Gabrb3 (gamma-aminobutyric acid type A receptor subunit beta 3) - Rat Genome Database

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Gene: Gabrb3 (gamma-aminobutyric acid type A receptor subunit beta 3) Rattus norvegicus
Analyze
Symbol: Gabrb3
Name: gamma-aminobutyric acid type A receptor subunit beta 3
RGD ID: 2651
Description: Enables AP-2 adaptor complex binding activity; GABA-A receptor activity; and GABA-gated chloride ion channel activity. Involved in GABAergic synaptic transmission and response to auditory stimulus. Located in several cellular components, including inhibitory synapse; sperm head; and terminal bouton. Part of GABA-A receptor complex. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Biomarker of fetal alcohol spectrum disorder and status epilepticus. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; childhood absence epilepsy; developmental and epileptic encephalopathy 43; and heroin dependence. Orthologous to human GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GABA(A) receptor subunit beta-3; GABA-alpha receptor beta-3 subunit; GABAAR subunit beta-3; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3; Gamma-aminobutyric acid receptor beta 3; gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid receptor, subunit beta 3; gamma-aminobutyric acid type A receptor beta 3 subunit; testis gamma-aminobutyric acid receptor subunit beta 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81117,602,772 - 117,838,230 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1117,431,842 - 117,836,725 (+)EnsemblGRCr8
mRatBN7.21108,467,047 - 108,702,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1108,296,124 - 108,698,961 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1113,838,572 - 114,068,957 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01122,311,079 - 122,541,470 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01115,559,397 - 115,789,792 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01113,034,251 - 113,265,364 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1112,976,770 - 113,265,364 (+)Ensemblrn6Rnor6.0
Rnor_5.01114,042,551 - 114,275,043 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41109,047,399 - 109,277,756 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1102,635,270 - 102,866,355 (+)NCBICelera
RGSC_v3.11109,125,741 - 109,356,099 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3-bis(trifluoromethyl)bicyclo[2.2.1]heptane-2,2-dicarbonitrile  (ISO)
3-chloropropane-1,2-diol  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-hexachlorocyclohexane  (ISO)
Alphaxolone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
bicuculline  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromochloroacetic acid  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clozapine  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
delta-hexachlorocyclohexane  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazepam  (EXP,ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (EXP)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etomidate  (ISO)
felbamate  (ISO)
fipronil  (ISO)
flumazenil  (ISO)
flunitrazepam  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gamma-aminobutyric acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
haloperidol  (EXP)
kainic acid  (ISO)
L-methionine  (ISO)
lanthanum atom  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methylmercury chloride  (ISO)
midazolam  (ISO)
muscimol  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
okadaic acid  (ISO)
oleamide  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
pentobarbital  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picrotoxin  (ISO)
picrotoxinin  (ISO)
propofol  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tert-Butylbicyclophosphorothionate  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zolpidem  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain development  (ISO)
cellular response to histamine  (ISO,ISS)
cellular response to zinc ion  (ISO)
cerebellum development  (ISO)
chloride transmembrane transport  (IBA,IEA,ISO)
chloride transport  (IEA)
circadian sleep/wake cycle, REM sleep  (ISO)
cochlea development  (ISO)
dendrite morphogenesis  (ISO)
dendritic spine organization  (ISO)
excitatory postsynaptic potential  (ISO)
exploration behavior  (ISO)
eye pigmentation  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO,ISS,NAS)
hard palate development  (ISO)
inhibitory chemical synaptic transmission  (ISO)
inhibitory postsynaptic potential  (ISO)
inhibitory synapse assembly  (ISO,ISS)
inner ear auditory receptor cell differentiation  (ISO)
inner ear receptor cell development  (ISO)
innervation  (ISO)
learning  (ISO)
memory  (ISO)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
motor behavior  (ISO)
negative regulation of synaptic transmission, GABAergic  (ISO)
nervous system development  (ISO)
neuromuscular process controlling posture  (ISO)
neuron development  (ISO)
neuron projection morphogenesis  (ISO)
noradrenergic neuron differentiation involved in brainstem development  (ISO)
postsynaptic signal transduction  (ISO)
psychomotor behavior  (ISO)
regulation of dopamine receptor signaling pathway  (ISO)
reproductive behavior  (ISO)
response to anesthetic  (ISO)
response to auditory stimulus  (IEP)
response to ethanol  (IDA)
response to L-glutamate  (ISO)
response to morphine  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
righting reflex  (ISO)
roof of mouth development  (ISO,ISS)
sensory perception of temperature stimulus  (ISO)
sensory perception of touch  (ISO)
social behavior  (ISO)
startle response  (ISO)
synaptic transmission, GABAergic  (IBA,IDA,IEA,ISO,NAS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Atomic force microscopy reveals the stoichiometry and subunit arrangement of the alpha4beta3delta GABA(A) receptor. Barrera NP, etal., Mol Pharmacol. 2008 Mar;73(3):960-7. doi: 10.1124/mol.107.042481. Epub 2007 Dec 13.
2. Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function. Bianchi MT and Macdonald RL, J Physiol 2002 Oct 1;544(Pt 1):3-18.
3. Functional characterization of the new human GABA(A) receptor mutation beta3(R192H). Buhr A, etal., Hum Genet. 2002 Aug;111(2):154-60. Epub 2002 Jul 16.
4. The brefeldin A-inhibited GDP/GTP exchange factor 2, a protein involved in vesicular trafficking, interacts with the beta subunits of the GABA receptors. Charych EI, etal., J Neurochem 2004 Jul;90(1):173-89.
5. Association analysis of GABRB3 promoter variants with heroin dependence. Chen CH, etal., PLoS One. 2014 Jul 15;9(7):e102227. doi: 10.1371/journal.pone.0102227. eCollection 2014.
6. GABAA Receptors and the Diversity in their Structure and Pharmacology. Chua HC and Chebib M, Adv Pharmacol. 2017;79:1-34. doi: 10.1016/bs.apha.2017.03.003. Epub 2017 May 2.
7. Association of gephyrin with synaptic and extrasynaptic GABAA receptors varies during development in cultured hippocampal neurons. Danglot L, etal., Mol Cell Neurosci. 2003 Jun;23(2):264-78.
8. Association of GABRG3 with alcohol dependence. Dick DM, etal., Alcohol Clin Exp Res. 2004 Jan;28(1):4-9. doi: 10.1097/01.ALC.0000108645.54345.98.
9. Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization. Feng HJ and Macdonald RL, J Neurophysiol 2004 Sep;92(3):1577-85. Epub 2004 May 19.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GABAA receptors: structure, function, pharmacology, and related disorders. Ghit A, etal., J Genet Eng Biotechnol. 2021 Aug 21;19(1):123. doi: 10.1186/s43141-021-00224-0.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular β3+β3- interface of homooligomeric β3 GABAA receptors. Hoerbelt P, etal., Neuropharmacology. 2016 Sep;108:252-63. doi: 10.1016/j.neuropharm.2016.04.042. Epub 2016 Apr 30.
14. Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. Kasugai Y, etal., Eur J Neurosci. 2010 Dec;32(11):1868-88. doi: 10.1111/j.1460-9568.2010.07473.x. Epub 2010 Nov 14.
15. Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Kittler JT, etal., Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14871-6. Epub 2005 Sep 28.
16. Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer. Laverty D, etal., Nature. 2019 Jan;565(7740):516-520. doi: 10.1038/s41586-018-0833-4. Epub 2019 Jan 2.
17. Heroin addiction in African Americans: a hypothesis-driven association study. Levran O, etal., Genes Brain Behav. 2009 Jul;8(5):531-40. Epub 2009 Jun 20.
18. Identification and characterization of a novel splice variant of beta3 subunit of GABA(A) receptor in rat testis and spermatozoa. Li SF, etal., Int J Biochem Cell Biol. 2005 Feb;37(2):350-60.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Changes in excitatory and inhibitory receptor expression and network activity during induction and establishment of epilepsy in the rat Reduced Intensity Status Epilepticus (RISE) model. Needs HI, etal., Neuropharmacology. 2019 Nov 1;158:107728. doi: 10.1016/j.neuropharm.2019.107728. Epub 2019 Jul 26.
21. Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors. Neelands TR and Macdonald RL, Mol Pharmacol. 1999 Sep;56(3):598-610. doi: 10.1124/mol.56.3.598.
22. D2 dopamine receptor and GABA(A) receptor beta3 subunit genes and alcoholism. Noble EP, etal., Psychiatry Res. 1998 Nov 16;81(2):133-47. doi: 10.1016/s0165-1781(98)00084-5.
23. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. Nusser Z, etal., J Neurosci. 1998 Mar 1;18(5):1693-703.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
26. Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn. Polgár E and Todd AJ, Neuroscience. 2008 Sep 22;156(1):193-202. doi: 10.1016/j.neuroscience.2008.07.009. Epub 2008 Jul 10.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry.PG - 241-57 Saha S, etal., Mol Cell Neurosci 2001 Jan;17(1):241-57.
31. Histaminergic pharmacology of homo-oligomeric β3 γ-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology. Seeger C, etal., Biochem Pharmacol. 2012 Aug 1;84(3):341-51. doi: 10.1016/j.bcp.2012.04.008. Epub 2012 Apr 15.
32. Deletion of TLR-4 attenuates fetal alcohol exposure-induced gene expression and social interaction deficits. Shukla PK, etal., Alcohol. 2018 Dec;73:73-78. doi: 10.1016/j.alcohol.2018.04.004. Epub 2018 Apr 18.
33. Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Smith KR, etal., Mol Cell Neurosci. 2010 Aug;44(4):330-41. doi: 10.1016/j.mcn.2010.04.004. Epub 2010 Apr 22.
34. Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. Tunc-Ozcan E, etal., Alcohol Clin Exp Res. 2013 Nov;37(11):1986-95. doi: 10.1111/acer.12183. Epub 2013 Jun 13.
35. A GABRB3 promoter haplotype associated with childhood absence epilepsy impairs transcriptional activity. Urak L, etal., Hum Mol Genet. 2006 Aug 15;15(16):2533-41. Epub 2006 Jul 11.
36. The GABAA receptor beta 3 subunit gene: characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7. Wagstaff J, etal., Genomics 1991 Dec;11(4):1071-8.
37. Early continuous white noise exposure alters l-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit glutamate receptor 2 and gamma-aminobutyric acid type a receptor subunit beta3 protein expression in rat auditory cortex. Xu J, etal., J Neurosci Res. 2010 Feb 15;88(3):614-9. doi: 10.1002/jnr.22232.
38. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Yamasaki T, etal., Neuron. 2017 Mar 8;93(5):1138-1152.e6. doi: 10.1016/j.neuron.2017.02.023.
39. GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. Ymer S, etal., EMBO J 1989 Jun;8(6):1665-70.
Additional References at PubMed
PMID:2540033   PMID:8382702   PMID:9039914   PMID:9108119   PMID:11528422   PMID:12522165   PMID:16537435   PMID:16979397   PMID:17021187   PMID:17317750   PMID:18281286   PMID:19179335  
PMID:19617557   PMID:19846622   PMID:21474450   PMID:21735059   PMID:22215379   PMID:22303015   PMID:22396422   PMID:23205938   PMID:24500446   PMID:24909990   PMID:24992900   PMID:25489750  
PMID:26950270   PMID:27129275   PMID:29706582   PMID:32383536  


Genomics

Comparative Map Data
Gabrb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81117,602,772 - 117,838,230 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1117,431,842 - 117,836,725 (+)EnsemblGRCr8
mRatBN7.21108,467,047 - 108,702,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1108,296,124 - 108,698,961 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1113,838,572 - 114,068,957 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01122,311,079 - 122,541,470 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01115,559,397 - 115,789,792 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01113,034,251 - 113,265,364 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1112,976,770 - 113,265,364 (+)Ensemblrn6Rnor6.0
Rnor_5.01114,042,551 - 114,275,043 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41109,047,399 - 109,277,756 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1102,635,270 - 102,866,355 (+)NCBICelera
RGSC_v3.11109,125,741 - 109,356,099 (+)NCBI
Cytogenetic Map1q22NCBI
GABRB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381526,543,552 - 26,773,763 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1526,543,552 - 26,939,539 (-)Ensemblhg38GRCh38
GRCh371526,788,699 - 27,018,910 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361524,339,786 - 24,570,020 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341524,342,555 - 24,570,020NCBI
Celera154,950,603 - 5,179,865 (-)NCBICelera
Cytogenetic Map15q12NCBI
HuRef154,917,779 - 5,148,361 (-)NCBIHuRef
CHM1_11526,738,348 - 26,968,576 (-)NCBICHM1_1
T2T-CHM13v2.01524,283,987 - 24,515,087 (-)NCBIT2T-CHM13v2.0
