RGD Reference Report - Basigin expression and hormonal regulation in the rat uterus during the peri-implantation period. - Rat Genome Database

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Basigin expression and hormonal regulation in the rat uterus during the peri-implantation period.

Authors: Xiao, LJ  Diao, HL  Ma, XH  Ding, NZ  Kadomatsu, K  Muramatsu, T  Yang, ZM 
Citation: Xiao LJ, etal., Reproduction. 2002 Aug;124(2):219-25.
RGD ID: 2289056
Pubmed: PMID:12141934   (View Abstract at PubMed)

Basigin is essential for fertilization and implantation. The aim of this study was to determine the expression and hormonal regulation of the basigin gene in the rat uterus during the peri-implantation period. Basigin mRNA was localized strongly in the luminal epithelium on day 1 of pregnancy and gradually decreased to a basal concentration from day 3 to day 5 of pregnancy. Basigin mRNA and protein were expressed strongly in the implanting blastocyst and primary decidua on day 6 of pregnancy. A similar expression pattern was also induced in the uterus after delayed implantation was terminated by oestrogen treatment and the embryo implanted, whereas expression was not detected during delayed implantation. Basigin expression was not detected on day 6 of pseudopregnancy. Basigin mRNA was expressed strongly in the decidua on days 7 and 8 of pregnancy. Furthermore, both basigin mRNA and protein were induced in the decidua during artificial decidualization. In addition, oestrogen stimulated strong expression of basigin mRNA in the uterine epithelium of ovariectomized rats. These findings indicate that basigin may play a role during implantation and decidualization in rats.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decidualization  IEP 2289056 RGD 
embryo implantation  IEP 2289056 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bsg  (basigin (Ok blood group))


Additional Information