Cst3 (cystatin C) - Rat Genome Database

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Gene: Cst3 (cystatin C) Rattus norvegicus
Analyze
Symbol: Cst3
Name: cystatin C
RGD ID: 2432
Description: Enables peptidase inhibitor activity and protease binding activity. Involved in several processes, including Sertoli cell development; cellular response to hydrogen peroxide; and embryo implantation. Located in several cellular components, including multivesicular body; neuronal cell body; and nuclear membrane. Biomarker of intracranial aneurysm; iron deficiency anemia; and obesity. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to human CST3 (cystatin C); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CYSC; cystatin 3; Cystatin C (cysteine proteinase inhibitor); cystatin-3; cystatin-C; MGC105556
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Cst3Tn(sb-T2/Bart3)2.172Mcwi   Cst3em1Mcwi   Cst3em3Mcwi  
Genetic Models: SS-Cst3em3Mcwi SS-Cst3em1Mcwi F344-Cst3Tn(sb-T2/Bart3)2.172Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,790,061 - 156,794,116 (-)NCBIGRCr8
mRatBN7.23136,336,923 - 136,340,796 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,336,920 - 136,340,822 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,288,803 - 140,292,676 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,872,958 - 148,876,831 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,562,563 - 146,566,436 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,219,671 - 143,223,544 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,219,686 - 143,223,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,628,692 - 149,632,565 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,650,903 - 137,654,776 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,556,481 - 137,560,243 (-)NCBI
Celera3135,178,032 - 135,181,905 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
adefovir  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
boric acid  (EXP)
boron atom  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcium dichloride  (ISO)
carbon nanotube  (ISO)
catalpol  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
cholesterol  (EXP)
choline  (ISO)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium cromoglycate  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental boron  (EXP)
elemental selenium  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP,ISO)
glyburide  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
Hexachloro-1,3-butadiene  (EXP)
isotretinoin  (ISO)
lipopolysaccharide  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
N-acetyl-L-cysteine  (EXP)
Nandrolone decanoate  (EXP)
nicotine  (ISO)
ochratoxin A  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
Phytolaccoside E  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
probenecid  (EXP)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium cholate  (EXP)
sodium fluoride  (EXP,ISO)
streptozocin  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (ISO)
tropisetron  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
vanillin  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc oxide  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2008 Sep;39(9):2603-10. Epub 2008 Jul 17.
2. Expression of the cysteine proteinase inhibitor cystatin C gene in rat heart: use of digoxigenin-labeled probes generated by polymerase chain reaction directly for in situ and northern blot hybridizations. Barka T and van der Noen H, J Histochem Cytochem. 1993 Dec;41(12):1863-7.
3. Amino acid sequence of an inducible cysteine proteinase inhibitor (cystatin) from submandibular glands of isoproterenol-treated rats. Bedi GS Arch Biochem Biophys 1989 Aug 15;273(1):245-53.
4. Is Cystatin C a Useful Marker in the Detection of Diabetic Kidney Disease? Borges RL, etal., Nephron Clin Pract. 2009 Nov 3;114(2):c127-c134.
5. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Carlson ES, etal., Brain Res. 2008 Aug 7.
6. The cDNA structure and expression analysis of the genes for the cysteine proteinase inhibitor cystatin C and for beta 2-microglobulin in rat brain. Cole T, etal., Eur J Biochem 1989 Dec 8;186(1-2):35-42.
7. Prediction of left ventricular dysfunction progression in patients with a first ST-elevation myocardial infarction--contribution of cystatin C assessment. Derzhko R, etal., Coron Artery Dis. 2009 Nov;20(7):453-61.
8. Apoptotic cell death and microglial cell responses in cultured rat retina. Engelsberg K, etal., Graefes Arch Clin Exp Ophthalmol. 2004 Mar;242(3):229-39. Epub 2004 Jan 27.
9. Genetic variation associated with bortezomib-induced peripheral neuropathy. Favis R, etal., Pharmacogenet Genomics. 2011 Mar;21(3):121-9.
10. Cystatin C and preeclampsia: a case control study. Franceschini N, etal., Ren Fail. 2008;30(1):89-95.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C). Ghiso J, etal., Proc Natl Acad Sci U S A. 1986 May;83(9):2974-8.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Potential participation of cystatin C in rapid eye movement sleep (REMS) modulation. Gonzalez-Rivera R, etal., Neurosci Lett. 2006 Nov 20;408(3):178-82. Epub 2006 Oct 5.
