RGD Reference Report - The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden.

Authors: Claes, S  Villafuerte, S  Forsgren, T  Sluijs, S  Del-Favero, J  Adolfsson, R  Van Broeckhoven, C 
Citation: Claes S, etal., Biol Psychiatry 2003 Nov 1;54(9):867-72.
RGD ID: 1358530
Pubmed: PMID:14573312   (View Abstract at PubMed)

BACKGROUND: Recent research suggests that central corticotropin releasing hormone hyperdrive is an important neurobiological risk factor for developing major depression. The availability of free corticotropin releasing hormone in the central nervous system is tightly regulated by the expression of corticotropin releasing hormone binding protein. Therefore, the gene encoding for corticotropin releasing hormone binding protein is a functional candidate gene for major depression. METHODS: We present a systematic study of single nucleotide polymorphisms in the corticotropin releasing hormone binding protein gene and their role in the liability for major depression. Seven single nucleotide polymorphisms were genotyped in a well-diagnosed sample of 89 patients with recurrent major depressions and matched controls. RESULTS: Two single nucleotide polymorphisms within the corticotropin releasing hormone binding protein gene were significantly associated with the disease (p <.05). An expectation-maximization algorithm estimated a specific haplotype to have a frequency of 53% in patients and 35% in controls (p <.001). CONCLUSIONS: The corticotropin releasing hormone binding protein gene is likely to be involved in the genetic vulnerability for major depression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
depressive disorder  IAGP 1358530DNA:snps:intron more ...RGD 
depressive disorder  ISOCRHBP (Homo sapiens)1358530; 1358530DNA:snps:intron more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crhbp  (corticotropin releasing hormone binding protein)

Genes (Mus musculus)
Crhbp  (corticotropin releasing hormone binding protein)

Genes (Homo sapiens)
CRHBP  (corticotropin releasing hormone binding protein)


Additional Information