Fxyd2 (FXYD domain-containing ion transport regulator 2) - Rat Genome Database

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Gene: Fxyd2 (FXYD domain-containing ion transport regulator 2) Rattus norvegicus
Analyze
Symbol: Fxyd2
Name: FXYD domain-containing ion transport regulator 2
RGD ID: 2173
Description: Predicted to enable ATPase activator activity; protein-macromolecule adaptor activity; and sodium channel regulator activity. Involved in cellular hyperosmotic salinity response; inorganic cation transmembrane transport; and negative regulation of cell population proliferation. Located in basolateral plasma membrane. Part of sodium:potassium-exchanging ATPase complex. Human ortholog(s) of this gene implicated in renal hypomagnesemia 2. Orthologous to human FXYD2 (FXYD domain containing ion transport regulator 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP1C; Atp1g1; ATPase Na+/K+ transporting gamma 1 polypeptide; ATPase, Na+/K+ transporting, gamma 1 polypeptide; FXTD domain-containing ion transport regulator 2; gamma subunit of sodium potassium ATPase; GNAKATP; na(+)/K(+) ATPase subunit gamma; sodium pump gamma chain; sodium/potassium-transporting ATPase gamma chain; sodium/potassium-transporting ATPase subunit gamma
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8854,609,658 - 54,616,788 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl854,609,658 - 54,616,957 (+)EnsemblGRCr8
mRatBN7.2845,712,901 - 45,720,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl845,712,903 - 45,720,203 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx851,214,299 - 51,220,774 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0849,493,069 - 49,499,544 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,357,158 - 47,363,642 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0849,710,334 - 49,717,492 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl849,710,477 - 49,716,955 (+)Ensemblrn6Rnor6.0
Rnor_5.0848,336,046 - 48,343,177 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4848,379,075 - 48,385,553 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera845,295,931 - 45,302,409 (+)NCBICelera
RGSC_v3.1848,387,840 - 48,394,319 (+)NCBI
Cytogenetic Map8q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-deoxy-D-glucose  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
barium(0)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
Deoxycorticosterone acetate  (EXP)
dicrotophos  (ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ethylparaben  (ISO)
flavonoids  (EXP)
furan  (EXP)
glycine betaine  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodimethylamine  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
potassium chloride  (EXP)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
spermidine  (ISO)
streptozocin  (EXP)
succimer  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Gamma structural variants differentially regulate Na,K-ATPase properties. Arystarkhova E and Wetzel RK, Ann N Y Acad Sci. 2003 Apr;986:416-9.
2. Distribution and oligomeric association of splice forms of Na(+)-K(+)-ATPase regulatory gamma-subunit in rat kidney. Arystarkhova E, etal., Am J Physiol Renal Physiol 2002 Mar;282(3):F393-407.
3. Differential regulation of renal Na,K-ATPase by splice variants of the gamma subunit. Arystarkhova E, etal., J Biol Chem 2002 Mar 22;277(12):10162-72.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Structure-function relations of interactions between Na,K-ATPase, the gamma subunit, and corticosteroid hormone-induced factor. Lindzen M, etal., J Biol Chem. 2003 May 23;278(21):18738-43. Epub 2003 Mar 7.
7. Structural interactions between FXYD proteins and Na+,K+-ATPase: alpha/beta/FXYD subunit stoichiometry and cross-linking. Lindzen M, etal., J Biol Chem. 2006 Mar 3;281(9):5947-55. Epub 2005 Dec 21.
8. Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit. Meij IC, etal., Nat Genet. 2000 Nov;26(3):265-6.
9. Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase. Mercer RW, etal., J Cell Biol 1993 May;121(3):579-86.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Locations, abundances, and possible functions of FXYD ion transport regulators in rat renal medulla. Pihakaski-Maunsbach K, etal., Am J Physiol Renal Physiol. 2006 Nov;291(5):F1033-44. Epub 2006 Jun 6.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Expression and functional role of the gamma subunit of the Na, K-ATPase in mammalian cells. Therien AG, etal., J Biol Chem 1999 Apr 30;274(18):12252-6.
18. Stress-induced expression of the gamma subunit (FXYD2) modulates Na,K-ATPase activity and cell growth. Wetzel RK, etal., J Biol Chem. 2004 Oct 1;279(40):41750-7. Epub 2004 Jul 26.
Additional References at PubMed
PMID:12907667   PMID:15755730   PMID:19056867   PMID:21460224   PMID:23376485  