15. Variable expression of cystatin C in cultured trans-differentiating rat hepatic stellate cells. Gressner AM, etal., World J Gastroenterol. 2006 Feb 7;12(5):731-8.
16. Mouse and rat cystatin C: Escherichia coli production, characterization and tissue distribution. Hakansson K, etal., Comp Biochem Physiol B Biochem Mol Biol. 1996 Jul;114(3):303-11.
17. Pioglitazone improves obesity type diabetic nephropathy: relation to the mitigation of renal oxidative reaction. Hirasawa Y, etal., Exp Anim. 2008 Oct;57(5):423-32.
18. Lung toxicity of hard metal particles and production of interleukin-1, tumor necrosis factor-alpha, fibronectin, and cystatin-c by lung phagocytes. Huaux F, etal., Toxicol Appl Pharmacol. 1995 May;132(1):53-62.
19. Association of chronic kidney disease with the spectrum of ankle brachial index the CHS (Cardiovascular Health Study). Ix JH, etal., J Am Coll Cardiol. 2009 Sep 22;54(13):1176-84.
20. Genomic profiling of the neuronal target genes of the plasticity-related transcription factor -- Zif268. James AB, etal., J Neurochem. 2005 Nov;95(3):796-810.
21. Changes in distribution of cystatin C, apolipoprotein E and ferritin in rat hypothalamus after hypophysectomy. Katakai K, etal., J Neuroendocrinol. 1997 Apr;9(4):247-53.
22. Evidence that even "normal" albuminuria may denote incipient GFR reduction in patients with type 2 diabetes mellitus. Kravaritou M, etal., Diabetes Res Clin Pract. 2009 Sep;85(3):317-21. Epub 2009 Jul 10.
23. Hydrogen peroxide induces lysosomal protease alterations in PC12 cells. Lee DC, etal., Neurochem Res. 2007 Sep;32(9):1499-510. Epub 2007 Apr 18.
24. Enhanced cystatin C and lysosomal protease expression following 6-hydroxydopamine exposure. Lee DC, etal., Neurotoxicology. 2006 Mar;27(2):260-76. Epub 2006 Jan 18.
25. Insulin resistance and inflammation may have an additional role in the link between cystatin C and cardiovascular disease in type 2 diabetes mellitus patients. Lee SH, etal., Metabolism. 2009 Sep 16.
26. Induced expression of cathepsins and cystatin C in a murine model of demyelination. Ma J, etal., Neurochem Res. 2007 Feb;32(2):311-20. Epub 2006 Nov 4.
27. Complementary prognostic value of cystatin C, N-terminal pro-B-type natriuretic Peptide and cardiac troponin T in patients with acute heart failure. Manzano-Fernandez S, etal., Am J Cardiol. 2009 Jun 15;103(12):1753-9.
28. Early renal failure detection by cystatin C in Type 2 diabetes mellitus: varying patterns of renal analyte expression. McNamara NV, etal., Pathology. 2009;41(3):269-75.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Up-regulation of cystatin C by microglia in the rat facial nucleus following axotomy. Miyake T, etal., Brain Res Mol Brain Res. 1996 Apr;37(1-2):273-82.
31. Immunocytochemical study of cathepsin L and rat salivary cystatin-3 in rat osteoclasts treated with E-64 in vivo. Moroi R, etal., Arch Oral Biol. 1997 Apr;42(4):305-15.
32. Interactions of proteases and protease inhibitors in Sertoli-germ cell cocultures preceding the formation of specialized Sertoli-germ cell junctions in vitro. Mruk D, etal., J Androl. 1997 Nov-Dec;18(6):612-22.
33. Overweight, obesity, and elevated serum cystatin C levels in adults in the United States. Muntner P, etal., Am J Med. 2008 Apr;121(4):341-8.
34. Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis. Nagai A, etal., Clin Chim Acta. 2003 Mar;329(1-2):53-60.
35. Cystatin C and cathepsin B in CSF from patients with inflammatory neurologic diseases. Nagai A, etal., Neurology. 2000 Dec 26;55(12):1828-32.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Cystatin C is associated with an increased coronary atherosclerotic burden and a stable plaque phenotype in patients with ischemic heart disease and normal glomerular filtration rate. Niccoli G, etal., Atherosclerosis. 2008 Jun;198(2):373-80. Epub 2007 Nov 5.