Gabrb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39757,240,266 - 57,478,550 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl757,069,440 - 57,478,550 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38757,590,518 - 57,828,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl757,419,692 - 57,828,802 (+)Ensemblmm10GRCm38
MGSCv37764,845,904 - 65,084,172 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36757,458,398 - 57,696,666 (+)NCBIMGSCv36mm8
Celera754,911,328 - 55,150,383 (+)NCBICelera
Cytogenetic Map7B5NCBI
cM Map733.53NCBI
Gabrb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555332,573,599 - 2,938,952 (+)Ensembl
ChiLan1.0NW_0049555332,879,437 - 2,938,952 (+)NCBIChiLan1.0ChiLan1.0
GABRB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2168,504,014 - 8,732,012 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11512,144,864 - 12,373,305 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0153,129,481 - 3,357,495 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11523,981,359 - 24,201,975 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1523,981,359 - 24,058,357 (-)EnsemblpanPan2panpan1.1
GABRB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1333,878,948 - 34,101,987 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl333,878,904 - 34,097,764 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha336,567,998 - 36,799,821 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0334,213,315 - 34,437,878 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl334,213,156 - 34,436,244 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1333,753,749 - 33,985,358 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0334,016,414 - 34,241,830 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0334,163,761 - 34,395,684 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gabrb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640122,077,313 - 122,344,190 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647139,791,613 - 40,187,923 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647139,791,633 - 40,193,049 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1140,566,540 - 140,905,623 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11140,566,443 - 140,906,516 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GABRB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12655,319,667 - 55,543,116 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2655,471,907 - 55,538,855 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605438,152,669 - 38,377,691 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabrb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624896966,487 - 1,173,625 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624896962,253 - 1,173,842 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gabrb3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12141,460,704 - 141,696,691 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gabrb3
2070 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:45
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000020099, ENSRNOT00000065223
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611131244255Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1111404407142582336Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
D1Arb10  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81117,834,041 - 117,834,434 (+)Marker Load Pipeline
mRatBN7.21108,698,333 - 108,698,726 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,737 - 113,265,129NCBIRnor6.0
Rnor_5.01114,274,416 - 114,274,808UniSTSRnor5.0
RGSC_v3.41109,277,129 - 109,277,521UniSTSRGSC3.4
RGSC_v3.41109,277,128 - 109,277,521RGDRGSC3.4
Celera1102,865,724 - 102,866,120UniSTS
RGSC_v3.11109,355,471 - 109,355,864RGD
FHH x ACI Map155.58UniSTS
FHH x ACI Map155.58RGD
Cytogenetic Map1q22UniSTS
D1Rat268  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81117,823,451 - 117,823,600 (+)Marker Load Pipeline
mRatBN7.21108,687,741 - 108,687,892 (+)MAPPERmRatBN7.2
Rnor_6.01113,254,147 - 113,254,295NCBIRnor6.0
Rnor_5.01114,263,826 - 114,263,974UniSTSRnor5.0
RGSC_v3.41109,266,539 - 109,266,687UniSTSRGSC3.4
RGSC_v3.41109,266,538 - 109,266,687RGDRGSC3.4
Celera1102,855,134 - 102,855,282UniSTS
RGSC_v3.11109,344,881 - 109,345,030RGD
SHRSP x BN Map153.79RGD
SHRSP x BN Map153.79UniSTS
Cytogenetic Map1q22UniSTS
D1Mco65  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,687,678 - 108,687,892 (+)MAPPERmRatBN7.2
Rnor_6.01113,254,084 - 113,254,295NCBIRnor6.0
