Grem1 (gremlin 1, DAN family BMP antagonist) - Rat Genome Database

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Gene: Grem1 (gremlin 1, DAN family BMP antagonist) Rattus norvegicus
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Symbol: Grem1
Name: gremlin 1, DAN family BMP antagonist
RGD ID: 2359
Description: Predicted to enable several functions, including BMP binding activity; protein homodimerization activity; and signaling receptor activator activity. Involved in negative regulation of cell growth; negative regulation of monocyte chemotaxis; and positive regulation of angiogenesis. Acts upstream of or within negative regulation of osteoblast differentiation. Located in cell surface and extracellular space. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2,4-trimethylbenzene; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cktsf1b1; cysteine knot superfamily 1, BMP antagonist 1; down-regulated in mos-transformed cells; drm; gremlin 1; gremlin 1 homolog, cysteine knot superfamily; gremlin 1 homolog, cysteine knot superfamily (Xenopus laevis); gremlin 1, cysteine knot superfamily, homolog; gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis); gremlin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83120,966,639 - 120,978,319 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3120,966,623 - 120,979,089 (-)EnsemblGRCr8
mRatBN7.23100,512,317 - 100,524,001 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3100,512,313 - 100,524,082 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3104,139,268 - 104,150,909 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03112,738,300 - 112,749,941 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03110,428,191 - 110,439,832 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03105,203,309 - 105,214,989 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3105,203,309 - 105,214,989 (-)Ensemblrn6Rnor6.0
Rnor_5.03111,779,965 - 111,791,645 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4399,597,201 - 99,608,935 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera399,483,712 - 99,495,442 (-)NCBICelera
RGSC_v3.1399,493,630 - 99,505,363 (-)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
calcitriol  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erianin  (ISO)
ethanol  (ISO)
fentanyl  (EXP)
fenvalerate  (EXP)
fructose  (ISO)
furan  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (EXP)
mercury dibromide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenylmercury acetate  (ISO)
progesterone  (EXP,ISO)
Ptaquiloside  (ISO)
purine-6-thiol  (EXP)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ morphogenesis  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle cell myoblast differentiation  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cell morphogenesis  (ISO)
cell-cell signaling  (ISO)
collagen fibril organization  (ISO)
determination of dorsal identity  (ISO)
embryonic limb morphogenesis  (ISO)
endothelial cell migration  (ISO)
limb development  (ISO)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of BMP signaling pathway  (ISO,ISS)
negative regulation of bone mineralization  (ISO)
negative regulation of bone mineralization involved in bone maturation  (ISO)
negative regulation of bone remodeling  (ISO)
negative regulation of bone trabecula formation  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell growth  (IMP)
negative regulation of chondrocyte differentiation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of leukocyte chemotaxis  (IDA)
negative regulation of monocyte chemotaxis  (IDA)
negative regulation of osteoblast differentiation  (IMP,ISO,ISS)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of osteoclast proliferation  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
obsolete positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of angiogenesis  (IMP,ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular endothelial growth factor signaling pathway  (ISO)
proximal/distal pattern formation  (ISO)
regulation of epithelial to mesenchymal transition  (ISO)
regulation of focal adhesion assembly  (ISO)
regulation of stress-activated MAPK cascade  (ISO)
sequestering of BMP from receptor via BMP binding  (IBA)
signal transduction  (IEA,ISO)
signal transduction by p53 class mediator  (ISO)
ureteric bud formation  (ISO)

Cellular Component
cell surface  (IDA,ISO)
extracellular region  (IEA,TAS)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. Chen B, etal., J Immunol. 2004 Nov 15;173(10):5914-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. miR-27a attenuates adipogenesis and promotes osteogenesis in steroid-induced rat BMSCs by targeting PPARγ and GREM1. Gu C, etal., Sci Rep. 2016 Dec 2;6:38491. doi: 10.1038/srep38491.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Stabile H, etal., Blood. 2007 Mar 1;109(5):1834-40. Epub 2006 Oct 31.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Biosynthesis, post-translation modification, and functional characterization of Drm/Gremlin. Topol LZ, etal., J Biol Chem. 2000 Mar 24;275(12):8785-93.
14. Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture. Topol LZ, etal., Mol Cell Biol 1997 Aug;17(8):4801-10.