38. Detection of immature dendritic cells in the enamel organ of rat incisors by using anti-cystatin C and anti-MHC class II immunocytochemistry. Nishikawa S and Sasaki F, J Histochem Cytochem. 2000 Sep;48(9):1243-55.
39. Presence of anti-cystatin C-positive dendritic cells or macrophages and localization of cysteine proteases in the apical bud of the enamel organ in the rat incisor. Nishikawa S J Histochem Cytochem. 2005 May;53(5):643-51.
40. Involvement of cystatin C in oxidative stress-induced apoptosis of cultured rat CNS neurons. Nishio C, etal., Brain Res. 2000 Aug 11;873(2):252-62.
41. Postnatal changes of gene expression for tissue inhibitors of metalloproteinase-1 and -2 and cystatins S and C, in rat submandibular gland demonstrated by quantitative reverse transcription-polymerase chain reaction. Nishiura T and Abe K, Arch Oral Biol. 1999 Jan;44(1):15-26.
42. Expression of cystatin C prevents oxidative stress-induced death in PC12 cells. Nishiyama K, etal., Brain Res Bull. 2005 Sep 30;67(1-2):94-9.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
45. Cystatin C, a protease inhibitor, in degenerating rat hippocampal neurons following transient forebrain ischemia. Palm DE, etal., Brain Res. 1995 Sep 11;691(1-2):1-8.
46. Clinical correlates and heritability of cystatin C (from the Framingham Offspring Study). Parikh NI, etal., Am J Cardiol. 2008 Nov 1;102(9):1194-8. Epub 2008 Sep 12.
47. Cystatin C expression is increased in the hippocampus following photothrombotic stroke in rat. Pirttila TJ and Pitkanen A, Neurosci Lett. 2006 Mar 6;395(2):108-13. Epub 2005 Nov 23.
48. Expression of Cystatin C in the rat endometrium during the peri-implantation period. Quinn CE, etal., Biochem Biophys Res Commun. 2006 Oct 13;349(1):236-44. Epub 2006 Aug 18.
49. GOA pipeline RGD automated data pipeline
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
53. Evaluation of urinary biomarkers for coronary artery disease, diabetes, and diabetic kidney disease. Snell-Bergeon JK, etal., Diabetes Technol Ther. 2009 Jan;11(1):1-9.
54. Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: a pilot study. Straface E, etal., FEBS Lett 2005 May 23;579(13):2759-66. Epub 2005 Apr 19.
55. Serum cystatin C and the risk of Alzheimer disease in elderly men. Sundelof J, etal., Neurology. 2008 Sep 30;71(14):1072-9.
56. FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Taupin P, etal., Neuron. 2000 Nov;28(2):385-97.
57. Cystatin C secretion by rat glomerular mesangial cells: autocrine loop for in vitro growth-promoting activity. Tavera C, etal., Biochem Biophys Res Commun. 1992 Feb 14;182(3):1082-8.
58. A rapid two-step purification of rat cystatin C, one major inhibitor of cysteine proteinases. Tavera C, etal., Prep Biochem. 1989;19(4):279-91.
59. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
60. Developmental patterns of gene expression of secreted proteins in brain and choroid plexus. Thomas T, etal., Dev Biol. 1989 Jul;134(1):38-47.
61. Sertoli cell and germ cell cystatin C: stage-dependent expression of two distinct messenger ribonucleic acid transcripts in rat testes. Tsuruta JK, etal., Biol Reprod. 1993 Nov;49(5):1045-54.
62. Cystatin C expression in ischemic white matter lesions. Umegae N, etal., Acta Neurol Scand. 2008 Jul;118(1):60-7.
63. Cystatin C in the anterior segment of rat and mouse eyes. Wasselius J, etal., Acta Ophthalmol Scand. 2004 Feb;82(1):68-75.
64. Identification and localization of retinal cystatin C. Wasselius J, etal., Invest Ophthalmol Vis Sci. 2001 Jul;42(8):1901-6.
65. Spinal cord genes enriched in rat dorsal horn and induced by noxious stimulation identified by subtraction cloning and differential hybridization. Yang HY, etal., Neuroscience. 2001;103(2):493-502.
