cytochrome P450, family 21, subfamily a, polypeptide 1
RGD ID:
2461
Description:
Enables steroid 21-monooxygenase activity. Involved in C21-steroid hormone metabolic process; cellular response to peptide hormone stimulus; and mineralocorticoid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to several human genes including CYP21A2 (cytochrome P450 family 21 subfamily A member 2); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH aristolochic acid A (ortholog); paracetamol (ortholog); tris(2-butoxyethyl) phosphate (ortholog).
Regulation of cytochrome P4501B1 in cultured rat adrenocortical cells by cyclic adenosine 3',5'-monophosphate and 2,3,7,8- tetrachlorodibenzo-p-dioxin.