Additional References at PubMed
PMID:9660951   PMID:10556075   PMID:12135612   PMID:12808456   PMID:15198975   PMID:15201225   PMID:15539560   PMID:16545136   PMID:16816361   PMID:17522159   PMID:17980714   PMID:18086474  
PMID:18505784   PMID:18545679   PMID:19142012   PMID:20660291   PMID:20705941   PMID:21281623   PMID:22206666   PMID:24614542   PMID:25356047   PMID:27036124   PMID:27863390   PMID:31657855  
PMID:32750294   PMID:34993960   PMID:35440754   PMID:37977053  


Genomics

Comparative Map Data
Grem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83120,966,639 - 120,978,319 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3120,966,623 - 120,979,089 (-)EnsemblGRCr8
mRatBN7.23100,512,317 - 100,524,001 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3100,512,313 - 100,524,082 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3104,139,268 - 104,150,909 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03112,738,300 - 112,749,941 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03110,428,191 - 110,439,832 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03105,203,309 - 105,214,989 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3105,203,309 - 105,214,989 (-)Ensemblrn6Rnor6.0
Rnor_5.03111,779,965 - 111,791,645 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4399,597,201 - 99,608,935 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera399,483,712 - 99,495,442 (-)NCBICelera
RGSC_v3.1399,493,630 - 99,505,363 (-)NCBI
Cytogenetic Map3q35NCBI
GREM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381532,718,004 - 32,745,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1532,716,998 - 32,745,106 (+)Ensemblhg38GRCh38
GRCh371533,010,205 - 33,037,307 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,797,497 - 30,814,158 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341530,797,593 - 30,814,158NCBI
Celera159,812,058 - 9,828,720 (+)NCBICelera
Cytogenetic Map15q13.3NCBI
HuRef159,872,067 - 9,888,724 (+)NCBIHuRef
CHM1_11533,128,259 - 33,144,912 (+)NCBICHM1_1
T2T-CHM13v2.01530,514,530 - 30,541,636 (+)NCBIT2T-CHM13v2.0
Grem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392113,579,020 - 113,588,993 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2113,576,509 - 113,588,991 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382113,748,675 - 113,758,648 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2113,746,164 - 113,758,646 (-)Ensemblmm10GRCm38
MGSCv372113,588,832 - 113,598,805 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362113,549,514 - 113,559,485 (-)NCBIMGSCv36mm8
Celera2114,881,929 - 114,891,879 (-)NCBICelera
Cytogenetic Map2E4NCBI
cM Map257.43NCBI
Grem1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554161,812,676 - 1,826,271 (-)Ensembl
ChiLan1.0NW_0049554161,812,725 - 1,825,528 (-)NCBIChiLan1.0ChiLan1.0
GREM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21621,486,504 - 21,503,390 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11526,208,169 - 26,225,051 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01511,213,870 - 11,230,619 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11530,051,483 - 30,068,243 (+)NCBIPanPan1.1PanPan1.1panPan2
GREM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1302,219,535 - 2,231,868 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl302,222,898 - 2,225,418 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha302,269,149 - 2,281,447 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0302,332,148 - 2,344,441 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1302,268,479 - 2,281,286 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0302,367,729 - 2,380,025 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0302,496,103 - 2,508,404 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864080,752,116 - 80,764,323 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366731,395,757 - 1,396,311 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366731,394,743 - 1,399,726 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GREM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1136,617,105 - 136,629,292 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11136,617,041 - 136,629,293 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21152,742,118 - 152,749,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GREM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12650,152,097 - 50,169,760 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604890,715,793 - 90,733,042 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grem1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248041,608,757 - 1,620,938 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248041,606,182 - 1,620,932 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grem1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1591,960,512 - 91,970,084 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grem1
101 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:419
Count of miRNA genes:235
Interacting mature miRNAs:279
Transcripts:ENSRNOT00000037895
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)3116582412122654872Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
Grem1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23100,515,669 - 100,515,772 (+)MAPPERmRatBN7.2
