Crhbp (corticotropin releasing hormone binding protein) - Rat Genome Database

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Gene: Crhbp (corticotropin releasing hormone binding protein) Rattus norvegicus
Analyze
Symbol: Crhbp
Name: corticotropin releasing hormone binding protein
RGD ID: 2403
Description: Enables corticotropin-releasing hormone binding activity and peptide binding activity. Involved in several processes, including cellular response to cocaine; cellular response to estradiol stimulus; and cellular response to estrogen stimulus. Located in several cellular components, including axon; cytoplasmic vesicle; and perikaryon. Biomarker of depressive disorder; obesity; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in depressive disorder and opioid abuse. Orthologous to human CRHBP (corticotropin releasing hormone binding protein); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: corticotropin releasing factor binding protein; corticotropin-releasing factor-binding protein; corticotropin-releasing hormone-binding protein; CRF-binding protein; CRF-BP; Crfbp; CRH-BP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,427,139 - 28,439,446 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl228,427,139 - 28,439,446 (-)EnsemblGRCr8
mRatBN7.2226,692,403 - 26,704,710 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,692,403 - 26,704,710 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx233,730,555 - 33,742,870 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,830,779 - 31,843,094 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,646,279 - 26,658,547 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0225,141,471 - 25,153,334 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,141,471 - 25,153,334 (-)Ensemblrn6Rnor6.0
Rnor_5.0244,299,507 - 44,311,225 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4225,801,371 - 25,813,457 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera222,758,077 - 22,770,045 (-)NCBICelera
RGSC_v3.1225,721,739 - 25,733,799 (-)NCBI
Cytogenetic Map2q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Sensitivity and Resilience to Predator Stress-Enhanced Ethanol Drinking Is Associated With Sex-Dependent Differences in Stress-Regulating Systems. Alavi M, etal., Front Behav Neurosci. 2022 May 11;16:834880. doi: 10.3389/fnbeh.2022.834880. eCollection 2022.
2. Corticotropin Releasing Factor Binding Protein and CRF2 Receptors in the Ventral Tegmental Area: Modulation of Ethanol Binge Drinking in C57BL/6J Mice. Albrechet-Souza L, etal., Alcohol Clin Exp Res. 2015 Sep;39(9):1609-18. doi: 10.1111/acer.12825. Epub 2015 Aug 6.
3. Expression and regulation of corticotropin-releasing hormone binding protein (CRH-BP) in rat adrenals. Chatzaki E, etal., J Neurochem. 2002 Jan;80(1):81-90. doi: 10.1046/j.0022-3042.2001.00667.x.
4. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. Claes S, etal., Biol Psychiatry 2003 Nov 1;54(9):867-72.
5. Isolation and characterization of the rat corticotropin-releasing hormone (CRH)-binding protein gene: transcriptional regulation by cyclic adenosine monophosphate and CRH. Cortright DN, etal., Endocrinology 1997 May;138(5):2098-108.
6. A single amino acid serves as an affinity switch between the receptor and the binding protein of corticotropin-releasing factor: implications for the design of agonists and antagonists. Eckart K, etal., Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11142-7.
7. Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. Enoch MA, etal., PLoS One. 2008;3(10):e3620. doi: 10.1371/journal.pone.0003620. Epub 2008 Oct 31.
8. Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis. Erb S, etal., Neuroscience. 2004;123(4):1003-9.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Genes involved in stress response and alcohol use among high-risk African American youth. Goyal N, etal., Subst Abus. 2016 Jul-Sep;37(3):450-458. doi: 10.1080/08897077.2015.1134756.
12. Defining the role of corticotropin releasing factor binding protein in alcohol consumption. Haass-Koffler CL, etal., Transl Psychiatry. 2016 Nov 15;6(11):e953. doi: 10.1038/tp.2016.208.
13. Corticotropin-releasing factor (CRF) or CRF binding-protein ligand inhibitor administration suppresses food intake in mice and elevates body temperature in rats. Heinrichs SC, etal., Brain Res. 2001 May 11;900(2):177-85. doi: 10.1016/s0006-8993(01)02286-7.
