Gp5 (glycoprotein V (platelet)) - Rat Genome Database

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Gene: Gp5 (glycoprotein V (platelet)) Rattus norvegicus
Analyze
Symbol: Gp5
Name: glycoprotein V (platelet)
RGD ID: 2724
Description: Predicted to enable collagen binding activity. Predicted to be involved in several processes, including blood coagulation, intrinsic pathway; megakaryocyte development; and positive regulation of platelet activation. Predicted to act upstream of or within cell-matrix adhesion and negative regulation of platelet activation. Located in cell surface. Orthologous to human GP5 (glycoprotein V platelet); PARTICIPATES IN platelet aggregation pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 3-chloropropane-1,2-diol; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glycoprotein 5; glycoprotein 5 (platelet); glycoprotein 5, platelet; glycoprotein V platelet; GPV; NEWGENE_2724; Platelet glycoprotein 5; platelet glycoprotein V; Platelete glycoprotein 5; PLGPV
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,948,507 - 83,952,362 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1183,948,507 - 83,952,367 (+)EnsemblGRCr8
mRatBN7.21170,443,613 - 70,446,705 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,443,613 - 70,446,705 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1179,287,682 - 79,290,774 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,922,456 - 71,925,549 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01170,976,783 - 70,979,875 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01173,015,380 - 73,017,570 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,014,983 - 74,018,075 (+)NCBIrn6Rnor6.0
Rnor_6.0 Ensembl1174,014,983 - 74,018,075 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1173,015,387 - 73,017,090 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1173,015,387 - 73,017,090 (+)NCBIrn6Rnor6.0
Rnor_5.01177,074,641 - 77,079,283 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41172,341,773 - 72,344,865 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1169,417,023 - 69,420,116 (+)NCBICelera
RGSC_v3.11172,400,270 - 72,401,974 (+)NCBI
Cytogenetic Map11q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The vascular biology of the glycoprotein Ib-IX-V complex. Berndt MC, etal., Thromb Haemost. 2001 Jul;86(1):178-88.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. Ravanat C, etal., Blood 1997 May 1;89(9):3253-62.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10557321   PMID:11435305   PMID:11493449   PMID:23533145  


