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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2754 Species: Rattus norvegicus RGD Object: Gene Symbol: Gsta2 Name: glutathione S-transferase alpha 2

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA] Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA]]	PMID:17690134
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:15644576 PMID:17690134 PMID:18178546 PMID:16960034 PMID:16054898
multiple interactions	ISO	RGD:10696	6480464	CTD	Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA] Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA] Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA] [Tetrachlorodibenzodioxin co-treated with Copper] results in increased activity of GSTA2 protein	PMID:15297030
decreases expression	ISO	RGD:737133	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of GSTA2 mRNA	PMID:18061397
affects expression	ISO	RGD:10696	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of GSTA2 mRNA	PMID:20702594
multiple interactions	ISO	RGD:10696	6480464	CTD	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTA2 mRNA	PMID:17942748
increases expression	ISO	RGD:10696	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:20005886 PMID:15297030 PMID:16611356 PMID:15328365 PMID:15800033 PMID:16960034
increases expression	ISO	RGD:10696	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:15800033 PMID:16611356 PMID:15297030 PMID:19770486 PMID:15328365 PMID:20005886 PMID:16960034
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:18178546 PMID:17690134 PMID:15644576 PMID:16960034 PMID:16054898
increases expression	ISO	RGD:10696	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:15800033 PMID:20005886 PMID:16611356 PMID:15297030 PMID:19770486 PMID:15328365 PMID:16960034
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:16054898 PMID:17690134 PMID:18178546 PMID:15644576 PMID:16960034
increases expression	ISO	RGD:10696	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:16611356 PMID:15297030 PMID:16960034 PMID:20005886 PMID:15328365 PMID:15800033 PMID:19770486
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:16054898 PMID:17690134 PMID:15644576 PMID:16960034 PMID:18178546
increases expression	ISO	RGD:10696	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:15328365 PMID:15297030 PMID:16960034 PMID:16611356 PMID:20005886 PMID:15800033 PMID:19770486
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:16054898 PMID:15644576 PMID:16960034 PMID:17690134 PMID:18178546
increases expression	ISO	RGD:10696	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:15297030 PMID:15328365 PMID:16960034 PMID:16611356 PMID:19770486 PMID:15800033 PMID:20005886
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:17690134 PMID:18178546 PMID:16054898 PMID:16960034 PMID:15644576
multiple interactions	ISO	RGD:10696	6480464	CTD	2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA] Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of GSTA2 mRNA]	PMID:21851831
affects expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin affects the expression of GSTA2 mRNA	PMID:22298810
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:15644576 PMID:16054898 PMID:16960034 PMID:17690134 PMID:18178546 PMID:20558275 PMID:20566336
increases expression	ISO	RGD:10696	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:15297030 PMID:15328365 PMID:15800033 PMID:16611356 PMID:16960034 PMID:19770486 PMID:20005886 PMID:21851831
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA	PMID:15644576 PMID:16054898 PMID:16960034 PMID:17690134 PMID:18178546 PMID:20558275 PMID:20566336 PMID:20959002
multiple interactions	EXP		6480464	CTD	Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA2 protein]	PMID:7587946
increases activity	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased activity of GSTA2 protein	PMID:7587946