14. The effects of acute stress on the regulation of central and basolateral amygdala CRF-binding protein gene expression. Herringa RJ, etal., Brain Res Mol Brain Res 2004 Nov 24;131(1-2):17-25.
15. A whole exome sequencing study to identify rare variants in multiplex families with alcohol use disorder. Hill SY and Hostyk J, Front Psychiatry. 2023 Oct 17;14:1216493. doi: 10.3389/fpsyt.2023.1216493. eCollection 2023.
16. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
17. Characterization of peptide-protein interactions using photoaffinity labeling and LC/MS. Jahn O, etal., Anal Bioanal Chem. 2004 Feb;378(4):1031-6. doi: 10.1007/s00216-003-2353-8. Epub 2003 Dec 11.
18. Three-amino acid motifs of urocortin II and III determine their CRF receptor subtype selectivity. Jahn O, etal., Neuropharmacology. 2004 Aug;47(2):233-42.
19. The binding protein of corticotropin-releasing factor: Ligand-binding site and subunit structure. Jahn O, etal., Proc Natl Acad Sci U S A 2002 Sep 17;99(19):12055-60.
20. Neurotransmitter and neuromodulator genes associated with a history of depressive symptoms in individuals with alcohol dependence. Kertes DA, etal., Alcohol Clin Exp Res. 2011 Mar;35(3):496-505. doi: 10.1111/j.1530-0277.2010.01366.x. Epub 2010 Dec 8.
21. Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats. Klampfl SM, etal., Horm Behav. 2016 Aug;84:136-44. doi: 10.1016/j.yhbeh.2016.06.009. Epub 2016 Jun 28.
22. Drug addiction and stress-response genetic variability: association study in African Americans. Levran O, etal., Ann Hum Genet. 2014 Jul;78(4):290-8. doi: 10.1111/ahg.12064. Epub 2014 Apr 26.
23. Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin. Levran O, etal., Pharmacogenomics. 2018 Mar;19(4):333-341. doi: 10.2217/pgs-2017-0179. Epub 2018 Feb 21.
24. Chronic ethanol ingestion modulates proanxiety factors expressed in rat central amygdala. Läck AK, etal., Alcohol. 2005 Jun;36(2):83-90. doi: 10.1016/j.alcohol.2005.07.004.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Behavioral economic analysis of stress effects on acute motivation for alcohol. Owens MM, etal., J Exp Anal Behav. 2015 Jan;103(1):77-86. doi: 10.1002/jeab.114. Epub 2014 Nov 20.
28. Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats. Pan Y, etal., Psychoneuroendocrinology. 2010 Feb;35(2):272-83. Epub 2009 Jul 23.
29. Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction. Peles E, etal., J Addict Med. 2019 Nov/Dec;13(6):430-435. doi: 10.1097/ADM.0000000000000515.
30. Ultrastructural localization of the corticotropin-releasing factor-binding protein in rat brain and pituitary. Peto CA, etal., J Comp Neurol. 1999 Oct 18;413(2):241-54.
31. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. Potter E, etal., Nature 1991 Jan 31;349(6308):423-6.
32. Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes. Ray LA, Alcohol Clin Exp Res. 2011 Jan;35(1):166-74. doi: 10.1111/j.1530-0277.2010.01333.x. Epub 2010 Oct 6.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system. Ribbe K, etal., Arch Gen Psychiatry. 2011 Dec;68(12):1247-56. doi: 10.1001/archgenpsychiatry.2011.100. Epub 2011 Aug 1.
36. CRF binding protein facilitates the presence of CRF type 2a receptor on the cell surface. Slater PG, etal., Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4075-80. doi: 10.1073/pnas.1523745113. Epub 2016 Mar 28.
37. Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus. Smith MA, etal., Brain Res. 1997 Jan 16;745(1-2):248-56.
38. Corticotropin-releasing hormone-binding protein in brain and pituitary of food-deprived obese (fa/fa) Zucker rats. Timofeeva E, etal., Am J Physiol. 1999 Dec;277(6 Pt 2):R1749-59.
