Cd80 (Cd80 molecule) - Rat Genome Database

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Gene: Cd80 (Cd80 molecule) Rattus norvegicus
Analyze
Symbol: Cd80
Name: Cd80 molecule
RGD ID: 2314
Description: Predicted to enable receptor ligand activity. Involved in positive regulation of T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia/lymphoma; anti-basement membrane glomerulonephritis; high grade glioma; and periodontal disease. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; aldosterone; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B7-1; Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1); CD80 antigen; CD80-like; LOC100360171; T-lymphocyte activation antigen CD80
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81175,760,073 - 75,798,978 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1175,760,147 - 75,797,540 (-)EnsemblGRCr8
mRatBN7.21162,254,543 - 62,293,414 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,254,624 - 62,292,030 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1171,079,261 - 71,104,269 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,741,518 - 63,766,516 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,792,324 - 62,817,199 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,815,201 - 64,855,293 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,827,635 - 64,855,353 (-)Ensemblrn6Rnor6.0
Rnor_5.01167,255,123 - 67,291,544 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41164,045,358 - 64,070,072 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1161,768,874 - 61,793,351 (-)NCBICelera
RGSC_v3.11164,102,946 - 64,127,661 (-)NCBI
RH 3.4 Map11500.9RGD
Cytogenetic Map11q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,4-benzoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (ISO)
4-methylhistamine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
adenine  (ISO)
adenosine 5'-[gamma-thio]triphosphate  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
baicalein  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucan  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
calcitriol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
daidzein  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diethyl maleate  (ISO)
diisononyl phthalate  (ISO)
Dimaprit  (ISO)
dioxygen  (EXP,ISO)
endosulfan  (EXP)
eplerenone  (EXP)
estriol  (ISO)
ethyl methanesulfonate  (ISO)
famotidine  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gardiquimod  (ISO)
genistein  (ISO)
glucuronoxylomannan  (ISO)
GSK-J4  (ISO)
helenalin  (ISO)
histamine  (ISO)
hydroquinone  (ISO)
hydroxycitronellal  (ISO)
imidurea  (ISO)
imiquimod  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lupane  (ISO)
methyl methanesulfonate  (ISO)
MK-2206  (ISO)
molybdenum trichloride  (ISO)
monosodium L-glutamate  (ISO)
muramyl dipeptide  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naproxen  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nystatin  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
PCB138  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
procyanidin B3  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
protosappanin A  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Senkirkine  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc protoporphyrin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Increased production of circulating soluble co-stimulatory molecules CTLA-4, CD28 and CD80 in patients with rheumatoid arthritis. Cao J, etal., Int Immunopharmacol. 2012 Aug 20.
2. Flt3 ligand expands CD103(+) dendritic cells and FoxP3(+) T regulatory cells, and attenuates Crohn's-like murine ileitis. Collins CB, etal., Gut. 2012 Aug;61(8):1154-62. Epub 2011 Nov 7.
3. Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus. Dolff S, etal., Arthritis Res Ther. 2010;12(4):R150. Epub 2010 Jul 23.
4. CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease. Duncan DS and Miller SD, PLoS One. 2011 Apr 8;6(4):e18548.
5. Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease. Freeman CM, etal., Am J Respir Crit Care Med. 2009 Dec 15;180(12):1179-88. Epub 2009 Sep 3.
6. Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model. Gallon L, etal., J Immunol. 1997 Nov 1;159(9):4212-6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade. Hanabuchi S, etal., J Virol. 2000 Jan;74(1):428-35.
10. Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses. Haspot F, etal., Blood 2002 Mar 15;99(6):2228-34.
11. CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis. Huang Y, etal., Inflammation. 2018 Feb;41(1):232-239. doi: 10.1007/s10753-017-0681-7.
12. Clonorchis sinensis-derived total protein attenuates airway inflammation in murine asthma model by inducing regulatory T cells and modulating dendritic cell functions. Jeong YI, etal., Biochem Biophys Res Commun. 2011 Apr 22;407(4):793-800. Epub 2011 Apr 1.
13. Cloning the rat homolog of the CD28/CTLA-4-ligand B7-1: structural and functional analysis. Judge TA, etal., Int Immunol 1995 Feb;7(2):171-8.
14. Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease. Kawai T, etal., J Immunol. 2000 Feb 15;164(4):2102-9.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Primed status of transitional B cells associated with their presence in the cerebrospinal fluid in early phases of multiple sclerosis. Lee-Chang C, etal., Clin Immunol. 2011 Apr;139(1):12-20.
17. Cholecystokinin octapeptide significantly suppresses collagen-induced arthritis in mice by inhibiting Th17 polarization primed by dendritic cells. Li Q, etal., Cell Immunol. 2011;272(1):53-60. Epub 2011 Sep 29.
18. Differential requirement for CD80 and CD80/CD86-dependent costimulation in the lung immune response to an influenza virus infection. Lumsden JM, etal., J Immunol. 2000 Jan 1;164(1):79-85.
19. Characterization of rat CD80 and CD86 by molecular cloning and mAb. Maeda K, etal., Int Immunol 1997 Jul;9(7):993-1000.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Early immunological response to German cockroach frass exposure induces a Th2/Th17 environment. Page K, etal., J Innate Immun. 2011;3(2):167-79. Epub 2010 Nov 5.
23. CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. Pang S, etal., Eur J Immunol. 2009 Oct;39(10):2716-24.
24. Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent. Pechhold K, etal., J Immunol. 2001 Feb 15;166(4):2531-9.
25. Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis. Phares TW, etal., J Immunol. 2010 Nov 1;185(9):5607-18. Epub 2010 Sep 27.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis. Reynolds J, etal., J Clin Invest. 2000 Mar;105(5):643-51.
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Comprehensive gene review and curation RGD comprehensive gene curation
31. CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia. Roquilly A, etal., PLoS One. 2010 Oct 7;5(10):e13228.
32. Expression of B7 molecules in the eye during experimental autoimmune anterior uveitis (EAAU). Shao H, etal., Curr Eye Res 2002 Nov;25(5):271-7.
33. Association of variants in innate immune genes with asthma and eczema. Sharma S, etal., Pediatr Allergy Immunol. 2012 Jun;23(4):315-23. doi: 10.1111/j.1399-3038.2011.01243.x. Epub 2011 Dec 23.
34. HLA-G-treated tolerogenic dendritic cells induce tolerogenic potential by increasing expression of B7-1 (CD80) molecules. Smith M, etal., Transplant Proc. 2008 Jun;40(5):1598-603.
35. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
36. Impaired immune responses in the lungs of aged mice following influenza infection. Toapanta FR and Ross TM, Respir Res. 2009 Nov 18;10:112.
37. Anti-allergic effects of Lactobacillus crispatus KT-11 strain on ovalbumin-sensitized BALB/c mice. Tobita K, etal., Anim Sci J. 2010 Dec;81(6):699-705. doi: 10.1111/j.1740-0929.2010.00795.x. Epub 2010 Oct 7.
38. Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells. Visse E, etal., Cancer Gene Ther 1999 Jan-Feb;6(1):37-44.
39. Valsartan inhibited the accumulation of dendritic cells in rat fibrotic renal tissue. Wu K, etal., Cell Mol Immunol. 2006 Jun;3(3):213-20.
40. Phenotype and function of GM-CSF independent dendritic cells generated by long-term propagation of rat bone marrow cells. Yan H, etal., Cell Immunol. 2004 Jun;229(2):117-29. doi: 10.1016/j.cellimm.2004.07.006.
41. A soluble thymic stromal lymphopoietin (TSLP) antagonist, TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cells. Zhang F, etal., Clin Exp Immunol. 2011 May;164(2):256-64. doi: 10.1111/j.1365-2249.2011.04328.x. Epub 2011 Feb 24.
