Chrna7 (cholinergic receptor nicotinic alpha 7 subunit) - Rat Genome Database

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Gene: Chrna7 (cholinergic receptor nicotinic alpha 7 subunit) Rattus norvegicus
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Symbol: Chrna7
Name: cholinergic receptor nicotinic alpha 7 subunit
RGD ID: 2348
Description: Enables several functions, including acetylcholine binding activity; acetylcholine-gated monoatomic cation-selective channel activity; and enzyme binding activity. Involved in several processes, including neuronal action potential; regulation of ERK1 and ERK2 cascade; and synaptic signaling. Acts upstream of or within regulation of membrane potential. Located in several cellular components, including dendrite; growth cone; and plasma membrane raft. Part of acetylcholine-gated channel complex. Is active in several cellular components, including glycinergic synapse; spine apparatus membrane; and synaptic membrane. Used to study cognitive disorder. Biomarker of rheumatoid arthritis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to several human genes including CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-Nornicotine; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BTX; bungarotoxin alpha; C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); cholinergic receptor, nicotinic, alpha 7; cholinergic receptor, nicotinic, alpha 7 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 7; nAChR7; nAChRa7; NARAD; neuronal acetylcholine receptor subunit alpha-7; neuronal nicotinic acetycholine receptor alpha 7; nicotinic acetylcholine receptor subunit alpha-7; nicotinic receptor alpha 7 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81126,123,425 - 126,249,181 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1126,123,425 - 126,446,858 (-)EnsemblGRCr8
mRatBN7.21116,711,559 - 116,837,269 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1116,714,711 - 116,837,240 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1124,676,761 - 124,793,917 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01131,859,276 - 131,976,435 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01124,684,982 - 124,802,138 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01123,897,341 - 124,039,263 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1123,899,657 - 124,039,196 (-)Ensemblrn6Rnor6.0
Rnor_5.01125,029,451 - 125,158,153 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41117,587,580 - 117,716,267 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1108,976,664 - 109,097,764 (-)NCBICelera
RGSC_v3.11117,665,347 - 117,794,621 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-Nornicotine  (EXP)
(-)-cotinine  (ISO)
(-)-lobeline  (ISO)
(R)-adrenaline  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dimethyl-4-phenylpiperazinium iodide  (ISO)
1,2-dichloroethane  (ISO)
13-desmethylspirolide C  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-hydroxyindole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamiprid  (EXP,ISO)
acetylcholine  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (EXP)
ammonium chloride  (EXP)
Anabaseine  (EXP)
Anatoxin a  (EXP)
arsenous acid  (ISO)
atracurium  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cannabidiol  (ISO)
carbachol  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
cisatracurium  (ISO)
cisplatin  (ISO)
Citreoviridin  (ISO)
clothianidin  (ISO)
Cuprizon  (EXP)
cytisine  (EXP,ISO)
decabromodiphenyl ether  (EXP)
Desformylflustrabromine  (ISO)
dextran sulfate  (ISO)
Diacetoxyscirpenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
dihydro-beta-erythroidine  (EXP,ISO)
dimethylarsinic acid  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
epibatidine  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
flupyradifurone  (ISO)
galanthamine  (ISO)
galanthamine Trifluoroacetic acid  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
herbicide  (ISO)
imidacloprid  (ISO)
ivermectin  (EXP)
lead diacetate  (EXP)
Licochalcone B  (ISO)
linoleic acid  (EXP)
lovastatin  (EXP,ISO)
LY294002  (ISO)
manganese(II) chloride  (ISO)
Mecamylamine  (EXP,ISO)
melittin  (EXP)
methyllycaconitine  (EXP,ISO)
methylmercury chloride  (ISO)
Mivacurium  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP)
nicotine  (EXP,ISO)
nicotinic acetylcholine receptor agonist  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
