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Gene: Ampd1 (adenosine monophosphate deaminase 1) Rattus norvegicus

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Symbol:

Ampd1

Name:

adenosine monophosphate deaminase 1

RGD ID:

2109

Description:

Enables AMP deaminase activity and myosin heavy chain binding activity. Involved in response to ATP. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congestive heart failure and coronary artery disease. Orthologous to human AMPD1 (adenosine monophosphate deaminase 1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adenosine monophosphate deaminase 1 (AMPD1); adenosine monophosphate deaminase 1 (isoform M); AMP deaminase 1; Ampd; Ampd isoform A; Ampd01; myoadenylate deaminase; RATAMPD01

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AMPD1 (adenosine monophosphate deaminase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Ampd1 (adenosine monophosphate deaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ampd1 (adenosine monophosphate deaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AMPD1 (adenosine monophosphate deaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AMPD1 (adenosine monophosphate deaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ampd1 (adenosine monophosphate deaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AMPD1 (adenosine monophosphate deaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AMPD1 (adenosine monophosphate deaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ampd1 (adenosine monophosphate deaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ampd1 (adenosine monophosphate deaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PPP2CB (protein phosphatase 2 catalytic subunit beta)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Ampd1 (adenosine monophosphate deaminase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ampd1 (adenosine monophosphate deaminase 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AMPD1 (adenosine monophosphate deaminase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AMPD1 (adenosine monophosphate deaminase 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ampd1 (adenosine monophosphate deaminase 1 (isoform M))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ampd1 (adenosine monophosphate deaminase 1 (isoform M))	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AMD1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AMD1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	AMPdeam	Alliance	DIOPT (OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YJL070C	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ampd-1	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ampd1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ampd1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	193,287,219 - 193,308,446 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	193,287,265 - 193,308,443 (+)	Ensembl				GRCr8
mRatBN7.2	2	190,598,707 - 190,619,938 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	190,598,700 - 190,619,938 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	198,196,323 - 198,217,325 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	196,068,738 - 196,089,807 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	190,886,015 - 190,907,019 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	205,568,934 - 205,589,961 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	205,568,935 - 205,590,021 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	224,999,541 - 225,020,451 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	198,308,512 - 198,331,019 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	183,072,165 - 183,093,534 (+)	NCBI		Celera
RGSC_v3.1	2	198,271,265 - 198,293,773 (+)	NCBI
RH 3.4 Map	2	1322.2	RGD
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adenosine Monophosphate Deaminase Deficiency (ISO)

autistic disorder (ISO)

congestive heart failure (ISO)

coronary artery disease (ISO)

familial combined hyperlipidemia (ISO)

Familial Hypercholesterolemia due to Ligand-Defective Apolipoprotein B (ISO)

genetic disease (ISO)

Hyperlipoproteinemia Type II (ISO)

left ventricular failure (ISO)

lung adenocarcinoma (ISO)

Muscle Weakness (ISO)

muscular atrophy (ISO)

muscular disease (ISO)

Myocardial Ischemia (ISO)

MYOPATHY DUE TO MYOADENYLATE DEAMINASE DEFICIENCY (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

aflatoxin B1 (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

Butylbenzyl phthalate (ISO)

cadmium atom (EXP,ISO)

cadmium dichloride (EXP)

cefaloridine (EXP)

Cuprizon (EXP)

curcumin (ISO)

flavonoids (EXP)

flutamide (EXP)

furan (EXP)

gentamycin (EXP)

graphite (ISO)

hypochlorous acid (ISO)

imidacloprid (EXP)

lidocaine (EXP)

methamphetamine (EXP)

methotrexate (ISO)

ozone (ISO)

perfluorooctanoic acid (EXP)

pioglitazone (ISO)

potassium chromate (ISO)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

triticonazole (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

AMP metabolic process (IBA)

GMP salvage (IEA,ISO)

IMP biosynthetic process (IBA)

IMP salvage (IEA,ISO)

nucleotide metabolic process (IEA)

purine ribonucleoside monophosphate biosynthetic process (IEA)

response to ATP (IDA)

Cellular Component

cytosol (IBA)

