Gadd45a (growth arrest and DNA-damage-inducible, alpha) - Rat Genome Database

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Gene: Gadd45a (growth arrest and DNA-damage-inducible, alpha) Rattus norvegicus
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Symbol: Gadd45a
Name: growth arrest and DNA-damage-inducible, alpha
RGD ID: 2654
Description: Predicted to enable kinase binding activity; promoter-specific chromatin binding activity; and protein dimerization activity. Involved in G2/M transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha); PARTICIPATES IN p38 MAPK signaling pathway; cell cycle pathway, mitotic; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DDIT-1; Ddit1; DNA damage-inducible transcript 1 protein; DNA-damage-inducible transcript 1; Gadd45; growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible 45 alpha; Growth arrest and DNA-damage-inducible protein; growth arrest and DNA-damage-inducible protein GADD45 alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,484,497 - 97,486,799 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl497,484,502 - 97,486,807 (-)EnsemblGRCr8
mRatBN7.2496,154,789 - 96,157,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,154,789 - 96,157,115 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4101,404,229 - 101,406,531 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0497,179,202 - 97,181,504 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0495,604,320 - 95,606,622 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0497,782,512 - 97,784,814 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl497,782,512 - 97,784,842 (-)Ensemblrn6Rnor6.0
Rnor_5.04162,568,472 - 162,570,774 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4496,649,941 - 96,652,243 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera490,851,517 - 90,853,819 (-)NCBICelera
RGSC_v3.1496,894,423 - 96,896,724 (-)NCBI
Cytogenetic Map4q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP,ISO)
2,5-hexanedione  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylcoumarin  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
9,11,13-octadecatrienoic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
acridines  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (ISO)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
atrazine  (ISO)
auraptene  (ISO)
Aurin  (ISO)
azoxystrobin  (ISO)
bacitracin  (EXP)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzyl isothiocyanate  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bortezomib  (EXP,ISO)
brequinar  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcidiol  (EXP)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
casticin  (ISO)
cefaloridine  (EXP)
CHIR 99021  (ISO)
chlordecone  (ISO)
chlornitrofen  (EXP)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chlorotoluron  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
D-penicillamine  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
demethoxycurcumin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibenz[a,j]acridine  (ISO)
Dibenz[c,h]acridine  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dicyclanil  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
Diglycolic acid  (EXP,ISO)
dihydroartemisinin  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
ethylparaben  (ISO)
etoposide  (ISO)
eugenol  (EXP)
fenamidone  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
ferric oxide  (EXP)
fluoranthene  (ISO)
flutamide  (EXP,ISO)
fluxapyroxad  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fotemustine  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furazolidone  (ISO)
furosemide  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
gliotoxin  (EXP)
glyphosate  (ISO)
graphite  (EXP)
GSK-J4  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hydroxytyrosol  (ISO)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
idarubicin  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
iprodione  (ISO)
irinotecan  (EXP)
iron dichloride  (ISO)
isobutanol  (ISO)
isoniazide  (EXP)
josamycin  (ISO)
kainic acid  (EXP)
ketoconazole  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
leflunomide  (EXP,ISO)
leptomycin B  (ISO)
Licochalcone B  (ISO)
limonene  (EXP)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lupeol  (ISO)
mancozeb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
MeIQx  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
Mitotane  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
myristicin  (ISO)
Myrtucommulone A  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naloxone  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP,ISO)
nimesulide  (EXP)
nitenpyram  (ISO)
nitrofen  (EXP)
Nodularin  (ISO)
Nonidet P-40  (ISO)
nonivamide  (ISO)
Nutlin-3  (ISO)
o-xylene  (ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
Paraoxon-methyl  (ISO)
paraquat  (EXP,ISO)
parathion-methyl  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorobutyric acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phalloidin  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pinostrobin  (ISO)
pinosylvin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propanal  (ISO)
Ptaquiloside  (ISO)
pyrazinecarboxamide  (EXP)
pyrethrins  (ISO)
quartz  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
quinoline yellow  (ISO)
quinomethionate  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
raspberry ketone  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
riddelliine  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S63845  (ISO)
Salinomycin  (ISO)
sarin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
theaflavin  (ISO)
thiabendazole  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tobramycin  (ISO)
toluene  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trans-caffeic acid  (ISO)
trans-pinosylvin  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
VX nerve agent  (ISO)
XAV939  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nuclear speck  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signaling. Meyer NJ, etal., FASEB J. 2009 May;23(5):1325-37. Epub 2009 Jan 5.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Tran H, etal., Science 2002 Apr 19;296(5567):530-4.
