Bsg (basigin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Bsg (basigin) Rattus norvegicus
Analyze
Symbol: Bsg
Name: basigin
RGD ID: 2220
Description: Predicted to enable cell-cell adhesion mediator activity; signaling receptor activity; and virus receptor activity. Involved in several processes, including decidualization; embryo implantation; and response to cAMP. Located in sarcolemma. Orthologous to human BSG (basigin (Ok blood group)); PARTICIPATES IN syndecan signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5A11; basigin (Ok blood group); Basigin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian); basignin; Basignin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian); CE9; EMMPRIN; glycoprotein CE9; HT7; neurothelin; OX-47 antigen; Ox47R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,643,788 - 10,651,005 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,643,789 - 10,651,005 (-)EnsemblGRCr8
mRatBN7.279,993,170 - 10,000,387 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,993,170 - 10,000,387 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,874,130 - 12,881,349 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,752,211 - 14,759,430 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,611,541 - 12,618,758 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,875,536 - 12,882,753 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,875,537 - 12,882,753 (-)Ensemblrn6Rnor6.0
Rnor_5.0713,044,572 - 13,051,789 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,507,914 - 11,515,132 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera78,166,570 - 8,173,787 (-)NCBICelera
RGSC_v3.1711,507,913 - 11,515,056 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-cotinine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carfilzomib  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cordycepin  (ISO)
corilagin  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
flavonoids  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
microcystin-LR  (ISO)
N(6),N(6)-dimethyladenosine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N6-(2-Hydroxyethyl)adenosine  (ISO)
ozone  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
solasodine  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
uridine 5'-monophosphate  (ISO)
valproic acid  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Emmprin and survivin predict response and survival following cisplatin-containing chemotherapy in patients with advanced bladder cancer. Als AB, etal., Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4407-14.
2. Matrix metalloproteinase induction by EMMPRIN in experimental focal cerebral ischemia. Burggraf D, etal., Eur J Neurosci. 2005 Jul;22(1):273-7.
3. MCT1 and its accessory protein CD147 are differentially regulated by TSH in rat thyroid cells. Fanelli A, etal., Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1223-9.
4. The MRC OX-47 antigen is a member of the immunoglobulin superfamily with an unusual transmembrane sequence. Fossum S, etal., Eur J Immunol 1991 Mar;21(3):671-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex. Hashimoto T, etal., Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1237-44. Epub 2006 Jan 24.
8. Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters. Jin JS, etal., Int J Gynecol Pathol. 2006 Apr;25(2):140-6.
9. EMMPRIN expression as a prognostic factor in radiotherapy of cervical cancer. Ju XZ, etal., Clin Cancer Res. 2008 Jan 15;14(2):494-501.
10. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. Kirk P, etal., EMBO J. 2000 Aug 1;19(15):3896-904.
11. Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Kuno N, etal., FEBS Lett 1998 Mar 27;425(2):191-4.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Abnormalities of sensory and memory functions in mice lacking Bsg gene. Naruhashi K, etal., Biochem Biophys Res Commun 1997 Jul 30;236(3):733-7.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Breaching the diffusion barrier that compartmentalizes the transmembrane glycoprotein CE9 to the posterior-tail plasma membrane domain of the rat spermatozoon. Nehme CL, etal., J Cell Biol 1993 Feb;120(3):687-94.
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Tumor collagenase stimulatory factor (TCSF) expression and localization in human lung and breast cancers. Polette M, etal., J Histochem Cytochem. 1997 May;45(5):703-9.
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Immunocytochemical and biochemical detection of EMMPRIN in the rat tooth germ: differentiation-dependent co-expression with MMPs and co-localization with caveolin-1 in membrane rafts of dental epithelial cells. Schwab W, etal., Histochem Cell Biol. 2007 Sep;128(3):195-203. Epub 2007 Aug 8.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Association of EMMPRIN and fascin expression in renal cell carcinoma: correlation with clinicopathological parameters. Tsai WC, etal., World J Urol. 2007 Mar;25(1):73-80. Epub 2006 Sep 23.
23. Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3. Ueda K, etal., Oncol Rep. 2007 Apr;17(4):731-5.
24. Inhibition of CD147 expression reduces tumor cell invasion in human prostate cancer cell line via RNA interference. Wang L, etal., Cancer Biol Ther. 2006 Jun;5(6):608-14. Epub 2006 Jun 5.
25. Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ. Wilson MC, etal., J Biol Chem. 2002 Feb 1;277(5):3666-72. Epub 2001 Nov 21.
26. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). Wilson MC, etal., J Biol Chem. 2005 Jul 22;280(29):27213-21. Epub 2005 May 24.
