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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2026
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Actc1
Name: actin, alpha, cardiac muscle 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Actc1decreases expressionISOActc1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ACTC1 mRNAPMID:19770486 PMID:22228805
Actc1decreases methylationISOACTC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of ACTC1 5' UTR; Benzo(a)pyrene results in decreased methylation of ACTC1 promoterPMID:27901495
Actc1increases expressionISOACTC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ACTC1 mRNAPMID:22316170
Actc1increases methylationISOACTC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ACTC1 3' UTRPMID:27901495
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