pancuronium  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion-methyl  (EXP)
PCB138  (EXP)
PNU-282987  (EXP,ISO)
potassium dichromate  (ISO)
propanal  (ISO)
resveratrol  (EXP,ISO)
rocuronium  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
spinosad  (ISO)
sterigmatocystin  (EXP)
sulfoxaflor  (ISO)
suramin  (ISO)
testosterone  (EXP)
tetrachloroethene  (EXP,ISO)
tetrodotoxin  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
topiramate  (EXP)
trichloroethene  (EXP)
tubocurarine  (ISO)
urethane  (ISO)
valproic acid  (ISO)
varenicline  (EXP)
vecuronium bromide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (IDA,IEA,ISO)
activation of protein kinase C activity  (ISO)
associative learning  (ISO)
B cell activation  (ISO)
behavioral response to ethanol  (ISO)
behavioral response to nicotine  (ISO)
calcium ion transport  (IBA,IDA,IMP,ISO)
chemical synaptic transmission  (IBA,ISO)
cognition  (ISO)
dendrite arborization  (IEA,ISO)
dendritic spine organization  (IEA,ISO)
endocytosis  (ISO)
excitatory postsynaptic potential  (IEA,ISO)
flagellated sperm motility  (ISO)
generation of ovulation cycle rhythm  (ISO)
intracellular calcium ion homeostasis  (ISO)
learning or memory  (IEA,IMP,ISO)
membrane depolarization  (IDA,ISO)
memory  (IDA,IEA,ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
modulation of excitatory postsynaptic potential  (IEA,ISO)
monoatomic cation transport  (IDA)
monoatomic ion transmembrane transport  (IBA,IEA,ISO)
monoatomic ion transport  (IEA,ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
negative regulation of cytokine production involved in inflammatory response  (IEA,ISO,ISS)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of intracellular signal transduction  (IEA)
negative regulation of tumor necrosis factor production  (ISO,ISS)
neuronal action potential  (IMP)
ovulation cycle  (ISO)
positive regulation of amyloid-beta formation  (IEA,ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA,IEA,IMP,ISO)
positive regulation of excitatory postsynaptic potential  (IEA,ISO)
positive regulation of gene expression  (IDA)
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure  (ISO)
positive regulation of long-term synaptic potentiation  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of protein metabolic process  (IEA,ISO)
presynaptic modulation of chemical synaptic transmission  (EXP,IDA)
regulation of amyloid fibril formation  (IEA,ISO)
regulation of amyloid precursor protein catabolic process  (ISO)
regulation of inflammatory response  (ISO)
regulation of membrane potential  (IBA,IDA,IMP,ISO)
regulation of nitric oxide metabolic process  (ISO)
regulation of norepinephrine secretion  (ISO)
regulation of postsynaptic membrane potential  (IEA)
regulation of synapse structural plasticity  (IEA,ISO)
regulation of synaptic transmission, dopaminergic  (ISO)
response to acetylcholine  (IDA,ISO)
response to amyloid-beta  (IEA,ISO)
response to carbamate  (IEP)
response to cold  (IEA,ISO)
response to ethanol  (IEA,IEP,ISO)
response to food  (ISO)
response to hypoxia  (ISO)
response to nicotine  (IDA,IEA,IGI,ISO)
sensory processing  (IDA,IEA,ISO)
signal transduction  (ISO)
synapse organization  (IEA,ISO)
synaptic transmission involved in micturition  (IDA)
synaptic transmission, cholinergic  (IDA,IEA,IMP,ISO)
T cell activation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. Alasmari F, etal., Chem Biol Interact. 2021 Jan 5;333:109308. doi: 10.1016/j.cbi.2020.109308. Epub 2020 Nov 23.
2. Mammalian nicotinic acetylcholine receptors: from structure to function. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
3. Up-regulation of the human-specific CHRFAM7A gene in inflammatory bowel disease. Baird A, etal., BBA Clin. 2016 Jan 8;5:66-71. doi: 10.1016/j.bbacli.2015.12.003. eCollection 2016 Jun.
4. Pro-cognitive and antipsychotic efficacy of the alpha7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia. Barak S, etal., Neuropsychopharmacology. 2009 Jun;34(7):1753-63. doi: 10.1038/npp.2008.232. Epub 2009 Jan 21.
5. Differential expression and function of nicotinic acetylcholine receptors in the urinary bladder epithelium of the rat. Beckel JM and Birder LA, J Physiol. 2012 Mar 15;590(6):1465-80. doi: 10.1113/jphysiol.2011.226860. Epub 2012 Jan 16.
6. Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. Bitner RS, etal., J Neurosci. 2007 Sep 26;27(39):10578-87.