Molecular Function

AMP deaminase activity (IBA,IDA,IEA,ISO)

deaminase activity (IEA)

hydrolase activity (IEA)

identical protein binding (IEA,ISO)

metal ion binding (IEA)

myosin heavy chain binding (IDA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

azathioprine pharmacodynamics pathway (ISO)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

purine metabolic pathway (IEA,ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A common variant of the AMPD1 gene predicts improved cardiovascular survival in patients with coronary artery disease.	Anderson JL, etal., J Am Coll Cardiol. 2000 Oct;36(4):1248-52. doi: 10.1016/s0735-1097(00)00850-0.
2.	Evaluation of AMPD1 C34T genotype as a predictor of mortality in heart failure and post-myocardial infarction patients.	Collins RP, etal., Am Heart J. 2006 Aug;152(2):312-20. doi: 10.1016/j.ahj.2005.12.015.
3.	Role of adenosine monophosphate deaminase-1 gene polymorphism in patients with congestive heart failure (influence on tumor necrosis factor-alpha level and outcome).	Gastmann A, etal., Am J Cardiol. 2004 May 15;93(10):1260-4. doi: 10.1016/j.amjcard.2004.02.011.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait.	Goodarzi MO, etal., Diabetes. 2005 Apr;54(4):1222-7.
7.	Control of AMP deaminase 1 binding to myosin heavy chain.	Hisatome I, etal., Am J Physiol. 1998 Sep;275(3 Pt 1):C870-81.
8.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9.	Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response.	Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
10.	Common variant in AMPD1 gene predicts improved clinical outcome in patients with heart failure.	Loh E, etal., Circulation. 1999 Mar 23;99(11):1422-5. doi: 10.1161/01.cir.99.11.1422.
11.	Regulation of rat AMP deaminase 3 (isoform C) by development and skeletal muscle fibre type.	Mahnke-Zizelman DK, etal., Biochem J 1997 Sep 1;326 ( Pt 2):521-9.
12.	A novel pathway for alternative splicing: identification of an RNA intermediate that generates an alternative 5' splice donor site not present in the primary transcript of AMPD1.	Mineo I, etal., Mol Cell Biol 1990 Oct;10(10):5271-8.
13.	Adenylate deaminase. A multigene family in humans and rats.	Morisaki T, etal., J Biol Chem 1990 Jul 15;265(20):11482-6.
14.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	A seven-gene prognostic model related to immune checkpoint PD-1 revealing overall survival in patients with lung adenocarcinoma.	Niu W and Jiang L, Math Biosci Eng. 2021 Jul 13;18(5):6136-6154. doi: 10.3934/mbe.2021307.
16.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
17.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
18.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
19.	GOA pipeline	RGD automated data pipeline
20.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
22.	Comprehensive gene review and curation	RGD comprehensive gene curation
23.	Cloning and expression of cDNA encoding heart-type isoform of AMP deaminase.	Wang X, etal., Gene. 1997 Apr 1;188(2):285-90. doi: 10.1016/s0378-1119(96)00818-9.
24.	A common variant of the AMPD1 gene predicts improved survival in patients with ischemic left ventricular dysfunction.	Yazaki Y, etal., J Card Fail. 2004 Aug;10(4):316-20. doi: 10.1016/j.cardfail.2003.10.008.

Additional References at PubMed

PMID:1429593	PMID:2345176	PMID:3624265	PMID:7287721	PMID:9857047	PMID:31880188	PMID:36815317

Genomics

Comparative Map Data

Ampd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	193,287,219 - 193,308,446 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	193,287,265 - 193,308,443 (+)	Ensembl				GRCr8
mRatBN7.2	2	190,598,707 - 190,619,938 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	190,598,700 - 190,619,938 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	198,196,323 - 198,217,325 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	196,068,738 - 196,089,807 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	190,886,015 - 190,907,019 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	205,568,934 - 205,589,961 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	205,568,935 - 205,590,021 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	224,999,541 - 225,020,451 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	198,308,512 - 198,331,019 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	183,072,165 - 183,093,534 (+)	NCBI		Celera
RGSC_v3.1	2	198,271,265 - 198,293,773 (+)	NCBI
RH 3.4 Map	2	1322.2	RGD
Cytogenetic Map	2	q34	NCBI

