Actc1 (actin, alpha, cardiac muscle 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Actc1 (actin, alpha, cardiac muscle 1) Rattus norvegicus
Analyze
Symbol: Actc1
Name: actin, alpha, cardiac muscle 1
RGD ID: 2026
Description: Predicted to enable ATP binding activity; microfilament motor activity; and myosin binding activity. Involved in cardiac muscle contraction; response to ethanol; and response to xenobiotic stimulus. Predicted to be located in several cellular components, including I band; filopodium; and lamellipodium. Predicted to be active in actin filament; glutamatergic synapse; and sarcomere. Biomarker of hypertension. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin alpha cardiac; actin alpha cardiac 1; actin, alpha cardiac muscle 1; actin, alpha, cardiac; actin, alpha, cardiac 1; alpha-actin cardiac; alpha-cardiac actin; MGC156490
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83121,266,291 - 121,271,827 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3121,266,291 - 121,271,827 (-)EnsemblGRCr8
mRatBN7.23100,811,987 - 100,817,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3100,811,987 - 100,817,523 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3104,444,093 - 104,449,627 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03113,043,134 - 113,048,668 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03110,726,488 - 110,732,015 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03105,507,403 - 105,512,939 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3105,507,403 - 105,512,939 (-)Ensemblrn6Rnor6.0
Rnor_5.03112,080,853 - 112,086,389 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4399,901,022 - 99,906,558 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera399,781,510 - 99,787,044 (-)NCBICelera
RGSC_v3.1399,797,449 - 99,798,402 (-)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diethyl malate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
estriol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
graphite  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
L-methionine  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. [Analysis of written enunciations of a patient as the basis for diagnosing schizophrenia] Falicki Z, etal., Pol Tyg Lek 1978 Aug 7;33(32):1259-60.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Current estimates from the Health Interview Survey: United States--1977. Howie LJ and Drury TF, Vital Health Stat 10 1978 Sep;(126):1-98.
4. Expression of the genes coding for the skeletal muscle and cardiac actions in the heart. Mayer Y, etal., Nucleic Acids Res 1984 Jan 25;12(2):1087-100.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. alpha-cardiac actin (ACTC) binds to the band 3 (AE1) cardiac isoform. Moura Lima PR, etal., J Cell Biochem. 2003 Aug 15;89(6):1215-21.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Olson TM, etal., Science. 1998 May 1;280(5364):750-2.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Endotoxin and cytokines alter contractile protein expression in cardiac myocytes in vivo. Patten M, etal., Pflugers Arch. 2001 Sep;442(6):920-7.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Medium perfusion enables engineering of compact and contractile cardiac tissue. Radisic M, etal., Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H507-16. Epub 2003 Oct 9.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion. Simkhovich BZ, etal., Arch Biochem Biophys. 2003 Dec 15;420(2):268-78.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Long-term alcohol administration inhibits synthesis of both myofibrillar and sarcoplasmic proteins in heart. Vary TC and Deiter G, Metabolism. 2005 Feb;54(2):212-9.
20. Nifedipine represses ion channels, transporters and Ca(2+)-binding proteins in hearts of spontaneously hypertensive rats. Zwadlo C and Borlak J, Toxicol Appl Pharmacol. 2006 Jun 15;213(3):224-34. Epub 2005 Dec 15.
Additional References at PubMed
PMID:8889548   PMID:9114002   PMID:12477932   PMID:12947022   PMID:14605248   PMID:15491989   PMID:16288873   PMID:16481394   PMID:16611632   PMID:16854843   PMID:17611253   PMID:17765196  
PMID:17947298   PMID:19182904   PMID:19666135   PMID:19799913   PMID:19946888   PMID:20962418   PMID:21362503   PMID:21423176   PMID:22364878   PMID:22516433   PMID:22664934   PMID:22750946  
PMID:23533145   PMID:23580065   PMID:24413018   PMID:29476059   PMID:30361391   PMID:35352799  