7. Targeting alpha7-nicotinic receptor for the treatment of pleural mesothelioma. Catassi A, etal., Eur J Cancer. 2008 Oct;44(15):2296-311. doi: 10.1016/j.ejca.2008.06.045. Epub 2008 Aug 20.
8. Involvement of the alpha 7 subunit of the nicotinic receptor in morphogenic and trophic effects of acetylcholine on embryonic rat spinal motoneurons in culture. Catone C and Ternaux JP, J Neurosci Res 2003 Apr 1;72(1):46-53.
9. Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value. Chianello Nicolau M, etal., World J Gastroenterol. 2016 Aug 21;22(31):7146-56. doi: 10.3748/wjg.v22.i31.7146.
10. The a7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane. Colón-Sáez JO and Yakel JL, J Physiol. 2011 Jul 1;589(Pt 13):3163-74. doi: 10.1113/jphysiol.2011.209494. Epub 2011 May 3.
11. HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype. Crews FT, etal., Mol Psychiatry. 2023 Dec;28(12):5159-5172. doi: 10.1038/s41380-023-02160-6. Epub 2023 Jul 4.
12. Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairment. Curzon P, etal., Neurosci Lett. 2006 Dec 13;410(1):15-9. doi: 10.1016/j.neulet.2006.09.061. Epub 2006 Oct 20.
13. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. Dineley KT, etal., J Neurosci. 2001 Jun 15;21(12):4125-33.
14. Neuronal alpha-bungarotoxin receptors are alpha7 subunit homomers. Drisdel RC and Green WN, J Neurosci. 2000 Jan 1;20(1):133-9.
15. Ultrastructural distribution of the alpha7 nicotinic acetylcholine receptor subunit in rat hippocampus. Fabian-Fine R, etal., J Neurosci. 2001 Oct 15;21(20):7993-8003.
16. Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons. Farias GG, etal., J Neurosci. 2007 May 16;27(20):5313-25.
17. Dendritic Ca2+ signalling due to activation of alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal neurons. Fayuk D and Yakel JL, J Physiol. 2007 Jul 15;582(Pt 2):597-611. doi: 10.1113/jphysiol.2007.135319. Epub 2007 May 17.
18. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Freedman R, etal., Proc Natl Acad Sci U S A 1997 Jan 21;94(2):587-92.
19. Ca2+ permeability of nicotinic acetylcholine receptors from rat dorsal root ganglion neurones. Fucile S, etal., J Physiol. 2005 May 15;565(Pt 1):219-28. Epub 2005 Mar 10.
20. Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum. Garção P, etal., Neurosci Lett. 2014 Apr 30;566:106-10. doi: 10.1016/j.neulet.2014.02.018. Epub 2014 Mar 4.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. PMCA2 via PSD-95 controls calcium signaling by alpha7-containing nicotinic acetylcholine receptors on aspiny interneurons. Gomez-Varela D, etal., J Neurosci. 2012 May 16;32(20):6894-905. doi: 10.1523/JNEUROSCI.5972-11.2012.
24. Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels. Khiroug SS, etal., J Physiol 2002 Apr 15;540(Pt 2):425-34.
25. Carbofuran induces apoptosis of rat cortical neurons and down-regulates surface alpha7 subunit of acetylcholine receptors. Kim SJ, etal., Mol Cells. 2004 Apr 30;17(2):242-7.
26. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. Klink R, etal., J Neurosci. 2001 Mar 1;21(5):1452-63.
27. The alpha7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of the rat. Kristensen SE, etal., Neurosci Lett. 2007 May 17;418(2):154-8. doi: 10.1016/j.neulet.2007.03.016. Epub 2007 Mar 12.
28. Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex. Levy RB and Aoki C, J Neurosci. 2002 Jun 15;22(12):5001-15.
29. Expression and localization analyses of the cholinergic anti-inflammatory pathway and α7nAchR in different tissues of rats with rheumatoid arthritis. Li Z, etal., Acta Histochem. 2019 Aug;121(6):742-749. doi: 10.1016/j.acthis.2019.07.001. Epub 2019 Jul 3.
30. A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. Liu Q, etal., J Neurosci. 2009 Jan 28;29(4):918-29. doi: 10.1523/JNEUROSCI.3952-08.2009.
