Dio1 (iodothyronine deiodinase 1) - Rat Genome Database

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Gene: Dio1 (iodothyronine deiodinase 1) Rattus norvegicus
Analyze
Symbol: Dio1
Name: iodothyronine deiodinase 1
RGD ID: 2504
Description: Enables thyroxine 5'-deiodinase activity. Involved in thyroid hormone catabolic process. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in thyroid gland disease. Orthologous to human DIO1 (iodothyronine deiodinase 1); INTERACTS WITH (+)-schisandrin B; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 5DI; deiodinase iodothyronine type 1; deiodinase, iodothyronine, type 1; deiodinase, iodothyronine, type I; DIOI; ITDI1; MGC93462; Thyroxine deiodinase type I; thyroxine deiodinase, type I; TXDI1; type 1 DI; type I iodothyronine deiodinase; type-I 5'-deiodinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Thshl2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85127,303,089 - 127,319,784 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5127,303,083 - 127,319,771 (-)EnsemblGRCr8
mRatBN7.25122,074,285 - 122,090,983 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5122,074,279 - 122,090,970 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5124,693,444 - 124,710,271 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05126,416,470 - 126,433,298 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05126,467,784 - 126,484,612 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05126,894,837 - 126,911,532 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,895,286 - 126,911,520 (-)Ensemblrn6Rnor6.0
Rnor_5.05130,744,425 - 130,760,658 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45128,385,702 - 128,404,015 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5120,820,006 - 120,836,676 (-)NCBICelera
RGSC_v3.15128,390,932 - 128,409,240 (-)NCBI
Cytogenetic Map5q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-benzyl-4-chlorophenol  (ISO)
2-Ethylhexyl acrylate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diiodothyronine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,5-dichloro-2-n-octyl-3(2H)-isothiazolone  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
alpha-linolenic acid  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
atrazine  (EXP)
auranofin  (ISO)
Aurothioglucose  (ISO)
azathioprine  (ISO)
azinphos-methyl  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (EXP)
Bisphenol B  (EXP)
bisphenol F  (EXP)
butachlor  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
captafol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
chromium(6+)  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyazofamid  (ISO)
cyclosporin A  (ISO)
daidzein  (EXP)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (ISO)
Diclosulam  (ISO)
dicofol  (ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
diethyl hydrogen phosphate  (EXP)
diiodine  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dinocap  (ISO)
elemental selenium  (EXP,ISO)
emamectin benzoate  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
Ethylenethiourea  (ISO)
fenthion  (ISO)
fipronil  (EXP,ISO)
fluazinam  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
glutathione  (EXP)
GW 4064  (ISO)
hexachlorobenzene  (EXP)
inulin  (ISO)
iodomethane  (EXP)
Iopanoic acid  (ISO)
lead diacetate  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
malathion  (ISO)
maneb  (ISO)
masoprocol  (ISO)
methimazole  (EXP,ISO)
methoxychlor  (EXP)
methyltrioctylammonium chloride  (ISO)
metolachlor  (ISO)
morin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
octhilinone  (ISO)
okadaic acid  (ISO)
oryzalin  (ISO)
oxytetracycline  (ISO)
paracetamol  (ISO)
pentachlorophenol  (EXP)
perfluorobutyric acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phthalaldehyde  (ISO)
pirinixic acid  (EXP,ISO)
Potassium Iodate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP)
selenium atom  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium perchlorate  (EXP)
streptozocin  (EXP)
sulfasalazine  (ISO)
tamoxifen  (ISO)
temephos  (ISO)
tetrachloromethane  (EXP,ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
thyroxine  (EXP,ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
wogonin  (ISO)
xanthohumol  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (ISO)
zoxamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Berry MJ, etal., Nature 1991 Jan 31;349(6308):438-40.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Mammary gland carcinoma-related increase of type I iodothyronine 5'-deiodinase activity in Sprague-Dawley rats. Macejova D, etal., Gen Physiol Biophys 2001 Sep;20(3):293-302.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Activation and inactivation of thyroid hormone by type I iodothyronine deiodinase. Moreno M, etal., FEBS Lett. 1994 May 16;344(2-3):143-6. doi: 10.1016/0014-5793(94)00365-3.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Topological analysis of the integral membrane protein, type 1 iodothyronine deiodinase (D1). Toyoda N, etal., J Biol Chem. 1995 May 19;270(20):12310-8. doi: 10.1074/jbc.270.20.12310.