AMPD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	114,673,098 - 114,695,546 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	114,673,090 - 114,695,618 (-)	Ensembl			hg38	GRCh38
GRCh37	1	115,215,719 - 115,238,167 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	115,017,245 - 115,039,699 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	114,927,763 - 114,950,218	NCBI
Celera	1	113,444,980 - 113,467,497 (-)	NCBI		Celera
Cytogenetic Map	1	p13.2	NCBI
HuRef	1	113,074,205 - 113,096,714 (-)	NCBI		HuRef
CHM1_1	1	115,330,528 - 115,353,046 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	114,684,545 - 114,707,007 (-)	NCBI		T2T-CHM13v2.0

Ampd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	102,981,330 - 103,007,038 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	102,981,330 - 103,007,036 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	103,073,897 - 103,099,720 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	103,074,014 - 103,099,720 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	102,877,937 - 102,903,643 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	103,203,085 - 103,228,775 (+)	NCBI		MGSCv36	mm8
Celera	3	105,279,015 - 105,304,764 (+)	NCBI		Celera
Cytogenetic Map	3	F2.2	NCBI
cM Map	3	45.25	NCBI

Ampd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955435	17,962,514 - 17,991,556 (-)	Ensembl
ChiLan1.0	NW_004955435	17,962,487 - 17,991,625 (-)	NCBI	ChiLan1.0	ChiLan1.0

AMPD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	107,335,357 - 107,358,132 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	106,929,421 - 106,952,175 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	87,858,602 - 87,881,348 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	122,912,417 - 122,934,476 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	122,912,417 - 122,934,476 (+)	Ensembl			panPan2	panpan1.1

AMPD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	52,377,411 - 52,399,525 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	52,377,402 - 52,399,520 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	52,027,974 - 52,050,104 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	53,254,745 - 53,276,859 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	53,254,751 - 53,276,817 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	52,288,891 - 52,311,015 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	52,331,044 - 52,353,189 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	52,904,387 - 52,926,524 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ampd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	14,431,737 - 14,455,624 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936627	33,350 - 57,166 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936627	33,350 - 57,231 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AMPD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	105,868,897 - 105,893,769 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	105,868,834 - 105,892,171 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	116,057,642 - 116,080,925 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AMPD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	18,973,547 - 18,996,082 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	18,974,204 - 18,996,293 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	21,728,019 - 21,751,276 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ampd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	10,320,735 - 10,348,464 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624772	10,320,837 - 10,350,237 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ampd1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	54,940,654 - 54,963,312 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ampd1
119 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	11
Count of miRNA genes:	11
Interacting mature miRNAs:	11
Transcripts:	ENSRNOT00000025248
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	163997722	225110681	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	169358774	214358774	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	149957381	221199885	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	138595962	205135428	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	124537199	209621565	Rat
1581578	Cm49	Cardiac mass QTL 49	4.9	0.01	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	145807215	220931416	Rat
61458	Bp10	Blood pressure QTL 10	3.42		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	191709311	217961898	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	122597372	215234002	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	154723085	199723085	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	154723085	199723085	Rat
10043139	Iddm55	Insulin dependent diabetes mellitus QTL 55	3.1	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	150313808	195313808	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	154723085	199723085	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	205135267	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	154723085	199723085	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170652929	215652929	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	220931218	Rat
4889834	Pur24	Proteinuria QTL 24	5.8	0.014	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	171994826	205135428	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	188565047	233565047	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	192287802	229609668	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	154723085	199723085	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	184856304	229856304	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	184856304	229856304	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	159440760	195313808	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	144882354	205135428	Rat
1298083	Bp158	Blood pressure QTL 158	2.62		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	191709311	217961898	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
1357991	Ael2	Aortic elastin QTL 2	4.2	0.000071	aorta elastin amount (VT:0003905)	aortic elastin	2	169227906	214227906	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1331745	Bp203	Blood pressure QTL 203	4.377		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	192287802	221089121	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	184856304	229856304	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	192287802	237287802	Rat
1578671	Bmd10	Bone mineral density QTL 10	5.4		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	175931416	220931416	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	182024327	227024327	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	159440760	228950743	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	184482291	229482291	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	143746578	205135428	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150096616	195096616	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	145306936	212705578	Rat
7488929	Bp366	Blood pressure QTL 366		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	187663373	195783351	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	186850607	231850607	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	192287802	237287802	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	223841096	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150096616	195096616	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	182635347	227635347	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	220008837	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	184856304	229856304	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	165453811	210453811	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	163253030	208253030	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166372086	229820014	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat

Markers in Region

D2Wox37

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	190,613,715 - 190,613,866 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	205,583,921 - 205,584,071	NCBI	Rnor6.0
Rnor_5.0	2	225,014,411 - 225,014,561	UniSTS	Rnor5.0
RGSC_v3.4	2	198,324,984 - 198,325,134	UniSTS	RGSC3.4
Celera	2	183,086,855 - 183,087,005	UniSTS
Cytogenetic Map	2	q34	UniSTS

D2Arb16

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	190,602,746 - 190,602,963 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	205,572,952 - 205,573,168	NCBI	Rnor6.0
Rnor_5.0	2	225,003,539 - 225,003,755	UniSTS	Rnor5.0
RGSC_v3.4	2	198,312,440 - 198,312,656	UniSTS	RGSC3.4
RGSC_v3.4	2	198,312,439 - 198,312,656	RGD	RGSC3.4
Celera	2	183,076,093 - 183,076,309	UniSTS
RGSC_v3.1	2	198,275,193 - 198,275,410	RGD
SHRSP x BN Map	2	72.7698	RGD
SHRSP x BN Map	2	72.7698	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH94453

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	190,599,884 - 190,600,079 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	205,570,090 - 205,570,284	NCBI	Rnor6.0
Rnor_5.0	2	225,000,677 - 225,000,871	UniSTS	Rnor5.0
RGSC_v3.4	2	198,309,578 - 198,309,772	UniSTS	RGSC3.4
Celera	2	183,073,231 - 183,073,425	UniSTS
RH 3.4 Map	2	1322.2	UniSTS
Cytogenetic Map	2	q34	UniSTS

AI553520

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	190,619,248 - 190,619,361 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	205,589,272 - 205,589,384	NCBI	Rnor6.0
Rnor_5.0	2	225,019,762 - 225,019,874	UniSTS	Rnor5.0
RGSC_v3.4	2	198,330,330 - 198,330,442	UniSTS	RGSC3.4
Celera	2	183,092,845 - 183,092,957	UniSTS
Cytogenetic Map	2	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
14	12	62	160	89	88	57	81	57	6	323	176	11	139	68	89	31	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AH003130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J02811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M58688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M58689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025248 ⟹ ENSRNOP00000025248

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	193,287,265 - 193,308,441 (+)	Ensembl
mRatBN7.2 Ensembl	2	190,598,700 - 190,619,938 (+)	Ensembl
Rnor_6.0 Ensembl	2	205,568,935 - 205,590,021 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094047 ⟹ ENSRNOP00000088318

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	193,287,265 - 193,308,440 (+)	Ensembl
mRatBN7.2 Ensembl	2	190,604,271 - 190,619,938 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099011 ⟹ ENSRNOP00000086025

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	193,290,929 - 193,308,443 (+)	Ensembl
mRatBN7.2 Ensembl	2	190,602,416 - 190,619,938 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112496 ⟹ ENSRNOP00000080039

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	193,287,266 - 193,308,441 (+)	Ensembl
mRatBN7.2 Ensembl	2	190,598,819 - 190,619,938 (+)	Ensembl

RefSeq Acc Id:

NM_138876 ⟹ NP_620231

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	193,287,332 - 193,308,443 (+)	NCBI
mRatBN7.2	2	190,598,819 - 190,619,938 (+)	NCBI
Rnor_6.0	2	205,569,024 - 205,589,961 (+)	NCBI
Rnor_5.0	2	224,999,541 - 225,020,451 (+)	NCBI
RGSC_v3.4	2	198,308,512 - 198,331,019 (+)	RGD
Celera	2	183,072,165 - 183,093,534 (+)	RGD

