RGD Reference Report - Plasma acidic glycohydrolases in insulin-dependent diabetes mellitus. - Rat Genome Database

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Plasma acidic glycohydrolases in insulin-dependent diabetes mellitus.

Authors: Kohler, E  Sheth, KJ  Good, TA 
Citation: Kohler E, etal., Acta Diabetol Lat. 1981 Jul-Sep;18(3):243-50.
RGD ID: 2315949
Pubmed: PMID:7304074   (View Abstract at PubMed)

We assayed plasma activities of beta-galactosidase, beta-hexosaminidase, alpha-fucosidase and alpha-galactosidase involved in degradation of the glycoprotein molecule in 110 insulin-dependent diabetics aged 3-1/2 to 19 years and compared them to a group of normal youngsters. We correlated the plasma enzyme activities with the duration, control and sequelae of insulin-dependent diabetes. Insulin-dependent diabetics had a significantly higher plasma activity of beta-hexosaminidase and alpha-mannosidase (p less than 0.01) and a significantly lower plasma activity of alpha-fucosidase and alpha-galactosidase (p less than 0.01). Of the 5 enzymes studied, only plasma beta-hexosaminidase correlated with fasting and postprandial blood sugar (p less than 0.01), cholesterol and triglycerides (p less than 0.05). Additionally, poor control of diabetes was also associated with a significantly higher plasma beta-hexosaminidase activity (p less than 0.01). Proteinuria or an abnormal Addis count suggestive of renal involvement was associated with various changes in plasma acidic hydrolases. These changes may be related to insulin deficiency rather than hyperglycemia and may be genetically determined.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 1 diabetes mellitus  IEP 2315949protein:decreased activity:plasmaRGD 
type 1 diabetes mellitus  ISOFUCA1 (Homo sapiens)2315949; 2315949protein:decreased activity:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fuca1  (alpha-L-fucosidase 1)

Genes (Mus musculus)
Fuca1  (fucosidase, alpha-L- 1, tissue)

Genes (Homo sapiens)
FUCA1  (alpha-L-fucosidase 1)


Additional Information