  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
allopurinol  (ISO)
Allylamine  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alternariol  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
androst-4-ene-3,17-dione  (ISO)
anethole  (EXP)
angelica lactone  (ISO)
antimycin A  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoquinones  (ISO)
benzothiazole  (EXP)
benzotriazole  (EXP)
benzylideneacetone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bifenthrin  (ISO)
bilirubin IXalpha  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cafestol  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
cetrorelix  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chlormequat chloride  (EXP)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clotrimazole  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (EXP,ISO)
coumarin  (ISO)
cumene hydroperoxide  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
DDT  (EXP)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (EXP)
diazinon  (EXP)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicyclanil  (ISO)
Dicyclohexyl phthalate  (ISO)
diethyl malate  (ISO)
diethylstilbestrol  (EXP)
diisononyl phthalate  (ISO)
dimercaprol  (ISO)
dimethylarsinic acid  (EXP)
diquat  (EXP,ISO)
diuron  (EXP)
doramapimod  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
etacrynic acid  (EXP)
ethanol  (EXP,ISO)
ethoxyquin  (EXP,ISO)
eugenol  (EXP)
felbamate  (EXP)
fenofibrate  (EXP)
finasteride  (EXP)
fipronil  (EXP,ISO)
flavone  (EXP)
flusilazole  (EXP)
flutamide  (EXP)
folpet  (ISO)
furan  (EXP,ISO)
gabapentin  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
graphite  (EXP)
GW 4064  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (ISO)
inulin  (ISO)
iodide salt  (EXP)
iprodione  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
isoimperatorin  (ISO)
isomethyleugenol  (EXP)
isoniazide  (EXP)
isopimpinellin  (ISO)
Isosafrole  (EXP)
isothiocyanate  (ISO)
ketoconazole  (ISO)
kojic acid  (EXP)
KT 5720  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP)
L-selenocysteine  (EXP)
lactacystin  (ISO)
lead diacetate  (EXP)
lead nitrate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
linsidomine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP)
LY294002  (EXP)
mechlorethamine  (ISO)
Meclizine  (ISO)
medroxyprogesterone acetate  (EXP)
mefenamic acid  (ISO)
meglumine amidotrizoate  (EXP)
menadione  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (ISO)
mercury(0)  (EXP,ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP,ISO)
methyl methacrylate  (ISO)
methylarsonic acid  (EXP)
methylisothiazolinone  (ISO)
miconazole  (EXP)
microcystin-LR  (EXP)
mifepristone  (EXP)
Mitotane  (EXP)
Moniliformin  (ISO)
N,N'-diphenylthiourea  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitroglycerin  (EXP)
Nonylphenol  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oltipraz  (EXP,ISO)
oxybenzone  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
peroxynitrous acid  (EXP)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propiconazole  (EXP,ISO)
prostaglandin A2  (ISO)
prostaglandin J2  (EXP,ISO)
pyrogallol  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
spermidine  (ISO)
staurosporine  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
tamoxifen  (EXP)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
Tetramethylthiourea  (EXP)
tetraphene  (EXP)
thiazoles  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-anethole  (EXP)
triadimefon  (EXP)
triazines  (ISO)
triazoles  (EXP)
tributyl phosphate  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trimethylarsine oxide  (EXP,ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (EXP,ISO)
tris(2-chloroethyl) phosphate  (EXP,ISO)
troglitazone  (EXP)
troleandomycin  (EXP)
uranium atom  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IDA,ISO)
mitochondrion  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1. Hayes JD, etal., J Biol Chem 1994 Aug 12;269(32):20707-17.
4. Rat glutathione S-transferase. Cloning of double-stranded cDNA and induction of its mRNA. Kalinyak JE and Taylor JM, J Biol Chem 1982 Jan 10;257(1):523-30.
5. Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz. Kang KW, etal., J Natl Cancer Inst 2003 Jan 1;95(1):53-66.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo. Koen YM, etal., Chem Res Toxicol. 2006 Nov;19(11):1426-34.
8. The nucleotide sequence of a rat liver glutathione S-transferase subunit cDNA clone. Lai HC, etal., J Biol Chem 1984 May 10;259(9):5536-42.
9. Age, gender and region-specific differences in drug metabolising enzymes in rat ocular tissues. Nakamura K, etal., Exp Eye Res. 2005 Dec;81(6):710-5. Epub 2005 Jun 20.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. The catalytic Tyr-9 of glutathione S-transferase A1-1 controls the dynamics of the C terminus. Nieslanik BS and Atkins WM, J Biol Chem. 2000 Jun 9;275(23):17447-51.
12. Expression and sequence analysis of rat liver glutathione S-transferase genes. Pickett CB, etal., Adv Exp Med Biol 1986;197:185-93.
13. Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital. Pickett CB, etal., J Biol Chem 1984 Apr 25;259(8):5182-8.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope. Stella L, etal., J Biol Chem. 2007 Mar 2;282(9):6372-9. Epub 2006 Dec 30.
18. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. The Yc and Ya subunits of rat liver glutathione S-transferases are the products of separate genes. Tu CP, etal., J Biol Chem 1984 Aug 10;259(15):9434-9.
22. Cloning and sequence analysis of a cDNA plasmid for one of the rat liver glutathione S-transferase subunits. Tu CP, etal., Nucleic Acids Res 1982 Sep 25;10(18):5407-19.
23. Heterodimers of wild-type and subunit interface mutant enzymes of glutathione S-transferase A1-1: interactive or independent active sites? Vargo MA and Colman RF, Protein Sci. 2004 Jun;13(6):1586-93.
24. Mechanism of negative regulation of rat glutathione S-transferase A2 by the cytokine interleukin 6. Voss SH, etal., Biochem J 2002 Jul 1;365(Pt 1):229-37.
Additional References at PubMed
PMID:2421763   PMID:2645828   PMID:2985614   PMID:3025841   PMID:6688942   PMID:8144363   PMID:10215608   PMID:15035604   PMID:15319326   PMID:15489334   PMID:15870285   PMID:17086191  
PMID:17786629   PMID:19191009   PMID:21492153   PMID:21905055   PMID:23012479  