Genomics

Comparative Map Data
Gp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,948,507 - 83,952,362 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1183,948,507 - 83,952,367 (+)EnsemblGRCr8
mRatBN7.21170,443,613 - 70,446,705 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,443,613 - 70,446,705 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1179,287,682 - 79,290,774 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,922,456 - 71,925,549 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01170,976,783 - 70,979,875 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01173,015,380 - 73,017,570 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,014,983 - 74,018,075 (+)NCBIrn6Rnor6.0
Rnor_6.0 Ensembl1174,014,983 - 74,018,075 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1173,015,387 - 73,017,090 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1173,015,387 - 73,017,090 (+)NCBIrn6Rnor6.0
Rnor_5.01177,074,641 - 77,079,283 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41172,341,773 - 72,344,865 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1169,417,023 - 69,420,116 (+)NCBICelera
RGSC_v3.11172,400,270 - 72,401,974 (+)NCBI
Cytogenetic Map11q22NCBI
GP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383194,394,821 - 194,399,266 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3194,394,821 - 194,399,266 (-)Ensemblhg38GRCh38
GRCh373194,115,550 - 194,119,995 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363195,596,839 - 195,601,284 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343195,595,355 - 195,601,531NCBI
Celera3192,530,959 - 192,535,404 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3191,495,068 - 191,499,519 (-)NCBIHuRef
CHM1_13194,078,326 - 194,082,777 (-)NCBICHM1_1
T2T-CHM13v2.03197,093,240 - 197,097,685 (-)NCBIT2T-CHM13v2.0
Gp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391630,126,503 - 30,129,599 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1630,126,503 - 30,129,597 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381630,307,685 - 30,310,781 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1630,307,685 - 30,310,779 (-)Ensemblmm10GRCm38
MGSCv371630,307,779 - 30,310,865 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361630,227,440 - 30,230,526 (-)NCBIMGSCv36mm8
Celera1630,814,803 - 30,817,890 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.26NCBI
Gp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542014,377,800 - 14,382,003 (+)NCBIChiLan1.0ChiLan1.0
GP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22192,316,531 - 192,322,413 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13192,324,054 - 192,327,782 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03191,691,432 - 191,696,906 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13202,007,943 - 202,010,005 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3202,008,334 - 202,010,005 (-)EnsemblpanPan2panpan1.1
Gp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602123,841,893 - 123,846,401 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936711403,876 - 405,570 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13131,385,044 - 131,386,753 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113131,382,722 - 131,389,841 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,881,469 - 140,883,604 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11588,491,781 - 88,495,601 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1588,492,336 - 88,494,018 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604162,179,277 - 62,182,525 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473063,381,060 - 63,383,193 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gp5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1415,219,731 - 15,221,661 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gp5
31 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:289
Count of miRNA genes:186
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000040884
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 15 24 67 125 92 11 18 26 32 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000040884   ⟹   ENSRNOP00000047810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1183,948,507 - 83,952,367 (+)Ensembl
mRatBN7.2 Ensembl1170,443,613 - 70,446,705 (+)Ensembl
Rnor_6.0 Ensembl1174,014,983 - 74,018,075 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090978   ⟹   ENSRNOP00000069774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1173,015,387 - 73,017,090 (+)Ensembl
RefSeq Acc Id: NM_012795   ⟹   NP_036927
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81183,948,507 - 83,951,599 (+)NCBI
mRatBN7.21170,443,613 - 70,446,705 (+)NCBI
Rnor_6.01173,015,380 - 73,017,570 (+)NCBI
Rnor_5.01177,074,641 - 77,079,283 (+)NCBI
RGSC_v3.41172,341,773 - 72,344,865 (+)RGD
Celera1169,417,023 - 69,420,116 (+)RGD
Sequence:
RefSeq Acc Id: XM_063270306   ⟹   XP_063126376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81183,948,530 - 83,952,362 (+)NCBI
Protein Sequences
Protein RefSeqs NP_036927 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126376 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA93440 (Get FASTA)   NCBI Sequence Viewer  
  EDL78156 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047810
GenBank Protein O08770 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036927   ⟸   NM_012795
- Peptide Label: precursor
- UniProtKB: O08770 (UniProtKB/Swiss-Prot),   G3V9H9 (UniProtKB/TrEMBL),   A6JRV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069774   ⟸   ENSRNOT00000090978
Ensembl Acc Id: ENSRNOP00000047810   ⟸   ENSRNOT00000040884
RefSeq Acc Id: XP_063126376   ⟸   XM_063270306
- Peptide Label: isoform X1
- UniProtKB: O08770 (UniProtKB/Swiss-Prot),   A6JRV1 (UniProtKB/TrEMBL),   G3V9H9 (UniProtKB/TrEMBL)
Protein Domains
LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9H9-F1-model_v2 AlphaFold G3V9H9 1-567 view protein structure
AF-O08770-F1-model_v2 AlphaFold O08770 1-567 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2724 AgrOrtholog
BioCyc Gene G2FUF-21003 BioCyc
Ensembl Genes ENSRNOG00000038540 Ensembl, ENTREZGENE
  ENSRNOG00000061705 Ensembl
Ensembl Transcript ENSRNOT00000040884 ENTREZGENE
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRR_TM_domain-containing UniProtKB/Swiss-Prot
KEGG Report rno:25259 UniProtKB/Swiss-Prot
NCBI Gene 25259 ENTREZGENE
PANTHER ANTIGEN BSP, PUTATIVE-RELATED UniProtKB/Swiss-Prot
  INSULIN LIKE GROWTH FACTOR BINDING PROTEIN ACID LABILE SUBUNIT UniProtKB/Swiss-Prot
Pfam LRR_8 UniProtKB/Swiss-Prot
PhenoGen Gp5 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000038540 RatGTEx
  ENSRNOG00000061705 RatGTEx
SMART LRR_TYP UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
UniProt A6JRV1 ENTREZGENE, UniProtKB/TrEMBL
  G3V9H9 ENTREZGENE, UniProtKB/TrEMBL
  GPV_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gp5  glycoprotein V (platelet)  NEWGENE_2724  glycoprotein V platelet  Data merged from RGD:11377642 737654 PROVISIONAL
2016-08-02 NEWGENE_2724  glycoprotein V platelet      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-26 Gp5  glycoprotein V (platelet)  Gp5  glycoprotein 5, platelet  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gp5  glycoprotein 5, platelet    glycoprotein 5   Name updated 1299863 APPROVED
2002-11-06 Gp5  glycoprotein 5     glycoprotein 5 (platelet)  Name updated 625702 APPROVED
2001-07-23 Gp5  Platelete glycoprotein 5      Name withdrawn 67952 WITHDRAWN
2001-07-23 Gp5  glycoprotein 5 (platelet)      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 551 amino acids 728633
gene_transcript contains TATA-less, megakaryocyte-type promoters with conserved tandem Ets and GATA recognition motifs 728633