Fuca1 (alpha-L-fucosidase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Fuca1 (alpha-L-fucosidase 1) Rattus norvegicus
Analyze
Symbol: Fuca1
Name: alpha-L-fucosidase 1
RGD ID: 2636
Description: Enables carbohydrate binding activity and fucosidase activity. Predicted to be involved in fucose metabolic process and glycoside catabolic process. Predicted to be active in lysosome. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in fucosidosis. Orthologous to human FUCA1 (alpha-L-fucosidase 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-L-fucosidase; alpha-L-fucosidase I; alpha-L-fucoside fucohydrolase 1; Fuca; Fucosidase alpha-L-1 tissue; fucosidase, alpha-L- 1, tissue; Fucosidase, alpha-L-1, tissue; tissue alpha-L-fucosidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,436,262 - 153,453,512 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5153,436,248 - 153,453,511 (+)EnsemblGRCr8
mRatBN7.25148,152,718 - 148,169,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,152,700 - 148,169,972 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5150,851,447 - 150,868,992 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,625,717 - 152,643,262 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,607,730 - 152,625,275 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,269,296 - 154,286,545 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,269,118 - 154,286,544 (+)Ensemblrn6Rnor6.0
Rnor_5.05158,034,147 - 158,051,397 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45154,703,722 - 154,720,971 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5146,559,858 - 146,577,113 (+)NCBICelera
RGSC_v3.15154,713,770 - 154,731,009 (+)NCBI
RH 3.4 Map51003.4RGD
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP)
capecitabine  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
doxifluridine  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
Evodiamine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gardiquimod  (ISO)
ivermectin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
propiconazole  (EXP)
protein kinase inhibitor  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
lysosome  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Isolation and sequence analysis of a cDNA encoding rat liver alpha-L-fucosidase. Fisher KJ and Aronson NN Jr, Biochem J 1989 Dec 15;264(3):695-701.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Serum enzymes of lysosomal origin as indicators of the metabolic control in diabetes: comparison with glycated hemoglobin and albumin. Goi G, etal., Acta Diabetol Lat. 1986 Apr-Jun;23(2):117-25.
5. Plasma acidic glycohydrolases in insulin-dependent diabetes mellitus. Kohler E, etal., Acta Diabetol Lat. 1981 Jul-Sep;18(3):243-50.
6. Alterations of glycosaminoglycan metabolism in the development of diabetic complications in relation to metabolic control. Komosinska-Vassev K, etal., Clin Chem Lab Med. 2005;43(9):924-9.
7. Characterization of EcoRI mutation in fucosidosis patients: a stop codon in the open reading frame. Kretz KA, etal., J Mol Neurosci. 1989;1(3):177-80.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Effect of diabetes mellitus on selected acid hydrolase activities in human platelets. Leoncini G, etal., Diabete Metab. 1987 Jun;13(3):198-204.
10. Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy. Miralles JM, etal., J Diabetes Complications. 1993 Jul-Sep;7(3):199-203.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
14. In vitro and in vivo alterations of enzymatic glycosylation in diabetes. Rellier N, etal., Life Sci. 1999;64(17):1571-83.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Carbohydrate contents, and glycosidase and glycosyl transferase activities in tissues from streptozotocin diabetic mice. Serrano MA, etal., Comp Biochem Physiol B. 1985;80(3):629-32.
20. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Increases in plasma lysosomal enzymes in type 1 (insulin-dependent) diabetes mellitus: relationship to diabetic complications and glycaemic control. Waters PJ, etal., Diabetologia. 1992 Oct;35(10):991-5.