Additional References at PubMed
PMID:1385153   PMID:7544393   PMID:8566034   PMID:9915850   PMID:14560001   PMID:15240714   PMID:15314074   PMID:15568026   PMID:16475216   PMID:17068184   PMID:17376836   PMID:17429054  
PMID:17457373   PMID:18089391   PMID:18684012   PMID:19047410   PMID:23793062   PMID:23981064   PMID:29360807   PMID:32733939   PMID:34129205  


Genomics

Comparative Map Data
Cd80
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81175,760,073 - 75,798,978 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1175,760,147 - 75,797,540 (-)EnsemblGRCr8
mRatBN7.21162,254,543 - 62,293,414 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,254,624 - 62,292,030 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1171,079,261 - 71,104,269 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,741,518 - 63,766,516 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,792,324 - 62,817,199 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,815,201 - 64,855,293 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,827,635 - 64,855,353 (-)Ensemblrn6Rnor6.0
Rnor_5.01167,255,123 - 67,291,544 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41164,045,358 - 64,070,072 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1161,768,874 - 61,793,351 (-)NCBICelera
RGSC_v3.11164,102,946 - 64,127,661 (-)NCBI
RH 3.4 Map11500.9RGD
Cytogenetic Map11q21NCBI
CD80
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,524,293 - 119,559,614 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,523,898 - 119,569,324 (-)Ensemblhg38GRCh38
GRCh373119,243,140 - 119,278,461 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363120,725,830 - 120,761,171 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343120,725,831 - 120,761,139NCBI
Celera3117,651,693 - 117,687,039 (-)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,618,830 - 116,654,199 (-)NCBIHuRef
CHM1_13119,206,623 - 119,241,981 (-)NCBICHM1_1
T2T-CHM13v2.03122,244,011 - 122,279,336 (-)NCBIT2T-CHM13v2.0
Cd80
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391638,277,793 - 38,316,682 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1638,275,923 - 38,316,697 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381638,457,430 - 38,495,958 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,455,561 - 38,496,335 (+)Ensemblmm10GRCm38
MGSCv371638,459,013 - 38,487,015 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361638,378,414 - 38,418,102 (+)NCBIMGSCv36mm8
Celera1638,869,381 - 38,897,547 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1626.86NCBI
Cd80
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,236,445 - 19,261,517 (-)Ensembl
ChiLan1.0NW_00495542719,237,251 - 19,274,001 (-)NCBIChiLan1.0ChiLan1.0
CD80
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22117,503,138 - 117,539,784 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13117,506,554 - 117,542,489 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03116,646,590 - 116,683,725 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13123,559,559 - 123,594,870 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,559,559 - 123,594,870 (-)EnsemblpanPan2panpan1.1
CD80
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,177,136 - 23,208,421 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,177,138 - 23,201,380 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3323,207,369 - 23,231,610 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03323,415,441 - 23,446,725 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,415,442 - 23,446,698 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,217,902 - 23,242,129 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,253,474 - 23,277,692 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03323,822,928 - 23,847,156 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cd80
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602131,033,618 - 131,058,267 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365366,462,080 - 6,483,450 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD80
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,693,382 - 140,728,976 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113140,693,312 - 140,730,541 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213150,031,804 - 150,044,259 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD80
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12261,258,281 - 61,294,772 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041105,020,341 - 105,055,630 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd80
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473128,630,446 - 28,651,994 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473128,630,540 - 28,655,297 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cd80
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1423,411,721 - 23,430,767 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cd80
246 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:114
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000002089
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat

Markers in Region
