Gata2 (GATA binding protein 2) - Rat Genome Database

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Gene: Gata2 (GATA binding protein 2) Rattus norvegicus
Analyze
Symbol: Gata2
Name: GATA binding protein 2
RGD ID: 2664
Description: Enables sequence-specific DNA binding activity. Involved in several processes, including cochlea development; positive regulation of transcription by RNA polymerase II; and regulation of vesicle-mediated transport. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; depressive disorder; immunodeficiency 21; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 17alpha-ethynylestradiol; amiodarone; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endothelial transcription factor GATA-2; GATA-binding protein 2; GATA-bindning protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84122,211,501 - 122,225,058 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4122,211,829 - 122,225,055 (+)EnsemblGRCr8
mRatBN7.24120,654,205 - 120,667,763 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4120,658,986 - 120,667,761 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4126,131,415 - 126,140,191 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04121,906,173 - 121,914,950 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04120,530,424 - 120,539,200 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04120,129,028 - 120,142,490 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4120,133,713 - 120,142,488 (+)Ensemblrn6Rnor6.0
Rnor_5.04185,369,926 - 185,383,944 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44122,279,753 - 122,288,528 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4109,615,354 - 109,624,129 (+)NCBICelera
RGSC_v3.14122,524,233 - 122,533,009 (+)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-m-cresol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
actinomycin D  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
berberine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
Chebulinic acid  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cypermethrin  (EXP)
deguelin  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dicrotophos  (ISO)
digitonin  (ISO)
diisononyl phthalate  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
hemin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manumycin A  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pomalidomide  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
raloxifene  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
Tellimagrandin I  (ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
cell differentiation  (IEA,ISO)
cell differentiation in hindbrain  (ISO)
cell fate commitment  (IBA)
cell fate determination  (ISO)
cell maturation  (ISO)
central nervous system neuron development  (ISO)
cochlea development  (IEP)
commitment of neuronal cell to specific neuron type in forebrain  (ISO)
definitive hemopoiesis  (ISO)
DNA-templated transcription  (IEA)
embryonic placenta development  (ISO)
eosinophil fate commitment  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
GABAergic neuron differentiation  (ISO)
homeostasis of number of cells within a tissue  (ISO)
inner ear morphogenesis  (ISO)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of macrophage differentiation  (ISO)
negative regulation of myeloid cell differentiation  (ISO)
negative regulation of neural precursor cell proliferation  (ISO)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,ISO)
neuron differentiation  (ISO)
neuron fate commitment  (ISO)
neuron migration  (IMP)
phagocytosis  (IEA)
pituitary gland development  (ISO)
positive regulation of angiogenesis  (IBA,ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA,ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of mast cell degranulation  (IMP)
positive regulation of megakaryocyte differentiation  (ISO)
positive regulation of miRNA transcription  (IBA,IEA,ISO)
positive regulation of neuron differentiation  (IMP)
positive regulation of phagocytosis  (IDA)
positive regulation of phagocytosis, engulfment  (IMP)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,IMP,ISO)
regulation of developmental process  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of forebrain neuron differentiation  (ISO)
regulation of primitive erythrocyte differentiation  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to lipid  (IEP)
semicircular canal development  (ISO)
somatic stem cell population maintenance  (ISO)
urogenital system development  (ISO)
vascular wound healing  (IEA,ISO)
ventral spinal cord interneuron differentiation  (ISO)

Cellular Component
cytoplasm  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
transcription regulator complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia. Celton M, etal., Leukemia. 2014 Aug;28(8):1617-26. doi: 10.1038/leu.2014.67. Epub 2014 Feb 11.
2. Overexpression of human GATA-1 and GATA-2 interferes with spine formation and produces depressive behavior in rats. Choi M, etal., PLoS One. 2014 Oct 23;9(10):e109253. doi: 10.1371/journal.pone.0109253. eCollection 2014.
3. GATA-1 and GATA-2 gene expression is related to the severity of dysplasia in myelodysplastic syndrome. Fadilah SA, etal., Leukemia. 2002 Aug;16(8):1563-5.
4. Decreased expression of transcription factor GATA-2 in haematopoietic stem cells in patients with aplastic anaemia. Fujimaki S, etal., Br J Haematol. 2001 Apr;113(1):52-7.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture. Gross J, etal., Hear Res. 2010 Mar;261(1-2):9-21. doi: 10.1016/j.heares.2009.12.017. Epub 2009 Dec 16.
