Prl8a2 (prolactin family 8, subfamily A, member 2) - Rat Genome Database

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Gene: Prl8a2 (prolactin family 8, subfamily A, member 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prl8a2
Name: prolactin family 8, subfamily A, member 2
RGD ID: 2516
Description: Predicted to enable hormone activity and prolactin receptor binding activity. Involved in female pregnancy. Predicted to be located in extracellular region. Predicted to be active in extracellular space; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: d/tPRP; decidual prolactin-related protein; decidual/trophoblast prolactin-related protein; Dprp; Dtprp; Ghd12; growth hormone d12
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81737,821,651 - 37,830,676 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1737,821,651 - 37,830,676 (-)EnsemblGRCr8
mRatBN7.21737,613,263 - 37,622,288 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1737,613,267 - 37,622,288 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1737,483,038 - 37,491,995 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01739,087,058 - 39,096,015 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01737,430,784 - 37,439,736 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01739,563,383 - 39,575,777 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1739,563,387 - 39,575,720 (-)Ensemblrn6Rnor6.0
Rnor_5.01741,481,072 - 41,490,310 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41744,202,721 - 44,212,845 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1737,117,051 - 37,126,000 (-)NCBICelera
RGSC_v3.11744,205,565 - 44,215,686 (-)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Decidual prolactin-related protein. Identification, molecular cloning, and characterization. Roby KF, etal., J Biol Chem 1993 Feb 15;268(5):3136-42.
7. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
Additional References at PubMed
PMID:12477932   PMID:26697363   PMID:26862561  


Genomics

Variants

.
Variants in Prl8a2
404 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:84
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000022923
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat


Expression

RNA-SEQ Expression

circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 31 13 14 11 3 11 22 9 31 2 25 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001418512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC097316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L06441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LM644205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U44438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022923   ⟹   ENSRNOP00000022923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1737,821,651 - 37,830,676 (-)Ensembl
mRatBN7.2 Ensembl1737,613,267 - 37,622,288 (-)Ensembl
Rnor_6.0 Ensembl1739,563,387 - 39,575,720 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099321   ⟹   ENSRNOP00000085551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1737,613,267 - 37,619,668 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106963   ⟹   ENSRNOP00000079151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1737,613,267 - 37,619,997 (-)Ensembl
RefSeq Acc Id: NM_001418512   ⟹   NP_001405441
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81737,821,651 - 37,830,676 (-)NCBI
mRatBN7.21737,613,263 - 37,622,288 (-)NCBI
RefSeq Acc Id: NM_022846   ⟹   NP_074037
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81737,821,651 - 37,830,676 (-)NCBI
mRatBN7.21737,613,263 - 37,622,288 (-)NCBI
Rnor_6.01739,563,383 - 39,575,720 (-)NCBI
Rnor_5.01741,481,072 - 41,490,310 (-)NCBI
RGSC_v3.41744,202,721 - 44,212,845 (-)RGD
Celera1737,117,051 - 37,126,000 (-)RGD
Sequence:
RefSeq Acc Id: NP_074037   ⟸   NM_022846
- Peptide Label: isoform 2 precursor
- UniProtKB: Q63545 (UniProtKB/TrEMBL),   Q62903 (UniProtKB/TrEMBL),   A0A8I5ZMH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022923   ⟸   ENSRNOT00000022923
Ensembl Acc Id: ENSRNOP00000079151   ⟸   ENSRNOT00000106963
Ensembl Acc Id: ENSRNOP00000085551   ⟸   ENSRNOT00000099321
RefSeq Acc Id: NP_001405441   ⟸   NM_001418512
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A8I5ZMH5 (UniProtKB/TrEMBL),   Q4QRA1 (UniProtKB/TrEMBL),   A0A0M6L0N8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63545-F1-model_v2 AlphaFold Q63545 1-239 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2516 AgrOrtholog
BioCyc Gene G2FUF-9452 BioCyc
Ensembl Genes ENSRNOG00000017048 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022923 ENTREZGENE
  ENSRNOT00000022923.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7442457 IMAGE-MGC_LOAD
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Somatotropin UniProtKB/TrEMBL
MGC_CLONE MGC:114317 IMAGE-MGC_LOAD
NCBI Gene 24315 ENTREZGENE
PANTHER DECIDUAL PRL-RELATED PROTEIN-RELATED UniProtKB/TrEMBL
  Somatotropin UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/TrEMBL
PhenoGen Prl8a2 PhenoGen
RatGTEx ENSRNOG00000017048 RatGTEx
Superfamily-SCOP 4_helix_cytokine UniProtKB/TrEMBL
UniProt A0A0M6L0N8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMH5 ENTREZGENE
  Q4QRA1 ENTREZGENE, UniProtKB/TrEMBL
  Q62903 ENTREZGENE
  Q63545 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q62903 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-07 Prl8a2  prolactin family 8, subfamily A, member 2  Prl8a2  prolactin family 8, subfamily a, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-05-04 Prl8a2  prolactin family 8, subfamily a, member 2  Dtprp  decidual/trophoblast prolactin-related protein   Symbol and Name updated 1624237 APPROVED
2003-04-09 Dtprp  decidual/trophoblast prolactin-related protein   Dprp  decidual prolactin-related protein  Symbol and Name updated 629477 APPROVED
2002-06-10 Dprp  decidual prolactin-related protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in decidual tissue 1298892
gene_expression produced abundantly at midgestation 1298892
gene_process may function in the physiology of pregnancy 1298892
gene_process possesses luteotropic actions 1298892