Sequence:

show sequence

TCCCAGTCACAATGCCTCTGTTCAAACTTACAGGTCAAGGAAAACAAATTGATGATGCAATGCG
TAGCTTTGCTGAAAAAGTATTTGCCTCAGAAGTCAAAGATGAGGGAGGTCGGCACGAGATCTCC
CCCTTCGACGTGGATGAGATCTGCCCAATTTCCCTTCGTGAGATGCAGGCCCACATATTCCACA
TGGAGAACCTGTCCATGTCCATGGATGGCAGGAGGAAAAGGCGCTTCCAAGGACGGAAGACTGT
TAATTTGTCCATTCCGCAAAGTGAAACGTCTTCTACCAAACTGTCCCACATTGAAGAATTTATT
TCTTCATCCCCGACCTATGAGAGTGTGCCTGACTTCCAGAGGGTGCAGATCACTGGTGACTATG
CCTCTGGGGTAACTGTTGAAGACTTTGAGGTGGTTTGTAAAGGTCTCTATCGGGCTTTGTGTAT
ACGAGAGAAATACATGCAGAAGTCATTCCAGAGGTTCCCCAAGACCCCCTCCAAGTACCTGAGG
AACATCGACGGCGAAGCTTTGGTAGCAATCGAAAGCTTCTATCCAGTATTTACCCCTCCTCCGA
AGAAGGGAGAAGACCCCTTTCGCAGAGAAGACCTTCCCGCAAACCTGGGCTATCACCTCAAGAT
GAAGGGTGGTGTGATTTACATCTACCCTGATGAAGCAGCAGCCAGCAGAGATGAGCCCAAGCCC
TACCCTTACCCAAATCTGGATGACTTCCTGGATGACATGAATTTTTTGCTTGCTCTAATTGCAC
AAGGGCCTGTGAAGACTTACACTCACCGCCGTCTGAAGTTCCTCTCCTCCAAGTTCCAGGTCCA
TCAGATGCTGAATGAGATGGACGAGCTAAAGGAGCTGAAGAACAACCCCCACCGGGACTTTTAT
AACTGCAGGAAGGTGGATACTCACATCCACGCAGCTGCCTGCATGAACCAGAAGCACCTGCTGC
GCTTTATTAAGAAATCTTACCATATTGATGCTGACAGAGTGGTCTACAGCACCAAAGAGAAGAA
CCTGACCCTGAAGGAACTTTTTGCTCAATTAAATATGCATCCATATGACCTGACTGTTGACTCT
CTGGATGTTCATGCTGGACGGCAGACGTTCCAACGCTTCGATAAGTTCAATGACAAATACAATC
CGGTGGGTGCGAGTGAGCTTCGGGACCTCTACCTAAAAACAGACAACTACATTAACGGAGAGTA
TTTTGCCACTATCATCAAGGAGGTGGGTGCAGACCTGGTGGACGCCAAGTATCAGCATGCGGAG
CCCCGCTTGTCCATCTACGGTCGCAGTCCAGATGAGTGGAGCAAACTCTCCTCTTGGTTTGTCG
GCAACCGTATTTATTGCCCCAACATGACATGGATGATCCAAGTCCCCAGGATCTATGATGTGTT
CCGATCCAAGAATTTCCTGCCACACTTTGGAAAGATGCTGGAGAATATTTTCCTTCCAGTGTTT
GAGGCCACCATCAACCCCCAGACTCATCCAGACCTCAGTGTCTTCCTCAAGCATATCACTGGCT
TTGACAGTGTGGATGATGAGTCCAAACACAGTGGTCACATGTTTTCCTCCAAGAGTCCCAAACC
TGAGGAGTGGACAATGGAAAACAACCCGTCTTACACATATTATGCCTACTACATGTATGCAAAC
ATCATGGTGCTCAACTGCCTGAGAAAGGAACGAGGCATGAATACATTTTTGTTTCGCCCCCATT
GTGGTGAGGCTGGGGCTCTCACTCACCTCATGACAGCCTTTATGATAGCGGACAATATTTCGCA
CGGCCTGAACTTAAAGAAGAGTCCTGTGTTACAGTACCTATTTTTCTTAGCCCAGATCCCCATT
GCAATGTCGCCATTGAGTAACAACAGCCTGTTCCTCGAATATGCAAAAAACCCTTTCTTAGATT
TCCTCCAGAAAGGCCTCATGATCTCGCTGTCGACCGATGACCCGATGCAGTTCCATTTCACCAA
GGAGCCCCTGATGGAAGAGTACGCCATCGCAGCCCAGGTCTTCAAGCTGAGCACTTGTGACATG
TGTGAGGTGGCAAGGAACAGTGTCCTGCAGTGTGGAATTTCTCATGAGGAAAAAGCAAAGTTTC
TGGGCAACAATTACCTTGAGGAAGGTCCTGTTGGAAATGACATCCGAAGGACAAATGTGGCTCA
GATTCGCATGGCCTATCGTTATGAAACTTGGTGTTATGAACTCAATTTGATTGCTGAGGGCCTT
AAATCAACAGAATGAATAAAGTATGTGAACCGAAA

hide sequence

RefSeq Acc Id:

XM_006233060 ⟹ XP_006233122

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	193,287,219 - 193,308,446 (+)	NCBI
mRatBN7.2	2	190,598,707 - 190,619,938 (+)	NCBI
Rnor_6.0	2	205,568,934 - 205,589,961 (+)	NCBI
Rnor_5.0	2	224,999,541 - 225,020,451 (+)	NCBI

Sequence:

show sequence

AATCAAATGAGTGTCTGGTATGTCACAGAGTCAGTCTGCCATCCCCACAGTCTCTCTCCTTCCT
CTGCTGTGCTGTCCTAGAATCCAGGATCCCAGTCACAATGCCTCTGTTCAAACTTACAGAAATT
GATGATGCAATGCGTAGCTTTGCTGAAAAAGTATTTGCCTCAGAAGTCAAAGATGAGGGAGGTC
GGCACGAGATCTCCCCCTTCGACGTGGATGAGATCTGCCCAATTTCCCTTCGTGAGATGCAGGC
CCACATATTCCACATGGAGAACCTGTCCATGTCCATGGATGGCAGGAGGAAAAGGCGCTTCCAA
GGACGGAAGACTGTTAATTTGTCCATTCCGCAAAGTGAAACGTCTTCTACCAAACTGTCCCACA
TTGAAGAATTTATTTCTTCATCCCCGACCTATGAGAGTGTGCCTGACTTCCAGAGGGTGCAGAT
CACTGGTGACTATGCCTCTGGGGTAACTGTTGAAGACTTTGAGGTGGTTTGTAAAGGTCTCTAT
CGGGCTTTGTGTATACGAGAGAAATACATGCAGAAGTCATTCCAGAGGTTCCCCAAGACCCCCT
CCAAGTACCTGAGGAACATCGACGGCGAAGCTTTGGTAGCAATCGAAAGCTTCTATCCAGTATT
TACCCCTCCTCCGAAGAAGGGAGAAGACCCCTTTCGCAGAGAAGACCTTCCCGCAAACCTGGGC
TATCACCTCAAGATGAAGGGTGGTGTGATTTACATCTACCCTGATGAAGCAGCAGCCAGCAGAG
ATGAGCCCAAGCCCTACCCTTACCCAAATCTGGATGACTTCCTGGATGACATGAATTTTTTGCT
TGCTCTAATTGCACAAGGGCCTGTGAAGACTTACACTCACCGCCGTCTGAAGTTCCTCTCCTCC
AAGTTCCAGGTCCATCAGATGCTGAATGAGATGGACGAGCTAAAGGAGCTGAAGAACAACCCCC
ACCGGGACTTTTATAACTGCAGGAAGGTGGATACTCACATCCACGCAGCTGCCTGCATGAACCA
GAAGCACCTGCTGCGCTTTATTAAGAAATCTTACCATATTGATGCTGACAGAGTGGTCTACAGC
ACCAAAGAGAAGAACCTGACCCTGAAGGAACTTTTTGCTCAATTAAATATGCATCCATATGACC
TGACTGTTGACTCTCTGGATGTTCATGCTGGACGGCAGACGTTCCAACGCTTCGATAAGTTCAA
TGACAAATACAATCCGGTGGGTGCGAGTGAGCTTCGGGACCTCTACCTAAAAACAGACAACTAC
ATTAACGGAGAGTATTTTGCCACTATCATCAAGGAGGTGGGTGCAGACCTGGTGGACGCCAAGT
ATCAGCATGCGGAGCCCCGCTTGTCCATCTACGGTCGCAGTCCAGATGAGTGGAGCAAACTCTC
CTCTTGGTTTGTCGGCAACCGTATTTATTGCCCCAACATGACATGGATGATCCAAGTCCCCAGG
ATCTATGATGTGTTCCGATCCAAGAATTTCCTGCCACACTTTGGAAAGATGCTGGAGAATATTT
TCCTTCCAGTGTTTGAGGCCACCATCAACCCCCAGACTCATCCAGACCTCAGTGTCTTCCTCAA
GCATATCACTGGCTTTGACAGTGTGGATGATGAGTCCAAACACAGTGGTCACATGTTTTCCTCC
AAGAGTCCCAAACCTGAGGAGTGGACAATGGAAAACAACCCGTCTTACACATATTATGCCTACT
ACATGTATGCAAACATCATGGTGCTCAACTGCCTGAGAAAGGAACGAGGCATGAATACATTTTT
GTTTCGCCCCCATTGTGGTGAGGCTGGGGCTCTCACTCACCTCATGACAGCCTTTATGATAGCG
GACAATATTTCGCACGGCCTGAACTTAAAGAAGAGTCCTGTGTTACAGTACCTATTTTTCTTAG
CCCAGATCCCCATTGCAATGTCGCCATTGAGTAACAACAGCCTGTTCCTCGAATATGCAAAAAA
CCCTTTCTTAGATTTCCTCCAGAAAGGCCTCATGATCTCGCTGTCGACCGATGACCCGATGCAG
TTCCATTTCACCAAGGAGCCCCTGATGGAAGAGTACGCCATCGCAGCCCAGGTCTTCAAGCTGA
GCACTTGTGACATGTGTGAGGTGGCAAGGAACAGTGTCCTGCAGTGTGGAATTTCTCATGAGGA
AAAAGCAAAGTTTCTGGGCAACAATTACCTTGAGGAAGGTCCTGTTGGAAATGACATCCGAAGG
ACAAATGTGGCTCAGATTCGCATGGCCTATCGTTATGAAACTTGGTGTTATGAACTCAATTTGA
TTGCTGAGGGCCTTAAATCAACAGAATGAATAAAGTATGTGAACCGAA

