Gata4 (GATA binding protein 4) - Rat Genome Database

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Gene: Gata4 (GATA binding protein 4) Rattus norvegicus
Analyze
Symbol: Gata4
Name: GATA binding protein 4
RGD ID: 2665
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; positive regulation of BMP signaling pathway; and transdifferentiation. Predicted to be located in chromatin. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study myocardial infarction. Biomarker of congenital heart disease and pulmonary hypertension. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4); INTERACTS WITH 17alpha-ethynylestradiol; 1D-myo-inositol 1,4,5-trisphosphate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA-binding protein GATA-GT2; GATA-binding factor 4; GATA-binding protein 4; transcription factor GATA-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,635,572 - 41,707,252 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1541,635,572 - 41,681,609 (-)EnsemblGRCr8
mRatBN7.21537,459,601 - 37,531,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,459,601 - 37,505,636 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1539,312,354 - 39,358,379 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,463,161 - 40,509,184 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,920,232 - 38,966,261 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,386,703 - 46,458,679 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,386,712 - 46,432,965 (-)Ensemblrn6Rnor6.0
Rnor_5.01550,151,497 - 50,197,708 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41542,472,793 - 42,519,569 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1537,143,928 - 37,189,874 (-)NCBICelera
RGSC_v3.11542,488,492 - 42,535,269 (-)NCBI
RH 3.4 Map15261.71RGD
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethyl-4-tridecylmorpholine  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
5-hydroxymethylfurfural  (ISO)
5-hydroxytryptophan  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (EXP)
acetic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
arecoline  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bosentan  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carvedilol  (EXP)
chromium(6+)  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dipentyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
fenofibrate  (EXP)
fenvalerate  (EXP)
fluoranthene  (ISO)
flusilazole  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
glucose  (ISO)
glyphosate  (ISO)
heparin  (EXP)
homocysteine  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
icariin  (ISO)
irinotecan  (EXP)
isoprenaline  (EXP,ISO)
L-ascorbic acid  (ISO)
latrunculin B  (EXP)
lipopolysaccharide  (EXP)
malathion  (ISO)
methamphetamine  (EXP,ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
mifepristone  (ISO)
mithramycin  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
permethrin  (ISO)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (EXP)
probucol  (EXP)
progesterone  (ISO)
prostaglandin F2alpha  (EXP)
pyrethrins  (EXP)
pyrogallol  (ISO)
quercetin  (EXP)
rac-lactic acid  (ISO)
remdesivir  (ISO)
ribavirin  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
tadalafil  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP,ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
warfarin  (ISO)
Y-27632  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IEA,ISO)
atrial septum morphogenesis  (IEA,ISO)
atrial septum primum morphogenesis  (ISO)
atrial septum secundum morphogenesis  (IEA,ISO)
atrioventricular canal development  (ISO)
atrioventricular valve formation  (ISO)
atrioventricular valve morphogenesis  (ISO)
cardiac muscle cell differentiation  (IEP,ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac muscle tissue development  (ISO)
cardiac muscle tissue regeneration  (ISO)
cardiac right ventricle morphogenesis  (ISO)
cardiac septum development  (ISO)
cell fate commitment  (IBA)
cell growth involved in cardiac muscle cell development  (IDA)
cell-cell signaling  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (IEP)
cellular response to gonadotropin stimulus  (ISO)
DNA-templated transcription  (IEA)
embryonic digestive tract morphogenesis  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic heart tube anterior/posterior pattern specification  (ISO)
embryonic heart tube development  (ISO)
embryonic morphogenesis  (ISO)
endocardial cushion development  (IEA,ISO)
endoderm formation  (ISO)
epithelial cell fate commitment  (ISO)
gastrulation with mouth forming second  (ISO)
heart development  (IEA,ISO,TAS)
heart looping  (ISO)
heart morphogenesis  (ISO)
in utero embryonic development  (ISO)
intestinal epithelial cell differentiation  (ISO)
lung lobe formation  (ISO)
male gonad development  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of autophagy  (IMP)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of connective tissue replacement  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA)
positive regulation of angiogenesis  (ISO)
positive regulation of BMP signaling pathway  (IDA)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
regulation of cardiac muscle cell contraction  (IMP)
regulation of cardiac muscle cell proliferation  (ISO)
regulation of DNA-templated transcription  (IDA,IEA,ISO)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to estrogen  (ISO)
response to mechanical stimulus  (IDA)
response to retinoic acid  (ISO)
response to vitamin A  (IEP)
response to xenobiotic stimulus  (IEA,ISO)
seminiferous tubule development  (ISO)
Sertoli cell differentiation  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
spermatogenesis  (ISO)
tissue development  (IEA)
transdifferentiation  (IMP)
tube morphogenesis  (ISO)
ventricular cardiac muscle tissue development  (ISO)
ventricular septum development  (ISO)
wound healing  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cooperative interaction between GATA-4 and GATA-6 regulates myocardial gene expression. Charron F, etal., Mol Cell Biol. 1999 Jun;19(6):4355-65.
2. Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2. Clabby ML, etal., J Biol Chem 2003 Feb 21;278(8):5760-7.
3. The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. Dai YS, etal., J Biol Chem 2002 Jul 5;277(27):24390-8.
4. Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart. Feng Y, etal., J Nutr Biochem. 2013 Jul;24(7):1373-80. doi: 10.1016/j.jnutbio.2012.11.005. Epub 2013 Jan 17.
5. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Garg V, etal., Nature. 2003 Jul 24;424(6947):443-7. Epub 2003 Jul 6.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Ginseng inhibits cardiomyocyte hypertrophy and heart failure via NHE-1 inhibition and attenuation of calcineurin activation. Guo J, etal., Circ Heart Fail. 2011 Jan 1;4(1):79-88. Epub 2010 Oct 22.
9. Myogenic differentiation in atrium-derived adult cardiac pluripotent cells and the transcriptional regulation of GATA4 and myogenin on ANP promoter. Kamrul Hasan M, etal., Genes Cells. 2010 May;15(5):439-54. Epub 2010 Apr 7.
10. Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response. Kerkela R, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Jan;300(1):R140-9. Epub 2010 Nov 17.
11. Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene.PG - 13752-60 Kerkela R, etal., J Biol Chem 2002 Apr 19;277(16):13752-60.
12. Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury. Kobayashi S, etal., J Biol Chem. 2007 Jul 27;282(30):21945-52. Epub 2007 May 24.
13. Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death. Kobayashi S, etal., J Biol Chem. 2010 Jan 1;285(1):793-804. Epub 2009 Nov 9.
14. Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility. Ku PM, etal., Cardiovasc Diabetol. 2011 Jun 24;10:57. doi: 10.1186/1475-2840-10-57.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Utilization of Whole Exome Sequencing to Identify Causative Mutations in Familial Congenital Heart Disease. LaHaye S, etal., Circ Cardiovasc Genet. 2016 Aug;9(4):320-9. doi: 10.1161/CIRCGENETICS.115.001324. Epub 2016 Jul 14.
17. PPARalpha activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4. Le K, etal., Arch Biochem Biophys. 2012 Feb 1;518(1):71-8. Epub 2011 Dec 16.
18. Involvement of a novel GATA4 mutation in atrial septal defects. Liu XY, etal., Int J Mol Med. 2011 Jul;28(1):17-23. doi: 10.3892/ijmm.2011.638. Epub 2011 Mar 3.
19. Cardiomyocyte differentiation of rat bone marrow multipotent progenitor cells is associated with downregulation of Oct-4 expression. Lu T, etal., Tissue Eng Part A. 2010 Oct;16(10):3111-7.
20. Increase in cardiac M(2)-muscarinic receptor expression is regulated by GATA binding protein 4 (GATA-4) in streptozotocin-induced diabetic rats. Mar GY, etal., Int J Cardiol. 2012 Jan 29.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Molkentin JD, etal., Mol Cell Biol. 1994 Jul;14(7):4947-57.
23. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. Morimoto T, etal., J Clin Invest. 2008 Mar;118(3):868-78.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6. Nemer G and Nemer M, Dev Biol. 2003 Feb 1;254(1):131-48.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
28. Pulmonary hypertension-induced GATA4 activation in the right ventricle. Park AM, etal., Hypertension. 2010 Dec;56(6):1145-51. doi: 10.1161/HYPERTENSIONAHA.110.160515. Epub 2010 Nov 8.
29. GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program. Pikkarainen S, etal., J Biol Chem. 2003 Jun 27;278(26):23807-16. Epub 2003 Apr 17.
30. Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3. Potvin E, etal., Mol Cell Biol. 2010 Nov;30(22):5348-63. doi: 10.1128/MCB.00353-09. Epub 2010 Sep 20.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. Sunagawa Y, etal., J Biol Chem. 2010 Mar 26;285(13):9556-68. doi: 10.1074/jbc.M109.070458. Epub 2010 Jan 17.
35. Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes. Tamura S, etal., Proc Natl Acad Sci U S A 1993 Nov 15;90(22):10876-80.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Transcription factor GATA-4 is activated by phosphorylation of serine 261 via the cAMP/protein kinase a signaling pathway in gonadal cells. Tremblay JJ and Viger RS, J Biol Chem 2003 Jun 13;278(24):22128-35.
38. Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. Yanazume T, etal., J Biol Chem 2002 Mar 8;277(10):8618-25.
39. Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. Zhang Y, etal., Aquat Toxicol. 2013 Jul 29;142-143C:26-32. doi: 10.1016/j.aquatox.2013.07.014.
Additional References at PubMed
PMID:8183957   PMID:8455608   PMID:8582296   PMID:8754853   PMID:9136932   PMID:9136933   PMID:9231805   PMID:9312027   PMID:9420335   PMID:9566909   PMID:9738004   PMID:9858576  
PMID:11297508   PMID:11810204   PMID:12530967   PMID:12606418   PMID:12801993   PMID:14978031   PMID:15051723   PMID:15059951   PMID:15082719   PMID:15220332   PMID:15310850   PMID:15464586  
PMID:15539431   PMID:15766748   PMID:15902305   PMID:16127717   PMID:16137232   PMID:16166646   PMID:16259952   PMID:16380715   PMID:16603706   PMID:16682116   PMID:16940177   PMID:17142311  
PMID:17227882   PMID:17272516   PMID:17360443   PMID:17495229   PMID:17498735   PMID:17548362   PMID:17643447   PMID:17848411   PMID:17975667   PMID:18252717   PMID:18259093   PMID:18400219  
PMID:18439490   PMID:18462699   PMID:19084512   PMID:19162035   PMID:19253817   PMID:19327894   PMID:19546173   PMID:19966502   PMID:20041118   PMID:20123909   PMID:20347099   PMID:20585342  
PMID:20691899   PMID:20705924   PMID:20708014   PMID:20833366   PMID:21029371   PMID:21146513   PMID:21172404   PMID:21179204   PMID:21220346   PMID:21330551   PMID:21379568   PMID:21571865  
PMID:21846294   PMID:22227582   PMID:22228770   PMID:22473995   PMID:22532871   PMID:22674427   PMID:23327965   PMID:23426975   PMID:23558708   PMID:23632743   PMID:24000169   PMID:24015301  
PMID:24268575   PMID:24582939   PMID:24866243   PMID:25000170   PMID:25241353   PMID:25332186   PMID:25501827   PMID:25590961   PMID:25869677   PMID:26100648   PMID:26252173   PMID:26388265  
PMID:26477491   PMID:26962868   PMID:27216460   PMID:27485101   PMID:27569279   PMID:27783597   PMID:28440427   PMID:29325903   PMID:31949236   PMID:34545275   PMID:34773653   PMID:35217336  
PMID:35286985   PMID:35659652   PMID:36694058   PMID:36814152   PMID:37712274  


Genomics

Comparative Map Data
Gata4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,635,572 - 41,707,252 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1541,635,572 - 41,681,609 (-)EnsemblGRCr8
mRatBN7.21537,459,601 - 37,531,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,459,601 - 37,505,636 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1539,312,354 - 39,358,379 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,463,161 - 40,509,184 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,920,232 - 38,966,261 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,386,703 - 46,458,679 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,386,712 - 46,432,965 (-)Ensemblrn6Rnor6.0
Rnor_5.01550,151,497 - 50,197,708 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41542,472,793 - 42,519,569 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1537,143,928 - 37,189,874 (-)NCBICelera
RGSC_v3.11542,488,492 - 42,535,269 (-)NCBI
RH 3.4 Map15261.71RGD
Cytogenetic Map15p12NCBI
GATA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38811,676,935 - 11,760,002 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl811,676,785 - 11,760,002 (+)Ensemblhg38GRCh38
