RGD Reference Report - CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia. - Rat Genome Database

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CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia.

Authors: Roquilly, A  Gautreau, L  Segain, JP  De Coppet, P  Sebille, V  Jacqueline, C  Caillon, J  Potel, G  Lejus, C  Josien, R  Asehnoune, K 
Citation: Roquilly A, etal., PLoS One. 2010 Oct 7;5(10):e13228.
RGD ID: 4892562
Pubmed: PMID:20949109   (View Abstract at PubMed)
PMCID: PMC2951351   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0013228   (Journal Full-text)

Infections are the most frequent cause of complications in trauma patients. Post-traumatic immune suppression (IS) exposes patients to pneumonia (PN). The main pathogen involved in PN is Methicillin Susceptible Staphylococcus aureus (MSSA). Dendritic cells () may be centrally involved in the IS. We assessed the consequences of hemorrhage on pneumonia outcomes and investigated its consequences on DCs functions. A murine model of hemorrhagic shock with a subsequent MSSA pneumonia was used. Hemorrhage decreased the survival rate of infected mice, increased systemic dissemination of sepsis and worsened inflammatory lung lesions. The mRNA expression of Tumor Necrosis Factor-alpha (TNF-alpha), Interferon-beta (IFN-beta) and Interleukin (IL)-12p40 were mitigated for hemorrhaged-mice. The effects of hemorrhage on subsequent PN were apparent on the pDCs phenotype (reduced MHC class II, CD80, and CD86 molecule membrane expression). In addition, hemorrhage dramatically decreased CD8(+) cDCs- and CD8(-) cDCs-induced allogeneic T-cell proliferation during PN compared with mice that did not undergo hemorrhage. In conclusion, hemorrhage increased morbidity and mortality associated with PN; induced severe phenotypic disturbances of the pDCs subset and functional alterations of the cDCs subset. After hemorrhage, a preventive treatment with CpG-ODN or Monophosphoryl Lipid A increased transcriptional activity in DCs (TNF-alpha, IFN-beta and IL-12p40) and decreased mortality of post-hemorrhage MSSA pneumonia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bacterial pneumonia  ISOCd80 (Mus musculus)4892562; 4892562 RGD 
bacterial pneumonia  IEP 4892562 RGD 
Staphylococcal Pneumonia  ISOCd86 (Mus musculus)4892562; 4892562protein:decreased expression:spleen and plasmacytoid dendritic cell (mouse)RGD 
Staphylococcal Pneumonia  IEP 4892562protein:decreased expression:spleen and plasmacytoid dendritic cell (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd80  (Cd80 molecule)
Cd86  (CD86 molecule)

Genes (Mus musculus)
Cd80  (CD80 antigen)
Cd86  (CD86 antigen)

Genes (Homo sapiens)
CD80  (CD80 molecule)
CD86  (CD86 molecule)


Additional Information