31. Postsynaptic alpha 4 beta 2 and alpha 7 type nicotinic acetylcholine receptors contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons. Matsubayashi H, etal., Brain Res. 2004 Apr 16;1005(1-2):1-8.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Nicotine inhibits Fc epsilon RI-induced cysteinyl leukotrienes and cytokine production without affecting mast cell degranulation through alpha 7/alpha 9/alpha 10-nicotinic receptors. Mishra NC, etal., J Immunol. 2010 Jul 1;185(1):588-96. doi: 10.4049/jimmunol.0902227. Epub 2010 May 26.
34. Modulation of neuronal nicotinic acetylcholine receptors by halothane in rat cortical neurons. Mori T, etal., Mol Pharmacol. 2001 Apr;59(4):732-43.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Axon targeting of the alpha 7 nicotinic receptor in developing hippocampal neurons by Gprin1 regulates growth. Nordman JC, etal., J Neurochem. 2014 May;129(4):649-62. doi: 10.1111/jnc.12641. Epub 2014 Jan 10.
37. Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts. Oshikawa J, etal., Am J Physiol Cell Physiol. 2003 Sep;285(3):C567-74. Epub 2003 May 14.
38. Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy. Pacini A, etal., Pain. 2010 Sep;150(3):542-549. doi: 10.1016/j.pain.2010.06.014. Epub 2010 Jul 8.
39. Inhibition of nonneuronal alpha7-nicotinic receptor for lung cancer treatment. Paleari L, etal., Am J Respir Crit Care Med. 2009 Jun 15;179(12):1141-50. doi: 10.1164/rccm.200806-908OC. Epub 2009 Jan 16.
40. Inhibition of non-neuronal alpha7-nicotinic receptor reduces tumorigenicity in A549 NSCLC xenografts. Paleari L, etal., Int J Cancer. 2009 Jul 1;125(1):199-211. doi: 10.1002/ijc.24299.
41. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
42. An alpha7 nicotinic acetylcholine receptor gain-of-function mutant that retains pharmacological fidelity. Placzek AN, etal., Mol Pharmacol. 2005 Dec;68(6):1863-76. Epub 2005 Sep 26.
43. GOA pipeline RGD automated data pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Involvement of alpha 7 nicotinic acetylcholine receptors in gene expression of dopamine biosynthetic enzymes in rat brain. Serova L and Sabban EL, J Pharmacol Exp Ther 2002 Dec;303(3):896-903.
47. Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid. Shaw S, etal., J Biol Chem 2002 Nov 22;277(47):44920-4.
48. Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3'] oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. Tatsumi R, etal., J Med Chem. 2005 Apr 7;48(7):2678-86.
49. Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology. Teaktong T, etal., J Neurol Sci 2004 Oct 15;225(1-2):39-49.
50. Lynx1 and Aβ1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes. Thomsen MS, etal., Neurobiol Aging. 2016 Oct;46:13-21. doi: 10.1016/j.neurobiolaging.2016.06.009. Epub 2016 Jun 17.
51. Functional properties of internalization-deficient P2X4 receptors reveal a novel mechanism of ligand-gated channel facilitation by ivermectin. Toulme E, etal., Mol Pharmacol. 2006 Feb;69(2):576-87. Epub 2005 Nov 10.
52. Role of the large cytoplasmic loop of the alpha 7 neuronal nicotinic acetylcholine receptor subunit in receptor expression and function. Valor LM, etal., Biochemistry 2002 Jun 25;41(25):7931-8.
53. Nicotinic acetylcholine receptor subtypes in rat superior cervical ganglion neurons as studied by sequential application of two alpha-subunit-specific antibodies. Voitenko LP, etal., Neurosci Lett. 2001 Apr 27;303(1):37-40.
54. Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer's disease pathogenesis. Wang HY, etal., Alzheimers Res Ther. 2017 Jul 27;9(1):54. doi: 10.1186/s13195-017-0280-8.
55. beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. Wang HY, etal., J Biol Chem. 2000 Feb 25;275(8):5626-32.
56. Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. Wang L, etal., Oncogene. 2021 Mar;40(11):1974-1987. doi: 10.1038/s41388-021-01682-z. Epub 2021 Feb 18.
57. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
58. Duplicated copy of CHRNA7 increases risk and worsens prognosis of COPD and lung cancer. Yang L, etal., Eur J Hum Genet. 2015 Aug;23(8):1019-24. doi: 10.1038/ejhg.2014.229. Epub 2014 Nov 19.
59. Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor. Young JW, etal., Neuropsychopharmacology. 2004 May;29(5):891-900. doi: 10.1038/sj.npp.1300393.
60. Different presynaptic nicotinic receptor subtypes modulate in vivo and in vitro the release of glycine in the rat hippocampus. Zappettini S, etal., Neurochem Int. 2011 Oct;59(5):729-38. doi: 10.1016/j.neuint.2011.06.022. Epub 2011 Jul 5.
Additional References at PubMed
PMID:1400473   PMID:7678857   PMID:8145738   PMID:8906617   PMID:9037516   PMID:9364063   PMID:9495872   PMID:10771023   PMID:10800961   PMID:10942027   PMID:11278551   PMID:11834293  
PMID:12059039   PMID:12079404   PMID:12189247   PMID:12411519   PMID:12508119   PMID:12605456   PMID:12898272   PMID:15296793   PMID:15322233   PMID:15364017   PMID:15469877   PMID:15489024  
PMID:15504725   PMID:15541879   PMID:15555774   PMID:15601930   PMID:15622441   PMID:15635599   PMID:15705531   PMID:15885267   PMID:15922075   PMID:15944242   PMID:15955596   PMID:15963492  
PMID:16025111   PMID:16025117   PMID:16033766   PMID:16141265   PMID:16144967   PMID:16253349   PMID:16269536   PMID:16280133   PMID:16403644   PMID:16652343   PMID:16690715   PMID:16754836  
PMID:16772172   PMID:16772524   PMID:16785311   PMID:16837558   PMID:16923147   PMID:16931547   PMID:16959216   PMID:17068140   PMID:17192608   PMID:17192655   PMID:17291692   PMID:17470777  
PMID:17498763   PMID:17545063   PMID:17548533   PMID:17950703   PMID:18096596   PMID:18164502   PMID:18174677   PMID:18215234   PMID:18222041   PMID:18256594   PMID:18297099   PMID:18310132  
PMID:18387948   PMID:18458158   PMID:18512214   PMID:18614620   PMID:19007816   PMID:19057014   PMID:19063868   PMID:19118188   PMID:19187266   PMID:19230830   PMID:19246390   PMID:19368825  
PMID:19372354   PMID:19374941   PMID:19424097   PMID:19586999   PMID:19587288   PMID:19602049   PMID:19619852   PMID:19637277   PMID:19682509   PMID:19688191   PMID:19762524   PMID:20004706  
PMID:20051354   PMID:20153739   PMID:20164328   PMID:20211606   PMID:20309583   PMID:20347906   PMID:20598018   PMID:20599427   PMID:20633015   PMID:20634896   PMID:20708605   PMID:20817852  
PMID:20837638   PMID:20857232   PMID:20943921   PMID:20974225   PMID:21099147   PMID:21103043   PMID:21339364   PMID:21343288   PMID:21346795   PMID:21665194   PMID:21718690   PMID:21857926  
PMID:21858872   PMID:22127290   PMID:22253754   PMID:22351110   PMID:22479351   PMID:22649244   PMID:22682236   PMID:22778816   PMID:22848433   PMID:22956546   PMID:22962286   PMID:23091164  
PMID:23157401   PMID:23184186   PMID:23201359   PMID:23219030   PMID:23270857   PMID:23749479   PMID:23842742   PMID:24032433   PMID:24177919   PMID:24340009   PMID:24360204   PMID:24486841  
PMID:24525957   PMID:24687992   PMID:25231613   PMID:25447771   PMID:25553616   PMID:25798813   PMID:25810076   PMID:25966616   PMID:26498641   PMID:26522221   PMID:26806304   PMID:27106269  
PMID:27129924   PMID:27339462   PMID:28039041   PMID:28834708   PMID:28842280   PMID:29117064   PMID:29307658   PMID:29665360   PMID:29672286   PMID:29679680   PMID:29768467   PMID:30249754  
PMID:30345917   PMID:30452951   PMID:30947238   PMID:31062470   PMID:31176021   PMID:31398352   PMID:31541709   PMID:33092257   PMID:33352289   PMID:33514001   PMID:33636639   PMID:33691518  
PMID:34052301   PMID:34061415   PMID:34225758   PMID:34920740   PMID:34946750   PMID:35141983   PMID:36167538   PMID:36375307   PMID:36634032   PMID:36912917   PMID:38070724   PMID:38198758  
PMID:38302679  


Genomics

Comparative Map Data
Chrna7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81126,123,425 - 126,249,181 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1126,123,425 - 126,446,858 (-)EnsemblGRCr8
mRatBN7.21116,711,559 - 116,837,269 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1116,714,711 - 116,837,240 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1124,676,761 - 124,793,917 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01131,859,276 - 131,976,435 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01124,684,982 - 124,802,138 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01123,897,341 - 124,039,263 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1123,899,657 - 124,039,196 (-)Ensemblrn6Rnor6.0
Rnor_5.01125,029,451 - 125,158,153 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41117,587,580 - 117,716,267 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1108,976,664 - 109,097,764 (-)NCBICelera
