DIO1 (deiodinase, iodothyronine, type I)

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Keyword

Gene: DIO1 (deiodinase, iodothyronine, type I) Homo sapiens

Symbol:

DIO1

Name:

deiodinase, iodothyronine, type I

Description:

The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

5DI; DIOI; MGC130050; MGC130051; OTTHUMP00000010105; OTTHUMP00000010106; OTTHUMP00000232057; OTTHUMP00000232063; OTTHUMP00000232065; OTTHUMP00000232066; thyroxine deiodinase type I (selenoprotein); TXDI1; type 1 DI; type I iodothyronine deiodinase; type-I 5'-deiodinase; type-I 5'deiodinase

Orthologs:

Mus musculus : Dio1 (deiodinase, iodothyronine, type I) MGI
Rattus norvegicus : Dio1 (deiodinase, iodothyronine, type I)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	1	54,439,107 - 54,456,008	+	NCBI
Human Genome Assembly HuRef	1	52,475,576 - 52,492,483	+	NCBI
Human Genome Assembly GRCh37	1	54,359,861 - 54,376,759	+	NCBI
Human Genome Assembly Build 36	1	54,132,449 - 54,149,347	+	NCBI
Human Cytogenetic Map	1	p33-p32		NCBI
Human Genome Assembly	1	54,071,881 - 54,088,779		NCBI