27. Basigin expression and hormonal regulation in the rat uterus during the peri-implantation period. Xiao LJ, etal., Reproduction. 2002 Aug;124(2):219-25.
28. [Expressions of CD147 and matrix metalloproteinase-2 in breast cancer and their correlations to prognosis] Zhou S, etal., Ai Zheng. 2005 Jul;24(7):874-9.
Additional References at PubMed
PMID:8889548   PMID:12939332   PMID:14645104   PMID:15215314   PMID:15758150   PMID:15946952   PMID:16733664   PMID:16791210   PMID:17869266   PMID:18000599   PMID:18243135   PMID:18769934  
PMID:19144954   PMID:19946888   PMID:20369476   PMID:20458337   PMID:20833797   PMID:21423176   PMID:21448785   PMID:21620857   PMID:22139963   PMID:22379341   PMID:23376485   PMID:23404084  
PMID:23525302   PMID:23856290   PMID:24968091   PMID:25468996   PMID:26195724   PMID:26261551   PMID:26316108   PMID:26697232   PMID:28716558   PMID:29914983   PMID:30446621   PMID:32594339  
PMID:32908452   PMID:33138345   PMID:37700592  


Genomics

Comparative Map Data
Bsg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,643,788 - 10,651,005 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,643,789 - 10,651,005 (-)EnsemblGRCr8
mRatBN7.279,993,170 - 10,000,387 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,993,170 - 10,000,387 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,874,130 - 12,881,349 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,752,211 - 14,759,430 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,611,541 - 12,618,758 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,875,536 - 12,882,753 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,875,537 - 12,882,753 (-)Ensemblrn6Rnor6.0
Rnor_5.0713,044,572 - 13,051,789 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,507,914 - 11,515,132 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera78,166,570 - 8,173,787 (-)NCBICelera
RGSC_v3.1711,507,913 - 11,515,056 (-)NCBI
Cytogenetic Map7q11NCBI
BSG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819571,283 - 583,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19571,277 - 583,498 (+)Ensemblhg38GRCh38
GRCh3719571,283 - 583,493 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619522,325 - 534,493 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3419522,324 - 534,492NCBI
Celera19234,501 - 246,669 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19342,018 - 354,031 (+)NCBIHuRef
CHM1_119570,866 - 583,082 (+)NCBICHM1_1
T2T-CHM13v2.019525,174 - 537,384 (+)NCBIT2T-CHM13v2.0
Bsg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,540,192 - 79,547,813 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,540,325 - 79,547,803 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381079,704,358 - 79,711,979 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,704,491 - 79,711,969 (+)Ensemblmm10GRCm38
MGSCv371079,167,103 - 79,174,724 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361079,107,629 - 79,115,022 (+)NCBIMGSCv36mm8
Celera1080,718,673 - 80,726,294 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Bsg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,148,051 - 7,156,178 (-)Ensembl
ChiLan1.0NW_0049554957,148,806 - 7,156,296 (-)NCBIChiLan1.0ChiLan1.0
BSG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,897,258 - 4,908,073 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,136,030 - 4,146,843 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl19539,815 - 551,456 (+)EnsemblpanPan2panpan1.1
BSG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,942,703 - 57,951,089 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,943,276 - 57,951,061 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2057,745,480 - 57,753,845 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02058,686,165 - 58,694,560 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,686,156 - 58,698,895 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,739,806 - 57,748,184 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,219,731 - 58,228,095 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,422,924 - 58,431,329 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bsg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,644,988 - 217,653,120 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588181,576 - 189,287 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936588181,688 - 189,795 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BSG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1277,735,586 - 77,743,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BSG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16309,579 - 320,209 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6309,506 - 321,785 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660818,757,164 - 8,768,688 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bsg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,913,099 - 7,920,804 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248287,913,297 - 7,920,891 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Bsg
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11155,161,261 - 155,168,495 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bsg