Additional References at PubMed
PMID:15489334   PMID:19056867   PMID:19666478   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Fuca1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,436,262 - 153,453,512 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5153,436,248 - 153,453,511 (+)EnsemblGRCr8
mRatBN7.25148,152,718 - 148,169,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,152,700 - 148,169,972 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5150,851,447 - 150,868,992 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,625,717 - 152,643,262 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,607,730 - 152,625,275 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,269,296 - 154,286,545 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,269,118 - 154,286,544 (+)Ensemblrn6Rnor6.0
Rnor_5.05158,034,147 - 158,051,397 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45154,703,722 - 154,720,971 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5146,559,858 - 146,577,113 (+)NCBICelera
RGSC_v3.15154,713,770 - 154,731,009 (+)NCBI
RH 3.4 Map51003.4RGD
Cytogenetic Map5q36NCBI
FUCA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,845,077 - 23,868,290 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl123,845,077 - 23,868,356 (-)Ensemblhg38GRCh38
GRCh37124,171,567 - 24,194,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,044,154 - 24,067,408 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34123,916,879 - 23,940,079NCBI
Celera122,500,442 - 22,523,489 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef122,423,234 - 22,446,489 (-)NCBIHuRef
CHM1_1124,284,300 - 24,307,588 (-)NCBICHM1_1
T2T-CHM13v2.0123,680,157 - 23,703,377 (-)NCBIT2T-CHM13v2.0
Fuca1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394135,648,037 - 135,667,611 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4135,648,046 - 135,667,622 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384135,920,726 - 135,940,300 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4135,920,735 - 135,940,311 (+)Ensemblmm10GRCm38
MGSCv374135,476,641 - 135,496,215 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364135,192,833 - 135,212,389 (+)NCBIMGSCv36mm8
Celera4134,121,527 - 134,141,456 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.01NCBI
Fuca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,744,755 - 3,759,676 (-)Ensembl
ChiLan1.0NW_0049554523,744,071 - 3,759,776 (-)NCBIChiLan1.0ChiLan1.0
FUCA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21203,072,184 - 203,093,659 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11202,175,209 - 202,196,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0123,039,126 - 23,060,514 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,022,960 - 24,043,850 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,022,967 - 24,043,850 (-)EnsemblpanPan2panpan1.1
FUCA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,665,473 - 75,677,087 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,665,469 - 75,688,629 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha272,235,627 - 72,247,237 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0276,224,732 - 76,236,351 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,224,694 - 76,243,380 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,047,152 - 73,058,769 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,053,782 - 74,065,389 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,059,639 - 75,071,248 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fuca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505843,170,743 - 43,187,687 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364748,996,129 - 9,012,310 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364748,995,525 - 9,012,396 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FUCA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl681,637,994 - 81,656,068 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1681,638,213 - 81,655,993 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2675,370,073 - 75,388,852 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FUCA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120108,823,047 - 108,832,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366648224,561 - 46,953 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fuca1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247648,371,167 - 8,386,134 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247648,371,251 - 8,385,855 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fuca1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1122,291,051 - 22,309,016 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fuca1
121 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000012455
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Mco22  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85153,453,999 - 153,454,250 (+)Marker Load Pipeline