11. Cloning of rat GADD45 gene and induction analysis following ionizing radiation in vivo. Yoshida T, etal., FEBS Lett 1996 Feb 12;380(1-2):87-92.
12. Cloning of the rat Gadd45 cDNA and its mRNA expression in the brain. Yoshida T, etal., Gene 1994 Dec 30;151(1-2):253-5.
Additional References at PubMed
PMID:9827804   PMID:10097101   PMID:12124778   PMID:12477932   PMID:15123655   PMID:15561781   PMID:17917095   PMID:19593445   PMID:19648647   PMID:19796622   PMID:20160708   PMID:20424134  
PMID:20460379   PMID:21337369   PMID:21396734   PMID:22323595   PMID:22559303   PMID:23227140   PMID:23329839   PMID:24432310   PMID:27086974   PMID:27190312   PMID:28346321   PMID:29244109  
PMID:31009659   PMID:32755658   PMID:36331027  


Genomics

Comparative Map Data
Gadd45a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,484,497 - 97,486,799 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl497,484,502 - 97,486,807 (-)EnsemblGRCr8
mRatBN7.2496,154,789 - 96,157,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,154,789 - 96,157,115 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4101,404,229 - 101,406,531 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0497,179,202 - 97,181,504 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0495,604,320 - 95,606,622 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0497,782,512 - 97,784,814 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl497,782,512 - 97,784,842 (-)Ensemblrn6Rnor6.0
Rnor_5.04162,568,472 - 162,570,774 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4496,649,941 - 96,652,243 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera490,851,517 - 90,853,819 (-)NCBICelera
RGSC_v3.1496,894,423 - 96,896,724 (-)NCBI
Cytogenetic Map4q31NCBI
GADD45A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38167,685,201 - 67,688,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl167,685,201 - 67,688,334 (+)Ensemblhg38GRCh38
GRCh37168,150,884 - 68,154,017 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36167,923,471 - 67,926,607 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34167,862,903 - 67,866,040NCBI
Celera166,441,746 - 66,444,882 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef166,261,120 - 66,264,281 (+)NCBIHuRef
CHM1_1168,265,339 - 68,268,500 (+)NCBICHM1_1
T2T-CHM13v2.0167,562,720 - 67,565,853 (+)NCBIT2T-CHM13v2.0
Gadd45a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39667,012,080 - 67,014,391 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl667,012,080 - 67,014,441 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38667,035,096 - 67,037,407 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl667,035,096 - 67,037,457 (-)Ensemblmm10GRCm38
MGSCv37666,985,090 - 66,987,401 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36666,964,674 - 66,966,985 (-)NCBIMGSCv36mm8
Celera669,156,594 - 69,158,906 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map630.72NCBI
Gadd45a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542323,656,458 - 23,658,367 (-)Ensembl
ChiLan1.0NW_00495542323,656,516 - 23,658,367 (-)NCBIChiLan1.0ChiLan1.0
GADD45A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21159,181,009 - 159,184,168 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11158,340,738 - 158,343,876 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0166,925,063 - 66,928,222 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1168,880,912 - 68,884,188 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl168,880,912 - 68,884,188 (+)EnsemblpanPan2panpan1.1
GADD45A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1677,393,026 - 77,396,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl677,393,036 - 77,396,618 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha680,002,561 - 80,006,283 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0677,992,921 - 77,996,356 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl677,992,931 - 77,996,499 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1677,573,227 - 77,576,562 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0677,441,881 - 77,445,351 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0677,928,564 - 77,931,987 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gadd45a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505880,488,019 - 80,491,186 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365913,998,340 - 4,001,830 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365913,998,359 - 4,001,491 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GADD45A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6144,940,697 - 144,944,089 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16144,940,702 - 144,944,089 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GADD45A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12065,422,668 - 65,425,845 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2065,422,451 - 65,425,840 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603352,186,272 - 52,189,568 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gadd45a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474227,727,660 - 27,730,316 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474227,727,801 - 27,730,252 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gadd45a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1676,571,662 - 76,573,976 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gadd45a