Rnor_5.01114,263,763 - 114,263,974UniSTSRnor5.0
RGSC_v3.41109,266,476 - 109,266,687UniSTSRGSC3.4
Celera1102,855,071 - 102,855,282UniSTS
Cytogenetic Map1q22UniSTS
D1Mco64  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,580,284 - 108,580,484 (+)MAPPERmRatBN7.2
Rnor_6.01113,146,686 - 113,146,883NCBIRnor6.0
Rnor_5.01114,156,365 - 114,156,562UniSTSRnor5.0
RGSC_v3.41109,159,076 - 109,159,273UniSTSRGSC3.4
Celera1102,747,697 - 102,747,894UniSTS
Cytogenetic Map1q22UniSTS
D1Wox53  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81117,834,215 - 117,834,459 (+)Marker Load Pipeline
mRatBN7.21108,698,507 - 108,698,751 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,911 - 113,265,154NCBIRnor6.0
Rnor_5.01114,274,590 - 114,274,833UniSTSRnor5.0
RGSC_v3.41109,277,303 - 109,277,546UniSTSRGSC3.4
Celera1102,865,898 - 102,866,145UniSTS
Cytogenetic Map1q22UniSTS
RH138257  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,682,588 - 108,682,830 (+)MAPPERmRatBN7.2
Rnor_6.01113,248,993 - 113,249,234NCBIRnor6.0
Rnor_5.01114,258,672 - 114,258,913UniSTSRnor5.0
RGSC_v3.41109,261,385 - 109,261,626UniSTSRGSC3.4
Celera1102,849,987 - 102,850,228UniSTS
Cytogenetic Map1q22UniSTS
AW531506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,653,215 - 108,653,385 (+)MAPPERmRatBN7.2
Rnor_6.01113,219,620 - 113,219,789NCBIRnor6.0
Rnor_5.01114,229,299 - 114,229,468UniSTSRnor5.0
RGSC_v3.41109,232,012 - 109,232,181UniSTSRGSC3.4
Celera1102,820,616 - 102,820,785UniSTS
RH 3.4 Map1967.01UniSTS
Cytogenetic Map1q22UniSTS
BE113547  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,661,984 - 108,662,136 (+)MAPPERmRatBN7.2
Rnor_6.01113,228,389 - 113,228,540NCBIRnor6.0
Rnor_5.01114,238,068 - 114,238,219UniSTSRnor5.0
RGSC_v3.41109,240,781 - 109,240,932UniSTSRGSC3.4
Celera1102,829,385 - 102,829,536UniSTS
RH 3.4 Map1965.91UniSTS
Cytogenetic Map1q22UniSTS
GDB:192789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,698,188 - 108,698,446 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,592 - 113,264,849NCBIRnor6.0
Rnor_5.01114,274,271 - 114,274,528UniSTSRnor5.0
RGSC_v3.41109,276,984 - 109,277,241UniSTSRGSC3.4
Celera1102,865,579 - 102,865,836UniSTS
Cytogenetic Map1q22UniSTS
RH11160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,698,508 - 108,698,648 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,912 - 113,265,051NCBIRnor6.0
Rnor_5.01114,274,591 - 114,274,730UniSTSRnor5.0
RGSC_v3.41109,277,304 - 109,277,443UniSTSRGSC3.4
Celera1102,865,899 - 102,866,042UniSTS
Cytogenetic Map1q22UniSTS
D1Wox53  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81117,834,215 - 117,834,458 (+)Marker Load Pipeline
mRatBN7.21108,698,507 - 108,698,750 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,911 - 113,265,153NCBIRnor6.0
Rnor_5.01114,274,590 - 114,274,832UniSTSRnor5.0
RGSC_v3.41109,277,303 - 109,277,545UniSTSRGSC3.4
Celera1102,865,898 - 102,866,144UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 57 144 64 61 32 33 32 5 233 112 1 133 66 91 29 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000077594   ⟹   ENSRNOP00000071680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,455,915 - 108,698,961 (+)Ensembl
Rnor_6.0 Ensembl1113,034,266 - 113,265,364 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077877   ⟹   ENSRNOP00000073384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,296,124 - 108,698,961 (+)Ensembl
Rnor_6.0 Ensembl1113,034,266 - 113,264,982 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079348   ⟹   ENSRNOP00000070416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,410,949 - 108,455,986 (+)Ensembl
Rnor_6.0 Ensembl1112,976,770 - 113,021,942 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081831   ⟹   ENSRNOP00000071478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,467,112 - 108,698,961 (+)Ensembl
Rnor_6.0 Ensembl1113,034,227 - 113,265,364 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082310   ⟹   ENSRNOP00000069990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1113,033,098 - 113,033,228 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113752   ⟹   ENSRNOP00000085111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1117,594,623 - 117,836,725 (+)Ensembl