Genomics

Comparative Map Data
Actc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83121,266,291 - 121,271,827 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3121,266,291 - 121,271,827 (-)EnsemblGRCr8
mRatBN7.23100,811,987 - 100,817,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3100,811,987 - 100,817,523 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3104,444,093 - 104,449,627 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03113,043,134 - 113,048,668 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03110,726,488 - 110,732,015 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03105,507,403 - 105,512,939 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3105,507,403 - 105,512,939 (-)Ensemblrn6Rnor6.0
Rnor_5.03112,080,853 - 112,086,389 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4399,901,022 - 99,906,558 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera399,781,510 - 99,787,044 (-)NCBICelera
RGSC_v3.1399,797,449 - 99,798,402 (-)NCBI
Cytogenetic Map3q35NCBI
ACTC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381534,790,230 - 34,795,549 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1534,790,107 - 34,795,912 (-)Ensemblhg38GRCh38
GRCh371535,082,431 - 35,087,750 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361532,867,589 - 32,875,219 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341532,869,723 - 32,875,153NCBI
Celera1511,839,644 - 11,847,274 (-)NCBICelera
Cytogenetic Map15q14ENTREZGENE
HuRef1511,925,790 - 11,933,402 (-)NCBIHuRef
CHM1_11535,198,283 - 35,205,917 (-)NCBICHM1_1
T2T-CHM13v2.01532,595,427 - 32,600,746 (-)NCBIT2T-CHM13v2.0
Actc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392113,877,763 - 113,883,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2113,877,763 - 113,884,029 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382114,047,282 - 114,052,875 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2114,047,282 - 114,053,548 (-)Ensemblmm10GRCm38
MGSCv372113,873,025 - 113,878,547 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362113,738,730 - 113,744,252 (-)NCBIMGSCv36mm8
Celera2115,178,495 - 115,181,826 (-)NCBICelera
Cytogenetic Map2E4NCBI
cM Map257.55NCBI
Actc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554162,137,101 - 2,145,416 (-)Ensembl
ChiLan1.0NW_0049554162,139,541 - 2,144,678 (-)NCBIChiLan1.0ChiLan1.0
LOC100987752
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21624,005,887 - 24,013,787 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11528,151,250 - 28,162,184 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01513,707,475 - 13,712,905 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11531,966,278 - 31,971,782 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1531,966,278 - 31,971,782 (-)EnsemblpanPan2panpan1.1
ACTC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1302,514,825 - 2,519,398 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl302,514,824 - 2,519,382 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha302,565,508 - 2,570,605 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0302,629,472 - 2,634,566 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl302,629,472 - 2,634,456 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1302,564,616 - 2,569,707 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0302,663,927 - 2,669,017 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0302,792,736 - 2,797,835 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Actc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864081,053,582 - 81,059,040 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366731,092,717 - 1,100,331 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366731,092,700 - 1,098,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1136,281,167 - 136,286,547 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11136,281,119 - 136,286,551 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21152,412,178 - 152,417,610 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12648,105,271 - 48,110,670 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2648,105,216 - 48,110,896 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604892,799,132 - 92,804,294 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248042,005,997 - 2,011,023 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248042,006,439 - 2,011,809 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Actc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1592,246,878 - 92,252,481 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Actc1
17 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:95
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000011773
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)3116582412122654872Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
BG373920  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23100,811,733 - 100,811,903 (+)MAPPERmRatBN7.2
Rnor_6.03105,507,150 - 105,507,319NCBIRnor6.0
Rnor_5.03112,080,600 - 112,080,769UniSTSRnor5.0
RGSC_v3.4399,900,769 - 99,900,938UniSTSRGSC3.4
Celera399,781,257 - 99,781,426UniSTS
RH 3.4 Map3815.2UniSTS
Cytogenetic Map3q35UniSTS
LOC345651  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,664,470 - 11,665,066 (+)MAPPERmRatBN7.2
Rnor_6.01213,717,202 - 13,717,797NCBIRnor6.0
Rnor_5.01215,747,215 - 15,747,810UniSTSRnor5.0
RGSC_v3.41212,048,429 - 12,049,024UniSTSRGSC3.4
Celera1213,453,802 - 13,454,397UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map3q35UniSTS
STS_ADH2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23100,812,851 - 100,813,988 (+)MAPPERmRatBN7.2
mRatBN7.2437,621,193 - 37,621,465 (+)MAPPERmRatBN7.2
Rnor_6.0435,593,637 - 35,593,908NCBIRnor6.0
Rnor_6.03105,508,268 - 105,509,404NCBIRnor6.0
Rnor_5.0435,451,038 - 35,451,309UniSTSRnor5.0
Rnor_5.03112,081,718 - 112,082,854UniSTSRnor5.0
RGSC_v3.4399,901,887 - 99,903,023UniSTSRGSC3.4
RGSC_v3.4434,652,200 - 34,652,471UniSTSRGSC3.4
Celera433,105,107 - 33,105,378UniSTS
Celera399,782,375 - 99,783,511UniSTS
Cytogenetic Map3q35UniSTS
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 12 74 142 68 68 37 36 37 6 269 144 12 116 72 79 31 26 26