66. Up-regulation of cystatin C expression in the murine hippocampus following perforant path transections. Ying GX, etal., Neuroscience. 2002;112(2):289-98.
Additional References at PubMed
PMID:1563513   PMID:2400577   PMID:3044831   PMID:3488317   PMID:6203523   PMID:7890620   PMID:8999869   PMID:10545518   PMID:12477932   PMID:15127951   PMID:15197734   PMID:15212960  
PMID:15489334   PMID:16502470   PMID:17241700   PMID:17462596   PMID:18026102   PMID:18256700   PMID:18613859   PMID:19056867   PMID:19199708   PMID:20352108   PMID:20489058   PMID:21551085  
PMID:22360852   PMID:22365146   PMID:23376485   PMID:23533145   PMID:24006456   PMID:25479090   PMID:26715107   PMID:26865059   PMID:28053285   PMID:28904096   PMID:29755460   PMID:30052474  
PMID:31801142   PMID:33030263   PMID:36899554  


Genomics

Comparative Map Data
Cst3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,790,061 - 156,794,116 (-)NCBIGRCr8
mRatBN7.23136,336,923 - 136,340,796 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,336,920 - 136,340,822 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,288,803 - 140,292,676 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,872,958 - 148,876,831 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,562,563 - 146,566,436 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,219,671 - 143,223,544 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,219,686 - 143,223,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,628,692 - 149,632,565 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,650,903 - 137,654,776 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,556,481 - 137,560,243 (-)NCBI
Celera3135,178,032 - 135,181,905 (-)NCBICelera
Cytogenetic Map3q41NCBI
CST3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382023,626,706 - 23,637,955 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2023,626,706 - 23,638,473 (-)EnsemblGRCh38hg38GRCh38
GRCh372023,607,343 - 23,618,592 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362023,562,294 - 23,566,574 (-)NCBINCBI36Build 36hg18NCBI36
Build 342023,562,293 - 23,566,574NCBI
Celera2023,687,561 - 23,691,841 (-)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2023,574,763 - 23,578,930 (-)NCBIHuRef
CHM1_12023,614,330 - 23,618,610 (-)NCBICHM1_1
T2T-CHM13v2.02023,686,282 - 23,697,531 (-)NCBIT2T-CHM13v2.0
Cst3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392148,713,642 - 148,717,432 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2148,713,642 - 148,717,612 (-)EnsemblGRCm39 Ensembl
GRCm382148,871,722 - 148,875,512 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,871,722 - 148,875,692 (-)EnsemblGRCm38mm10GRCm38
MGSCv372148,697,468 - 148,701,204 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362148,563,173 - 148,566,909 (-)NCBIMGSCv36mm8
Celera2150,137,951 - 150,141,688 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.6NCBI
Cst3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541530,507,972 - 30,512,109 (-)NCBIChiLan1.0ChiLan1.0
CST3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22124,514,583 - 24,519,015 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12024,511,416 - 24,515,772 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02023,583,043 - 23,587,399 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12023,935,942 - 23,940,420 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2023,935,942 - 23,940,425 (-)Ensemblpanpan1.1panPan2
LOC607874
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12349,562 - 53,618 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2381,423 - 85,399 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.023292,507 - 296,492 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.123151,270 - 155,246 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.023233,470 - 237,470 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.023222,517 - 226,484 (-)NCBIUU_Cfam_GSD_1.0
CST3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1730,470,855 - 30,474,590 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11730,471,056 - 30,474,486 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,560,206 - 34,563,637 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CST3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1252,834,497 - 52,838,785 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl252,832,181 - 52,838,865 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605092,907,879 - 92,912,191 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cst3
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:38
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000007175
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat

Markers in Region
RH127375  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23136,337,031 - 136,337,233 (+)MAPPERmRatBN7.2
mRatBN7.27129,758,363 - 129,758,565 (+)MAPPERmRatBN7.2
Rnor_6.07140,286,211 - 140,286,412NCBIRnor6.0
Rnor_6.03143,219,780 - 143,219,981NCBIRnor6.0
Rnor_5.03149,628,801 - 149,629,002UniSTSRnor5.0
Rnor_5.0X114,789,909 - 114,790,110UniSTSRnor5.0
RGSC_v3.43137,651,012 - 137,651,213UniSTSRGSC3.4
RGSC_v3.47137,355,452 - 137,355,653UniSTSRGSC3.4
Celera7126,248,838 - 126,249,039UniSTS
Celera3135,178,141 - 135,178,342UniSTS
Cytogenetic Map3q41UniSTS
Cytogenetic Map7q36UniSTS
UniSTS:532125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27129,758,219 - 129,758,426 (+)MAPPERmRatBN7.2
Rnor_6.07140,286,067 - 140,286,273NCBIRnor6.0
Rnor_5.0X114,789,765 - 114,789,971UniSTSRnor5.0
Celera7126,248,694 - 126,248,900UniSTS
Cytogenetic Map3q41UniSTS
Cytogenetic Map7q36UniSTS


Genetic Models
This gene Cst3 is modified in the following models/strains:
SS-Cst3em3Mcwi     SS-Cst3em1Mcwi     F344-Cst3Tn(sb-T2/Bart3)2.172Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 29 3 3
Medium 3 43 57 41 19 41 8 11 45 35 38 8 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC087591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB314369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB608544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB692474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000007175   ⟹   ENSRNOP00000007175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3136,336,920 - 136,340,819 (-)Ensembl
Rnor_6.0 Ensembl3143,219,686 - 143,223,615 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101785   ⟹   ENSRNOP00000090275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3136,336,920 - 136,340,822 (-)Ensembl
RefSeq Acc Id: NM_012837   ⟹   NP_036969
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83156,790,064 - 156,793,937 (-)NCBI
mRatBN7.23136,336,923 - 136,340,796 (-)NCBI
Rnor_6.03143,219,671 - 143,223,544 (-)NCBI
Rnor_5.03149,628,692 - 149,632,565 (-)NCBI
RGSC_v3.43137,650,903 - 137,654,776 (-)RGD
Celera3135,178,032 - 135,181,905 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283149   ⟹   XP_063139219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83156,790,061 - 156,794,116 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036969   ⟸   NM_012837
- Peptide Label: precursor
- UniProtKB: Q5M968 (UniProtKB/Swiss-Prot),   P14841 (UniProtKB/Swiss-Prot),   A6K7D9 (UniProtKB/TrEMBL),   A0A8L2Q336 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007175   ⟸   ENSRNOT00000007175
RefSeq Acc Id: ENSRNOP00000090275   ⟸   ENSRNOT00000101785
RefSeq Acc Id: XP_063139219   ⟸   XM_063283149
- Peptide Label: isoform X1
- UniProtKB: A6K7E1 (UniProtKB/TrEMBL)
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14841-F1-model_v2 AlphaFold P14841 1-140 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692506
Promoter ID:EPDNEW_R3030
Type:initiation region
Name:Cst3_1
Description:cystatin C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03143,223,497 - 143,223,557EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2432 AgrOrtholog
BioCyc Gene G2FUF-47482 BioCyc
Ensembl Genes ENSRNOG00000005195 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007175 ENTREZGENE
  ENSRNOT00000007175.7 UniProtKB/TrEMBL
  ENSRNOT00000101785.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7307694 IMAGE-MGC_LOAD
InterPro Cystatin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inh_cystat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105556 IMAGE-MGC_LOAD
NCBI Gene 25307 ENTREZGENE
PANTHER CYSTATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTATIN-C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CST3 RGD
PhenoGen Cst3 PhenoGen
PROSITE CYSTATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005195 RatGTEx
SMART SM00043 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216467
UniProt A0A8I6AD91_RAT UniProtKB/TrEMBL
  A0A8L2Q336 ENTREZGENE, UniProtKB/TrEMBL
  A6K7D9 ENTREZGENE, UniProtKB/TrEMBL
  A6K7E1 ENTREZGENE, UniProtKB/TrEMBL
  CYTC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5M968 ENTREZGENE
UniProt Secondary Q5M968 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Cst3  cystatin C    cystatin 3  Name updated 625702 APPROVED
2002-06-10 Cst3  cystatin 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization extracellular protein 728248
gene_expression expressed in choroid plexus of brain, cerebrospinal fluid, plasma, testis, epididymis, seminal vesicles, prostate, ovary, submandibular gland and small amounts in liver 728248
gene_protein contains 120 amino acids and a potential N-linked glycosylation site 728248