RGSC_v3.11117,665,347 - 117,794,621 (-)NCBI
Cytogenetic Map1q22NCBI
CHRNA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381532,030,483 - 32,173,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1531,923,438 - 32,173,018 (+)Ensemblhg38GRCh38
GRCh371532,322,686 - 32,465,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,110,018 - 30,248,541 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341530,110,017 - 30,248,525NCBI
Celera158,162,865 - 8,292,202 (-)NCBICelera
Cytogenetic Map15q13.3NCBI
HuRef159,499,328 - 9,603,273 (+)NCBIHuRef
CHM1_11532,312,897 - 32,452,812 (+)NCBICHM1_1
T2T-CHM13v2.01529,824,630 - 29,967,342 (+)NCBIT2T-CHM13v2.0
Chrna7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39762,748,440 - 62,862,274 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl762,748,440 - 62,862,317 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38763,098,692 - 63,212,526 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl763,098,692 - 63,212,569 (-)Ensemblmm10GRCm38
MGSCv37770,243,578 - 70,357,412 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36762,977,642 - 63,091,468 (-)NCBIMGSCv36mm8
Celera760,542,827 - 60,660,378 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map734.47NCBI
Chrna7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541630,687,478 - 30,798,700 (+)Ensembl
ChiLan1.0NW_00495541630,687,518 - 30,798,700 (+)NCBIChiLan1.0ChiLan1.0
LOC100977072
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21620,841,679 - 20,981,068 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11525,565,746 - 25,705,121 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01510,525,535 - 10,667,227 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11529,565,885 - 29,705,194 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1529,565,885 - 29,705,194 (+)EnsemblpanPan2panpan1.1
CHRNA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1336,852,082 - 37,164,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl336,852,543 - 36,978,399 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha339,517,659 - 39,644,156 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0337,232,973 - 37,359,572 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl337,231,040 - 37,360,220 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1336,756,424 - 36,882,829 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0337,011,929 - 37,138,401 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0337,222,873 - 37,349,426 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Chrna7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640146,502,956 - 146,512,072 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493735134,921 - 47,246 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493735132,324 - 46,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1142,803,701 - 142,937,123 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11142,803,697 - 142,937,124 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21158,717,002 - 158,849,994 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103245932
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12650,554,143 - 50,686,847 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2650,551,829 - 50,686,803 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604890,139,706 - 90,283,400 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrna7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624768909,099 - 1,024,902 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624768908,907 - 1,024,953 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Chrna7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12136,950,666 - 137,071,611 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Chrna7
1133 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:53
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000051883
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611131244255Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1111404407142582336Rat

Markers in Region
D1Got316  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21116,831,353 - 116,831,565 (+)MAPPERmRatBN7.2
Rnor_6.01124,033,325 - 124,033,536NCBIRnor6.0
Rnor_5.01125,152,285 - 125,152,496UniSTSRnor5.0
RGSC_v3.41117,710,426 - 117,710,637UniSTSRGSC3.4
Celera1109,091,897 - 109,092,108UniSTS
Cytogenetic Map1q22UniSTS
D1Bda22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21116,714,895 - 116,715,248 (+)MAPPERmRatBN7.2
Rnor_6.01123,900,674 - 123,901,026NCBIRnor6.0
Rnor_5.01125,029,061 - 125,029,413UniSTSRnor5.0