Sequence


Ensembl Acc Id: ENSRNOT00000011773   ⟹   ENSRNOP00000011773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3121,266,291 - 121,271,827 (-)Ensembl
mRatBN7.2 Ensembl3100,811,987 - 100,817,523 (-)Ensembl
Rnor_6.0 Ensembl3105,507,403 - 105,512,939 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116592   ⟹   ENSRNOP00000082679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3100,811,987 - 100,817,523 (-)Ensembl
RefSeq Acc Id: NM_019183   ⟹   NP_062056
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83121,266,291 - 121,271,827 (-)NCBI
mRatBN7.23100,811,987 - 100,817,523 (-)NCBI
Rnor_6.03105,507,403 - 105,512,939 (-)NCBI
Rnor_5.03112,080,853 - 112,086,389 (-)NCBI
RGSC_v3.4399,901,022 - 99,906,558 (-)RGD
Celera399,781,510 - 99,787,044 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062056 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI27452 (Get FASTA)   NCBI Sequence Viewer  
  EDL79827 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011773
  ENSRNOP00000011773.3
GenBank Protein P68035 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062056   ⟸   NM_019183
- UniProtKB: A0JPJ4 (UniProtKB/Swiss-Prot),   P68035 (UniProtKB/Swiss-Prot),   A6HP76 (UniProtKB/TrEMBL),   A0A0G2K4M6 (UniProtKB/TrEMBL),   A0A8I5ZVP6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011773   ⟸   ENSRNOT00000011773
Ensembl Acc Id: ENSRNOP00000082679   ⟸   ENSRNOT00000116592

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68035-F1-model_v2 AlphaFold P68035 1-377 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692298
Promoter ID:EPDNEW_R2822
Type:single initiation site
Name:Actc1_1
Description:actin, alpha, cardiac muscle 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03105,512,826 - 105,512,886EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2026 AgrOrtholog
BioCyc Gene G2FUF-48347 BioCyc
Ensembl Genes ENSRNOG00000008536 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011773 ENTREZGENE
  ENSRNOT00000011773.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7379877 IMAGE-MGC_LOAD
InterPro Actin UniProtKB/Swiss-Prot
  Actin/actin-like_CS UniProtKB/Swiss-Prot
  Actin_CS UniProtKB/Swiss-Prot
  ATPase_NBD UniProtKB/Swiss-Prot
KEGG Report rno:29275 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156490 IMAGE-MGC_LOAD
NCBI Gene 29275 ENTREZGENE
PANTHER PTHR11937 UniProtKB/Swiss-Prot
Pfam Actin UniProtKB/Swiss-Prot
PhenoGen Actc1 PhenoGen
PRINTS ACTIN UniProtKB/Swiss-Prot
PROSITE ACTINS_1 UniProtKB/Swiss-Prot
  ACTINS_2 UniProtKB/Swiss-Prot
  ACTINS_ACT_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008536 RatGTEx
SMART ACTIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
TIGR TC204129
UniProt A0A0G2K4M6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVP6 ENTREZGENE, UniProtKB/TrEMBL
  A0JPJ4 ENTREZGENE
  A6HP76 ENTREZGENE, UniProtKB/TrEMBL
  ACTC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0JPJ4 UniProtKB/Swiss-Prot
  P04270 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-15 Actc1  actin, alpha, cardiac muscle 1  Actc1  actin, alpha, cardiac 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Actc1  actin, alpha, cardiac 1  Actc1  actin alpha cardiac 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Actc1  actin alpha cardiac 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in cardiac muscle 69737
gene_homology gene has high similarity to the skeletal muscle actin Acta1 except for high divergence in the 3' untranslated sequence 69737
gene_homology has high similarity over 3'untranslated sequence with human cardiac muscle actin 69737
gene_product member of the actin family 69737