GRCh37811,534,444 - 11,617,511 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,599,162 - 11,654,918 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34811,599,161 - 11,654,918NCBI
Celera810,690,994 - 10,746,848 (+)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef810,492,698 - 10,548,485 (+)NCBIHuRef
CHM1_1811,627,233 - 11,683,005 (+)NCBICHM1_1
T2T-CHM13v2.087,980,285 - 8,063,322 (-)NCBIT2T-CHM13v2.0
Gata4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391463,436,363 - 63,509,161 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1463,436,371 - 63,509,141 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381463,198,914 - 63,271,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,198,922 - 63,271,692 (-)Ensemblmm10GRCm38
MGSCv371463,817,752 - 63,864,097 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361462,153,032 - 62,199,370 (-)NCBIMGSCv36mm8
Celera1460,962,648 - 61,008,982 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.24NCBI
Gata4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540352,987,644 - 53,029,267 (+)Ensembl
ChiLan1.0NW_00495540352,958,318 - 53,029,267 (+)NCBIChiLan1.0ChiLan1.0
GATA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2728,171,698 - 28,227,399 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan184,197,937 - 4,253,651 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v087,442,921 - 7,526,731 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GATA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12526,126,172 - 26,211,474 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2526,127,853 - 26,182,989 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2526,784,428 - 26,835,191 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02526,280,507 - 26,366,154 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2526,280,510 - 26,337,654 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12526,235,249 - 26,286,037 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02526,131,847 - 26,182,607 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02526,283,313 - 26,334,650 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gata4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049435,165,238 - 5,177,602 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366753,412,056 - 3,419,422 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366753,408,549 - 3,420,828 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1414,884,662 - 14,939,941 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11414,858,470 - 14,938,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21416,046,527 - 16,126,816 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GATA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.187,348,145 - 7,432,574 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl87,349,660 - 7,400,562 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605235,034,077 - 35,087,089 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gata4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475825,278,874 - 25,319,318 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475825,278,878 - 25,319,317 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gata4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11261,134,062 - 61,180,630 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gata4
264 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI19188439

Predicted Target Of
Summary Value
Count of predictions:234
Count of miRNA genes:153
Interacting mature miRNAs:188
Transcripts:ENSRNOT00000014320
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH94862  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,459,757 - 37,459,931 (+)MAPPERmRatBN7.2
Rnor_6.01546,386,862 - 46,387,035NCBIRnor6.0
Rnor_5.01550,151,656 - 50,151,829UniSTSRnor5.0
RGSC_v3.41542,472,950 - 42,473,123UniSTSRGSC3.4
Celera1537,144,085 - 37,144,258UniSTS
RH 3.4 Map15261.71UniSTS
Cytogenetic Map15p12UniSTS
Gata4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,461,088 - 37,462,178 (+)MAPPERmRatBN7.2
Rnor_6.01546,388,193 - 46,389,282NCBIRnor6.0
Rnor_5.01550,152,987 - 50,154,076UniSTSRnor5.0
RGSC_v3.41542,474,281 - 42,475,370UniSTSRGSC3.4
Celera1537,145,416 - 37,146,505UniSTS
Cytogenetic Map15p12UniSTS
Gata4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,463,987 - 37,465,196 (+)MAPPERmRatBN7.2