8. GATA2 mutations in patients with acute myeloid leukemia-paired samples analyses show that the mutation is unstable during disease evolution. Hou HA, etal., Ann Hematol. 2015 Feb;94(2):211-21. doi: 10.1007/s00277-014-2208-8. Epub 2014 Sep 21.
9. Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Hsu AP, etal., Blood. 2011 Sep 8;118(10):2653-5. doi: 10.1182/blood-2011-05-356352. Epub 2011 Jun 13.
10. GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-gamma1. Ishijima Y, etal., Genes Cells. 2012 Apr;17(4):285-301. doi: 10.1111/j.1365-2443.2012.01588.x. Epub 2012 Mar 5.
11. Effect of Transcription Factor GATA-2 on Phagocytic Activity of Alveolar Macrophages from Pneumocystis carinii-Infected Hosts. Lasbury ME, etal., Infect Immun 2003 Sep;71(9):4943-52.
12. Effect of the transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts. Lasbury ME, etal., J Eukaryot Microbiol 2001;Suppl:158S-159S.
13. Retinoid receptor-specific agonists alleviate experimental glomerulonephritis. Lehrke I, etal., Am J Physiol Renal Physiol. 2002 Apr;282(4):F741-51.
14. Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning. Lim KC, etal., J Clin Invest. 2012 Oct;122(10):3705-17. doi: 10.1172/JCI61619. Epub 2012 Sep 10.
15. High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia. Luesink M, etal., Blood. 2012 Sep 6;120(10):2064-75. doi: 10.1182/blood-2011-12-397083. Epub 2012 Jul 11.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
20. Decreased mRNA expression of GATA1 and GATA2 is associated with tumor aggressiveness and poor outcome in clear cell renal cell carcinoma. Peters I, etal., Target Oncol. 2015 Jun;10(2):267-75. doi: 10.1007/s11523-014-0335-8. Epub 2014 Sep 19.
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2. Sakuma K, etal., Acta Neuropathol. 2003 Mar;105(3):271-80. Epub 2002 Dec 19.
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
28. Simple and effective method for generating single-stranded DNA targets and probes. Tang X, etal., Biotechniques. 2006 Jun;40(6):759-63.
29. Decoy oligodeoxynucleotide characterization of transcription factors controlling endothelin-B receptor expression in vascular smooth muscle cells. Wagner AH, etal., Mol Pharmacol. 2000 Dec;58(6):1333-40.
30. Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin. Whigham CA, etal., Sci Rep. 2019 Jan 18;9(1):235. doi: 10.1038/s41598-018-36645-0.
31. Gata2 is required for migration and differentiation of retinorecipient neurons in the superior colliculus. Willett RT and Greene LA, J Neurosci. 2011 Mar 23;31(12):4444-55. doi: 10.1523/JNEUROSCI.4616-10.2011.
32. GATA-2 L359 V mutation is exclusively associated with CML progression but not other hematological malignancies and GATA-2 P250A is a novel single nucleotide polymorphism. Zhang SJ, etal., Leuk Res. 2009 Aug;33(8):1141-3. doi: 10.1016/j.leukres.2009.02.025. Epub 2009 Mar 21.