Genomics

Comparative Map Data
Gsta2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8888,064,829 - 88,077,168 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl888,064,616 - 88,077,092 (-)EnsemblGRCr8
mRatBN7.2879,184,535 - 79,196,827 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,184,322 - 79,196,798 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx884,705,976 - 84,719,310 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,982,644 - 82,995,978 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,805,340 - 80,818,674 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,640,081 - 85,645,621 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0885,197,052 - 85,202,588 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4883,299,249 - 83,312,958 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera878,931,925 - 78,944,156 (-)NCBICelera
RGSC_v3.1883,318,303 - 83,332,012 (-)NCBI
Cytogenetic Map8q31NCBI
GSTA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,750,087 - 52,763,475 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,747,975 - 52,763,525 (-)Ensemblhg38GRCh38
GRCh37652,614,885 - 52,628,273 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,723,140 - 52,736,283 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34652,723,139 - 52,736,283NCBI
Celera654,275,978 - 54,289,456 (-)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef652,446,103 - 52,459,571 (-)NCBIHuRef
CHM1_1652,617,113 - 52,630,562 (-)NCBICHM1_1
T2T-CHM13v2.0652,588,869 - 52,602,258 (-)NCBIT2T-CHM13v2.0
Gsta2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39978,238,300 - 78,254,474 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl978,238,300 - 78,263,070 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38978,331,018 - 78,347,192 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl978,331,018 - 78,355,788 (-)Ensemblmm10GRCm38
MGSCv37978,178,827 - 78,194,952 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36978,116,704 - 78,132,829 (-)NCBIMGSCv36mm8
Celera975,504,493 - 75,521,021 (-)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.65NCBI
LOC481841
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,319,222 - 20,338,681 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,215,030 - 20,233,827 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01220,817,395 - 20,835,810 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11220,323,240 - 20,341,615 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01220,426,863 - 20,445,653 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,565,510 - 20,584,316 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

Variants

.
Variants in Gsta2
82 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:347
Count of miRNA genes:195
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000032185, ENSRNOT00000044944
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat

Markers in Region
PMC133753P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0885,110,551 - 85,110,671NCBIRnor5.0
Rnor_5.0885,246,703 - 85,246,823NCBIRnor5.0
RGSC_v3.4883,313,599 - 83,313,718UniSTSRGSC3.4
Celera878,849,420 - 78,849,539UniSTS
Cytogenetic Map8q31UniSTS
RH143684  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2879,112,440 - 79,112,544 (-)MAPPERmRatBN7.2
mRatBN7.2879,112,440 - 79,112,544 (+)MAPPERmRatBN7.2
mRatBN7.2879,189,476 - 79,189,580 (-)MAPPERmRatBN7.2
mRatBN7.2879,189,476 - 79,189,580 (+)MAPPERmRatBN7.2
Rnor_6.0885,644,665 - 85,644,768NCBIRnor6.0
Rnor_6.0885,559,883 - 85,559,986NCBIRnor6.0
Rnor_5.0885,117,591 - 85,117,694UniSTSRnor5.0
Rnor_5.0885,201,632 - 85,201,735UniSTSRnor5.0
RGSC_v3.4883,206,967 - 83,207,070UniSTSRGSC3.4
RGSC_v3.4883,304,715 - 83,304,818UniSTSRGSC3.4
Celera878,936,867 - 78,936,970UniSTS
Celera878,857,199 - 78,857,302UniSTS
RH 3.4 Map8927.59UniSTS
Cytogenetic Map8q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
16 4 12 32 78 76 55 15 55 6 191 40 16 76 63 21

Sequence


Ensembl Acc Id: ENSRNOT00000032185   ⟹   ENSRNOP00000037786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl879,184,322 - 79,196,798 (-)Ensembl
Rnor_6.0 Ensembl885,640,055 - 85,645,718 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106378   ⟹   ENSRNOP00000091487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl879,184,322 - 79,191,537 (-)Ensembl
RefSeq Acc Id: NM_017013   ⟹   NP_058709
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8888,064,829 - 88,077,092 (-)NCBI
mRatBN7.2879,184,535 - 79,196,798 (-)NCBI
Rnor_5.0885,197,052 - 85,202,588 (-)NCBI
RGSC_v3.4883,299,249 - 83,312,958 (-)RGD
Celera878,931,925 - 78,944,156 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080797   ⟹   XP_038936725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8888,064,829 - 88,077,168 (-)NCBI
mRatBN7.2879,184,563 - 79,196,827 (-)NCBI
RefSeq Acc Id: NP_058709   ⟸   NM_017013
- UniProtKB: Q63715 (UniProtKB/Swiss-Prot),   P04903 (UniProtKB/Swiss-Prot),   Q6AZ72 (UniProtKB/Swiss-Prot),   P00502 (UniProtKB/Swiss-Prot),   B6DYP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038936725   ⟸   XM_039080797
- Peptide Label: isoform X1
- UniProtKB: Q63715 (UniProtKB/Swiss-Prot),   P04903 (UniProtKB/Swiss-Prot),   P00502 (UniProtKB/Swiss-Prot),   Q6AZ72 (UniProtKB/Swiss-Prot),   B6DYP7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091487   ⟸   ENSRNOT00000106378
Ensembl Acc Id: ENSRNOP00000037786   ⟸   ENSRNOT00000032185
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00502-F1-model_v2 AlphaFold P00502 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2754 AgrOrtholog
BioCyc Gene G2FUF-29765 BioCyc
Ensembl Genes ENSRNOG00000000201 Ensembl, ENTREZGENE
  ENSRNOG00000029861 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032185 ENTREZGENE
  ENSRNOT00000032185.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7128611 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_alpha UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_superfamily UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:24422 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93118 IMAGE-MGC_LOAD
NCBI Gene 24422 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
  GLUTATHIONE S-TRANSFERASE-RELATED UniProtKB/Swiss-Prot
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PharmGKB GSTA2 RGD
PhenoGen Gsta2 PhenoGen
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000201 RatGTEx
  ENSRNOG00000029861 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
TIGR TC239508
UniProt A0A8I6GJP0_RAT UniProtKB/TrEMBL
  B6DYP7 ENTREZGENE, UniProtKB/TrEMBL
  F7F2H5_RAT UniProtKB/TrEMBL
  GSTA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P04903 ENTREZGENE
  Q63715 ENTREZGENE
  Q6AZ72 ENTREZGENE
UniProt Secondary Q6AZ72 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-10-22 Gsta2  glutathione S-transferase alpha 2  Gsta2  glutathione S-transferase A2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Gsta2  glutathione S-transferase A2  Gsta2  glutathione S-transferase, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Gsta2  glutathione S-transferase, alpha 2  Gsta2  glutathione-S-transferase, alpha type2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gsta2  glutathione-S-transferase, alpha type2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the alpha class of glutathione S-transferases 633010