Additional References at PubMed
PMID:1517238   PMID:8419134   PMID:12477932   PMID:12586753   PMID:12775843   PMID:15489334   PMID:15821744   PMID:16230777   PMID:18197581   PMID:18467445   PMID:18539729   PMID:19646447  
PMID:21397282   PMID:22815055   PMID:22956722   PMID:25874614   PMID:33746903   PMID:34137693   PMID:34195279  


Genomics

Comparative Map Data
Dio1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85127,303,089 - 127,319,784 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5127,303,083 - 127,319,771 (-)EnsemblGRCr8
mRatBN7.25122,074,285 - 122,090,983 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5122,074,279 - 122,090,970 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5124,693,444 - 124,710,271 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05126,416,470 - 126,433,298 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05126,467,784 - 126,484,612 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05126,894,837 - 126,911,532 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,895,286 - 126,911,520 (-)Ensemblrn6Rnor6.0
Rnor_5.05130,744,425 - 130,760,658 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45128,385,702 - 128,404,015 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5120,820,006 - 120,836,676 (-)NCBICelera
RGSC_v3.15128,390,932 - 128,409,240 (-)NCBI
Cytogenetic Map5q34NCBI
DIO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38153,894,187 - 53,911,086 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl153,891,239 - 53,911,086 (+)Ensemblhg38GRCh38
GRCh37154,359,860 - 54,376,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36154,132,449 - 54,149,347 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34154,071,881 - 54,088,779NCBI
Celera152,647,532 - 52,664,449 (+)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef152,475,576 - 52,492,483 (+)NCBIHuRef
CHM1_1154,476,233 - 54,493,132 (+)NCBICHM1_1
T2T-CHM13v2.0153,777,070 - 53,793,996 (+)NCBIT2T-CHM13v2.0
Dio1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394107,148,662 - 107,164,365 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4107,148,662 - 107,164,366 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384107,291,465 - 107,307,168 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4107,291,465 - 107,307,169 (-)Ensemblmm10GRCm38
MGSCv374106,964,070 - 106,979,748 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364106,789,399 - 106,805,075 (-)NCBIMGSCv36mm8
Celera4105,641,752 - 105,661,893 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.18NCBI
Dio1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554645,341,245 - 5,355,118 (-)Ensembl
ChiLan1.0NW_0049554645,340,219 - 5,355,182 (-)NCBIChiLan1.0ChiLan1.0
DIO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21172,925,775 - 172,942,895 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11172,066,563 - 172,083,693 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0153,167,840 - 53,184,961 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1154,762,699 - 54,779,679 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl154,762,744 - 54,779,679 (+)EnsemblpanPan2panpan1.1
DIO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1555,081,894 - 55,098,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl555,082,604 - 55,098,529 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha555,148,537 - 55,165,212 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0555,269,989 - 55,286,873 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl555,269,977 - 55,286,866 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1555,264,159 - 55,281,245 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0555,154,202 - 55,171,254 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0555,543,697 - 55,560,784 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dio1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505868,166,168 - 68,182,106 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365227,234,367 - 7,250,099 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365227,234,270 - 7,250,263 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6158,375,602 - 158,392,754 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16158,376,744 - 158,392,745 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26146,078,270 - 146,094,281 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DIO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12079,024,209 - 79,041,607 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603338,237,236 - 38,258,803 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dio1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624934584,294 - 597,908 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624934583,302 - 597,982 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dio1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1147,499,059 - 47,518,542 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dio1