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:66
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000007698
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
2317587Eae26Experimental allergic encephalomyelitis QTL 26nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)489986808101226978Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
RH134659  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2496,154,966 - 96,155,158 (+)MAPPERmRatBN7.2
mRatBN7.245,045,547 - 5,045,737 (-)MAPPERmRatBN7.2
Rnor_6.043,206,849 - 3,207,038NCBIRnor6.0
Rnor_6.0497,782,690 - 97,782,881NCBIRnor6.0
Rnor_5.043,256,390 - 3,256,579UniSTSRnor5.0
Rnor_5.04162,568,650 - 162,568,841UniSTSRnor5.0
RGSC_v3.4496,650,119 - 96,650,310UniSTSRGSC3.4
RGSC_v3.44244,921 - 245,110UniSTSRGSC3.4
Celera45,261,302 - 5,261,491UniSTS
Celera490,851,695 - 90,851,886UniSTS
Cytogenetic Map4q31-q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000007698   ⟹   ENSRNOP00000007698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl497,484,502 - 97,486,799 (-)Ensembl
mRatBN7.2 Ensembl496,154,789 - 96,157,115 (-)Ensembl
Rnor_6.0 Ensembl497,782,512 - 97,784,842 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102107   ⟹   ENSRNOP00000084463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl497,485,139 - 97,486,807 (-)Ensembl
mRatBN7.2 Ensembl496,154,942 - 96,157,115 (-)Ensembl
RefSeq Acc Id: NM_024127   ⟹   NP_077041
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,484,497 - 97,486,799 (-)NCBI
mRatBN7.2496,154,789 - 96,157,091 (-)NCBI
Rnor_6.0497,782,512 - 97,784,814 (-)NCBI
Rnor_5.04162,568,472 - 162,570,774 (-)NCBI
RGSC_v3.4496,649,941 - 96,652,243 (-)RGD
Celera490,851,517 - 90,853,819 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077041 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA96332 (Get FASTA)   NCBI Sequence Viewer  
  AAB02030 (Get FASTA)   NCBI Sequence Viewer  
  AAH81795 (Get FASTA)   NCBI Sequence Viewer  
  BAG30818 (Get FASTA)   NCBI Sequence Viewer  
  BAG30819 (Get FASTA)   NCBI Sequence Viewer  
  EDL91582 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007698
GenBank Protein P48317 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077041   ⟸   NM_024127
- UniProtKB: P48317 (UniProtKB/Swiss-Prot),   Q66HL6 (UniProtKB/TrEMBL),   B2DBD9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007698   ⟸   ENSRNOT00000007698
Ensembl Acc Id: ENSRNOP00000084463   ⟸   ENSRNOT00000102107
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48317-F1-model_v2 AlphaFold P48317 1-165 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693102
Promoter ID:EPDNEW_R3626
Type:multiple initiation site
Name:Gadd45a_1
Description:growth arrest and DNA-damage-inducible, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0497,784,822 - 97,784,882EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2654 AgrOrtholog
BioCyc Gene G2FUF-44579 BioCyc
Ensembl Genes ENSRNOG00000005615 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007698 ENTREZGENE
Gene3D-CATH 3.30.1330.30 UniProtKB/Swiss-Prot
InterPro GADD45 UniProtKB/Swiss-Prot
  L30e-like UniProtKB/Swiss-Prot
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/Swiss-Prot
NCBI Gene 25112 ENTREZGENE
PANTHER GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA UniProtKB/Swiss-Prot
  PTHR10411 UniProtKB/Swiss-Prot
Pfam Ribosomal_L7Ae UniProtKB/Swiss-Prot
PhenoGen Gadd45a PhenoGen
RatGTEx ENSRNOG00000005615 RatGTEx
Superfamily-SCOP SSF55315 UniProtKB/Swiss-Prot
TIGR TC206559
UniProt A0A8I6GBV3_RAT UniProtKB/TrEMBL
  B2DBD9 ENTREZGENE, UniProtKB/TrEMBL
  GA45A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HL6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-14 Gadd45a  growth arrest and DNA-damage-inducible, alpha  Gadd45a  growth arrest and DNA-damage-inducible 45 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Gadd45a  growth arrest and DNA-damage-inducible 45 alpha      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Gadd45a  growth arrest and DNA-damage-inducible 45 alpha      Name updated 70585 PROVISIONAL
2001-04-10 Ddit1  DNA-damage inducible transcript 1      Symbol withdrawn, duplicate entry of Gadd45a (RGD:2654) 61478 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_process stress related protein  
gene_process mediates activation of the p38/JNK pathway via MTK1/MEKK4 kinase  
gene_regulation transcription may be induced by forkhead transcription factor FOXO3a 728684