Additional References at PubMed
PMID:7720565   PMID:8078582   PMID:9043071   PMID:9305891   PMID:9822612   PMID:10357893   PMID:10367888   PMID:10934027   PMID:12023274   PMID:12045236   PMID:12483298   PMID:12530967  
PMID:14504093   PMID:14512418   PMID:14973276   PMID:15016828   PMID:15489334   PMID:15811962   PMID:16082385   PMID:16153155   PMID:16254139   PMID:16543408   PMID:16621992   PMID:16672344  
PMID:17948249   PMID:17962413   PMID:18184866   PMID:18653622   PMID:18779319   PMID:19088086   PMID:19242469   PMID:19323994   PMID:19357811   PMID:20206639   PMID:20652952   PMID:20705609  
PMID:21245044   PMID:21571865   PMID:21788589   PMID:22499991   PMID:22991444   PMID:23211524   PMID:27780851  


Genomics

Comparative Map Data
Gata2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84122,211,501 - 122,225,058 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4122,211,829 - 122,225,055 (+)EnsemblGRCr8
mRatBN7.24120,654,205 - 120,667,763 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4120,658,986 - 120,667,761 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4126,131,415 - 126,140,191 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04121,906,173 - 121,914,950 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04120,530,424 - 120,539,200 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04120,129,028 - 120,142,490 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4120,133,713 - 120,142,488 (+)Ensemblrn6Rnor6.0
Rnor_5.04185,369,926 - 185,383,944 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44122,279,753 - 122,288,528 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4109,615,354 - 109,624,129 (+)NCBICelera
RGSC_v3.14122,524,233 - 122,533,009 (+)NCBI
Cytogenetic Map4q34NCBI
GATA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383128,479,422 - 128,493,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3128,479,423 - 128,493,208 (-)Ensemblhg38GRCh38
GRCh373128,198,265 - 128,212,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,680,960 - 129,694,718 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343129,680,969 - 129,694,726NCBI
Celera3126,626,234 - 126,639,997 (-)NCBICelera
Cytogenetic Map3q21.3NCBI
HuRef3125,582,307 - 125,596,070 (-)NCBIHuRef
CHM1_13128,161,207 - 128,175,078 (-)NCBICHM1_1
T2T-CHM13v2.03131,220,983 - 131,234,760 (-)NCBIT2T-CHM13v2.0
Gata2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,170,873 - 88,184,014 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl688,170,873 - 88,184,014 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38688,193,891 - 88,207,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,193,891 - 88,207,032 (+)Ensemblmm10GRCm38
MGSCv37688,148,658 - 88,157,026 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36688,164,309 - 88,172,670 (+)NCBIMGSCv36mm8
Celera690,136,051 - 90,144,243 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map639.2NCBI
Gata2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542915,327,113 - 15,336,460 (+)Ensembl
ChiLan1.0NW_00495542915,326,551 - 15,334,774 (+)NCBIChiLan1.0ChiLan1.0
GATA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22126,405,346 - 126,413,849 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13126,410,062 - 126,418,571 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03125,526,537 - 125,535,649 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13132,890,508 - 132,899,035 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3132,890,508 - 132,899,035 (-)EnsemblpanPan2panpan1.1
GATA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1202,472,251 - 2,488,380 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl202,473,912 - 2,480,991 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha202,508,307 - 2,517,105 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0202,492,701 - 2,501,504 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl202,492,704 - 2,565,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1202,213,473 - 2,222,266 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0202,540,074 - 2,548,847 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0202,500,417 - 2,509,217 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gata2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494220,364,390 - 20,372,921 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936798406,258 - 414,931 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936798406,258 - 414,785 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1371,984,067 - 71,997,619 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11371,981,139 - 71,997,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21379,606,930 - 79,613,715 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GATA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12252,549,112 - 52,562,911 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2252,555,738 - 52,562,909 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041113,794,573 - 113,808,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gata2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624961143,358 - 154,003 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624961147,685 - 155,614 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gata2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1658,117,627 - 58,125,914 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gata2