70 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5124314582133270832Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
Dio1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25122,091,100 - 122,091,683 (+)MAPPERmRatBN7.2
Rnor_6.05126,911,650 - 126,912,232NCBIRnor6.0
Rnor_5.05130,760,788 - 130,761,370UniSTSRnor5.0
RGSC_v3.45128,404,145 - 128,404,727UniSTSRGSC3.4
Celera5120,836,794 - 120,837,376UniSTS
Cytogenetic Map5q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 23 87 87 90 59 29 59 6 239 75 6 66 81 80 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000091521   ⟹   ENSRNOP00000070330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5127,303,083 - 127,319,771 (-)Ensembl
mRatBN7.2 Ensembl5122,074,279 - 122,090,970 (-)Ensembl
Rnor_6.0 Ensembl5126,895,286 - 126,911,520 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145952   ⟹   ENSRNOP00000099666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5127,303,083 - 127,319,771 (-)Ensembl
RefSeq Acc Id: NM_001324210   ⟹   NP_001311139
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,303,089 - 127,319,784 (-)NCBI
mRatBN7.25122,074,285 - 122,090,983 (-)NCBI
Rnor_6.05126,894,837 - 126,911,532 (-)NCBI
Celera5120,820,006 - 120,836,676 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021653   ⟹   NP_067685
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,303,089 - 127,319,784 (-)NCBI
mRatBN7.25122,074,285 - 122,090,983 (-)NCBI
Rnor_6.05126,894,837 - 126,911,532 (-)NCBI
Rnor_5.05130,744,425 - 130,760,658 (-)NCBI
RGSC_v3.45128,385,702 - 128,404,015 (-)RGD
Celera5120,820,006 - 120,836,676 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001311139 (Get FASTA)   NCBI Sequence Viewer  
  NP_067685 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83557 (Get FASTA)   NCBI Sequence Viewer  
  CAA41063 (Get FASTA)   NCBI Sequence Viewer  
  EDL90437 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070330
  ENSRNOP00000070330.2
GenBank Protein P24389 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067685   ⟸   NM_021653
- Peptide Label: isoform 1
- UniProtKB: P24389 (UniProtKB/Swiss-Prot),   A0A0G2JXM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001311139   ⟸   NM_001324210
- Peptide Label: isoform 2
- UniProtKB: P24389 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070330   ⟸   ENSRNOT00000091521
Ensembl Acc Id: ENSRNOP00000099666   ⟸   ENSRNOT00000145952

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693892
Promoter ID:EPDNEW_R4417
Type:multiple initiation site
Name:Dio1_1
Description:iodothyronine deiodinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05126,911,532 - 126,911,592EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2504 AgrOrtholog
BioCyc Gene G2FUF-40419 BioCyc
BioCyc Pathway PWY-6260 [thyroid hormone metabolism I (via deiodination)] BioCyc
  PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
BioCyc Pathway Image PWY-6260 BioCyc
  PWY-6261 BioCyc
Ensembl Genes ENSRNOG00000061237 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000091521 ENTREZGENE
  ENSRNOT00000091521.2 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110283 IMAGE-MGC_LOAD
InterPro Iodothyronine_deiodinase UniProtKB/Swiss-Prot
  Iodothyronine_deiodinase_AS UniProtKB/Swiss-Prot
  Iodothyronine_deiodinase_I/III UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:25430 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93462 IMAGE-MGC_LOAD
NCBI Gene 25430 ENTREZGENE
PANTHER PTHR11781 UniProtKB/Swiss-Prot
  TYPE I IODOTHYRONINE DEIODINASE UniProtKB/Swiss-Prot
Pfam T4_deiodinase UniProtKB/Swiss-Prot
PhenoGen Dio1 PhenoGen
PIRSF IOD UniProtKB/Swiss-Prot
  IODI_III UniProtKB/Swiss-Prot
PROSITE T4_DEIODINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061237 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A0A0G2JXM4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L9W0_RAT UniProtKB/TrEMBL
  A6JYR6_RAT UniProtKB/TrEMBL
  IOD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-30 Dio1  iodothyronine deiodinase 1  Dio1  deiodinase, iodothyronine, type I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Dio1  deiodinase, iodothyronine, type I    deiodinase, iodothyronine, type 1  Name updated 629478 APPROVED
2001-07-23 Dio1  deiodinase, iodothyronine, type 1      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Dio1  Thyroxine deiodinase, type I      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_disease increased activity is detected in chemically induced mammary gland tumors 727335