Rnor_5.05158,051,883 - 158,052,146NCBIRnor5.0
RGSC_v3.45154,721,462 - 154,721,724RGDRGSC3.4
RGSC_v3.15154,731,501 - 154,731,763RGD
Cytogenetic Map5q36UniSTS
D5Got277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,160,391 - 148,160,527 (+)MAPPERmRatBN7.2
Rnor_6.05154,276,966 - 154,277,101NCBIRnor6.0
Rnor_5.05158,041,817 - 158,041,952UniSTSRnor5.0
RGSC_v3.45154,711,392 - 154,711,527UniSTSRGSC3.4
Celera5146,567,538 - 146,567,673UniSTS
Cytogenetic Map5q36UniSTS
RH94576  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,169,892 - 148,169,971 (+)MAPPERmRatBN7.2
Rnor_6.05154,286,466 - 154,286,544NCBIRnor6.0
Rnor_5.05158,051,318 - 158,051,396UniSTSRnor5.0
RGSC_v3.45154,720,892 - 154,720,970UniSTSRGSC3.4
Celera5146,577,034 - 146,577,112UniSTS
RH 3.4 Map51003.4UniSTS
Cytogenetic Map5q36UniSTS
AI579525  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map51003.0UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012455   ⟹   ENSRNOP00000012455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5153,436,248 - 153,453,511 (+)Ensembl
mRatBN7.2 Ensembl5148,152,700 - 148,169,972 (+)Ensembl
Rnor_6.0 Ensembl5154,269,118 - 154,286,544 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000169798   ⟹   ENSRNOP00000106361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5153,436,248 - 153,453,511 (+)Ensembl
RefSeq Acc Id: NM_012562   ⟹   NP_036694
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,436,262 - 153,453,512 (+)NCBI
mRatBN7.25148,152,718 - 148,169,972 (+)NCBI
Rnor_6.05154,269,296 - 154,286,545 (+)NCBI
Rnor_5.05158,034,147 - 158,051,397 (+)NCBI
RGSC_v3.45154,703,722 - 154,720,971 (+)RGD
Celera5146,559,858 - 146,577,113 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036694 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81844 (Get FASTA)   NCBI Sequence Viewer  
  CAA34268 (Get FASTA)   NCBI Sequence Viewer  
  EDL80777 (Get FASTA)   NCBI Sequence Viewer  
  EDL80778 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012455
GenBank Protein P17164 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036694   ⟸   NM_012562
- Peptide Label: precursor
- UniProtKB: Q642C6 (UniProtKB/Swiss-Prot),   P17164 (UniProtKB/Swiss-Prot),   A0A0G2JSJ8 (UniProtKB/TrEMBL),   A6IT76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012455   ⟸   ENSRNOT00000012455
Ensembl Acc Id: ENSRNOP00000106361   ⟸   ENSRNOT00000169798
Protein Domains
Alpha-L-fucosidase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17164-F1-model_v2 AlphaFold P17164 1-462 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694161
Promoter ID:EPDNEW_R4685
Type:initiation region
Name:Fuca1_1
Description:alpha-L-fucosidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05154,269,300 - 154,269,360EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2636 AgrOrtholog
BioCyc Gene G2FUF-39524 BioCyc
Ensembl Genes ENSRNOG00000009325 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012455 ENTREZGENE
Gene3D-CATH 2.60.40.1180 UniProtKB/Swiss-Prot
  Glycosidases UniProtKB/Swiss-Prot
InterPro FUC_metazoa-typ UniProtKB/Swiss-Prot
  Fucosidase_C UniProtKB/Swiss-Prot
  Glyco_hydro_29 UniProtKB/Swiss-Prot
  Glyco_hydro_29_CS UniProtKB/Swiss-Prot
  Glyco_hydro_b UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
KEGG Report rno:24375 UniProtKB/Swiss-Prot
NCBI Gene 24375 ENTREZGENE
PANTHER PTHR10030 UniProtKB/Swiss-Prot
  PTHR10030:SF2 UniProtKB/Swiss-Prot
Pfam Alpha_L_fucos UniProtKB/Swiss-Prot
  Fucosidase_C UniProtKB/Swiss-Prot
PhenoGen Fuca1 PhenoGen
PIRSF Alpha-L-fucosidase UniProtKB/Swiss-Prot
PRINTS GLHYDRLASE29 UniProtKB/Swiss-Prot
PROSITE ALPHA_L_FUCOSIDASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009325 RatGTEx
SMART Alpha_L_fucos UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot
TIGR TC217512
UniProt A0A0G2JSJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LX48_RAT UniProtKB/TrEMBL
  A6IT76 ENTREZGENE, UniProtKB/TrEMBL
  FUCO_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q642C6 ENTREZGENE
UniProt Secondary Q642C6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-05 Fuca1  alpha-L-fucosidase 1  Fuca1  fucosidase, alpha-L- 1, tissue  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Fuca1  fucosidase, alpha-L- 1, tissue  Fuca  fucosidase, alpha-L- 1, tissue  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Fuca  Fucosidase, alpha-L-1, tissue    fucosidase, alpha-L-1, tissue  Symbol and Name updated 629477 APPROVED
2003-03-14 Fuca  Fucosidase, alpha-L-1, tissue  Fuca1    Data merged from RGD:620602 628472 PROVISIONAL
2002-08-07 Fuca1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Fuca  Fucosidase, alpha-L-1, tissue      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 632702
gene_homology sequence is 82% similar to human fucosidase 632702
gene_protein 434 amino acid in size, has a high tyrptophan content 632702