157 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:142
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000011275, ENSRNOT00000044275
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY120888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ199464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV119278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000011275   ⟹   ENSRNOP00000011275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,643,789 - 10,651,005 (-)Ensembl
mRatBN7.2 Ensembl79,993,171 - 10,000,387 (-)Ensembl
Rnor_6.0 Ensembl712,875,537 - 12,882,753 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000044275   ⟹   ENSRNOP00000050252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,643,789 - 10,651,005 (-)Ensembl
mRatBN7.2 Ensembl79,993,171 - 10,000,387 (-)Ensembl
Rnor_6.0 Ensembl712,875,537 - 12,882,753 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098215   ⟹   ENSRNOP00000078709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,644,194 - 10,651,005 (-)Ensembl
mRatBN7.2 Ensembl79,993,576 - 10,000,387 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105142   ⟹   ENSRNOP00000077586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,993,170 - 9,995,277 (-)Ensembl
RefSeq Acc Id: NM_001109882   ⟹   NP_001103352
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,643,788 - 10,651,005 (-)NCBI
mRatBN7.279,993,170 - 10,000,387 (-)NCBI
Rnor_6.0712,875,536 - 12,882,753 (-)NCBI
Rnor_5.0713,044,572 - 13,051,789 (-)NCBI
RGSC_v3.4711,507,914 - 11,515,132 (-)RGD
Celera78,166,570 - 8,173,787 (-)RGD
Sequence:
RefSeq Acc Id: NM_012783   ⟹   NP_036915
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,643,788 - 10,651,005 (-)NCBI
mRatBN7.279,993,170 - 10,000,387 (-)NCBI
Rnor_6.0712,875,536 - 12,882,753 (-)NCBI
Rnor_5.0713,044,572 - 13,051,789 (-)NCBI
RGSC_v3.4711,507,914 - 11,515,132 (-)RGD
Celera78,166,570 - 8,173,787 (-)RGD
Sequence:
RefSeq Acc Id: NP_036915   ⟸   NM_012783
- Peptide Label: isoform 2 precursor
- UniProtKB: Q6GT74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103352   ⟸   NM_001109882
- Peptide Label: isoform 1 precursor
- UniProtKB: Q7TNP1 (UniProtKB/Swiss-Prot),   P26453 (UniProtKB/Swiss-Prot),   A6K8Y4 (UniProtKB/TrEMBL),   A0A8I5ZLB7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050252   ⟸   ENSRNOT00000044275
Ensembl Acc Id: ENSRNOP00000011275   ⟸   ENSRNOT00000011275
Ensembl Acc Id: ENSRNOP00000078709   ⟸   ENSRNOT00000098215
Ensembl Acc Id: ENSRNOP00000077586   ⟸   ENSRNOT00000105142
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26453-F1-model_v2 AlphaFold P26453 1-388 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695055
Promoter ID:EPDNEW_R5579
Type:initiation region
Name:Bsg_1
Description:basigin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,882,673 - 12,882,733EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2220 AgrOrtholog
BioCyc Gene G2FUF-34883 BioCyc
Ensembl Genes ENSRNOG00000008414 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011275 ENTREZGENE
  ENSRNOT00000011275.9 UniProtKB/Swiss-Prot
  ENSRNOT00000044275 ENTREZGENE
  ENSRNOT00000044275.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889785 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
KEGG Report rno:25246 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72895 IMAGE-MGC_LOAD
NCBI Gene 25246 ENTREZGENE
PANTHER BASIGIN UniProtKB/Swiss-Prot
  PTHR10075 UniProtKB/Swiss-Prot
Pfam Ig_3 UniProtKB/Swiss-Prot
PhenoGen Bsg PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008414 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
TIGR TC204379
UniProt A0A8I5ZLB7 ENTREZGENE, UniProtKB/TrEMBL
  A6K8Y4 ENTREZGENE, UniProtKB/TrEMBL
  A6K8Y5_RAT UniProtKB/TrEMBL
  A6K8Y6_RAT UniProtKB/TrEMBL
  BASI_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6GT74 ENTREZGENE, UniProtKB/TrEMBL
  Q7TNP1 ENTREZGENE
UniProt Secondary Q7TNP1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-06-03 Bsg  basigin  Bsg  basigin (Ok blood group)  Name changed 629549 APPROVED
2019-05-06 Bsg  basigin (Ok blood group)  Bsg  basigin (Ok blood group)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-10 Bsg  basigin (Ok blood group)  Bsg  basigin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-11 Bsg  basigin  Bsg  basigin (Ok blood group)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Bsg  basigin (Ok blood group)  Bsg  basigin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Bsg  basigin       Symbol and Name status set to approved 70586 APPROVED
2001-12-21 Bsg  Basignin      Name withdrawn 61478 WITHDRAWN
2001-12-21 Bsg  basigin      Name updated 61478 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to the plasma membrane 69779
gene_cellular_localization localizes to the anterior-tail plasma membrane domain of the spermatozoon 69778
gene_domains contains one transmembrane domain, a cytoplasmic domain and an extracellular domain with two immunoglobulin-like domains 69779
gene_expression expressed in various immature cells, endothelia and cells with excitable membranes 69779
gene_expression expressed in spermatozoon 69778
gene_product member of the immunoglobulin superfamily 69779