Rnor_6.01546,391,092 - 46,392,300NCBIRnor6.0
Rnor_5.01550,155,886 - 50,157,094UniSTSRnor5.0
RGSC_v3.41542,477,180 - 42,478,388UniSTSRGSC3.4
Celera1537,148,315 - 37,149,523UniSTS
Cytogenetic Map15p12UniSTS
Gata4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,461,101 - 37,462,231 (+)MAPPERmRatBN7.2
Rnor_6.01546,388,206 - 46,389,335NCBIRnor6.0
Rnor_5.01550,153,000 - 50,154,129UniSTSRnor5.0
RGSC_v3.41542,474,294 - 42,475,423UniSTSRGSC3.4
Celera1537,145,429 - 37,146,558UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 7 61 58 86 87 59 23 59 1 221 102 1 42 47 69 28 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000014320   ⟹   ENSRNOP00000014320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1541,635,572 - 41,681,609 (-)Ensembl
mRatBN7.2 Ensembl1537,459,601 - 37,505,636 (-)Ensembl
Rnor_6.0 Ensembl1546,386,712 - 46,432,965 (-)Ensembl
RefSeq Acc Id: NM_144730   ⟹   NP_653331
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81541,635,572 - 41,681,609 (-)NCBI
mRatBN7.21537,459,601 - 37,505,636 (-)NCBI
Rnor_6.01546,386,705 - 46,432,914 (-)NCBI
Rnor_5.01550,151,497 - 50,197,708 (-)NCBI
RGSC_v3.41542,472,793 - 42,519,569 (-)RGD
Celera1537,143,928 - 37,189,874 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252189   ⟹   XP_006252251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81541,635,572 - 41,681,695 (-)NCBI
mRatBN7.21537,459,601 - 37,505,713 (-)NCBI
Rnor_6.01546,386,703 - 46,433,144 (-)NCBI
Rnor_5.01550,151,497 - 50,197,708 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599788   ⟹   XP_017455277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81541,635,572 - 41,707,252 (-)NCBI
mRatBN7.21537,459,601 - 37,531,291 (-)NCBI
Rnor_6.01546,386,703 - 46,458,679 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063274589   ⟹   XP_063130659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81541,635,572 - 41,707,252 (-)NCBI
RefSeq Acc Id: NP_653331   ⟸   NM_144730
- UniProtKB: P46152 (UniProtKB/Swiss-Prot),   A6K6F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252251   ⟸   XM_006252189
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017455277   ⟸   XM_017599788
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000014320   ⟸   ENSRNOT00000014320
RefSeq Acc Id: XP_063130659   ⟸   XM_063274589
- Peptide Label: isoform X2
- UniProtKB: P46152 (UniProtKB/Swiss-Prot),   A6K6F9 (UniProtKB/TrEMBL)
Protein Domains
GATA-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46152-F1-model_v2 AlphaFold P46152 1-440 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699777
Promoter ID:EPDNEW_R10299
Type:multiple initiation site
Name:Gata4_1
Description:GATA binding protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01546,432,946 - 46,433,006EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2665 AgrOrtholog
BioCyc Gene G2FUF-13435 BioCyc
Ensembl Genes ENSRNOG00000010708 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014320 ENTREZGENE
  ENSRNOT00000014320.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.50.10 UniProtKB/Swiss-Prot
InterPro GATA_N UniProtKB/Swiss-Prot
  TF_GATA_4/5/6 UniProtKB/Swiss-Prot
  Transcription_factor_GATA UniProtKB/Swiss-Prot
  Znf_GATA UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:54254 UniProtKB/Swiss-Prot
NCBI Gene 54254 ENTREZGENE
PANTHER PTHR10071 UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR GATA-4 UniProtKB/Swiss-Prot
Pfam GATA UniProtKB/Swiss-Prot
  GATA-N UniProtKB/Swiss-Prot
PhenoGen Gata4 PhenoGen
PIRSF TF_GATA_4/5/6 UniProtKB/Swiss-Prot
PRINTS GATAZNFINGER UniProtKB/Swiss-Prot
PROSITE GATA_ZN_FINGER_1 UniProtKB/Swiss-Prot
  GATA_ZN_FINGER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010708 RatGTEx
SMART ZnF_GATA UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
TIGR TC204221
UniProt A4K500_RAT UniProtKB/TrEMBL
  A6K6F9 ENTREZGENE, UniProtKB/TrEMBL
  GATA4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gata4  GATA-binding protein 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a DNA binding domain composed of two conserved zinc fingers 625524
gene_process may mediate hypertrophic signaling in cardiac myocytes 625524
gene_process plays a role in the cardiac muscle development during embryogenesis 625524