hide sequence

RefSeq Acc Id:

XM_039101761 ⟹ XP_038957689

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	193,288,959 - 193,308,446 (+)	NCBI
mRatBN7.2	2	190,600,179 - 190,619,938 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_620231	(Get FASTA)	NCBI Sequence Viewer
	XP_006233122	(Get FASTA)	NCBI Sequence Viewer
	XP_038957689	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40726	(Get FASTA)	NCBI Sequence Viewer
	AAA40727	(Get FASTA)	NCBI Sequence Viewer
	AAB54086	(Get FASTA)	NCBI Sequence Viewer
	EDL85496	(Get FASTA)	NCBI Sequence Viewer
	EDL85497	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025248
	ENSRNOP00000080039
	ENSRNOP00000080039.1
	ENSRNOP00000088318
GenBank Protein	P10759	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_620231 ⟸ NM_138876

- UniProtKB:

Q6LDJ4 (UniProtKB/Swiss-Prot), P10759 (UniProtKB/Swiss-Prot), A6K3K3 (UniProtKB/TrEMBL), A0A8I6A1E3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPLFKLTGQGKQIDDAMRSFAEKVFASEVKDEGGRHEISPFDVDEICPISLREMQAHIFHMENL
SMSMDGRRKRRFQGRKTVNLSIPQSETSSTKLSHIEEFISSSPTYESVPDFQRVQITGDYASGV
TVEDFEVVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEALVAIESFYPVFTPPPKKGE
DPFRREDLPANLGYHLKMKGGVIYIYPDEAAASRDEPKPYPYPNLDDFLDDMNFLLALIAQGPV
KTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIK
KSYHIDADRVVYSTKEKNLTLKELFAQLNMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGA
SELRDLYLKTDNYINGEYFATIIKEVGADLVDAKYQHAEPRLSIYGRSPDEWSKLSSWFVGNRI
YCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFLPVFEATINPQTHPDLSVFLKHITGFDSV
DDESKHSGHMFSSKSPKPEEWTMENNPSYTYYAYYMYANIMVLNCLRKERGMNTFLFRPHCGEA
GALTHLMTAFMIADNISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQK
GLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKAKFLGNN
YLEEGPVGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE

hide sequence

RefSeq Acc Id:	XP_006233122 ⟸ XM_006233060
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2QD93 (UniProtKB/TrEMBL), A6K3K4 (UniProtKB/TrEMBL), A0A8I6A1E3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPLFKLTEIDDAMRSFAEKVFASEVKDEGGRHEISPFDVDEICPISLREMQAHIFHMENLSMSM DGRRKRRFQGRKTVNLSIPQSETSSTKLSHIEEFISSSPTYESVPDFQRVQITGDYASGVTVED FEVVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEALVAIESFYPVFTPPPKKGEDPFR REDLPANLGYHLKMKGGVIYIYPDEAAASRDEPKPYPYPNLDDFLDDMNFLLALIAQGPVKTYT HRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYH IDADRVVYSTKEKNLTLKELFAQLNMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASELR DLYLKTDNYINGEYFATIIKEVGADLVDAKYQHAEPRLSIYGRSPDEWSKLSSWFVGNRIYCPN MTWMIQVPRIYDVFRSKNFLPHFGKMLENIFLPVFEATINPQTHPDLSVFLKHITGFDSVDDES KHSGHMFSSKSPKPEEWTMENNPSYTYYAYYMYANIMVLNCLRKERGMNTFLFRPHCGEAGALT HLMTAFMIADNISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMI SLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKAKFLGNNYLEE GPVGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE hide sequence

Ensembl Acc Id:

ENSRNOP00000025248 ⟸ ENSRNOT00000025248

RefSeq Acc Id:	XP_038957689 ⟸ XM_039101761
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A1E3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000080039 ⟸ ENSRNOT00000112496

Ensembl Acc Id:

ENSRNOP00000088318 ⟸ ENSRNOT00000094047

Ensembl Acc Id:

ENSRNOP00000086025 ⟸ ENSRNOT00000099011

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P10759-F1-model_v2	AlphaFold	P10759	1-747	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691626

Promoter ID:

EPDNEW_R2151

Type:

initiation region

Name:

Ampd1_1

Description:

adenosine monophosphate deaminase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	205,568,958 - 205,569,018	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2109	AgrOrtholog
BioCyc Gene	G2FUF-51823	BioCyc
Ensembl Genes	ENSRNOG00000018656	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000025248	ENTREZGENE
	ENSRNOT00000094047	ENTREZGENE
	ENSRNOT00000112496	ENTREZGENE
	ENSRNOT00000112496.1	UniProtKB/Swiss-Prot
Gene3D-CATH	4.10.800.20	UniProtKB/Swiss-Prot
	Metal-dependent hydrolases	UniProtKB/Swiss-Prot
InterPro	A/AMP_deam_AS	UniProtKB/Swiss-Prot
	AMPD	UniProtKB/Swiss-Prot
	Metal_Hydrolase	UniProtKB/Swiss-Prot
KEGG Report	rno:25028	UniProtKB/Swiss-Prot
NCBI Gene	25028	ENTREZGENE
PANTHER	PTHR11359	UniProtKB/Swiss-Prot
	PTHR11359:SF1	UniProtKB/Swiss-Prot
Pfam	AMP_deaminase	UniProtKB/Swiss-Prot
PhenoGen	Ampd1	PhenoGen
PIRSF	AMP_deaminase_met	UniProtKB/Swiss-Prot
PROSITE	A_DEAMINASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000018656	RatGTEx
Superfamily-SCOP	SSF51556	UniProtKB/Swiss-Prot
UniProt	A0A8I6A1E3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GGZ6_RAT	UniProtKB/TrEMBL
	A0A8L2QD93	ENTREZGENE, UniProtKB/TrEMBL
	A6K3K3	ENTREZGENE, UniProtKB/TrEMBL
	A6K3K4	ENTREZGENE, UniProtKB/TrEMBL
	AMPD1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q63047_RAT	UniProtKB/TrEMBL
	Q6LDJ4	ENTREZGENE
UniProt Secondary	P78501	UniProtKB/Swiss-Prot
	Q6LDJ4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-07-28	Ampd1	adenosine monophosphate deaminase 1	Ampd1	adenosine monophosphate deaminase 1 (isoform M)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Ampd1	adenosine monophosphate deaminase 1 (isoform M)		adenosine monophosphate deaminase 1	Name updated	1299863	APPROVED
2002-06-10	Ampd1	Adenosine monophosphate deaminase 1			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in skeletal muscle	69751
gene_expression	expressed in adult cardiac muscle	69751
gene_function	catalyzes the conversion of AMP to IMP	632202
gene_process	plays a role in energy metabolism	632202

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)