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:623
Count of miRNA genes:302
Interacting mature miRNAs:357
Transcripts:ENSRNOT00000017240
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat

Markers in Region
BF397922  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24120,663,301 - 120,663,445 (+)MAPPERmRatBN7.2
Rnor_6.04120,138,029 - 120,138,172NCBIRnor6.0
Rnor_5.04185,379,483 - 185,379,626UniSTSRnor5.0
RGSC_v3.44122,284,069 - 122,284,212UniSTSRGSC3.4
Celera4109,619,670 - 109,619,813UniSTS
RH 3.4 Map4715.7UniSTS
Cytogenetic Map4q34-q41UniSTS
RH139419  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24120,666,683 - 120,666,893 (+)MAPPERmRatBN7.2
Rnor_6.04120,141,411 - 120,141,620NCBIRnor6.0
Rnor_5.04185,382,865 - 185,383,074UniSTSRnor5.0
RGSC_v3.44122,287,451 - 122,287,660UniSTSRGSC3.4
Celera4109,623,052 - 109,623,261UniSTS
Cytogenetic Map4q34-q41UniSTS
RH140357  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24120,667,412 - 120,667,533 (+)MAPPERmRatBN7.2
Rnor_6.04120,142,140 - 120,142,260NCBIRnor6.0
Rnor_5.04185,383,594 - 185,383,714UniSTSRnor5.0
RGSC_v3.44122,288,180 - 122,288,300UniSTSRGSC3.4
Celera4109,623,781 - 109,623,901UniSTS
RH 3.4 Map4714.6UniSTS
Cytogenetic Map4q34-q41UniSTS
PMC58532P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84122,222,653 - 122,223,363 (+)Marker Load Pipeline
mRatBN7.24120,665,358 - 120,666,068 (+)MAPPERmRatBN7.2
Rnor_6.04120,140,086 - 120,140,795NCBIRnor6.0
Rnor_5.04185,381,540 - 185,382,249UniSTSRnor5.0
RGSC_v3.44122,286,126 - 122,286,835UniSTSRGSC3.4
Celera4109,621,727 - 109,622,436UniSTS
Cytogenetic Map4q34-q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 153 91 90 59 88 59 6 352 188 11 132 81 92 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000017240   ⟹   ENSRNOP00000017240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4122,211,829 - 122,225,055 (+)Ensembl
mRatBN7.2 Ensembl4120,658,986 - 120,667,761 (+)Ensembl
Rnor_6.0 Ensembl4120,133,713 - 120,142,488 (+)Ensembl
RefSeq Acc Id: NM_033442   ⟹   NP_254277
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84122,216,281 - 122,225,056 (+)NCBI
mRatBN7.24120,658,986 - 120,667,761 (+)NCBI
Rnor_6.04120,133,713 - 120,142,488 (+)NCBI
Rnor_5.04185,369,926 - 185,383,944 (+)NCBI
RGSC_v3.44122,279,753 - 122,288,528 (+)RGD
Celera4109,615,354 - 109,624,129 (+)RGD
Sequence:
RefSeq Acc Id: XM_017592480   ⟹   XP_017447969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84122,211,501 - 122,225,058 (+)NCBI
mRatBN7.24120,654,205 - 120,667,763 (+)NCBI
Rnor_6.04120,129,028 - 120,142,490 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107091   ⟹   XP_038963019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84122,211,501 - 122,225,058 (+)NCBI
mRatBN7.24120,654,205 - 120,667,763 (+)NCBI
RefSeq Acc Id: NP_254277   ⟸   NM_033442
- UniProtKB: Q8VHY4 (UniProtKB/Swiss-Prot),   Q924Y4 (UniProtKB/Swiss-Prot),   B2DBE1 (UniProtKB/TrEMBL),   A6IB40 (UniProtKB/TrEMBL),   B2DBE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447969   ⟸   XM_017592480
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000017240   ⟸   ENSRNOT00000017240
RefSeq Acc Id: XP_038963019   ⟸   XM_039107091
- Peptide Label: isoform X1
Protein Domains
GATA-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924Y4-F1-model_v2 AlphaFold Q924Y4 1-480 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2664 AgrOrtholog
BioCyc Gene G2FUF-43821 BioCyc
Ensembl Genes ENSRNOG00000012347 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017240 ENTREZGENE
  ENSRNOT00000017240.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.50.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599740 IMAGE-MGC_LOAD
InterPro TF_GATA-2/3 UniProtKB/Swiss-Prot
  Transcription_factor_GATA UniProtKB/Swiss-Prot
  Znf_GATA UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:25159 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72369 IMAGE-MGC_LOAD
NCBI Gene 25159 ENTREZGENE
PANTHER PTHR10071 UniProtKB/Swiss-Prot
  PTHR10071:SF149 UniProtKB/Swiss-Prot
Pfam GATA UniProtKB/Swiss-Prot
PhenoGen Gata2 PhenoGen
PIRSF TF_GATA-1/2/3 UniProtKB/Swiss-Prot
PRINTS GATAZNFINGER UniProtKB/Swiss-Prot
PROSITE GATA_ZN_FINGER_1 UniProtKB/Swiss-Prot
  GATA_ZN_FINGER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012347 RatGTEx
SMART ZnF_GATA UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
UniProt A6IB40 ENTREZGENE, UniProtKB/TrEMBL
  B2DBE1 ENTREZGENE
  B2DBE2 ENTREZGENE, UniProtKB/TrEMBL
  GATA2_RAT UniProtKB/Swiss-Prot
  Q8VHY4 ENTREZGENE
  Q924Y4 ENTREZGENE
UniProt Secondary Q8VHY4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gata2  GATA-bindning protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process expression involved in regulation of phagocytosis in alveolar macrophages during Pneumocystis carinii infection 632788