mRatBN7.2 Ensembl1108,467,741 - 108,698,961 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120754   ⟹   ENSRNOP00000098380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1117,431,842 - 117,836,725 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120755   ⟹   ENSRNOP00000107168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1117,546,641 - 117,836,725 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000168164   ⟹   ENSRNOP00000100201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1117,602,846 - 117,836,725 (+)Ensembl
RefSeq Acc Id: NM_017065   ⟹   NP_058761
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,603,460 - 117,834,669 (+)NCBI
mRatBN7.21108,467,741 - 108,698,961 (+)NCBI
Rnor_6.01113,034,251 - 113,265,364 (+)NCBI
Rnor_5.01114,042,551 - 114,275,043 (+)NCBI
RGSC_v3.41109,047,399 - 109,277,756 (+)RGD
Celera1102,635,270 - 102,866,355 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101122   ⟹   XP_038957050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,602,772 - 117,838,230 (+)NCBI
mRatBN7.21108,467,047 - 108,702,522 (+)NCBI
RefSeq Acc Id: XM_039101126   ⟹   XP_038957054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,603,736 - 117,838,230 (+)NCBI
mRatBN7.21108,468,017 - 108,702,522 (+)NCBI
RefSeq Acc Id: NP_058761   ⟸   NM_017065
- Peptide Label: precursor
- UniProtKB: P63079 (UniProtKB/Swiss-Prot),   A6KD41 (UniProtKB/TrEMBL),   A0A0G2K131 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070416   ⟸   ENSRNOT00000079348
Ensembl Acc Id: ENSRNOP00000069990   ⟸   ENSRNOT00000082310
Ensembl Acc Id: ENSRNOP00000071680   ⟸   ENSRNOT00000077594
Ensembl Acc Id: ENSRNOP00000073384   ⟸   ENSRNOT00000077877
Ensembl Acc Id: ENSRNOP00000071478   ⟸   ENSRNOT00000081831
RefSeq Acc Id: XP_038957050   ⟸   XM_039101122
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0J9 (UniProtKB/TrEMBL),   A6KD40 (UniProtKB/TrEMBL),   A0A0G2K131 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957054   ⟸   XM_039101126
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K131 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085111   ⟸   ENSRNOT00000113752
Ensembl Acc Id: ENSRNOP00000098380   ⟸   ENSRNOT00000120754
Ensembl Acc Id: ENSRNOP00000100201   ⟸   ENSRNOT00000168164
Ensembl Acc Id: ENSRNOP00000107168   ⟸   ENSRNOT00000120755
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63079-F1-model_v2 AlphaFold P63079 1-473 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2651 AgrOrtholog
BioCyc Gene G2FUF-59441 BioCyc
Ensembl Genes ENSRNOG00000060599 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000113752 ENTREZGENE
  ENSRNOT00000113752.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot
  GABAAb_rcpt UniProtKB/Swiss-Prot
  Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
KEGG Report rno:24922 UniProtKB/Swiss-Prot
NCBI Gene 24922 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PhenoGen Gabrb3 PhenoGen
PRINTS GABAARBETA UniProtKB/Swiss-Prot
  GABAARECEPTR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060599 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A0A0G2K0J9 ENTREZGENE
  A0A0G2K131 ENTREZGENE
  A0ABK0KYR4_RAT UniProtKB/TrEMBL
  A0ABK0L3Y3_RAT UniProtKB/TrEMBL
  A0ABK0L9V4_RAT UniProtKB/TrEMBL
  A6KD40 ENTREZGENE, UniProtKB/TrEMBL
  A6KD41 ENTREZGENE, UniProtKB/TrEMBL
  GBRB3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5XPT5_RAT UniProtKB/TrEMBL
UniProt Secondary P15433 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabrb3  gamma-aminobutyric acid type A receptor subunit beta 3  Gabrb3  gamma-aminobutyric acid type A receptor beta 3 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabrb3  gamma-aminobutyric acid type A receptor beta 3 subunit  Gabrb3  gamma-aminobutyric acid (GABA) A receptor, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Gabrb3  gamma-aminobutyric acid (GABA) A receptor, beta 3  Gabrb3  gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gabrb3  gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3    gamma-aminobutyric acid receptor, subunit beta 3  Name updated 1299863 APPROVED
2002-06-10 Gabrb3  Gamma-aminobutyric acid receptor beta 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to both cytoplasmic and subsynaptic sites of NTS neurons 625528
gene_expression mRNA is expressed in high amounts in nucleus tractus solitarii and protein expression is seen in many areas of the medulla like cuneate, gracile, olivary and spinal trigeminal nuclei 625528
gene_process may mediate inhibitory GABA responses in nucleus tractus solitarii (NTS) in the brain 625528