RH94722  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,291,798 - 62,291,983 (+)MAPPERmRatBN7.2
Rnor_6.01164,853,738 - 64,853,922NCBIRnor6.0
Rnor_5.01167,256,456 - 67,256,640UniSTSRnor5.0
RGSC_v3.41164,070,129 - 64,070,313UniSTSRGSC3.4
Celera1161,793,408 - 61,793,592UniSTS
RH 3.4 Map11500.9UniSTS
Cytogenetic Map11q21UniSTS
BF402875  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,274,405 - 62,274,498 (+)MAPPERmRatBN7.2
Rnor_6.01164,836,350 - 64,836,442NCBIRnor6.0
Rnor_5.01167,273,465 - 67,273,557UniSTSRnor5.0
RGSC_v3.41164,053,020 - 64,053,112UniSTSRGSC3.4
Celera1161,776,536 - 61,776,628UniSTS
RH 3.4 Map11508.3UniSTS
Cytogenetic Map11q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 161 85 84 53 92 53 6 343 190 11 140 76 90 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002089   ⟹   ENSRNOP00000002089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1175,760,147 - 75,797,540 (-)Ensembl
mRatBN7.2 Ensembl1162,254,624 - 62,292,030 (-)Ensembl
Rnor_6.0 Ensembl1164,828,671 - 64,853,692 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089625   ⟹   ENSRNOP00000071419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1164,827,635 - 64,855,353 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172449   ⟹   ENSRNOP00000110921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1175,760,898 - 75,797,540 (-)Ensembl
RefSeq Acc Id: NM_001418663   ⟹   NP_001405592
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,760,138 - 75,797,540 (-)NCBI
mRatBN7.21162,254,621 - 62,292,026 (-)NCBI
RefSeq Acc Id: NM_012926   ⟹   NP_037058
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,772,260 - 75,797,256 (-)NCBI
mRatBN7.21162,266,744 - 62,291,742 (-)NCBI
Rnor_6.01164,828,688 - 64,853,681 (-)NCBI
Rnor_5.01167,255,123 - 67,291,544 (+)NCBI
RGSC_v3.41164,045,358 - 64,070,072 (-)RGD
Celera1161,768,874 - 61,793,351 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088035   ⟹   XP_038943963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,760,073 - 75,798,978 (-)NCBI
mRatBN7.21162,254,543 - 62,293,414 (-)NCBI
RefSeq Acc Id: XM_039088036   ⟹   XP_038943964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,760,073 - 75,798,908 (-)NCBI
mRatBN7.21162,254,543 - 62,293,393 (-)NCBI
RefSeq Acc Id: XM_063270307   ⟹   XP_063126377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,760,073 - 75,798,892 (-)NCBI
RefSeq Acc Id: XM_063270308   ⟹   XP_063126378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,760,073 - 75,798,892 (-)NCBI
RefSeq Acc Id: NP_037058   ⟸   NM_012926
- UniProtKB: A6IR66 (UniProtKB/TrEMBL),   O35187 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002089   ⟸   ENSRNOT00000002089
Ensembl Acc Id: ENSRNOP00000071419   ⟸   ENSRNOT00000089625
RefSeq Acc Id: XP_038943963   ⟸   XM_039088035
- Peptide Label: isoform X1
- UniProtKB: G3V671 (UniProtKB/TrEMBL),   O35187 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943964   ⟸   XM_039088036
- Peptide Label: isoform X1
- UniProtKB: G3V671 (UniProtKB/TrEMBL),   O35187 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001405592   ⟸   NM_001418663
- UniProtKB: O35187 (UniProtKB/TrEMBL),   A6IR66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126378   ⟸   XM_063270308
- Peptide Label: isoform X2
- UniProtKB: O35187 (UniProtKB/TrEMBL),   A6IR66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126377   ⟸   XM_063270307
- Peptide Label: isoform X1
- UniProtKB: O35187 (UniProtKB/TrEMBL),   G3V671 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110921   ⟸   ENSRNOT00000172449
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V671-F1-model_v2 AlphaFold G3V671 1-321 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2314 AgrOrtholog
BioCyc Gene G2FUF-21275 BioCyc
Ensembl Genes ENSRNOG00000001527 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002089 ENTREZGENE
  ENSRNOT00000002089.6 UniProtKB/TrEMBL
  ENSRNOT00000172449 ENTREZGENE
  ENSRNOT00000172449.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro CD80_C2-set UniProtKB/TrEMBL
  CD80_IgC UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  T-cell_Activation_Regulation UniProtKB/TrEMBL
NCBI Gene 25408 ENTREZGENE
PANTHER T-LYMPHOCYTE ACTIVATION ANTIGEN UniProtKB/TrEMBL
  T-LYMPHOCYTE ACTIVATION ANTIGEN CD80 UniProtKB/TrEMBL
Pfam C2-set_2 UniProtKB/TrEMBL
PhenoGen Cd80 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001527 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
TIGR TC221438
UniProt A0ABK0M1R6_RAT UniProtKB/TrEMBL
  A6IR62_RAT UniProtKB/TrEMBL
  A6IR63_RAT UniProtKB/TrEMBL
  A6IR66 ENTREZGENE, UniProtKB/TrEMBL
  G3V671 ENTREZGENE, UniProtKB/TrEMBL
  O35187 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Cd80  Cd80 molecule  LOC100360171  CD80-like  Data merged from RGD:2322678 737654 PROVISIONAL
2010-05-06 LOC100360171  CD80-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-29 Cd80  Cd80 molecule  Cd80  CD80 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cd80  CD80 antigen    Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1)  Name updated 625702 APPROVED
2002-06-10 Cd80  Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may be involved in induction of acute phase of experimental autoimmune anterior uveitis (EAAU) 1298745