Genomics

Comparative Map Data
Fxyd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8854,609,658 - 54,616,788 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl854,609,658 - 54,616,957 (+)EnsemblGRCr8
mRatBN7.2845,712,901 - 45,720,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl845,712,903 - 45,720,203 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx851,214,299 - 51,220,774 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0849,493,069 - 49,499,544 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,357,158 - 47,363,642 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0849,710,334 - 49,717,492 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl849,710,477 - 49,716,955 (+)Ensemblrn6Rnor6.0
Rnor_5.0848,336,046 - 48,343,177 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4848,379,075 - 48,385,553 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera845,295,931 - 45,302,409 (+)NCBICelera
RGSC_v3.1848,387,840 - 48,394,319 (+)NCBI
Cytogenetic Map8q22NCBI
FXYD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811117,820,057 - 117,828,089 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11117,800,839 - 117,828,698 (-)Ensemblhg38GRCh38
GRCh3711117,690,772 - 117,698,804 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,196,000 - 117,204,017 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411117,195,999 - 117,204,017NCBI
Celera11114,848,637 - 114,856,650 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11113,624,622 - 113,632,639 (-)NCBIHuRef
CHM1_111117,576,366 - 117,584,383 (-)NCBICHM1_1
T2T-CHM13v2.011117,836,469 - 117,844,497 (-)NCBIT2T-CHM13v2.0
Fxyd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,311,007 - 45,321,576 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,310,967 - 45,321,576 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38945,399,709 - 45,410,278 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,399,669 - 45,410,278 (+)Ensemblmm10GRCm38
MGSCv37945,207,792 - 45,218,361 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36945,150,213 - 45,161,273 (+)NCBIMGSCv36mm8
Celera942,679,863 - 42,690,444 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
Fxyd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541219,039,635 - 19,046,159 (-)Ensembl
ChiLan1.0NW_00495541219,039,635 - 19,046,172 (-)NCBIChiLan1.0ChiLan1.0
FXYD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29118,521,067 - 118,537,885 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111119,626,001 - 119,642,808 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011112,654,774 - 112,666,630 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111116,587,226 - 116,598,684 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11116,587,226 - 116,595,197 (-)EnsemblpanPan2panpan1.1
FXYD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1515,812,335 - 15,824,552 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl515,815,969 - 15,823,057 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha515,865,958 - 15,873,046 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0515,753,844 - 15,766,049 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl515,757,465 - 15,764,547 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1515,895,521 - 15,902,609 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0515,798,806 - 15,805,894 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0515,840,422 - 15,847,514 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fxyd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947100,035,374 - 100,039,684 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,956,785 - 2,963,506 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,956,784 - 2,961,076 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FXYD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl945,165,809 - 45,172,421 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1945,165,314 - 45,172,440 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2950,244,542 - 50,252,397 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FXYD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11109,187,301 - 109,199,729 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1109,186,886 - 109,198,267 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604316,860,199 - 16,864,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fxyd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478413,200,018 - 13,206,131 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478413,198,308 - 13,209,780 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fxyd2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1839,937,302 - 39,944,330 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fxyd2
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:522
Count of miRNA genes:172
Interacting mature miRNAs:192
Transcripts:ENSRNOT00000022074, ENSRNOT00000064611
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
RH141188  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8854,616,234 - 54,616,706 (+)Marker Load Pipeline
mRatBN7.2845,719,478 - 45,719,950 (+)MAPPERmRatBN7.2
Rnor_6.0849,716,939 - 49,717,410NCBIRnor6.0
Rnor_5.0848,342,624 - 48,343,095UniSTSRnor5.0
RGSC_v3.4848,385,537 - 48,386,008UniSTSRGSC3.4
Celera845,302,393 - 45,302,864UniSTS
RH 3.4 Map8460.3UniSTS
Cytogenetic Map8q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 145 91 90 59 91 59 6 353 189 11 121 81 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000022074   ⟹   ENSRNOP00000022074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl845,715,729 - 45,718,482 (+)Ensembl
Rnor_6.0 Ensembl849,713,190 - 49,716,955 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000064611   ⟹   ENSRNOP00000061133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl854,609,658 - 54,616,788 (+)Ensembl
mRatBN7.2 Ensembl845,712,903 - 45,720,201 (+)Ensembl
Rnor_6.0 Ensembl849,710,477 - 49,716,955 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108038   ⟹   ENSRNOP00000076935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl854,612,521 - 54,616,957 (+)Ensembl
mRatBN7.2 Ensembl845,712,907 - 45,720,203 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000168026   ⟹   ENSRNOP00000109670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl854,612,347 - 54,616,781 (+)Ensembl
RefSeq Acc Id: NM_017349   ⟹   NP_059045
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,609,658 - 54,616,788 (+)NCBI
mRatBN7.2845,712,901 - 45,720,032 (+)NCBI
Rnor_6.0849,710,477 - 49,716,955 (+)NCBI
Rnor_5.0848,336,046 - 48,343,177 (+)NCBI
RGSC_v3.4848,379,075 - 48,385,553 (+)RGD
Celera845,295,931 - 45,302,409 (+)RGD
Sequence:
RefSeq Acc Id: NM_145717   ⟹   NP_663769
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,612,466 - 54,616,788 (+)NCBI
mRatBN7.2845,715,709 - 45,720,032 (+)NCBI
Rnor_6.0849,713,190 - 49,716,955 (+)NCBI
Rnor_5.0848,336,046 - 48,343,177 (+)NCBI
RGSC_v3.4848,379,075 - 48,385,553 (+)RGD
Celera845,298,644 - 45,302,409 (+)NCBI
Sequence:
RefSeq Acc Id: NP_059045   ⟸   NM_017349
- Peptide Label: isoform b
- UniProtKB: A6J442 (UniProtKB/TrEMBL),   A0A8L2QTU3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_663769   ⟸   NM_145717
- Peptide Label: isoform a
- UniProtKB: Q9JKN3 (UniProtKB/Swiss-Prot),   Q9WUD3 (UniProtKB/Swiss-Prot),   Q04679 (UniProtKB/Swiss-Prot),   A6J444 (UniProtKB/TrEMBL),   A0A8L2QTU3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022074   ⟸   ENSRNOT00000022074
Ensembl Acc Id: ENSRNOP00000061133   ⟸   ENSRNOT00000064611
Ensembl Acc Id: ENSRNOP00000076935   ⟸   ENSRNOT00000108038
Ensembl Acc Id: ENSRNOP00000109670   ⟸   ENSRNOT00000168026