39. Nicotine withdrawal increases stress-associated genes in the nucleus accumbens of female rats in a hormone-dependent manner. Torres OV, etal., Nicotine Tob Res. 2015 Apr;17(4):422-30. doi: 10.1093/ntr/ntu278. Epub 2015 Mar 11.
40. Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta. van de Stolpe A, etal., Mol Endocrinol. 2004 Dec;18(12):2908-23. Epub 2004 Sep 2.
41. Corticotropin-releasing factor binding protein within the ventral tegmental area is expressed in a subset of dopaminergic neurons. Wang HL and Morales M, J Comp Neurol. 2008 Jul 20;509(3):302-18. doi: 10.1002/cne.21751.
42. Performance-enhancing effects of CRF-BP ligand inhibitors. Zorrilla EP, etal., Neuroreport. 2001 May 8;12(6):1231-4. doi: 10.1097/00001756-200105080-00035.
Additional References at PubMed
PMID:7556876   PMID:12895416   PMID:13150566   PMID:15976007   PMID:17437087   PMID:18234674   PMID:18559919   PMID:18929624   PMID:21624661   PMID:26503565  


Genomics

Comparative Map Data
Crhbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,427,139 - 28,439,446 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl228,427,139 - 28,439,446 (-)EnsemblGRCr8
mRatBN7.2226,692,403 - 26,704,710 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,692,403 - 26,704,710 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx233,730,555 - 33,742,870 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,830,779 - 31,843,094 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,646,279 - 26,658,547 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0225,141,471 - 25,153,334 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,141,471 - 25,153,334 (-)Ensemblrn6Rnor6.0
Rnor_5.0244,299,507 - 44,311,225 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4225,801,371 - 25,813,457 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera222,758,077 - 22,770,045 (-)NCBICelera
RGSC_v3.1225,721,739 - 25,733,799 (-)NCBI
Cytogenetic Map2q12NCBI
CRHBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,953,045 - 76,981,159 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,953,044 - 76,981,158 (+)Ensemblhg38GRCh38
GRCh37576,248,870 - 76,265,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,284,436 - 76,301,055 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34576,284,435 - 76,301,054NCBI
Celera572,143,194 - 72,159,812 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,455,341 - 71,471,960 (+)NCBIHuRef
CHM1_1575,681,815 - 75,698,436 (+)NCBICHM1_1
T2T-CHM13v2.0577,434,877 - 77,462,968 (+)NCBIT2T-CHM13v2.0
Crhbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,567,884 - 95,581,339 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,567,879 - 95,581,432 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381395,431,376 - 95,444,831 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,431,371 - 95,444,924 (-)Ensemblmm10GRCm38
MGSCv371396,201,331 - 96,214,786 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361396,532,075 - 96,545,471 (-)NCBIMGSCv36mm8
Celera1399,051,989 - 99,065,285 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.5NCBI
Crhbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542523,953,912 - 23,966,352 (-)Ensembl
ChiLan1.0NW_00495542523,953,957 - 23,966,207 (-)NCBIChiLan1.0ChiLan1.0
CRHBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2438,323,975 - 38,341,995 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,477,602 - 36,495,622 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0538,327,305 - 38,343,901 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1538,852,934 - 38,869,529 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl538,845,925 - 38,869,549 (-)EnsemblpanPan2panpan1.1
CRHBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,726,316 - 29,737,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,705,031 - 29,758,111 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha330,965,624 - 30,977,333 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0329,645,525 - 29,657,242 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,645,521 - 29,657,131 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,582,245 - 29,593,950 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,562,941 - 29,574,639 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,932,261 - 29,943,976 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Crhbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,780,826 - 190,794,463 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493654964,866 - 78,272 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493654964,866 - 78,272 