RGSC_v3.41117,587,190 - 117,587,542UniSTSRGSC3.4
Celera1108,976,274 - 108,976,626UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 50 134 83 82 51 26 51 6 236 104 6 116 57 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000051883   ⟹   ENSRNOP00000045255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1126,127,149 - 126,249,086 (-)Ensembl
mRatBN7.2 Ensembl1116,715,283 - 116,837,226 (-)Ensembl
Rnor_6.0 Ensembl1123,901,061 - 124,039,196 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082487   ⟹   ENSRNOP00000073551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1126,123,425 - 126,249,129 (-)Ensembl
mRatBN7.2 Ensembl1116,714,711 - 116,837,240 (-)Ensembl
Rnor_6.0 Ensembl1123,899,657 - 124,038,966 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100474   ⟹   ENSRNOP00000082768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1116,714,711 - 116,786,132 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000163971   ⟹   ENSRNOP00000102293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1126,123,425 - 126,214,372 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170905   ⟹   ENSRNOP00000101701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1126,123,425 - 126,446,858 (-)Ensembl
RefSeq Acc Id: NM_012832   ⟹   NP_036964
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81126,123,425 - 126,249,129 (-)NCBI
mRatBN7.21116,711,559 - 116,837,269 (-)NCBI
Rnor_6.01123,901,064 - 124,039,193 (-)NCBI
Rnor_5.01125,029,451 - 125,158,153 (-)NCBI
RGSC_v3.41117,587,580 - 117,716,267 (-)RGD
Celera1108,976,664 - 109,097,764 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281670   ⟹   XP_063137740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81126,123,425 - 126,249,181 (-)NCBI
RefSeq Acc Id: NP_036964   ⟸   NM_012832
- Peptide Label: precursor
- UniProtKB: Q53YK2 (UniProtKB/Swiss-Prot),   Q05941 (UniProtKB/Swiss-Prot),   A6JBJ4 (UniProtKB/TrEMBL),   A0A0G2K5T5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073551   ⟸   ENSRNOT00000082487
Ensembl Acc Id: ENSRNOP00000045255   ⟸   ENSRNOT00000051883
Ensembl Acc Id: ENSRNOP00000082768   ⟸   ENSRNOT00000100474
RefSeq Acc Id: XP_063137740   ⟸   XM_063281670
- Peptide Label: isoform X1
- UniProtKB: Q5UMH9 (UniProtKB/TrEMBL),   A0A0G2K5T5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102293   ⟸   ENSRNOT00000163971
Ensembl Acc Id: ENSRNOP00000101701   ⟸   ENSRNOT00000170905
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05941-F1-model_v2 AlphaFold Q05941 1-502 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2348 AgrOrtholog
BioCyc Gene G2FUF-59106 BioCyc
Ensembl Genes ENSRNOG00000010853 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000051883 ENTREZGENE
  ENSRNOT00000082487 ENTREZGENE
  ENSRNOT00000082487.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:25302 UniProtKB/Swiss-Prot
NCBI Gene 25302 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PharmGKB CHRNA7 RGD
PhenoGen Chrna7 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010853 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A0A0G2K5T5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L1I3_RAT UniProtKB/TrEMBL
  A0ABK0L9H7_RAT UniProtKB/TrEMBL
  A6JBJ4 ENTREZGENE, UniProtKB/TrEMBL
  A6JBJ5_RAT UniProtKB/TrEMBL
  A6JBJ6_RAT UniProtKB/TrEMBL
  A6JBJ7_RAT UniProtKB/TrEMBL
  ACHA7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q53YK2 ENTREZGENE
  Q5UMH9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q53YK2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Chrna7  cholinergic receptor nicotinic alpha 7 subunit  Chrna7  cholinergic receptor, nicotinic, alpha 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-12 Chrna7  cholinergic receptor, nicotinic, alpha 7  Chrna7  cholinergic receptor, nicotinic, alpha 7 (neuronal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Chrna7  cholinergic receptor, nicotinic, alpha 7 (neuronal)  Chrna7  cholinergic receptor, nicotinic, alpha 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Chrna7  cholinergic receptor, nicotinic, alpha 7  Chrna7  cholinergic receptor, nicotinic, alpha polypeptide 7   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Chrna7  cholinergic receptor, nicotinic, alpha polypeptide 7     C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)  Name updated 625702 APPROVED
2002-06-10 Chrna7  C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_pathway activates phosphatidylinositol 3-kinase via Janus kinase 2 (JAK2) activation pathway 633056