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04679-F1-model_v2 AlphaFold Q04679 1-66 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695917
Promoter ID:EPDNEW_R6442
Type:multiple initiation site
Name:Fxyd2_1
Description:FXYD domain-containing ion transport regulator 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0849,713,170 - 49,713,230EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2173 AgrOrtholog
BioCyc Gene G2FUF-30668 BioCyc
Ensembl Genes ENSRNOG00000016469 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064611 ENTREZGENE
  ENSRNOT00000168026 ENTREZGENE
Gene3D-CATH Single helix bin UniProtKB/Swiss-Prot
InterPro ATNG UniProtKB/Swiss-Prot
  FXYD_motif UniProtKB/Swiss-Prot
  Ion-transport_regulator_FXYD UniProtKB/Swiss-Prot
KEGG Report rno:29639 UniProtKB/Swiss-Prot
NCBI Gene 29639 ENTREZGENE
PANTHER SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA UniProtKB/Swiss-Prot
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA UniProtKB/Swiss-Prot
Pfam ATP1G1_PLM_MAT8 UniProtKB/Swiss-Prot
PhenoGen Fxyd2 PhenoGen
PROSITE FXYD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016469 RatGTEx
UniProt A0A8I5YBZ9_RAT UniProtKB/TrEMBL
  A0A8L2QTU3 ENTREZGENE, UniProtKB/TrEMBL
  A6J441_RAT UniProtKB/TrEMBL
  A6J442 ENTREZGENE, UniProtKB/TrEMBL
  A6J443_RAT UniProtKB/TrEMBL
  A6J444 ENTREZGENE, UniProtKB/TrEMBL
  A6J445_RAT UniProtKB/TrEMBL
  A6J446_RAT UniProtKB/TrEMBL
  ATNG_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JKN3 ENTREZGENE
  Q9WUD3 ENTREZGENE
UniProt Secondary Q9JKN3 UniProtKB/Swiss-Prot
  Q9WUD3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fxyd2  FXYD domain-containing ion transport regulator 2       Symbol and Name status set to approved 70586 APPROVED
2001-06-12 Atp1g1  ATPase, Na+/K+ transporting, gamma 1 polypeptide      Symbol and Name withdrawn 62408 WITHDRAWN
2001-06-12 Fxyd2  FXTD domain-containing ion transport regulator 2      Symbol and Name updated to reflect Human and Mouse nomenclature 62408 APPROVED

RGD Curation Notes
Note Type Note Reference
null modifies ATPase properties  
gene_expression gamma(b) isoform expressed predominantly in the distal convoluted tubule and connecting tubule of the kidney; gamma(a) isoform predominately expressed in isolated proximal tubule cells of kidney 631313
gene_physical_interaction interacts with renal Na(+)-K(+)-ATPase 631313
gene_process involved in regulation of sodium pump properties in kidney 625472
gene_process regulates affinity of Na+/K+ ATPase for ATP 1299857
gene_transcript two isoforms exist that differ in N-termini; gamma (a) and gamma (b) forms 631313