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRHBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,816,816 - 85,831,179 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1285,814,399 - 85,830,598 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,431,375 - 87,447,099 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRHBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,203,335 - 71,223,179 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,205,932 - 71,223,172 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604920,043,907 - 20,061,809 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crhbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248691,412,499 - 1,423,932 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248691,412,541 - 1,423,891 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Crhbp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13222,769,474 - 222,781,805 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Crhbp
71 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:67
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000024191
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat

Markers in Region
D2Wox56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,692,458 - 26,692,656 (+)MAPPERmRatBN7.2
Rnor_6.0225,141,527 - 25,141,724NCBIRnor6.0
Rnor_5.0244,299,563 - 44,299,760UniSTSRnor5.0
RGSC_v3.4225,801,427 - 25,801,624UniSTSRGSC3.4
Celera222,758,133 - 22,758,330UniSTS
Cytogenetic Map2q12UniSTS
RH132846  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,692,646 - 26,692,838 (+)MAPPERmRatBN7.2
Rnor_6.0225,141,715 - 25,141,906NCBIRnor6.0
Rnor_5.0244,299,751 - 44,299,942UniSTSRnor5.0
RGSC_v3.4225,801,615 - 25,801,806UniSTSRGSC3.4
Celera222,758,321 - 22,758,512UniSTS
RH 3.4 Map213.3UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 9 18 125 39 36 12 25 12 6 112 64 4 111 18 45 24 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000024191   ⟹   ENSRNOP00000024191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl228,427,139 - 28,439,446 (-)Ensembl
mRatBN7.2 Ensembl226,692,403 - 26,704,710 (-)Ensembl
Rnor_6.0 Ensembl225,141,471 - 25,153,334 (-)Ensembl
RefSeq Acc Id: NM_139183   ⟹   NP_631922
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,427,139 - 28,439,446 (-)NCBI
mRatBN7.2226,692,403 - 26,704,710 (-)NCBI
Rnor_6.0225,141,471 - 25,153,334 (-)NCBI
Rnor_5.0244,299,507 - 44,311,225 (-)NCBI
RGSC_v3.4225,801,371 - 25,813,457 (-)RGD
Celera222,758,077 - 22,770,045 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_631922 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB65241 (Get FASTA)   NCBI Sequence Viewer  
  EDM10099 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024191
GenBank Protein P24388 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_631922   ⟸   NM_139183
- Peptide Label: precursor
- UniProtKB: P24388 (UniProtKB/Swiss-Prot),   O35761 (UniProtKB/TrEMBL),   F7EU31 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024191   ⟸   ENSRNOT00000024191
Protein Domains
Corticotropin-releasing factor binding protein C-   Corticotropin-releasing factor binding protein N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24388-F1-model_v2 AlphaFold P24388 1-322 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2403 AgrOrtholog
BioCyc Gene G2FUF-54807 BioCyc
Ensembl Genes ENSRNOG00000017890 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024191 ENTREZGENE
Gene3D-CATH 2.60.120.290 UniProtKB/Swiss-Prot
InterPro CRF-bd UniProtKB/Swiss-Prot
  CRF-BP_C UniProtKB/Swiss-Prot
  CRF-BP_N UniProtKB/Swiss-Prot
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 29625 ENTREZGENE
PANTHER CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN UniProtKB/Swiss-Prot
  PTHR10278 UniProtKB/Swiss-Prot
Pfam CRF-BP UniProtKB/Swiss-Prot
  CRF-BP_C UniProtKB/Swiss-Prot
PhenoGen Crhbp PhenoGen
PIRSF CRF_bd UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017890 RatGTEx
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot
UniProt CRHBP_RAT UniProtKB/Swiss-Prot
  F7EU31 ENTREZGENE, UniProtKB/TrEMBL
  O35761 ENTREZGENE, UniProtKB/TrEMBL
  P24388 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Crhbp  corticotropin releasing hormone binding protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains the peptide sequence of amino acid residues 23-36 is the ligand binding site for CRH 625587
gene_physical_interaction amino acid residues 23-36 are involved in binding to corticotropin releasing hormone 625587
gene_process mediates the function of corticotropin-releasing hormone (CRH) 625587
gene_protein 37 kDa 625587