Rnor_6.03105,206,662 - 105,206,764NCBIRnor6.0
Rnor_5.03111,783,318 - 111,783,420UniSTSRnor5.0
Celera399,487,115 - 99,487,217UniSTS
Cytogenetic Map3q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 5 63 153 69 74 43 49 43 6 280 137 11 137 81 81 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000037895   ⟹   ENSRNOP00000035888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3120,966,623 - 120,979,089 (-)Ensembl
mRatBN7.2 Ensembl3100,512,313 - 100,524,082 (-)Ensembl
Rnor_6.0 Ensembl3105,203,309 - 105,214,989 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104302   ⟹   ENSRNOP00000084612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3120,966,635 - 120,978,078 (-)Ensembl
mRatBN7.2 Ensembl3100,512,333 - 100,523,795 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125363   ⟹   ENSRNOP00000109430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3120,969,589 - 120,977,016 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000133512   ⟹   ENSRNOP00000102329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3120,966,635 - 120,978,834 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159945   ⟹   ENSRNOP00000111734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3120,968,753 - 120,976,586 (-)Ensembl
RefSeq Acc Id: NM_019282   ⟹   NP_062155
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83120,966,639 - 120,978,319 (-)NCBI
mRatBN7.23100,512,317 - 100,524,001 (-)NCBI
Rnor_6.03105,203,309 - 105,214,989 (-)NCBI
Rnor_5.03111,779,965 - 111,791,645 (-)NCBI
RGSC_v3.4399,597,201 - 99,608,935 (-)RGD
Celera399,483,712 - 99,495,442 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062155 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA71126 (Get FASTA)   NCBI Sequence Viewer  
  EDL79816 (Get FASTA)   NCBI Sequence Viewer  
  EDL79817 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035888.2
  ENSRNOP00000084612.1
  ENSRNOP00000102329
GenBank Protein O35793 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062155   ⟸   NM_019282
- Peptide Label: precursor
- UniProtKB: O35793 (UniProtKB/Swiss-Prot),   A6HP66 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035888   ⟸   ENSRNOT00000037895
Ensembl Acc Id: ENSRNOP00000084612   ⟸   ENSRNOT00000104302
Ensembl Acc Id: ENSRNOP00000109430   ⟸   ENSRNOT00000125363
Ensembl Acc Id: ENSRNOP00000111734   ⟸   ENSRNOT00000159945
Ensembl Acc Id: ENSRNOP00000102329   ⟸   ENSRNOT00000133512
Protein Domains
CTCK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35793-F1-model_v2 AlphaFold O35793 1-184 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692297
Promoter ID:EPDNEW_R2820
Type:multiple initiation site
Name:Grem1_1
Description:gremlin 1, DAN family BMP antagonist
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03105,215,002 - 105,215,062EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2359 AgrOrtholog
BioCyc Gene G2FUF-48361 BioCyc
Ensembl Genes ENSRNOG00000026053 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000037895.4 UniProtKB/Swiss-Prot
  ENSRNOT00000104302.1 UniProtKB/Swiss-Prot
  ENSRNOT00000133512 ENTREZGENE
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro Cys_knot_C UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  DAN UniProtKB/Swiss-Prot
  Gremlin-1/2 UniProtKB/Swiss-Prot
KEGG Report rno:50566 UniProtKB/Swiss-Prot
NCBI Gene 50566 ENTREZGENE
PANTHER GREMLIN 1 UniProtKB/Swiss-Prot
  GREMLIN-1 UniProtKB/Swiss-Prot
Pfam DAN UniProtKB/Swiss-Prot
PhenoGen Grem1 PhenoGen
PIRSF Gremlin_precursor UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000026053 RatGTEx
SMART SM00041 UniProtKB/Swiss-Prot
TIGR TC208374
UniProt A0ABK0LVV5_RAT UniProtKB/TrEMBL
  A0ABK0M545_RAT UniProtKB/TrEMBL
  A6HP66 ENTREZGENE, UniProtKB/TrEMBL
  GREM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Grem1  gremlin 1, DAN family BMP antagonist  Grem1  gremlin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Grem1  gremlin 1  Grem1  gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Grem1  gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)  Grem1  gremlin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Grem1  gremlin 1  Grem1  gremlin 1 homolog, cysteine knot superfamily (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-03-17 Grem1  gremlin 1 homolog, cysteine knot superfamily (Xenopus laevis)  Cktsf1b1  cysteine knot superfamily 1, BMP antagonist 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 Cktsf1b1  cysteine knot superfamily 1, BMP antagonist 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at high levels in normal fibroblasts (REF-1 cells) and in revertant v-mos transformed cells; downregulated in parental v-mos transformed cells 69808
gene_expression expressed at high levels in brain, spleen, kidney, testis; little to no expression in heart, liver, skeletal muscle 69808
gene_process high expression levels may induce cellular apoptosis if cells are not transformed by oncogenes 69808
gene_process may play a role in cellular growth control, cellular viability and tissue-specific cellular differentiation 69808
gene_protein 184 amino acid protein predicted from open reading frame; 20.7 kDa protein detected 69808
gene_regulation expression in fibroblasts suppressed by v-ras, v-src, v-raf and v-fos 69808